EE200000581A - Kasvajavastase toimega indolüül-3-glüoksüülhappe derivaadid - Google Patents

Kasvajavastase toimega indolüül-3-glüoksüülhappe derivaadid

Info

Publication number: EE200000581A
Authority: EE; Estonia
Prior art keywords: indolyl; acid derivatives; antitumor activity; glyoxylic acid; glyoxylic
Prior art date: 1998-04-02

Application number

EEP200000581A

Other languages

English (en)

Inventor

Nickel Bernd

Szelenyi Istvan

Schmidt Jrgen

Emig Peter-Paul

Reichert Dietmar

G�Nther Eckhard

Brune Kay

Original Assignee

Asta Medica Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-02

Filing date

1999-03-22

Publication date

2002-02-15

1999-03-22 Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft

2002-02-15 Publication of EE200000581A publication Critical patent/EE200000581A/et

2004-10-15 Publication of EE04354B1 publication Critical patent/EE04354B1/et

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)

EEP200000581A 1998-04-02 1999-03-22 Indolüül-3-glüoksüülhappe derivaadid, nende kasutamine ravimite valmistamiseks ja neid sisaldavad kasvajavastase toimega ravimid EE04354B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19814838A DE19814838C2 (de)	1998-04-02	1998-04-02	Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP1999/001918 WO1999051224A1 (de)	1998-04-02	1999-03-22	Indolyl-3-glyoxylsäure-derivate mit antitumorwirkung

Publications (2)

Publication Number	Publication Date
EE200000581A true EE200000581A (et)	2002-02-15
EE04354B1 EE04354B1 (et)	2004-10-15

Family

ID=7863398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000581A EE04354B1 (et)	1998-04-02	1999-03-22	Indolüül-3-glüoksüülhappe derivaadid, nende kasutamine ravimite valmistamiseks ja neid sisaldavad kasvajavastase toimega ravimid

Country Status (33)

Country	Link
US (4)	US6232327B1 (et)
EP (1)	EP1071420B1 (et)
JP (2)	JP5253696B2 (et)
KR (1)	KR100583545B1 (et)
CN (1)	CN1148183C (et)
AR (1)	AR018175A1 (et)
AT (1)	ATE304352T1 (et)
AU (1)	AU768510B2 (et)
BG (1)	BG64838B1 (et)
BR (1)	BR9909902A (et)
CA (1)	CA2326833C (et)
DE (2)	DE19814838C2 (et)
DK (1)	DK1071420T3 (et)
EE (1)	EE04354B1 (et)
ES (1)	ES2249884T3 (et)
GE (1)	GEP20032967B (et)
HK (1)	HK1036408A1 (et)
HR (1)	HRP20000643A2 (et)
HU (1)	HUP0101530A3 (et)
ID (1)	ID26504A (et)
IL (2)	IL138737A0 (et)
IS (1)	IS2307B (et)
NO (1)	NO327721B1 (et)
NZ (1)	NZ507084A (et)
PL (1)	PL192779B1 (et)
RS (1)	RS49866B (et)
RU (1)	RU2262339C2 (et)
SK (1)	SK286393B6 (et)
TR (1)	TR200002853T2 (et)
TW (1)	TWI230608B (et)
UA (1)	UA70942C2 (et)
WO (1)	WO1999051224A1 (et)
ZA (1)	ZA200006150B (et)

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1998
- 1998-04-02 DE DE19814838A patent/DE19814838C2/de not_active Expired - Fee Related
1999
- 1999-03-22 ID IDW20001988A patent/ID26504A/id unknown
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- 1999-03-22 AU AU29349/99A patent/AU768510B2/en not_active Ceased
- 1999-03-22 IL IL13873799A patent/IL138737A0/xx active IP Right Grant
- 1999-03-22 AT AT99910372T patent/ATE304352T1/de active
- 1999-03-22 RS YUP-593/00A patent/RS49866B/sr unknown
- 1999-03-22 WO PCT/EP1999/001918 patent/WO1999051224A1/de active IP Right Grant
- 1999-03-22 CA CA002326833A patent/CA2326833C/en not_active Expired - Fee Related
- 1999-03-22 BR BR9909902-0A patent/BR9909902A/pt not_active IP Right Cessation
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- 1999-03-22 TR TR2000/02853T patent/TR200002853T2/xx unknown
- 1999-03-22 SK SK1430-2000A patent/SK286393B6/sk not_active IP Right Cessation
- 1999-03-22 EP EP99910372A patent/EP1071420B1/de not_active Expired - Lifetime
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- 1999-03-22 NZ NZ507084A patent/NZ507084A/en not_active IP Right Cessation
- 1999-03-23 TW TW088104599A patent/TWI230608B/zh not_active IP Right Cessation
- 1999-03-31 AR ARP990101501A patent/AR018175A1/es unknown
- 1999-04-02 US US09/285,058 patent/US6232327B1/en not_active Expired - Lifetime
2000
- 2000-09-22 IS IS5635A patent/IS2307B/is unknown
- 2000-09-27 IL IL138737A patent/IL138737A/en not_active IP Right Cessation
- 2000-09-29 NO NO20004916A patent/NO327721B1/no not_active IP Right Cessation
- 2000-10-02 HR HR20000643A patent/HRP20000643A2/hr not_active Application Discontinuation
- 2000-10-12 BG BG104849A patent/BG64838B1/bg unknown
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2001
- 2001-03-19 US US09/810,604 patent/US20030023093A1/en not_active Abandoned
- 2001-10-24 HK HK01107405A patent/HK1036408A1/xx not_active IP Right Cessation
2002
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2007
- 2007-08-20 US US11/894,591 patent/US20080027110A1/en not_active Abandoned
2011
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Also Published As

Publication number	Publication date
IL138737A (en)	2007-02-11
IS5635A (is)	2000-09-22
AR018175A1 (es)	2001-10-31
AU768510B2 (en)	2003-12-18
US20080027110A1 (en)	2008-01-31
HRP20000643A2 (en)	2001-04-30
YU59300A (sh)	2002-11-15
HUP0101530A2 (hu)	2001-11-28
CA2326833A1 (en)	1999-10-14
NO20004916L (no)	2000-12-01
NZ507084A (en)	2003-10-31
JP2002510622A (ja)	2002-04-09
KR100583545B1 (ko)	2006-05-26
ZA200006150B (en)	2001-01-11
NO20004916D0 (no)	2000-09-29
WO1999051224A1 (de)	1999-10-14
DE19814838C2 (de)	2001-01-18
IS2307B (is)	2007-10-15
KR20010042368A (ko)	2001-05-25
CN1299280A (zh)	2001-06-13
EE04354B1 (et)	2004-10-15
SK286393B6 (sk)	2008-09-05
DK1071420T3 (da)	2006-01-16
UA70942C2 (uk)	2004-11-15
DE19814838A1 (de)	1999-10-14
IL138737A0 (en)	2001-10-31
JP2011148809A (ja)	2011-08-04
ID26504A (id)	2001-01-11
TWI230608B (en)	2005-04-11
PL343525A1 (en)	2001-08-27
US20030195360A1 (en)	2003-10-16
RU2262339C2 (ru)	2005-10-20
BG64838B1 (bg)	2006-06-30
CN1148183C (zh)	2004-05-05
SK14302000A3 (sk)	2001-11-06
ES2249884T3 (es)	2006-04-01
GEP20032967B (en)	2003-05-27
BR9909902A (pt)	2000-12-26
US7579365B2 (en)	2009-08-25
EP1071420B1 (de)	2005-09-14
BG104849A (en)	2001-05-31
AU2934999A (en)	1999-10-25
US20030023093A1 (en)	2003-01-30
HUP0101530A3 (en)	2002-12-28
US6232327B1 (en)	2001-05-15
NO327721B1 (no)	2009-09-14
PL192779B1 (pl)	2006-12-29
JP5253696B2 (ja)	2013-07-31
HK1036408A1 (en)	2002-01-04
TR200002853T2 (tr)	2001-02-21
EP1071420A1 (de)	2001-01-31
DE59912562D1 (en)	2005-10-20
CA2326833C (en)	2009-06-23
RS49866B (sr)	2008-08-07
ATE304352T1 (de)	2005-09-15

Publication	Publication Date	Title
EE200000581A (et)	2002-02-15	Kasvajavastase toimega indolüül-3-glüoksüülhappe derivaadid
NO20004787D0 (no)	2000-09-25	Indolderivater med antiviral aktivitet
ATE248812T1 (de)	2003-09-15	Arylsulfonylhydroxamsäurederivate
DK1003720T3 (da)	2004-05-10	Aryloxyarylsulfonylaminohydroxamsyrederivater
EE200100466A (et)	2002-12-16	Tuumorivastase toimega kamptotetsiiniderivaadid
NO20010743D0 (no)	2001-02-14	Antivirale indoloksoacetyl-piperazin-derivater
PT1084114E (pt)	2004-12-31	Derivados isotiazole uteis como agentes anticancerigenos
NO20010193L (no)	2001-01-12	Tiobenzimidazol-derivater
PT1077957E (pt)	2004-10-29	Derivados do acido oxi-iminoalcanoico
ATE236136T1 (de)	2003-04-15	Benzosulfonderivate
PT1090019E (pt)	2005-01-31	Derivados de adenosina
ATE259810T1 (de)	2004-03-15	Phenyl-xanthinderivate
NO20010514D0 (no)	2001-01-30	Aminometylkarboksylsyre-derivater
TR199802289A3 (tr)	1999-06-21	Fosfonasit-ikame etmis benzazepinon-n-asetikasit türevleri.
ATE259364T1 (de)	2004-02-15	Substituierte n-benzyl-indol-3-yl- glyoxylsäure- derivate mit antitumorwirkung
IS5562A (is)	2000-07-14	Nýjar díhýdroxýhexanósýru afleiður
DE59909387D1 (de)	2004-06-09	Elektrokardiogramm-Anordnung
PT1056716E (pt)	2003-04-30	Derivados de ciclo-hexanodiolo
DK1115716T3 (da)	2003-02-24	2-phenylpyran-4-on-derivater
ATE233253T1 (de)	2003-03-15	Chromanderivate
DK1134219T3 (da)	2005-10-17	Cucloalkylsubstituerede aminomethylpyrrolidinderivater
TR200002831A3 (tr)	2001-04-20	Kinolin-4-Il türevleri I
EE04061B1 (et)	2003-06-16	Metüleenbisfosfoonhappe derivaadid
DE59907635D1 (de)	2003-12-11	Pyrazolyldioxothiochromanoyl-derivate
ATA138898A (de)	1999-07-15	Hackmaschine

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