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ATE455749T1 - Verbindungen mit verbrückten ringen als pharmazeutische mittel - Google Patents

Verbindungen mit verbrückten ringen als pharmazeutische mittel

Info

Publication number
ATE455749T1
ATE455749T1 AT04794900T AT04794900T ATE455749T1 AT E455749 T1 ATE455749 T1 AT E455749T1 AT 04794900 T AT04794900 T AT 04794900T AT 04794900 T AT04794900 T AT 04794900T AT E455749 T1 ATE455749 T1 AT E455749T1
Authority
AT
Austria
Prior art keywords
pharmaceutical agents
bridged ring
ring compounds
vitamin
receptor
Prior art date
Application number
AT04794900T
Other languages
English (en)
Inventor
Brenton Flatt
Richard Martin
Raju Mohan
Brett Murphy
Original Assignee
X Ceptor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by X Ceptor Therapeutics Inc filed Critical X Ceptor Therapeutics Inc
Application granted granted Critical
Publication of ATE455749T1 publication Critical patent/ATE455749T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/16—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
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    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms using aldehydes or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C07C39/16—Bis-(hydroxyphenyl) alkanes; Tris-(hydroxyphenyl)alkanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C43/02—Ethers
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
AT04794900T 2003-10-14 2004-10-13 Verbindungen mit verbrückten ringen als pharmazeutische mittel ATE455749T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51145703P 2003-10-14 2003-10-14
PCT/US2004/033666 WO2005037755A2 (en) 2003-10-14 2004-10-13 Bridged ring structures as pharmaceutical agents

Publications (1)

Publication Number Publication Date
ATE455749T1 true ATE455749T1 (de) 2010-02-15

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AT04794900T ATE455749T1 (de) 2003-10-14 2004-10-13 Verbindungen mit verbrückten ringen als pharmazeutische mittel

Country Status (8)

Country Link
US (1) US7863298B2 (de)
EP (1) EP1675812B1 (de)
JP (1) JP4782688B2 (de)
AT (1) ATE455749T1 (de)
AU (1) AU2004282162B2 (de)
CA (1) CA2542650C (de)
DE (1) DE602004025261D1 (de)
WO (1) WO2005037755A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601850B2 (en) * 2002-05-29 2009-10-13 Eli Lilly And Company Phenyl-thiophene type vitamin D receptor modulators
EP1687292B1 (de) * 2003-11-20 2007-08-22 Eli Lilly And Company Modulatoren des vitamin-d-rezeptors
JP4717005B2 (ja) * 2003-11-20 2011-07-06 イーライ リリー アンド カンパニー ビタミンｄ受容体モジュレータ
TW200600494A (en) * 2004-03-08 2006-01-01 Chugai Pharmaceutical Co Ltd Bisphenyl compounds useful as vitamin d3 receptor agonists
US7825265B2 (en) 2004-05-04 2010-11-02 Acadia Pharmaceuticals Inc. Compounds with activity at estrogen receptors
TW200716536A (en) 2005-06-09 2007-05-01 Chugai Pharmaceutical Co Ltd Vitamin D compounds
EP2265266B1 (de) 2008-03-10 2016-06-15 Wisconsin Alumni Research Foundation Vitamin-d-verbindungen und verfahren zur reduzierung von okularer hypertonie (oht)
AU2009337184A1 (en) * 2009-01-16 2011-07-28 Anzamed International Limited Medicament for the treatment of pain and inflammation
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
KR101880032B1 (ko) 2009-08-14 2018-07-20 베르그 엘엘씨 탈모증 치료용 비타민 ｄ3 및 이의 유사체들
JP5375502B2 (ja) * 2009-10-06 2013-12-25 信越化学工業株式会社 アルコール性水酸基含有化合物及びその製造方法
CA2913543C (en) 2013-05-29 2024-01-09 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
WO2019046433A1 (en) 2017-08-29 2019-03-07 National Jewish Health METHODS AND COMPOSITIONS FOR TREATING INFECTION AND INFLAMMATION WITH SELENOCYANATE

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543908A1 (de) * 1966-07-05 1970-01-02 Stecker Chemicals Inc Verfahren zur Herstellung von keimtoetend wirkenden,durch zwei Fluormethylgruppen substituierten Methylen-bisphenolen
JPS4931651A (de) * 1972-07-20 1974-03-22
US4717760A (en) * 1986-07-10 1988-01-05 The Dow Chemical Company Fluorinated tris-epoxides based on triphenyl methane
EP0285160B1 (de) * 1987-04-03 1993-12-08 Daikin Industries, Limited Fluor enthaltende aromatische Verbindung, Verfahren für ihre Herstellung und ihre Verwendung
EP0317884B1 (de) * 1987-11-24 1993-03-10 Hoechst Aktiengesellschaft Teilfluorierte Carbonsäuren sowie Derivate davon, Verfahren zu ihrer Herstellung und Verwendung
DE4001932A1 (de) * 1990-01-24 1991-07-25 Bayer Ag 1,1-bicyclo-substituierte fluorhaltige cyclopentane und verfahren zu deren herstellung
JPH03255067A (ja) * 1990-03-05 1991-11-13 Nitto Denko Corp 含フッ素ビスマレイミド及びその製造方法
US5210353A (en) * 1990-11-30 1993-05-11 Amoco Corporation Aromatic transformation process
JP2784882B2 (ja) * 1994-04-28 1998-08-06 第一工業製薬株式会社 粉末状高融点２，２−ビス［４′−（２″，３″−ジブロモプロポキシ）−３′，５′−ジブロモフェニル］プロパンの製造方法
US6218430B1 (en) * 1998-08-24 2001-04-17 Ligand Pharmaceuticals Incorporated Vitamin D3 mimics
US20060014811A1 (en) 2002-06-10 2006-01-19 Susumu Muto Medicament for treatment of cancer
CA2488979A1 (en) 2002-06-11 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Medicament for treatment of neurodegenerative diseases
WO2004048309A1 (en) * 2002-11-22 2004-06-10 Eli Lilly And Company Vitamin d receptor modulators
WO2004063345A2 (en) * 2003-01-10 2004-07-29 Eli Lilly And Company Vesicant treatment with phenyl-phenyl type vitamin d receptor modulators

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DE602004025261D1 (de) 2010-03-11
EP1675812A2 (de) 2006-07-05
AU2004282162A1 (en) 2005-04-28
US20070225377A1 (en) 2007-09-27
CA2542650A1 (en) 2005-04-28
EP1675812B1 (de) 2010-01-20
JP4782688B2 (ja) 2011-09-28
US7863298B2 (en) 2011-01-04
CA2542650C (en) 2013-04-23
WO2005037755A2 (en) 2005-04-28
WO2005037755A3 (en) 2005-08-18
JP2007509847A (ja) 2007-04-19
AU2004282162B2 (en) 2012-01-19

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