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FR2182915A1 - Substd indoles, benzimidazoles - as anti-immune agents , antitumour agents, serotonin inhibitors, hypnotics - Google Patents

Substd indoles, benzimidazoles - as anti-immune agents , antitumour agents, serotonin inhibitors, hypnotics

Info

Publication number
FR2182915A1
FR2182915A1 FR7311450A FR7311450A FR2182915A1 FR 2182915 A1 FR2182915 A1 FR 2182915A1 FR 7311450 A FR7311450 A FR 7311450A FR 7311450 A FR7311450 A FR 7311450A FR 2182915 A1 FR2182915 A1 FR 2182915A1
Authority
FR
France
Prior art keywords
agents
substd
hypnotics
benzimidazoles
indoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7311450A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nelson Research and Development Co
Original Assignee
Nelson Research and Development Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nelson Research and Development Co filed Critical Nelson Research and Development Co
Publication of FR2182915A1 publication Critical patent/FR2182915A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Title cpds. have formulae (I) and (II):- (where R1-3 are H or 1-8C alkyl; R4 is H or benzyl opt. 0-5 times substd. by 1-8C alkyl or alkoxy halogen), esp. 2-benzyl-5-hydroxytryptamine and 1-(2-aminoethyl)-2-benzyl-5-methoxybenzimidazole.
FR7311450A 1972-03-30 1973-03-29 Substd indoles, benzimidazoles - as anti-immune agents , antitumour agents, serotonin inhibitors, hypnotics Withdrawn FR2182915A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1515272 1972-03-30

Publications (1)

Publication Number Publication Date
FR2182915A1 true FR2182915A1 (en) 1973-12-14

Family

ID=10053967

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7311450A Withdrawn FR2182915A1 (en) 1972-03-30 1973-03-29 Substd indoles, benzimidazoles - as anti-immune agents , antitumour agents, serotonin inhibitors, hypnotics

Country Status (4)

Country Link
JP (1) JPS497271A (en)
BE (1) BE797617A (en)
DE (1) DE2315989A1 (en)
FR (1) FR2182915A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998013368A1 (en) * 1996-09-25 1998-04-02 Astra Aktiebolag (Publ) New pharmaceutically active compounds
US6153641A (en) * 1996-09-10 2000-11-28 Astra Aktiebolag Pharmaceutically active compounds
US6337342B1 (en) 1997-12-23 2002-01-08 Astrazeneca Ab Bis-aryl or heteroaryl indoles
US6346625B1 (en) 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
US6458792B1 (en) 1998-03-13 2002-10-01 Astrazeneca Ab Compounds
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034223B2 (en) * 1980-06-18 1985-08-07 株式会社東芝 metal vapor discharge lamp
DE3684992D1 (en) * 1985-05-31 1992-05-27 Don D Porteous TOOTH RESTORATION, STRUCTURE AND PROCEDURE.
DE19946301A1 (en) 1998-04-02 2001-04-19 Asta Medica Ag Antitumor agents and angiogenesis inhibitors having low neurotoxicity, comprise indole-3-glyoxylamide derivatives, are effective against resistant and metastasis-forming carcinomas
DE19814838C2 (en) 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylic acid derivatives with anti-tumor effects
CN108997172B (en) * 2018-08-08 2020-12-15 中国人民解放军总医院 antitumor compounds
WO2020072675A1 (en) 2018-10-02 2020-04-09 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c)
CN112358433B (en) * 2020-11-20 2022-03-01 河北维达康生物科技有限公司 A kind of method that utilizes 5-hydroxytryptamine-containing enzyme-catalyzed fermentation broth to prepare 5-hydroxytryptamine hydrochloride

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153641A (en) * 1996-09-10 2000-11-28 Astra Aktiebolag Pharmaceutically active compounds
WO1998013368A1 (en) * 1996-09-25 1998-04-02 Astra Aktiebolag (Publ) New pharmaceutically active compounds
US6271231B1 (en) 1996-09-25 2001-08-07 Astra Aktiebolag Pharmaceutically active compounds
US6337342B1 (en) 1997-12-23 2002-01-08 Astrazeneca Ab Bis-aryl or heteroaryl indoles
US6458792B1 (en) 1998-03-13 2002-10-01 Astrazeneca Ab Compounds
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6346625B1 (en) 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors

Also Published As

Publication number Publication date
DE2315989A1 (en) 1973-10-04
BE797617A (en) 1973-07-16
JPS497271A (en) 1974-01-22

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Legal Events

Date Code Title Description
ST Notification of lapse