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EA201891157A1 - Способы и промежуточные соединения при получении ингибитора jak - Google Patents

Способы и промежуточные соединения при получении ингибитора jak

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Publication number
EA201891157A1
EA201891157A1 EA201891157A EA201891157A EA201891157A1 EA 201891157 A1 EA201891157 A1 EA 201891157A1 EA 201891157 A EA201891157 A EA 201891157A EA 201891157 A EA201891157 A EA 201891157A EA 201891157 A1 EA201891157 A1 EA 201891157A1
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EA
Eurasian Patent Office
Prior art keywords
methods
intermediate compounds
receiving
jak inhibitor
diseases
Prior art date
Application number
EA201891157A
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English (en)
Inventor
Пинли Лю
Дэнцзинь Ван
Юнчжун У
Ганьфэн Цао
Майкл Ксиа
Original Assignee
Инсайт Холдингс Корпорейшн
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50382653&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201891157(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Инсайт Холдингс Корпорейшн filed Critical Инсайт Холдингс Корпорейшн
Publication of EA201891157A1 publication Critical patent/EA201891157A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
    • B01J31/28—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24 of the platinum group metals, iron group metals or copper
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к способам и промежуточным соединениям для изготовления {1-{1-[3-фтор-2-(трифторметил)изоникотиноил]пиперидин-4-ил}-3-[4-(7H-пирроло[2,3-d]пиримидин-4-ил)-1Н-пиразол-1-ил]азетидин-3-ил}ацетонитрил, полезными при лечении заболеваний, связанных с активностью киназы Януса (JAK), включая воспалительные заболевания, аутоиммунные заболевания, рак, и других заболеваний.
EA201891157A 2013-03-06 2014-03-05 Способы и промежуточные соединения при получении ингибитора jak EA201891157A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361773659P 2013-03-06 2013-03-06

Publications (1)

Publication Number Publication Date
EA201891157A1 true EA201891157A1 (ru) 2019-02-28

Family

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EA201891157A EA201891157A1 (ru) 2013-03-06 2014-03-05 Способы и промежуточные соединения при получении ингибитора jak
EA201591650A EA030705B1 (ru) 2013-03-06 2014-03-05 Способы и промежуточные соединения при получении ингибитора jak

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Country Status (36)

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US (3) US8987443B2 (ru)
EP (3) EP3489239B1 (ru)
JP (2) JP6397831B2 (ru)
KR (2) KR102366356B1 (ru)
CN (1) CN105189509B (ru)
AR (2) AR095018A1 (ru)
AU (1) AU2014225938B2 (ru)
BR (2) BR122021015061B1 (ru)
CA (2) CA3091179C (ru)
CL (2) CL2015002468A1 (ru)
CR (2) CR20190518A (ru)
CY (2) CY1121512T1 (ru)
DK (1) DK2964650T3 (ru)
EA (2) EA201891157A1 (ru)
ES (2) ES2900492T3 (ru)
HK (1) HK1218540A1 (ru)
HR (2) HRP20211922T1 (ru)
HU (2) HUE057262T2 (ru)
IL (3) IL240891A0 (ru)
LT (2) LT3489239T (ru)
ME (1) ME03350B (ru)
MX (2) MX2015011667A (ru)
NZ (2) NZ749437A (ru)
PE (2) PE20151902A1 (ru)
PH (1) PH12015501958B1 (ru)
PL (2) PL2964650T3 (ru)
PT (2) PT2964650T (ru)
RS (2) RS62867B1 (ru)
SG (2) SG10201707259PA (ru)
SI (2) SI2964650T1 (ru)
SM (2) SMT202100694T1 (ru)
TR (1) TR201820520T4 (ru)
TW (1) TWI634121B (ru)
UA (2) UA121532C2 (ru)
WO (1) WO2014138168A1 (ru)
ZA (1) ZA201908345B (ru)

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