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EA201492082A1 - Кристаллические формы ингибитора тирозинкиназы брутона - Google Patents

Кристаллические формы ингибитора тирозинкиназы брутона

Info

Publication number
EA201492082A1
EA201492082A1 EA201492082A EA201492082A EA201492082A1 EA 201492082 A1 EA201492082 A1 EA 201492082A1 EA 201492082 A EA201492082 A EA 201492082A EA 201492082 A EA201492082 A EA 201492082A EA 201492082 A1 EA201492082 A1 EA 201492082A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitor
pathological conditions
bluton
crystal forms
btk
Prior art date
Application number
EA201492082A
Other languages
English (en)
Inventor
Норберт Пурро
Марк Смит
Эрик Голдман
Дэвид Верт
Original Assignee
Фармасайкликс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201492082(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Фармасайкликс, Инк. filed Critical Фармасайкликс, Инк.
Publication of EA201492082A1 publication Critical patent/EA201492082A1/ru

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

В заявке раскрывается ингибитор тирозинкиназы Брутона (Btk) 1-((R)-3-(4-амино-3-(4-феноксифенил)-1H-пиразоло[3,4-d]пиримидин-1-ил)пиперидин-1-ил)проп-2-ен-1-он, включая его кристаллические формы, сольваты и фармацевтически приемлемые соли. Также раскрываются фармацевтические композиции, которые включают ингибитор Btk, и способы применения ингибитора Btk, самостоятельно или в комбинации с другими терапевтическими агентами, для лечения аутоиммунных заболеваний или патологических состояний, гетероиммунных заболеваний или патологических состояний, рака, включая лимфому, и воспалительных заболеваний или патологических состояний.
EA201492082A 2012-06-04 2013-06-03 Кристаллические формы ингибитора тирозинкиназы брутона EA201492082A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261655381P 2012-06-04 2012-06-04
PCT/US2013/043888 WO2013184572A1 (en) 2012-06-04 2013-06-03 Crystalline forms of a bruton's tyrosine kinase inhibitor

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EA201492082A1 true EA201492082A1 (ru) 2015-03-31

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2702660C2 (ru) * 2015-01-30 2019-10-09 Тайхо Фармасьютикал Ко., Лтд. Новая соль конденсированного пиримидинового соединения и ее кристалл

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE025459T2 (hu) 2006-09-22 2016-05-30 Pharmacyclics Inc A Bruton-féle tirozin-kináz inhibitorai
US20120101114A1 (en) 2007-03-28 2012-04-26 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
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ZA202303227B (en) 2024-01-31
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US9725455B1 (en) 2017-08-08
JP2020015744A (ja) 2020-01-30
US9713617B2 (en) 2017-07-25
CL2014003306A1 (es) 2015-04-17
KR20150015021A (ko) 2015-02-09
US20170334921A1 (en) 2017-11-23
CN110354132A (zh) 2019-10-22
PE20190390A1 (es) 2019-03-13
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MY187999A (en) 2021-11-08
US20180362535A1 (en) 2018-12-20
MA37711A1 (fr) 2017-05-31
US20200231595A1 (en) 2020-07-23
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AU2016250445B2 (en) 2018-07-26
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PH12014502681A1 (en) 2015-01-26
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AU2013271918C1 (en) 2017-02-09
UA126959C2 (uk) 2023-03-01
JOP20200222A1 (ar) 2022-10-30
MA41654A1 (fr) 2018-07-31
AU2013271918B2 (en) 2016-08-04
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IL254739A0 (en) 2017-11-30
US20210032258A1 (en) 2021-02-04
BR112014030424A2 (pt) 2017-06-27
DOP2014000274A (es) 2015-03-31
KR20230170108A (ko) 2023-12-18
MX2021012478A (es) 2021-11-12
CA2875986C (en) 2020-06-09
US20180179214A1 (en) 2018-06-28
CO7240408A2 (es) 2015-04-17
MA41654B2 (fr) 2020-12-31
US20240409545A1 (en) 2024-12-12
IL235894A0 (en) 2015-01-29
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GT201400281A (es) 2019-08-12
IL315394A (en) 2024-11-01
AU2018211216B2 (en) 2020-06-25
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BR112014030424A8 (pt) 2017-07-11
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US10961251B1 (en) 2021-03-30
US20180319805A1 (en) 2018-11-08
CA2991994C (en) 2022-06-28
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ZA202105174B (en) 2022-07-27
AU2013271918A1 (en) 2015-01-22
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HK1208803A1 (en) 2016-03-18
US10294231B2 (en) 2019-05-21
KR20220093389A (ko) 2022-07-05
US20220112196A1 (en) 2022-04-14
TN2014000492A1 (en) 2016-03-30
SG10202101389TA (en) 2021-03-30
PH12020500028A1 (en) 2022-02-21
CA3218491A1 (en) 2013-12-12
US20180170940A1 (en) 2018-06-21
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CL2017000371A1 (es) 2017-10-30
EP2854859A4 (en) 2016-01-13
US10065968B2 (en) 2018-09-04
UY39740A (es) 2022-06-30
JP2021193095A (ja) 2021-12-23
US20170305919A1 (en) 2017-10-26
CA2991994A1 (en) 2013-12-12
TWI662963B (zh) 2019-06-21
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US20190248799A1 (en) 2019-08-15

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