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EE04706B1 - Aparaat pulbrilise medikamendi aerosoolimiseks ning meetodid selle kasutamiseks - Google Patents

Aparaat pulbrilise medikamendi aerosoolimiseks ning meetodid selle kasutamiseks

Info

Publication number
EE04706B1
EE04706B1 EEP200000721A EEP200000721A EE04706B1 EE 04706 B1 EE04706 B1 EE 04706B1 EE P200000721 A EEP200000721 A EE P200000721A EE P200000721 A EEP200000721 A EE P200000721A EE 04706 B1 EE04706 B1 EE 04706B1
Authority
EE
Estonia
Prior art keywords
aerosolizing
methods
powdered medicament
powdered
medicament
Prior art date
Application number
EEP200000721A
Other languages
English (en)
Estonian (et)
Inventor
D. Burr John
E. Smith Adrian
K. Hall Randy
Snyder Herm
Schuler Carlos
S. Axford George
Ray Charles
Original Assignee
Inhale Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutic Systems filed Critical Inhale Therapeutic Systems
Publication of EE200000721A publication Critical patent/EE200000721A/xx
Publication of EE04706B1 publication Critical patent/EE04706B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medicinal Preparation (AREA)
  • Nozzles (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Drying Of Solid Materials (AREA)
  • Glanulating (AREA)
EEP200000721A 1998-06-04 1999-05-19 Aparaat pulbrilise medikamendi aerosoolimiseks ning meetodid selle kasutamiseks EE04706B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8792998P 1998-06-04 1998-06-04
US09/312,434 US6257233B1 (en) 1998-06-04 1999-05-14 Dry powder dispersing apparatus and methods for their use
PCT/US1999/011180 WO1999062495A2 (en) 1998-06-04 1999-05-19 Dry powder dispersing apparatus and methods for their use

Publications (2)

Publication Number Publication Date
EE200000721A EE200000721A (et) 2002-04-15
EE04706B1 true EE04706B1 (et) 2006-10-16

Family

ID=26777530

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000721A EE04706B1 (et) 1998-06-04 1999-05-19 Aparaat pulbrilise medikamendi aerosoolimiseks ning meetodid selle kasutamiseks

Country Status (42)

Country Link
US (5) US6257233B1 (bg)
EP (1) EP1082155B1 (bg)
JP (2) JP4044734B2 (bg)
KR (1) KR100608118B1 (bg)
CN (1) CN1217711C (bg)
AP (1) AP1443A (bg)
AR (1) AR018443A1 (bg)
AT (1) ATE339232T1 (bg)
AU (1) AU775629B2 (bg)
BG (1) BG65349B1 (bg)
BR (1) BR9910931A (bg)
CA (1) CA2332853C (bg)
CO (1) CO5021133A1 (bg)
CY (1) CY1105808T1 (bg)
DE (1) DE69933210T2 (bg)
DK (1) DK1082155T3 (bg)
DZ (1) DZ2810A1 (bg)
EA (1) EA002869B1 (bg)
EE (1) EE04706B1 (bg)
ES (1) ES2273490T3 (bg)
HK (1) HK1031696A1 (bg)
HR (1) HRP20010008A2 (bg)
HU (1) HUP0103610A3 (bg)
ID (1) ID29131A (bg)
IL (1) IL139791A (bg)
IS (1) IS5706A (bg)
MA (1) MA24907A1 (bg)
MY (1) MY135967A (bg)
NO (1) NO20006167L (bg)
NZ (1) NZ508536A (bg)
OA (1) OA11692A (bg)
PA (1) PA8474901A1 (bg)
PE (1) PE20000626A1 (bg)
PL (1) PL196080B1 (bg)
PT (1) PT1082155E (bg)
RS (1) RS49669B (bg)
SA (1) SA99200468B1 (bg)
SK (1) SK285882B6 (bg)
TR (1) TR200003611T2 (bg)
TW (1) TW509069U (bg)
UY (1) UY25537A1 (bg)
WO (1) WO1999062495A2 (bg)

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
CA2555600C (en) * 1994-09-21 2008-01-29 Nektar Therapeutics Apparatus and methods for dispersing dry powder medicaments
US6082358A (en) 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US6257233B1 (en) * 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
WO2001026720A1 (en) * 1999-10-12 2001-04-19 Shl Medical Ab Inhaler
EP1223915B1 (en) * 1999-10-29 2005-12-21 Nektar Therapeutics Dry powder compositions having improved dispersivity
US6679256B2 (en) * 1999-12-17 2004-01-20 Nektar Therapeutics Systems and methods for extracting powders from receptacles
US7304750B2 (en) * 1999-12-17 2007-12-04 Nektar Therapeutics Systems and methods for non-destructive mass sensing
US20010035184A1 (en) 1999-12-17 2001-11-01 Carlos Schuler Systems and methods for treating packaged powders
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US6948494B1 (en) * 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US6668827B2 (en) 2000-05-16 2003-12-30 Nektar Therapeutics Systems devices and methods for opening receptacles having a powder to be fluidized
GB0025749D0 (en) * 2000-10-20 2000-12-06 Glaxo Group Ltd Inhaler
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US20110301569A1 (en) 2001-01-20 2011-12-08 Gordon Wayne Dyer Methods and apparatus for the CVCS
US6595204B2 (en) * 2001-03-01 2003-07-22 Iep Pharmaceutical Devices Inc. Spacer for an inhaler
US7905230B2 (en) * 2001-05-09 2011-03-15 Novartis Ag Metered dose inhaler with lockout
AU2002344809A1 (en) 2001-06-20 2003-01-08 Inhale Therapeutic Systems, Inc. Flow regulator for aerosol drug delivery device and methods
US7540284B2 (en) * 2001-06-20 2009-06-02 Novartis Pharma Ag Powder aerosolization apparatus and method
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6779520B2 (en) * 2001-10-30 2004-08-24 Iep Pharmaceutical Devices Inc. Breath actuated dry powder inhaler
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
TWI324518B (en) * 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
AU2002360491A1 (en) * 2001-12-21 2003-07-24 Nektar Therapeutics Apparatus and method for sealing cavities
EP1458630A1 (en) * 2001-12-21 2004-09-22 Nektar Therapeutics Capsule package with moisture barrier
US6591832B1 (en) * 2002-02-21 2003-07-15 Saint-Gobain Calmar Inc. Dry powder dispenser
US6705316B2 (en) 2002-03-11 2004-03-16 Battelle Pulmonary Therapeutics, Inc. Pulmonary dosing system and method
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
US6799571B1 (en) * 2002-06-19 2004-10-05 Molecular Rotation, Llc Medicinal powder delivery system
US6941980B2 (en) * 2002-06-27 2005-09-13 Nektar Therapeutics Apparatus and method for filling a receptacle with powder
US7516741B2 (en) * 2002-12-06 2009-04-14 Novartis Ag Aerosolization apparatus with feedback mechanism
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US20050236296A1 (en) * 2002-12-30 2005-10-27 Nektar Therapeutics (Formerly Inhale Therapeutic Systems, Inc.) Carry case for aerosolization apparatus
US20050056280A1 (en) * 2002-12-31 2005-03-17 Nektar Therapeutics Receptacle for an aerosolizable pharmaceutical formulation
ES2589578T5 (es) * 2002-12-31 2019-07-23 Novartis Ag Formulación farmacéutica con un agente activo insoluble para administración pulmonar
AU2003302274A1 (en) * 2002-12-31 2004-07-29 Novartis Ag Aerosolizable pharmaceutical formulation for fungal infection therapy
US7669596B2 (en) * 2002-12-31 2010-03-02 Novartis Pharma Ag Aerosolization apparatus with rotating capsule
US8869794B1 (en) 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
DK1610850T3 (da) * 2003-04-09 2012-06-25 Novartis Ag Aerosolapparat med luftindløbsskærm
ES2564165T3 (es) * 2003-04-09 2016-03-18 Novartis Ag Aparato de aerosolización con guía de alineación para la perforación de la cápsula
US7726308B1 (en) 2003-05-09 2010-06-01 Maurino Flora Apparatus and method for respiratory drug delivery
EP1488819A1 (en) 2003-06-16 2004-12-22 Rijksuniversiteit te Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
GB2405798A (en) * 2003-09-15 2005-03-16 Vectura Ltd Dry powder inhaler with primary and secondary piercing elements and a medicament pack for use with an inhalation device.
US20050214224A1 (en) * 2003-11-04 2005-09-29 Nektar Therapeutics Lipid formulations for spontaneous drug encapsulation
DE10352277A1 (de) * 2003-11-08 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
US7311270B2 (en) * 2003-12-23 2007-12-25 M-I L.L.C. Device and methodology for improved mixing of liquids and solids
CA2553392A1 (en) * 2004-01-16 2005-08-11 Biodel Inc Sublingual drug delivery device
JP2007522246A (ja) * 2004-02-12 2007-08-09 ネクター セラピューティクス インターロイキン−１３拮抗剤粉末剤、スプレードライ粒子、及び方法
DE102004009434A1 (de) 2004-02-24 2005-12-15 Boehringer Ingelheim International Gmbh Zerstäuber
DE102004012093A1 (de) * 2004-03-05 2005-09-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Merkanaldüse
BE1015883A3 (fr) * 2004-06-08 2005-10-04 Occhio Procede et dispositif de dispersion de poudres seches.
WO2006002140A2 (en) * 2004-06-21 2006-01-05 Nektar Therapeutics Compositions comprising amphotericin b
US8513204B2 (en) * 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
SE0401786D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Inhaler device
KR101276754B1 (ko) 2004-07-19 2013-06-19 바이오콘 리미티드 인슐린―올리고머 접합체，제형 및 이들의 용도
EP1786784B1 (en) 2004-08-20 2010-10-27 MannKind Corporation Catalysis of diketopiperazine synthesis
KR20150039211A (ko) 2004-08-23 2015-04-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
GB0420513D0 (en) 2004-09-15 2004-10-20 Optinose As Powder delivery devices
EP1807136A2 (en) * 2004-10-12 2007-07-18 Aradigm Corporation Device and method for generating an aerosol from a liquid formulation and ensuring its sterility
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
CN101184522B (zh) 2005-05-18 2011-12-21 尼克塔治疗公司 用于支气管内治疗的阀、设备和方法
NZ563417A (en) 2005-05-18 2012-01-12 Mpex Pharmaceuticals Inc Aerosolized fluoroquinolones and uses thereof
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
EP1901793A1 (en) * 2005-07-13 2008-03-26 Cipla Ltd. Inhaler device
US8763605B2 (en) 2005-07-20 2014-07-01 Manta Devices, Llc Inhalation device
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
CA2623256A1 (en) * 2005-09-29 2007-04-12 Nektar Therapeutics Receptacles and kits, such as for dry powder packaging
JP5096363B2 (ja) 2005-12-16 2012-12-12 ネクター セラピューティックス Ｇｌｐ−１のポリマ複合体
GB2433207B (en) * 2006-02-21 2009-01-07 Jianhe Li Active suction actuated inhalers with timing devices
MX360812B (es) 2006-02-22 2018-11-16 Mannkind Corp Un método para mejorar las propiedades farmacéuticas de micropartículas que contienen dicetopiperazina y un agente activo.
CN101437562A (zh) * 2006-03-03 2009-05-20 Stc.Unm公司 具有气动力弹性分散机构的干粉吸入器
EP2077882A2 (en) 2006-10-25 2009-07-15 Nektar Therapeutics Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices
US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
WO2008091355A2 (en) * 2007-01-24 2008-07-31 Breathe Pharmaceuticals, Inc. Drug transfer device
FR2918352B1 (fr) * 2007-07-03 2009-10-09 Valois Sas Dispositif d'ouverture de reservoir pour dispositif de distribution de produit fluide
JP5528336B2 (ja) * 2007-07-06 2014-06-25 マンタ デバイシス，エルエルシー デリバリー装置及び関連方法
US11224704B2 (en) 2007-07-06 2022-01-18 Manta Devices, Llc Dose delivery device for inhalation
MX2010004507A (es) * 2007-10-25 2010-07-05 Novartis Ag Acondicionamiento de polvo de paquetes de farmaco dosis unitaria.
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
EP2082763A1 (en) 2008-01-24 2009-07-29 Boehringer Ingelheim International Gmbh Inhaler
BRPI0913021A2 (pt) * 2008-05-15 2015-10-13 Novartis Ag distribuição pulmonar de uma fluoroquinolona
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
TWI677355B (zh) 2008-06-13 2019-11-21 美商曼凱公司 用於藥物傳輸之乾粉吸入器及系統
EP2300083B1 (en) 2008-06-20 2013-05-22 MannKind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US20110166063A1 (en) 2008-09-19 2011-07-07 Nektar Therapeutics Polymer conjugates of therapeutic peptides
US20110171312A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Modified therapeutic peptides, methods of their preparation and use
NZ592717A (en) 2008-10-07 2013-03-28 Mpex Pharmaceuticals Inc Aerosol fluoroquinolone formulations for improved pharmacokinetics comprising levofloxacin or ofloxacin and a di- or trivalent cation
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
PL2413902T3 (pl) 2009-03-18 2020-01-31 Incarda Therapeutics, Inc. Dawki jednostkowe, aerozole, zestawy oraz sposoby leczenia chorób serca przez podawanie dopłucne
EP2662472B1 (de) 2009-03-31 2019-02-27 Boehringer Ingelheim International Gmbh Verfahren zur Beschichtung einer Oberfläche eines Bauteils
GB0908129D0 (en) * 2009-05-12 2009-06-24 Innovata Ltd Composition
WO2010133294A2 (de) 2009-05-18 2010-11-25 Boehringer Ingelheim International Gmbh Adapter, inhalationseinrichtung und zerstäuber
SG176738A1 (en) 2009-06-12 2012-01-30 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
SG176961A1 (en) * 2009-06-25 2012-02-28 Boehringer Ingelheim Vetmed Inhaler
PT2473170T (pt) 2009-09-04 2019-08-23 Horizon Orphan Llc Utilização de levofloxacina em aerossol para tratamento de fibrose cística
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064164A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
GB0921481D0 (en) 2009-12-08 2010-01-20 Vectura Ltd Process and product
PH12012501114A1 (en) 2010-01-05 2024-06-03 Microdose Therapeutx Inc Inhalation device and method
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
EP2585151B1 (en) 2010-06-24 2018-04-04 Boehringer Ingelheim International GmbH Nebulizer
TW201304822A (zh) 2010-11-15 2013-02-01 Vectura Ltd 組成物及用途
TW201306847A (zh) 2010-11-30 2013-02-16 Vectura Ltd 組成物及用途
ES2646748T3 (es) 2010-12-07 2017-12-15 Respira Therapeutics, Inc. Inhalador de polvo seco
US10092552B2 (en) 2011-01-31 2018-10-09 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
CN103826988B (zh) 2011-04-01 2016-03-09 曼金德公司 用于药物药盒的泡罩包装
EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN103945859A (zh) 2011-10-24 2014-07-23 曼金德公司 用于治疗疼痛的方法和组合物
WO2013114374A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US9757529B2 (en) * 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
WO2014106727A1 (en) 2013-01-03 2014-07-10 Vectura Limited Inhaler and formulation
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
GB201305813D0 (en) 2013-03-28 2013-05-15 Vectura Ltd Compositions and methods
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
AU2014290438B2 (en) 2013-07-18 2019-11-07 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
WO2015017728A1 (en) 2013-07-31 2015-02-05 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
CN105517607A (zh) 2013-08-05 2016-04-20 曼金德公司 吹入设备和方法
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
WO2015018904A1 (en) 2013-08-09 2015-02-12 Boehringer Ingelheim International Gmbh Nebulizer
CA2913811C (en) 2013-08-20 2022-06-07 Boehringer Ingelheim Vetmedica Gmbh Inhaler
KR102411751B1 (ko) 2013-08-20 2022-06-23 베링거잉겔하임베트메디카게엠베하 흡입기
PT3035886T (pt) 2013-08-20 2021-01-04 Boehringer Ingelheim Vetmedica Gmbh Nalador
JP6023891B2 (ja) * 2013-09-30 2016-11-09 日本たばこ産業株式会社 非燃焼型香味吸引器及びカプセルユニット
NZ722927A (en) 2014-01-10 2022-07-29 Avalyn Pharma Inc Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
DK3139984T3 (da) 2014-05-07 2021-07-19 Boehringer Ingelheim Int Forstøver
PL3139981T3 (pl) 2014-05-07 2021-06-14 Boehringer Ingelheim International Gmbh Nebulizator
WO2015169732A1 (en) 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US20170304459A1 (en) 2014-10-10 2017-10-26 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
JP2018501903A (ja) 2015-01-14 2018-01-25 レスピラ セラピューティクス インコーポレイテッドＲｅｓｐｉｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． パウダー分散方法および装置
CA2983026A1 (en) * 2015-04-15 2016-10-20 Sansa Corporation (Barbados) Inc. Dry powder inhaler and method of use
WO2017136421A1 (en) 2016-02-01 2017-08-10 Incarda Therapeutics, Inc. Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation
CA3040828A1 (en) 2016-10-31 2018-05-03 Vectura Limited Inhalable powder composition comprising il-13 antibody
EP3621616A4 (en) 2017-05-10 2021-01-13 InCarda Therapeutics, Inc. UNIT DOSES, AEROSOLS, KITS, AND METHODS FOR TREATING HEART CONDITIONS BY PULMONARY ADMINISTRATION
US10370176B2 (en) * 2017-09-12 2019-08-06 Wd-40 Company Child resistant aerosol actuator
US10744087B2 (en) 2018-03-22 2020-08-18 Incarda Therapeutics, Inc. Method to slow ventricular rate
CN113301933B (zh) * 2019-01-24 2023-08-22 伊莱利利公司 鼻腔药品输送装置
EP3962472A4 (en) 2019-04-29 2023-01-25 Insmed Incorporated DRY POWDER COMPOSITIONS OF TREPROSTINIL PRODRUGS AND METHODS OF USE THEREOF
US11020384B2 (en) 2019-08-01 2021-06-01 Incarda Therapeutics, Inc. Antiarrhythmic formulation
CN111990388B (zh) * 2020-05-27 2021-11-16 农业农村部南京农业机械化研究所 选择性喷洒系统，地空协同施药系统及协作方法
CA3184282A1 (en) 2020-06-27 2021-12-30 Emre Koyuncu Composition of compounds that modulate cell metabolism and methods of use
EP4304582A1 (en) 2021-03-12 2024-01-17 Alvarius Pharmaceuticals Ltd. Compositions and methods for treating addictions comprising 5-meo-dmt
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof
US12138243B2 (en) 2021-12-31 2024-11-12 Crescenta Biosciences Antiviral use of FABP4 modulating compounds
CN114366663B (zh) * 2022-01-29 2024-03-19 湖南淳芝宝医药科技有限公司 一种中药饮片循环雾化润药设备
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof

Family Cites Families (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487744A (en) 1892-12-13 Self-lighting gas-burner
US2603216A (en) 1952-07-15 Powder inhaler
US513189A (en) 1894-01-23 Powder-blower
DE471490C (de) 1931-08-12 Karl Zeyen Vorrichtung zum Zerstaeuben mehlfoermiger Stoffe
US2533065A (en) 1947-03-08 1950-12-05 George V Taplin Micropulverized therapeutic agents
US2570774A (en) 1947-10-21 1951-10-09 Frank P C Davis Insufflator
GB636854A (en) 1948-05-20 1950-05-10 Thomas James Chalmers Macdonal Apparatus for administering anaesthetics
US2549303A (en) 1949-04-20 1951-04-17 Bristol Lab Inc Inhaler for crystalline pencilllin or the like
US2598525A (en) 1950-04-08 1952-05-27 E & J Mfg Co Automatic positive pressure breathing machine
DE1147354B (de) 1961-08-07 1963-04-18 Paul Ritzau Vernebler, insbesondere Handvernebler fuer Inhalationszwecke
US3362405A (en) 1964-04-06 1968-01-09 Hamilton O. Hazel Method and apparatus for admixing gas with solid particles
US3425600A (en) 1966-08-11 1969-02-04 Abplanalp Robert H Pressurized powder dispensing device
US3812854A (en) 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
FR2224175B1 (bg) 1973-04-04 1978-04-14 Isf Spa
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
GB1479283A (en) 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
DE2346914C3 (de) 1973-09-18 1980-10-16 Paul Ritzau Pari-Werk, Gmbh & Co, 8130 Starnberg Inhalator für pulverförmige Substanzen
FR2257351A1 (en) 1974-01-11 1975-08-08 Obert Jean Claude Aerosol device for solid vaccines - feed and breaker screws deliver material sideways into blower chamber
IT1016489B (it) 1974-03-18 1977-05-30 Isf Spa Inalatore
US3967761A (en) 1974-04-08 1976-07-06 Southwest Research Institute System for injecting particulate material into the combustion chamber of a repetitive combustion coating apparatus
YU41046B (en) 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
SU628930A1 (ru) 1974-11-26 1978-10-25 Московский научно-исследовательский институт туберкулеза Устройство дл введени порошкообразного лекарственного вещества
US4005711A (en) 1975-01-13 1977-02-01 Syntex Puerto Rico, Inc. Inhalation device
US3964483A (en) 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
FR2299011A1 (fr) 1975-01-29 1976-08-27 Obert Jean Claude Generateur d'aerosols de part
US3991304A (en) 1975-05-19 1976-11-09 Hillsman Dean Respiratory biofeedback and performance evaluation system
GB1521000A (en) 1975-06-13 1978-08-09 Syntex Puerto Rico Inc Inhalation device
US3994421A (en) 1975-09-29 1976-11-30 American Cyanamid Company Unitary therapeutic aerosol dispenser
SE408265B (sv) 1975-12-12 1979-06-05 Draco Ab Anordning for koldioxiddriven endosaerosol, avsedd for inhalering
US4018185A (en) 1975-12-15 1977-04-19 Coors Container Company Powder feeder pick-up tube
NL7712041A (en) 1977-11-01 1979-05-03 Handelmaatschappij Voorheen Be Suction equipment for powdery material - incorporates ejector type suction pump and cyclone type separator
DE2960616D1 (en) 1978-05-03 1981-11-12 Fisons Plc Inhalation device
US4253468A (en) 1978-08-14 1981-03-03 Steven Lehmbeck Nebulizer attachment
SU1003926A1 (ru) 1979-01-24 1983-03-15 Всесоюзный Научно-Исследовательский И Конструкторский Институт Автогенного Машиностроения Порошковый питатель
IT1116047B (it) 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
AU545574B2 (en) 1979-10-30 1985-07-18 Riker Laboratories, Inc. Breath actuated devices for adminstering powdered medicaments
GB2063075B (en) 1979-11-07 1983-11-09 Sterwin Ag Dose indicator for inhalers
US4452239A (en) 1980-03-25 1984-06-05 Hilal Malem Medical nebulizing apparatus
DE3023648A1 (de) 1980-06-24 1982-01-21 Jaeger, Erich, 8700 Würzburg Einrichtung zur untersuchung der atemwege auf reizstoff-ueberempfindlichkeit
ES506585A0 (es) 1980-10-30 1982-09-01 Riker Laboratories Inc Un dispositivo para facilitar la inhalacion oral de medica- mentos en forma de polvo
US4484577A (en) 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US4823784A (en) 1982-04-30 1989-04-25 Cadema Medical Products, Inc. Aerosol inhalation apparatus
EP0094231A1 (en) * 1982-05-08 1983-11-16 E.J. Price (Developments) Limited Nebulizers
IN160851B (bg) 1982-10-08 1987-08-08 Glaxo Group Ltd
US4778054A (en) 1982-10-08 1988-10-18 Glaxo Group Limited Pack for administering medicaments to patients
GB8314308D0 (en) 1983-05-24 1983-06-29 Matburn Holdings Ltd Medical administration devices
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
US4649911A (en) 1983-09-08 1987-03-17 Baylor College Of Medicine Small particle aerosol generator for treatment of respiratory disease including the lungs
DE3345722A1 (de) 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim Inhalator
US4534343A (en) 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
US4624251A (en) 1984-09-13 1986-11-25 Riker Laboratories, Inc. Apparatus for administering a nebulized substance
FI76929C (fi) 1984-09-25 1989-01-10 Etelae Haemeen Keuhkovammayhdi Inhalationsdoseringsanordning, som aer avsedd foer nogrann dosering av disponerande laekemedel som ges aot andningssjuka i undersoekningsskedet och/eller laekemedel som ges som spray under behandlingen.
NZ209900A (en) 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
FR2575678B1 (fr) 1985-01-04 1988-06-03 Saint Gobain Vitrage Ejecteur pneumatique de poudre
US4942544A (en) 1985-02-19 1990-07-17 Kenneth B. McIntosh Medication clock
SE448277B (sv) 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
FI81500C (fi) 1985-05-23 1990-11-12 Etelae Haemeen Keuhkovammayhdi Andningsbehandlingsapparat.
NL8601949A (nl) 1985-07-30 1987-02-16 Glaxo Group Ltd Inrichtingen voor het toedienen van medicamenten aan patienten.
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
US4739754A (en) 1986-05-06 1988-04-26 Shaner William T Suction resistant inhalator
US4790305A (en) 1986-06-23 1988-12-13 The Johns Hopkins University Medication delivery system
US4926852B1 (en) 1986-06-23 1995-05-23 Univ Johns Hopkins Medication delivery system phase one
DE3636669C2 (de) 1986-10-28 2001-08-16 Siemens Ag Anordnung zur Zufuhr von Aerosol zu den Luftwegen und/oder Lungen eines Patienten
IT1222509B (it) 1987-08-17 1990-09-05 Miat Spa Insufflatore per la somministrazione di farmaci sotto forma di polvere predosata in opercoli
US4860470A (en) 1988-02-01 1989-08-29 Nei Canada Limited Single core display device
IT1217890B (it) 1988-06-22 1990-03-30 Chiesi Farma Spa Dispositivo per l'inalazione di aerosol dosati
US4852561A (en) 1988-07-27 1989-08-01 Sperry C R Inhalation device
ATE104867T1 (de) 1988-10-04 1994-05-15 Univ Johns Hopkins Inhalationsgeraet fuer aerosolen.
US4984158A (en) 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
DK479189D0 (da) 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
SE466684B (sv) 1989-03-07 1992-03-23 Draco Ab Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator
GB8908647D0 (en) 1989-04-17 1989-06-01 Glaxo Group Ltd Device
IT1230313B (it) 1989-07-07 1991-10-18 Somova Spa Inalatore per medicamenti in capsule.
GB8917775D0 (en) 1989-08-03 1989-09-20 Atomic Energy Authority Uk Aerosol inhaler
DE3927170A1 (de) 1989-08-17 1991-02-21 Boehringer Ingelheim Kg Inhalator
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5113855A (en) 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
US5201308A (en) 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
DE4004904A1 (de) 1990-02-16 1990-09-13 Gerhard Brendel Trommel-applikator
US5020527A (en) 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
IT1243344B (it) 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
US5037912A (en) 1990-07-26 1991-08-06 The Goodyear Tire & Rubber Company Polymerization of 1,3-butadiene to trans-1,4-polybutadiene with organolithium and alkali metal alkoxide
DE4027749A1 (de) 1990-09-01 1992-03-05 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer medien
ATE140629T1 (de) 1990-09-12 1996-08-15 Hans Bisgaard Inhaliervorrichtung
US5217004A (en) 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
US5099833A (en) 1991-02-19 1992-03-31 Baxter International Inc. High efficiency nebulizer having a flexible reservoir
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5186164A (en) 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
DE59107894D1 (de) 1991-03-21 1996-07-11 Ritzau Pari Werk Gmbh Paul Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie
US5797391A (en) * 1991-03-28 1998-08-25 Rhone-Poulenc Rorer Limited Inhaler
GB9106648D0 (en) 1991-03-28 1991-05-15 Rhone Poulenc Rorer Ltd New inhaler
BR9106690A (pt) 1991-04-15 1993-06-29 Huhtamaeki Yhthymae Oy Disposicao para medir uma dose de medicamentos pulverulento para inalacao e aparelho de inalacao dotado do mesmo
ATE171630T1 (de) 1991-05-21 1998-10-15 Abbott Lab Aerosolinhalationsvorrichtung
ATE189124T1 (de) 1991-07-02 2000-02-15 Inhale Inc Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform
US5337740A (en) 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5161524A (en) 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5287850A (en) 1991-08-20 1994-02-22 Habley Medical Technology Corporation Timing and velocity controlled powered pharmaceutical inhaler
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
DE4128295A1 (de) 1991-08-27 1993-03-04 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer fliessfaehige medien
GB9123953D0 (en) 1991-11-12 1992-01-02 Minnesota Mining & Mfg Inhalation device
DE4142238A1 (de) 1991-12-20 1993-06-24 Boehringer Ingelheim Kg Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
US5355872B1 (en) 1992-03-04 1998-10-20 John H Riggs Low flow rate nebulizer apparatus and method of nebulization
US5186166A (en) 1992-03-04 1993-02-16 Riggs John H Powder nebulizer apparatus and method of nebulization
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
CH689443A5 (fr) * 1992-09-16 1999-04-30 Debiotech Sa Ensemble constituant une pompe à usage médical.
DK0665759T3 (da) 1992-10-19 1999-08-23 Dura Pharma Inc Tørpulverinhalator
FR2700279B1 (fr) 1993-01-14 1995-03-17 Valois Dispositif portatif pour projeter des doses d'une substance fluide à l'aide d'un flux d'air comprimé.
US5533502A (en) 1993-05-28 1996-07-09 Vortran Medical Technology, Inc. Powder inhaler with aerosolization occurring within each individual powder receptacle
US5392961A (en) * 1993-06-18 1995-02-28 Casco International, Inc. Safety tab device and the combination with an aerosol container system
US5349947A (en) 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
US5524613A (en) 1993-08-25 1996-06-11 Habley Medical Technology Corporation Controlled multi-pharmaceutical inhaler
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5505194A (en) 1994-03-23 1996-04-09 Abbott Laboratories Aerosol inhalation device having slideably and rotatably connected elliptical cylinder portions
EP0682955B1 (de) 1994-05-19 2001-09-05 PARI GmbH Spezialisten für effektive Inhalation Vorrichtung zur Trocknung und Pufferung von Aerosolen
CA2555600C (en) 1994-09-21 2008-01-29 Nektar Therapeutics Apparatus and methods for dispersing dry powder medicaments
US5645051A (en) * 1995-04-21 1997-07-08 Dura Pharmaceuticals, Inc. Unit dose dry powder inhaler
US5622166A (en) * 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
CN1181896C (zh) 1995-06-21 2004-12-29 索福泰克两合公司 带整体计量装置的药筒和药粉吸入器
US5694920A (en) * 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
BR9709174A (pt) * 1996-04-25 1999-08-03 Schuckmann Alfred Von Inalador
AU724503B2 (en) * 1996-04-29 2000-09-21 Dura Pharmaceuticals, Inc. Methods of dry powder inhalation
US6123070A (en) * 1996-06-07 2000-09-26 Valois S.A. Device for enhancing the emptying of an inhaler metering chamber
DE19704849B4 (de) * 1997-02-08 2011-02-17 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für Medien
US6006747A (en) * 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
EE200000373A (et) * 1997-12-22 2001-10-15 Astrazeneca Ab Inhalatsiooniseade
DE19817417A1 (de) * 1998-04-18 1999-10-21 Pfeiffer Erich Gmbh & Co Kg Spender für Medien, insbesondere Pulver
US6257233B1 (en) * 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
DE19831525A1 (de) * 1998-07-14 2000-01-20 Pfeiffer Erich Gmbh & Co Kg Spender für Medien

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YU76300A (sh) 2002-10-18
CA2332853A1 (en) 1999-12-09
US8161969B2 (en) 2012-04-24
SA99200468B1 (ar) 2006-05-06

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