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EA200200758A1 - Способ получения 5-цианофталида - Google Patents

Способ получения 5-цианофталида

Info

Publication number
EA200200758A1
EA200200758A1 EA200200758A EA200200758A EA200200758A1 EA 200200758 A1 EA200200758 A1 EA 200200758A1 EA 200200758 A EA200200758 A EA 200200758A EA 200200758 A EA200200758 A EA 200200758A EA 200200758 A1 EA200200758 A1 EA 200200758A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyanophthalide
alkyl
hydrogen
ring
alkylene chain
Prior art date
Application number
EA200200758A
Other languages
English (en)
Other versions
EA005134B1 (ru
Inventor
Ханс Петерсен
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200200758A1 publication Critical patent/EA200200758A1/ru
Publication of EA005134B1 publication Critical patent/EA005134B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)

Abstract

Предложен способ получения 5-цианофталида, включающий обработку соединения формулы IV, в которой Х представляет собой О или S; каждый из R-Rнезависимо друг от друга выбирают из водорода и Cалкила или Rи Rсовместно образуют Салкиленовую цепочку, замыкающуюся в спиро-кольцо; Rвыбирают из водорода и Cалкила, Rвыбирают из водорода, Cалкила, карбоксигруппы или ее предшественника, либо Rи Rсовместно образуют Cалкиленовую цепочку, которая замыкается в спиро-кольцо; дегидратирующим агентом или, в том случае, когда Х представляет собой S, осуществляют термическое расщепление тиазолинового кольца или проводят обработку инициатором радикалов, таким как пероксид или свет, с образованием 5-цианофталида, который представляет собой важное промежуточное соединение, используемое в получении антидепрессанта циталопрама.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200758A 2000-01-14 2000-01-14 Способ получения 5-цианофталида EA005134B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK2000/000016 WO2001051477A1 (en) 2000-01-14 2000-01-14 Method for the preparation of 5-cyanophthalide

Publications (2)

Publication Number Publication Date
EA200200758A1 true EA200200758A1 (ru) 2002-12-26
EA005134B1 EA005134B1 (ru) 2004-12-30

Family

ID=8149377

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200758A EA005134B1 (ru) 2000-01-14 2000-01-14 Способ получения 5-цианофталида

Country Status (27)

Country Link
US (1) US6911548B2 (ru)
EP (1) EP1254129B1 (ru)
JP (1) JP2003519691A (ru)
KR (1) KR100660802B1 (ru)
CN (1) CN1195749C (ru)
AT (1) ATE252570T1 (ru)
AU (1) AU3033700A (ru)
CA (1) CA2397270C (ru)
CZ (1) CZ20022601A3 (ru)
DE (1) DE60006163T2 (ru)
DK (1) DK1254129T3 (ru)
EA (1) EA005134B1 (ru)
ES (1) ES2206177T3 (ru)
HK (1) HK1054392B (ru)
HU (1) HUP0300343A2 (ru)
IL (2) IL150561A0 (ru)
IS (1) IS2168B (ru)
IT (1) ITMI20010040A1 (ru)
MX (1) MXPA02006915A (ru)
NO (1) NO20023405L (ru)
PL (1) PL197821B1 (ru)
PT (1) PT1254129E (ru)
SI (1) SI1254129T1 (ru)
SK (1) SK286879B6 (ru)
TR (1) TR200201783T2 (ru)
UA (1) UA72569C2 (ru)
WO (1) WO2001051477A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ514671A (en) 1999-04-14 2003-10-31 H Method for the preparation of citalopram
DE69915713T2 (de) 1999-12-28 2005-03-03 H. Lundbeck A/S Verfahren zur herstellung von citalopram
HK1052512B (zh) 1999-12-30 2006-03-03 H. 隆德贝克有限公司 西酞普兰的制备方法
SK286879B6 (sk) 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
WO2001068629A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
DE60101786T2 (de) 2000-03-14 2004-07-15 H. Lundbeck A/S, Valby Verfahren zur herstellung von citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
US6982335B2 (en) * 2002-05-15 2006-01-03 Genzyme Corporation Synthesis of substituted thiazoline carboxylic acids
WO2005111010A1 (en) * 2004-05-13 2005-11-24 Suven Life Sciences Ltd, An improved process for the preparation of 5-cyanophthalide
CN116022748B (zh) * 2022-12-16 2024-02-27 山东惟普新能源有限公司 一种含水双氟磺酰亚胺锂的除水方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (ru) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DK1015416T3 (da) 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
NZ514671A (en) 1999-04-14 2003-10-31 H Method for the preparation of citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
DE69915713T2 (de) 1999-12-28 2005-03-03 H. Lundbeck A/S Verfahren zur herstellung von citalopram
HK1052512B (zh) 1999-12-30 2006-03-03 H. 隆德贝克有限公司 西酞普兰的制备方法
SK286879B6 (sk) 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
CN1282648C (zh) 2000-12-22 2006-11-01 H·隆德贝克有限公司 制备纯西酞普兰的方法
KR100430746B1 (ko) 2000-12-28 2004-05-10 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법

Also Published As

Publication number Publication date
IS2168B (is) 2006-11-15
SI1254129T1 (en) 2004-02-29
DK1254129T3 (da) 2004-03-29
HK1054392B (zh) 2005-11-18
IL150561A0 (en) 2003-02-12
SK286879B6 (sk) 2009-07-06
CA2397270A1 (en) 2001-07-19
HUP0300343A2 (hu) 2003-06-28
CN1423643A (zh) 2003-06-11
DE60006163T2 (de) 2004-04-15
NO20023405D0 (no) 2002-07-15
WO2001051477A1 (en) 2001-07-19
JP2003519691A (ja) 2003-06-24
KR100660802B1 (ko) 2006-12-26
NO20023405L (no) 2002-08-30
UA72569C2 (ru) 2005-03-15
IS6449A (is) 2002-06-28
ATE252570T1 (de) 2003-11-15
TR200201783T2 (tr) 2002-12-23
EP1254129B1 (en) 2003-10-22
PL356712A1 (en) 2004-06-28
US20030013895A1 (en) 2003-01-16
CA2397270C (en) 2007-08-21
CZ20022601A3 (cs) 2002-10-16
ES2206177T3 (es) 2004-05-16
KR20020073501A (ko) 2002-09-26
EA005134B1 (ru) 2004-12-30
ITMI20010040A1 (it) 2002-07-11
IL150561A (en) 2007-07-04
MXPA02006915A (es) 2002-10-23
DE60006163D1 (de) 2003-11-27
EP1254129A1 (en) 2002-11-06
HK1054392A1 (en) 2003-11-28
US6911548B2 (en) 2005-06-28
PL197821B1 (pl) 2008-04-30
CN1195749C (zh) 2005-04-06
PT1254129E (pt) 2004-03-31
AU3033700A (en) 2001-07-24
SK11662002A3 (sk) 2003-01-09

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU