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EA201690618A1 - Ингибиторы тирозинкиназы брутона - Google Patents

Ингибиторы тирозинкиназы брутона

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Publication number
EA201690618A1
EA201690618A1 EA201690618A EA201690618A EA201690618A1 EA 201690618 A1 EA201690618 A1 EA 201690618A1 EA 201690618 A EA201690618 A EA 201690618A EA 201690618 A EA201690618 A EA 201690618A EA 201690618 A1 EA201690618 A1 EA 201690618A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
btk
conditions
compounds
bluton
Prior art date
Application number
EA201690618A
Other languages
English (en)
Inventor
Лунчэн Ван
Вэй Чэнь
Чжаочжун Дж. Цзя
Дэвид Дж. Лоури
Original Assignee
Фармасайкликс Элэлси
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармасайкликс Элэлси filed Critical Фармасайкликс Элэлси
Publication of EA201690618A1 publication Critical patent/EA201690618A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Описанные в данном документе соединения, представляют собой соединения, которые образуют ковалентные связи с тирозинкиназой Брутона (Btk). Также описанны необратимые ингибиторы Btk. Кроме того, также описаны обратимые ингибиторы Btk. Также описанны фармацевтические композиции, которые включают соединения. Описаны способы использования ингибиторов Btk, отдельно или в комбинации с другими лекарственными средствами, для лечения аутоиммунных заболеваний или состояний, гетероиммунных заболеваний или состояний, рака, включая лимфому, и воспалительных заболеваний или состояний.
EA201690618A 2013-09-30 2014-09-29 Ингибиторы тирозинкиназы брутона EA201690618A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361884888P 2013-09-30 2013-09-30
PCT/US2014/058132 WO2015048689A1 (en) 2013-09-30 2014-09-29 Inhibitors of bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
EA201690618A1 true EA201690618A1 (ru) 2016-09-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690618A EA201690618A1 (ru) 2013-09-30 2014-09-29 Ингибиторы тирозинкиназы брутона

Country Status (20)

Country Link
US (2) US9624224B2 (ru)
EP (1) EP3052486A1 (ru)
JP (1) JP2016531941A (ru)
KR (1) KR20160062103A (ru)
CN (1) CN105764896A (ru)
AR (1) AR097862A1 (ru)
AU (1) AU2014324532A1 (ru)
BR (1) BR112016006978A2 (ru)
CA (1) CA2925124A1 (ru)
CR (1) CR20160203A (ru)
DO (1) DOP2016000071A (ru)
EA (1) EA201690618A1 (ru)
IL (1) IL244492A0 (ru)
MA (1) MA38961A1 (ru)
PE (1) PE20160560A1 (ru)
PH (1) PH12016500575A1 (ru)
SG (1) SG11201602421VA (ru)
TN (1) TN2016000094A1 (ru)
TW (1) TW201546061A (ru)
WO (1) WO2015048689A1 (ru)

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KR101956815B1 (ko) 2017-02-14 2019-03-12 한국화학연구원 트리아졸로피리다진 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물
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CN109748929A (zh) * 2017-11-06 2019-05-14 苏州鹏旭医药科技有限公司 一种化合物的制备方法
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JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN112961159B (zh) * 2020-03-05 2022-07-01 四川大学华西医院 氨基嘧啶并吡唑/吡咯类衍生物及其制备方法和用途
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KR102637915B1 (ko) 2021-06-25 2024-02-19 한국화학연구원 유비퀴틴 프로테오좀 경로를 통해 비티케이 분해작용을 가지는 신규한 이작용성 헤테로사이클릭 화합물과 이의 용도
WO2022270994A1 (ko) 2021-06-25 2022-12-29 한국화학연구원 유비퀴틴 프로테오좀 경로를 통해 비티케이 분해작용을 가지는 신규한 이작용성 헤테로사이클릭 화합물과 이의 용도
TW202317086A (zh) * 2021-09-29 2023-05-01 加拿大商修復治療公司 化合物、醫藥組成物及製備化合物之方法及其使用方法
CN114213416B (zh) * 2021-11-05 2023-06-06 杭州医学院 一种恶唑并[4,5-b]吡啶结构的不可逆BTK抑制剂及其应用
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US20150094319A1 (en) 2015-04-02
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