DK0717034T3 - Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser - Google Patents
Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelserInfo
- Publication number
- DK0717034T3 DK0717034T3 DK95203412T DK95203412T DK0717034T3 DK 0717034 T3 DK0717034 T3 DK 0717034T3 DK 95203412 T DK95203412 T DK 95203412T DK 95203412 T DK95203412 T DK 95203412T DK 0717034 T3 DK0717034 T3 DK 0717034T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- compounds
- branched
- alkyl group
- vitamin
- Prior art date
Links
- 229930003316 Vitamin D Natural products 0.000 title abstract 2
- -1 Vitamin D compounds Chemical class 0.000 title abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 235000019166 vitamin D Nutrition 0.000 title abstract 2
- 239000011710 vitamin D Substances 0.000 title abstract 2
- 229940046008 vitamin d Drugs 0.000 title abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 230000000079 pharmacotherapeutic effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94203616 | 1994-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0717034T3 true DK0717034T3 (da) | 1999-10-18 |
Family
ID=8217451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95203412T DK0717034T3 (da) | 1994-12-14 | 1995-12-08 | Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5929056A (da) |
| EP (1) | EP0717034B1 (da) |
| JP (1) | JP4036490B2 (da) |
| AT (1) | ATE178596T1 (da) |
| CA (1) | CA2164916A1 (da) |
| DE (1) | DE69508895T2 (da) |
| DK (1) | DK0717034T3 (da) |
| ES (1) | ES2130522T3 (da) |
| IL (1) | IL116326A (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0884308B1 (en) * | 1997-05-02 | 2003-04-16 | Duphar International Research B.V | A method of preparing 16-dehydro vitamin D compounds |
| GB9721156D0 (en) * | 1997-10-06 | 1997-12-03 | Leo Pharm Prod Ltd | Novel vitamin d analogues |
| DE19935771A1 (de) | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| JP2005504279A (ja) * | 2001-09-27 | 2005-02-10 | ザ・コカ−コーラ・カンパニー | 食品のビタミン強化 |
| MX2007006262A (es) * | 2004-11-22 | 2007-07-10 | Wisconsin Alumni Res Found | 2-metilen-19-nor-1a-hidroxi-17-en homopregnacalciferol y sus usos. |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| US7879829B2 (en) * | 2008-07-10 | 2011-02-01 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2-dihydrofuran ring |
| US8193170B2 (en) * | 2008-07-10 | 2012-06-05 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs |
| US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| US7713953B2 (en) * | 2008-07-10 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs |
| US7648974B1 (en) * | 2008-07-10 | 2010-01-19 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 3,2-dihydrofuran ring |
| US8399439B2 (en) | 2008-07-10 | 2013-03-19 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
| EA201691980A1 (ru) | 2009-01-27 | 2017-07-31 | БЕРГ ЭлЭлСи | Способы уменьшения побочных эффектов, связанных с химиотерапией |
| KR101880032B1 (ko) | 2009-08-14 | 2018-07-20 | 베르그 엘엘씨 | 탈모증 치료용 비타민 ｄ3 및 이의 유사체들 |
| US8217023B2 (en) | 2009-10-02 | 2012-07-10 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring |
| WO2011041579A2 (en) | 2009-10-02 | 2011-04-07 | Wisconsin Alumni Research Foundation | (20S,22E)-2-METHYLENE-19-NOR-22-ENE-1α,25-DIHYDROXYVITAMIN D3 ANALOGS |
| US9834512B2 (en) | 2011-06-03 | 2017-12-05 | Wisconsin Alumni Research Foundation | (22E)-2-methylene-26,27-cyclo-22-dehydro-1α-hydroxy-19-norvitamin D3 derivatives |
| WO2013003307A1 (en) | 2011-06-28 | 2013-01-03 | Wisconsin Alumni Research Foundation | 2-methylene-(22e)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin d analogs |
| US20130178449A1 (en) | 2011-07-18 | 2013-07-11 | Wisconsin Alumni Research Foundation | 2-Methylene-20(21)-Dehydro-19,24,25,26,27-Pentanor-Vitamin D Analogs |
| US9416102B2 (en) | 2013-01-23 | 2016-08-16 | Wisconsin Alumni Research Foundation | (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs |
| CA2913543C (en) | 2013-05-29 | 2024-01-09 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| CN106279239B (zh) * | 2015-05-29 | 2019-06-28 | 上海彩迩文生化科技有限公司 | 多烯化合物、制备方法及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU206316B (en) * | 1988-04-29 | 1992-10-28 | Wisconsin Alumni Res Found | Process for producing 1-alpha-hydroxy-d-vitamine homologues with unsaturated side-chain and pharmaceutical compositions containing them |
| NZ232734A (en) * | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| FR2677022B1 (fr) * | 1991-05-29 | 1995-03-10 | Medgenix Group Sa | Derives de la vitamine d comportant un groupe epoxyde sur la chaine laterale. |
| ATE143007T1 (de) * | 1991-07-05 | 1996-10-15 | Duphar Int Res | Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür |
| DE4220757A1 (de) * | 1992-06-24 | 1994-01-05 | Schering Ag | Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| GB9214202D0 (en) * | 1992-07-03 | 1992-08-12 | Leo Pharm Prod Ltd | Chemical compounds |
-
1995
- 1995-12-08 ES ES95203412T patent/ES2130522T3/es not_active Expired - Lifetime
- 1995-12-08 EP EP95203412A patent/EP0717034B1/en not_active Expired - Lifetime
- 1995-12-08 DK DK95203412T patent/DK0717034T3/da active
- 1995-12-08 AT AT95203412T patent/ATE178596T1/de not_active IP Right Cessation
- 1995-12-08 DE DE69508895T patent/DE69508895T2/de not_active Expired - Fee Related
- 1995-12-11 CA CA002164916A patent/CA2164916A1/en not_active Abandoned
- 1995-12-11 IL IL11632695A patent/IL116326A/xx not_active IP Right Cessation
- 1995-12-11 US US08/570,560 patent/US5929056A/en not_active Expired - Fee Related
- 1995-12-11 JP JP34890195A patent/JP4036490B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0717034B1 (en) | 1999-04-07 |
| US5929056A (en) | 1999-07-27 |
| IL116326A (en) | 2000-08-13 |
| DE69508895D1 (de) | 1999-05-12 |
| IL116326A0 (en) | 1996-03-31 |
| ATE178596T1 (de) | 1999-04-15 |
| DE69508895T2 (de) | 1999-10-21 |
| EP0717034A1 (en) | 1996-06-19 |
| JPH08319268A (ja) | 1996-12-03 |
| JP4036490B2 (ja) | 2008-01-23 |
| CA2164916A1 (en) | 1996-06-15 |
| ES2130522T3 (es) | 1999-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0717034T3 (da) | Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser | |
| ATE142198T1 (de) | Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen | |
| MX9201244A (es) | Aminoguanidinas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. | |
| DK0513104T3 (da) | Anvendelse af et alfa-tocopherolphosphat eller et af dets derivater til fremstilling af kosmetiske, dermatologiske eller farmaceutiske præparater, og således opnåede præparater | |
| AR004672A1 (es) | Derivados de la banzo(g)quinolina, proceso para prepararlos,su utilizacion como productos farmaceuticos, las composiciones farmaceuticas que los contieneny los metodos de tratamiento de la depresion, ansiedad y desordenes bipolares que utilizan dichos compuestos. | |
| ATE52498T1 (de) | Amidderivate. | |
| ES2141137T3 (es) | Agentes terapeuticos para la enfermedad de parkinson. | |
| RS49906B (sr) | Benzociklohepteni, postupak za njihovo dobijanje, farmaceutski preparati koji ove sadrže kao i njihova primena za izradu lekova | |
| HUP9902576A1 (hu) | Új eritromicinszármazékok, eljárás előállításukra és alkalmazásuk gyógyászati készítményekben | |
| UA41869C2 (uk) | Похідні етаноламіну, спосіб їх одержання, фармацевтична композиція, спосіб лікування | |
| ES2063309T3 (es) | Derivados de pirimidina 3-oxido halogenados, su utilizacion para el tratamiento y la prevencion de la caida de los cabellos y para estimular su crecimiento. | |
| HUP0402076A2 (hu) | Szubsztituált indolok, eljárás az előállításukra és fájdalomcsillapítókénti alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| PT1022276E (pt) | Derivados de epoxissuccinamida | |
| ATE116647T1 (de) | Thiophenderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen. | |
| ATE417831T1 (de) | Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel | |
| TR200003877T2 (tr) | İnsan CD23 üretiminin ve TNF salınmasının ihhibitörleri olan hiydroxamic acid türevleri | |
| ES466795A1 (es) | Un procedimiento para la produccion de imidazo(1,5-b)pirida-zinas | |
| ES2016931B3 (es) | Procedimiento de preparación de nuevas amidas alifáticas y cicloalifáticas de piridilalquilaminas o de sus derivados N-óxidos. | |
| DK0434560T3 (da) | Hidtil ukendte substituerede aminosyrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem | |
| FR2633622B1 (fr) | Derives de sulfonyl indolizine, leur procede de preparation et leur utilisation comme intermediaires de synthese | |
| ATE233266T1 (de) | 8h-(2,3-b)-pyrrolozin-8-one derivate, verfahren zur ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen | |
| DK161090D0 (da) | Nyt topikalt praeparat til behandling af alopeci | |
| FI824062A0 (fi) | Foerfarande foer framstaellning av ketaler av nya 3'''-dehydro-kardenolid-tridigitoxosider och anvaendning av dem som laekemedel | |
| FR2611715B1 (fr) | Nouveaux acetamides derives de la dihydro-2,3 phenyl-3 benzofurannone-2, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent | |
| MX9802679A (es) | Derivados de ditiolan, su preparacion y su efecto terapeutico. |