[go: up one dir, main page]

EA201270226A1 - Витамин d3 и его аналогии для лечения алопеции - Google Patents

Витамин d3 и его аналогии для лечения алопеции

Info

Publication number
EA201270226A1
EA201270226A1 EA201270226A EA201270226A EA201270226A1 EA 201270226 A1 EA201270226 A1 EA 201270226A1 EA 201270226 A EA201270226 A EA 201270226A EA 201270226 A EA201270226 A EA 201270226A EA 201270226 A1 EA201270226 A1 EA 201270226A1
Authority
EA
Eurasian Patent Office
Prior art keywords
vitamin
alopecia
treatment
chemotherapy
analogy
Prior art date
Application number
EA201270226A
Other languages
English (en)
Inventor
Хоакин Дж. Хименез
Нивен Раджин Нарэн
Джон Патрик Маккук
Original Assignee
БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи filed Critical БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи
Publication of EA201270226A1 publication Critical patent/EA201270226A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Данное изобретение предусматривает способы и фармацевтические композиции для профилактики или лечения алопеции, такой как алопеция, индуцированная проведением химиотерапии (CIA). Фармацевтическая композиция по изобретению содержит эффективное количество соединения витамина D в составе, который местно доставляет соединение витамина D в слой эпидермиса, но практически не доставляет его в слой дермиса. В случае пациентов, проходящих курс химиотерапии, фармацевтические композиции согласно изобретению могут быть введены или до проведения химиотерапии, или параллельно с ней.
EA201270226A 2009-08-14 2010-08-06 Витамин d3 и его аналогии для лечения алопеции EA201270226A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23417809P 2009-08-14 2009-08-14
PCT/US2010/044765 WO2011019617A2 (en) 2009-08-14 2010-08-06 Vitamin d3 and analogs thereof for treating alopecia

Publications (1)

Publication Number Publication Date
EA201270226A1 true EA201270226A1 (ru) 2012-09-28

Family

ID=43586756

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270226A EA201270226A1 (ru) 2009-08-14 2010-08-06 Витамин d3 и его аналогии для лечения алопеции

Country Status (18)

Country Link
US (2) US9901637B2 (ru)
EP (2) EP3603646B1 (ru)
JP (2) JP5978130B2 (ru)
KR (2) KR101791828B1 (ru)
CN (3) CN105663146B (ru)
AR (1) AR077922A1 (ru)
AU (3) AU2010282731C1 (ru)
BR (1) BR112012003372A2 (ru)
CA (1) CA2770683C (ru)
EA (1) EA201270226A1 (ru)
ES (1) ES2742750T3 (ru)
IL (1) IL218043B (ru)
IN (1) IN2012DN02137A (ru)
MX (2) MX338746B (ru)
SG (2) SG178382A1 (ru)
TW (2) TW201733593A (ru)
WO (1) WO2011019617A2 (ru)
ZA (2) ZA201702812B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20170434A (es) * 2009-01-27 2017-11-21 Berg Llc VITAMINA D3 Y ANALOGOS DE LA MISMA PARA ALIVIAR EFECTOS SECUNDARIOS ASOCIADOS CON LA QUIMIOTERAPIA. (Divisional 2011-0445)
KR101791828B1 (ko) * 2009-08-14 2017-10-31 베르그 엘엘씨 탈모증 치료용 비타민 ｄ3 및 이의 유사체들
JP5537352B2 (ja) * 2010-09-09 2014-07-02 花王株式会社 毛成長抑制剤
JP5654808B2 (ja) * 2010-09-09 2015-01-14 花王株式会社 毛成長制御剤の評価又は選択方法
EP2614813B1 (en) * 2010-09-09 2017-03-15 Kao Corporation Method for selecting or evaluating hair growth control agent
FR2996128B1 (fr) * 2012-09-28 2015-01-02 Inneov Lab Utilisation d'une association de taurine ou un de ses derives, et d'extrait de raisins pour ameliorer la qualite des ongles.
JP6300897B2 (ja) * 2013-03-15 2018-03-28 マース インコーポレーテッドＭａｒｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 特発性嘔吐を予防、低減、緩和または治療するための組成物および方法
AU2014274099A1 (en) * 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
WO2017147420A1 (en) * 2016-02-25 2017-08-31 The University Of Florida Research Foundation, Inc. Methods and compositions with vitamin d compounds for treatment of cystic fibrosis and respiratory disorders
CN105842459A (zh) * 2016-03-24 2016-08-10 泰州海路生物技术有限公司 快速定量检测粪便钙卫蛋白的免疫层析试剂盒
CA3026495A1 (en) * 2016-06-05 2017-12-14 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
US10500217B2 (en) 2018-04-30 2019-12-10 Leslie Ray Matthews, M.D., Llc Vitamin D3, heat shock proteins, and glutathione for the treatment of chronic inflammation and chronic diseases
KR20220034042A (ko) * 2019-05-17 2022-03-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 비만 및/또는 피부 장애를 치료하기 위한 방법 및 조성물
CN110604098B (zh) * 2019-09-23 2021-09-07 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种类风湿关节炎合并间质性肺病动物模型的构建方法

Family Cites Families (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4425916A (en) 1979-06-01 1984-01-17 Therapeutic Products, Inc. Cap structure for creating temperature controlled environment for reducing alopecia
US4248791A (en) 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4307231A (en) 1980-07-18 1981-12-22 Wisconsin Alumni Research Foundation Vitamin D-lactone derivative and process for preparing same
US4336193A (en) 1980-08-04 1982-06-22 Wisconsin Alumni Research Foundation Process for preparing vitamin D-lactones
US4305880A (en) 1980-09-22 1981-12-15 Wisconsin Alumni Research Foundation Process for preparing 24-fluoro-25-hydroxycholecalciferol
US4279826A (en) 1980-09-22 1981-07-21 Wisconsin Alumni Research Foundation 23,25-Dihydroxyvitamin D3
US4367177A (en) 1981-04-15 1983-01-04 Wisconsin Alumni Research Foundation Process for preparing 23,25-dihydroxyvitamin D3
US4307025A (en) 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
JPS57149224A (en) 1981-03-13 1982-09-14 Chugai Pharmaceut Co Ltd Tumor-suppressing agent
US4358406A (en) 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4360471A (en) 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4360472A (en) 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation Trihydroxyvitamin D3 compounds
US4411833A (en) 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4428946A (en) 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
US4448721A (en) 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US5036061A (en) 1983-05-09 1991-07-30 Deluca Hector F Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds
US4448726A (en) 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4502991A (en) 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4564474A (en) 1983-08-18 1986-01-14 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
US4769181A (en) 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4505906A (en) 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4719205A (en) 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
US4689180A (en) 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US5120722A (en) 1984-02-08 1992-06-09 Hoffmann-La Roche Inc. Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia
US4481198A (en) 1984-02-13 1984-11-06 Wisconsin Alumni Research Foundation Vitamin D metabolism inhibitor
US4719204A (en) 1984-03-05 1988-01-12 Wisconsin Alumni Research Foundation Fowl bone mineralization with 28-NOR 1α-hydroxyvitamin D2 analogs
US4566455A (en) 1984-03-27 1986-01-28 H. Mervin Hughes, II Skin temperature control
US4588716A (en) 1984-05-04 1986-05-13 Wisconsin Alumni Research Foundation Method for treating metabolic bone disease in mammals
US4588528A (en) 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4857518A (en) 1984-10-04 1989-08-15 Wisconsin Alumni Research Foundation Hydroxylated 24-homo-vitamin D derivatives and methods for preparing same
US4717721A (en) 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity
JPS62501505A (ja) 1985-01-17 1987-06-18 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ビタミンｄ誘導体
US4594192A (en) 1985-03-20 1986-06-10 Wisconsin Alumni Research Foundation 2α-fluorovitamin D3
JPS62502545A (ja) 1985-04-23 1987-10-01 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン セコステロール化合物
US4755329A (en) 1985-06-10 1988-07-05 Wisconsin Alumni Research Foundation Process and intermediates for preparing 1α-hydroxyvitamin D compounds
JPH07100685B2 (ja) 1985-08-02 1995-11-01 レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ／エス（レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ） 新規ビタミンｄ類似体
US4619920A (en) 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
US5017371A (en) 1988-01-06 1991-05-21 Amarillo Cell Culture Company, Incorporated Method for reducing side effects of cancer therapy
US4804502A (en) 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5342411A (en) 1988-04-16 1994-08-30 Greater Glasgow Health Board Scalp cooling device
US5354744A (en) 1988-04-29 1994-10-11 Wisconsin Alumni Research Foundation Side chain unsaturated 1 alpha-hydroxyvitamin D analogs
US4847012A (en) 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US4927815A (en) 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US5250523A (en) 1988-04-29 1993-10-05 Wisconsin Alumni Research Foundation Side chain unsaturated 1α-hydroxyvitanim D homologs
US5232836A (en) 1988-05-04 1993-08-03 Ire-Medgenix S.A. Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D
US4851401A (en) 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US5246925A (en) 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
US5321018A (en) 1989-03-09 1994-06-14 Wisconsin Alumni Research Foundation Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
US4973584A (en) 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
CA1333616C (en) 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
DE3933034A1 (de) 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
US5254538A (en) 1989-10-04 1993-10-19 Trustees Of Boston University Method of treating periodontal disease
US5532228A (en) 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
US5260290A (en) 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
GB9007236D0 (en) 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9017890D0 (en) 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5185150A (en) 1990-08-24 1993-02-09 Wisconsin Alumni Research Fdn. Cosmetic compositions containing 19-nor-vitamin D compounds
DE4101953A1 (de) 1991-01-19 1992-07-23 Schering Ag 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
AU650751B2 (en) 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
US5086191A (en) 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
AU667675B2 (en) * 1991-06-28 1996-04-04 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
EP0521550B1 (en) 1991-07-05 1996-09-18 Duphar International Research B.V Vitamin D compound, method of preparing this compound and intermediate therefor
DE4141746A1 (de) 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
DE69214617T2 (de) 1991-12-26 1997-05-28 Wisconsin Alumni Res Found 26,27-Dimethylen-1-Alpha, 25-Dihydroxyvitamin-D2 und 26,27-Dihydroxyvitamin-D2 und Verfahren zu ihrer Herstellung
GB9201920D0 (en) * 1992-01-29 1992-03-18 Leo Pharm Prod Ltd Novel treatment i
US5830885A (en) 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
GB9206648D0 (en) 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
KR960013798B1 (ko) 1992-04-24 1996-10-10 재단법인 한국전자통신연구소 평면 도파로형 공간 스위치
AU666529B2 (en) 1992-04-24 1996-02-15 Wisconsin Alumni Research Foundation Method of treating osteoporosis with 1 alpha, 24 (R)-dihydroxy-22 (E)-dehydro-vitamin D3
JP2876547B2 (ja) 1992-06-23 1999-03-31 呉羽化学工業株式会社 抗クル病剤
DE4220757A1 (de) 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
GB9214202D0 (en) 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds
US5194431A (en) 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
AU666563B2 (en) 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
IL103224A (en) 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
GB9220272D0 (en) 1992-09-25 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
GB9220439D0 (en) 1992-09-28 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
IL107185A (en) 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
GB9223061D0 (en) 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
US5247104A (en) 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
WO1994013280A1 (en) 1992-12-04 1994-06-23 Mayor Pharmaceutical Laboratories, Inc. Sprayable analgesic composition and method of use
GB9226877D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
DE69331833T2 (de) 1992-12-29 2002-11-14 Michael F. Holick Verwendung von vitamin d-glykosiden zur behandlung oder prävention von osteoporose
US5547947A (en) 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9309422D0 (en) 1993-05-07 1993-06-23 Res Inst Medicine Chem Chemical compounds
US5371249A (en) 1993-05-11 1994-12-06 Wisconsin Alumni Research Foundation Iodo vitamin D3 compounds and method for preparing same
US5449668A (en) 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
WO1995001960A1 (en) 1993-07-09 1995-01-19 Laboratoire Theramex S.A. Novel structural analogues of vitamin d
GB9314400D0 (en) 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
GB9315253D0 (en) 1993-07-23 1993-09-08 Res Inst Medicine Chem Chemical compounds
US5552392A (en) 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5565589A (en) 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5373004A (en) 1993-11-24 1994-12-13 Wisconsin Alumni Research Foundation 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
US5384313A (en) 1993-11-24 1995-01-24 Wisconsin Alumni Research Foundation 21-norvitamin D compounds
GB9325415D0 (en) 1993-12-13 1994-02-16 Res Inst Medicine Chem Chemical compounds
US6103709A (en) 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
GB9405715D0 (en) 1994-03-23 1994-05-11 Res Inst Medicine Chem Chemical compounds
DK0755922T3 (da) 1994-04-11 2000-11-13 Chugai Pharmaceutical Co Ltd 22-Thiavitamin D3-derivat
EP0793649B1 (en) 1994-11-21 1999-02-03 Wisconsin Alumni Research Foundation 18,19-dinor-vitamin d compounds
US5661140A (en) 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
DK0717034T3 (da) 1994-12-14 1999-10-18 Duphar Int Res Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
ES2169220T3 (es) 1995-01-23 2002-07-01 Chugai Pharmaceutical Co Ltd Derivados de vitamina d3 con sustituyentes en la posicion 2.
US5877168A (en) 1995-02-10 1999-03-02 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivative with substituent at the 2β-position
JPH08295628A (ja) * 1995-04-27 1996-11-12 Teijin Ltd 脱毛症外用治療剤
DE19519273A1 (de) * 1995-05-22 1996-11-28 Schering Ag Topisch applizierbare Mittel zur Behandlung und Prophylaxe der Alopezie
US6844326B2 (en) 1995-06-07 2005-01-18 Anticancer, Inc. Treatment of alopecia
HUP9801059A3 (en) 1995-06-14 1999-05-28 Schering Ag Vitamin d derivatives with c-25 substituents, process for their preparation, intermediate products and their use in preparing medicaments
ATE189812T1 (de) 1995-10-30 2000-03-15 Hoffmann La Roche 1-alpha, 26-dihydroxy-d-homo-vitamin d3
GB9524812D0 (en) 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
GB9526208D0 (en) 1995-12-21 1996-02-21 Res Inst Medicine Chem Chemical compounds
GB9607034D0 (en) 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
US6288249B1 (en) 1996-05-02 2001-09-11 Kingdom Of The Netherlands Vitamin D analogs and methods of preparing these compounds
JPH09299484A (ja) 1996-05-10 1997-11-25 Maeda Sangyo Kk シリンジ・スプレーポンプ
GB9611603D0 (en) 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
US5976784A (en) 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
GB9622590D0 (en) 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
CA2275382A1 (en) 1996-12-20 1998-07-02 Chugai Seiyaku Kabushiki Kaisha 16-ene-vitamin d derivatives
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6392071B1 (en) 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
DE69813380T2 (de) 1997-05-02 2003-12-04 Duphar International Research B.V., Weesp Verfahren zur Herstellung von 16-Dehydro Vitamin D Verbindungen
US6017908A (en) 1997-05-16 2000-01-25 Women And Infants Hospital 3-EPI vitamin D2 compounds and uses thereof
CA2290772A1 (en) 1997-05-22 1998-11-26 Cephalon, Inc. Vitamin d analogues and their neuronal effects
WO1998055104A1 (fr) 1997-06-06 1998-12-10 Shionogi & Co., Ltd. Perfectionnement d'un systeme d'administration de medicament
AUPO727097A0 (en) * 1997-06-10 1997-07-03 Unisearch Limited Method of treatment of hepatoma and pharmaceutical compositions for use therein
US5936105A (en) 1997-06-13 1999-08-10 Tetrionics, Inc. 14-EPI-19-nor-vitamin D compounds and methods
US6359152B2 (en) 1997-07-21 2002-03-19 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US5939406A (en) 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
GB9721156D0 (en) 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
US5919986A (en) 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
US6043385A (en) 1997-12-16 2000-03-28 Hoffman-La Roche Inc. Vitamin D derivatives
WO1999031112A1 (de) * 1997-12-17 1999-06-24 Schering Aktiengesellschaft Vitamin d-derivate mit phosphoratomen in den seitenketten
US6184422B1 (en) 1998-02-26 2001-02-06 Hoffman-La Roche Inc. Cyclohexanediol derivatives
EP1064000B1 (en) 1998-03-27 2011-07-06 Oregon Health & Science University Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
US6410523B1 (en) 1998-04-10 2002-06-25 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivatives substituted at the 2beta-position
US6114317A (en) 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
IL139354A (en) 1998-05-29 2005-08-31 Bone Care Internat Inc Method for making hydroxy-25 ene-vitamin d compounds
US5972917A (en) 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US20010002396A1 (en) 1998-07-16 2001-05-31 Charles Achkar Compositions and methods of treating skin conditions
US6218430B1 (en) 1998-08-24 2001-04-17 Ligand Pharmaceuticals Incorporated Vitamin D3 mimics
AU758792B2 (en) * 1998-10-23 2003-03-27 Teijin Limited Vitamin D3 derivatives and remedies for inflammatory respiratory diseases containing the same
FR2785284B1 (fr) 1998-11-02 2000-12-01 Galderma Res & Dev Analogues de la vitamine d
US6238683B1 (en) * 1998-12-04 2001-05-29 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
KR200257098Y1 (ko) * 1999-01-21 2001-12-24 신석균 양면투시용 입체 투시기
FR2801307B1 (fr) 1999-11-24 2002-12-06 Galderma Res & Dev Analogues de la vitamine d
FR2801305B1 (fr) 1999-11-24 2002-12-06 Galderma Res & Dev Analogues de la vitamine d
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
WO2006120681A2 (en) 2005-05-10 2006-11-16 Dermipsor Ltd. Compositions and methods for skin care
WO2002030430A1 (en) * 2000-10-06 2002-04-18 Abbott Laboratories Use of vitamin d2 compounds for alopecia
FR2825087B1 (fr) * 2001-05-22 2005-01-14 Galderma Res & Dev Analogues de la vitamine d
GB0128628D0 (en) 2001-11-29 2002-01-23 Univ Sheffield Disease treatment
EP1477483A4 (en) 2002-02-20 2006-12-06 Teijin Ltd VITAMIN D3 DERIVATIVES AND MEDICAMENTS IN WHICH THEY ARE USED
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
BR0315553A (pt) * 2002-10-23 2005-08-23 Leo Pharma As Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, método de tratamento ou profilaxia de hiperparatireoidismo secundário, e, uso de um composto, opcionalmente em conjunto com outro composto terapeuticamente ativo
AR041696A1 (es) * 2002-10-23 2005-05-26 Leo Pharm Prod Ltd Compuestos analogos de vitamina d, composiciones que comprenden dichos compuestos analogos y su uso
WO2004110151A1 (en) 2003-06-11 2004-12-23 Novacea, Inc. Treatment of cancer with active vitamin d compounds in combination with radiotherapeutic agents and treatments
ATE455749T1 (de) 2003-10-14 2010-02-15 X Ceptor Therapeutics Inc Verbindungen mit verbrückten ringen als pharmazeutische mittel
FR2862540B1 (fr) 2003-11-21 2007-03-30 Galderma Res & Dev Composition sous forme de spray comprenant un actif pharmaceutique, au moins un silicone volatile et une phase non polaire non volatile
EP1952808A3 (en) 2003-11-21 2008-09-03 Galderma Research & Development Composition in the form of a spray comprising calcitriol
CN1732902A (zh) 2005-09-01 2006-02-15 晏四平 含有维生素类物质的喷雾剂
US8530463B2 (en) 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
CA2715811A1 (en) * 2008-03-06 2009-09-11 Wisconsin Alumni Research Foundation Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound
KR101791828B1 (ko) * 2009-08-14 2017-10-31 베르그 엘엘씨 탈모증 치료용 비타민 ｄ3 및 이의 유사체들
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
CA3026495A1 (en) 2016-06-05 2017-12-14 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Also Published As

Publication number Publication date
EP2464357A4 (en) 2013-08-14
AU2017210660B2 (en) 2019-04-18
WO2011019617A2 (en) 2011-02-17
CN102655869A (zh) 2012-09-05
WO2011019617A3 (en) 2011-06-30
KR20170121323A (ko) 2017-11-01
JP5978130B2 (ja) 2016-08-24
AU2017210660A1 (en) 2017-08-31
US11305016B2 (en) 2022-04-19
AU2010282731C1 (en) 2016-04-21
CA2770683A1 (en) 2011-02-17
AU2015238850A1 (en) 2015-10-29
BR112012003372A2 (pt) 2019-09-24
EP2464357A2 (en) 2012-06-20
AU2010282731B2 (en) 2015-08-13
JP2017008064A (ja) 2017-01-12
KR20120050479A (ko) 2012-05-18
JP2013501790A (ja) 2013-01-17
IL218043B (en) 2019-07-31
TW201733593A (zh) 2017-10-01
JP6336523B2 (ja) 2018-06-06
ES2742750T3 (es) 2020-02-17
EP3603646B1 (en) 2024-04-03
CN106265695A (zh) 2017-01-04
IL218043A0 (en) 2012-04-30
US20180369381A1 (en) 2018-12-27
CN105663146A (zh) 2016-06-15
TW201110971A (en) 2011-04-01
MX366076B (es) 2019-06-27
IN2012DN02137A (ru) 2015-08-07
CN105663146B (zh) 2020-09-11
SG178382A1 (en) 2012-04-27
MX338746B (es) 2016-04-29
MX2012001885A (es) 2012-06-01
CN106265695B (zh) 2021-05-07
TWI595877B (zh) 2017-08-21
CN102655869B (zh) 2016-08-10
CA2770683C (en) 2018-09-04
KR101880032B1 (ko) 2018-07-20
SG10201404883YA (en) 2014-10-30
EP2464357B1 (en) 2019-05-22
US9901637B2 (en) 2018-02-27
KR101791828B1 (ko) 2017-10-31
EP3603646A1 (en) 2020-02-05
AR077922A1 (es) 2011-10-05
ZA201707693B (en) 2019-05-29
AU2017210660C1 (en) 2019-10-24
AU2010282731A1 (en) 2012-03-08
US20110059917A1 (en) 2011-03-10
AU2015238850B2 (en) 2017-08-24
ZA201702812B (en) 2018-08-29

Similar Documents

Publication Publication Date Title
EA201270226A1 (ru) Витамин d3 и его аналогии для лечения алопеции
MX2020010535A (es) Inhibidor de ezh2 para usarse en el tratamiento de sarcoma epiteloide.
PH12014501560A1 (en) Carbamate compounds and of making and using same
PH12015501067A1 (en) Pyrrolopyrimidine compounds as kinase inhibitors
SG10201810888XA (en) Compositions and methods comprising bupropion or related compounds and dextromethorphan
BR112012016797A2 (pt) intensificador dinâmico de baixo utilizando compressor com equalizador incorporado
CR20120625A (es) Métodos de tratamiento contra el cáncer pancreático
MY166014A (en) Combination therapy methods for treating proliferative diseases
MX2012007806A (es) Composiciones farmaceuticas para administracion oral de peptidos de insulina.
MY162146A (en) Pharmaceutical composition
BR112014031394A2 (pt) composições e métodos para absorção transmucosa
MY153948A (en) Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
TN2012000059A1 (en) Compositions comprising tramadol and celecoxib in the treatment of pain
BR112013020586A2 (pt) Uso de células derivadas de tecido do cordão umbilical
EA201200428A1 (ru) Композиция и способ для лечения ожирения
MX2015012526A (es) Inhibodores macrociclicos de cinasa rip2.
WO2014071168A3 (en) Administering inhibitors of tgfbeta signaling to improve muscle function in cancer patients
PH12013501163A1 (en) Compositions comprising a p13k inhibitor and a mek inhibitor and their use for treating cancer
BR112015022196A2 (pt) composições de liberação prolongada, que compreendem hidrocodona e acetaminofeno para rápido início e analgesia prolongada, que podem ser administradas independentemente de alimentos
BR112012006070A2 (pt) composições e métodos para tratar distúrbios convulsivos.
PH12013500371A1 (en) Therapeutic agent for pain
MY161853A (en) Pharmaceutical composition and method for treating hypertension
EA201491836A1 (ru) Способы лечения рака с использованием ингибитора pi3k и ингибитора mek
MX358072B (es) Composiciones tópicas que comprenden diaminooxidasa para el tratamiento o la prevención de enfermedades asociadas a un nivel de histamina elevada que involucran un aumento del dolor.
WO2014023869A3 (es) Aplicacion terapéutica de agentes inhibidores de cd44 frente a la leucemia linfoblástica aguda (all) humana