EA027922B1 - Средства для лечения нарушений, вовлекающих модуляцию рецепторов рианодина - Google Patents

Средства для лечения нарушений, вовлекающих модуляцию рецепторов рианодина Download PDF

Info

Publication number: EA027922B1
Authority: EA; Eurasian Patent Office
Prior art keywords: compound; disorders; diseases; pharmaceutical composition; muscle
Prior art date: 2012-04-18

Application number

EA201401141A

Other languages

English (en)

Russian (ru)

Other versions

EA201401141A8 (ru

EA201401141A1 (ru

Inventor

Цзямин Ян

Сандро Бельведере

Яел Уэбб

Марк Бертран

Николь Вийенёв

Эндрью Р. Маркс

Жан-Луи Пеглион

Original Assignee

Ле Лаборатуар Сервье

Армго Фарма Инк.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-04-18

Filing date

2013-04-17

Publication date

2017-09-29

2013-04-17 Application filed by Ле Лаборатуар Сервье, Армго Фарма Инк. filed Critical Ле Лаборатуар Сервье

2015-04-30 Publication of EA201401141A1 publication Critical patent/EA201401141A1/ru

2015-08-31 Publication of EA201401141A8 publication Critical patent/EA201401141A8/ru

2017-09-29 Publication of EA027922B1 publication Critical patent/EA027922B1/ru

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/841—Muscles; heart

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Oncology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Obesity (AREA)

EA201401141A 2012-04-18 2013-04-17 Средства для лечения нарушений, вовлекающих модуляцию рецепторов рианодина EA027922B1 (ru)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261625890P	2012-04-18	2012-04-18
EP12167732.2A EP2708535A1 (en)	2012-05-11	2012-05-11	Agents for treating disorders involving modulation of ryanodine receptors
PCT/EP2013/057958 WO2013156505A1 (en)	2012-04-18	2013-04-17	Agents for treating disorders involving modulation of ryanodine receptors

Publications (3)

Publication Number	Publication Date
EA201401141A1 EA201401141A1 (ru)	2015-04-30
EA201401141A8 EA201401141A8 (ru)	2015-08-31
EA027922B1 true EA027922B1 (ru)	2017-09-29

Family

ID=49165460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EA201401141A EA027922B1 (ru)	2012-04-18	2013-04-17	Средства для лечения нарушений, вовлекающих модуляцию рецепторов рианодина

Country Status (48)

Country	Link
US (3)	US20130281512A1 (me)
EP (2)	EP2708535A1 (me)
JP (1)	JP5965542B2 (me)
KR (1)	KR101731459B1 (me)
CN (1)	CN104350045B (me)
AP (1)	AP3591A (me)
AR (1)	AR090712A1 (me)
AU (1)	AU2013248313B2 (me)
BR (1)	BR112014025670B1 (me)
CA (1)	CA2870599C (me)
CL (1)	CL2014002756A1 (me)
CO (1)	CO7091184A2 (me)
CR (1)	CR20140476A (me)
CU (1)	CU24327B1 (me)
CY (1)	CY1115826T1 (me)
DK (1)	DK2653466T3 (me)
DO (1)	DOP2014000230A (me)
EA (1)	EA027922B1 (me)
EC (1)	ECSP14027564A (me)
ES (1)	ES2529890T3 (me)
GT (1)	GT201400222A (me)
HK (2)	HK1192537A1 (me)
HR (1)	HRP20141113T8 (me)
HU (1)	HUE024284T2 (me)
IL (1)	IL235043A (me)
JO (1)	JO3070B1 (me)
MA (1)	MA37525B1 (me)
MD (1)	MD4489C1 (me)
ME (1)	ME01969B (me)
MX (1)	MX350890B (me)
MY (1)	MY167783A (me)
NI (1)	NI201400123A (me)
NZ (1)	NZ701122A (me)
PE (1)	PE20142193A1 (me)
PH (1)	PH12014502256A1 (me)
PL (1)	PL2653466T3 (me)
PT (1)	PT2653466E (me)
RS (1)	RS53711B1 (me)
RU (1)	RU2644350C2 (me)
SA (1)	SA113340479B1 (me)
SG (1)	SG11201406404YA (me)
SI (1)	SI2653466T1 (me)
TN (1)	TN2014000424A1 (me)
TW (1)	TWI507399B (me)
UA (1)	UA113759C2 (me)
UY (1)	UY34742A (me)
WO (1)	WO2013156505A1 (me)
ZA (1)	ZA201407499B (me)

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US9102645B2 (en)	2013-03-15	2015-08-11	Rosalind Franklin University Of Medicine And Science	Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release
EP3021841B1 (en)	2013-07-18	2022-11-16	Baylor College Of Medicine	Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia
WO2015197562A1 (en) *	2014-06-23	2015-12-30	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of disorders or diseases associated with ryanodine receptor dysfunction
US10071996B2 (en)	2014-07-30	2018-09-11	Aetas Pharma Co., Ltd.	Optical isomer of 1,4-benzothiazepine-1-oxide derivative, and pharmaceutical composition prepared using same
AU2015374155A1 (en) *	2014-12-30	2017-07-20	Myotherix, Inc.	Novel calcium modulators
ES2643856B1 (es)	2016-05-24	2018-08-03	Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea	Triazoles para la regulación de la homeostasis de calcio intracelular
US11426415B2 (en)	2017-03-06	2022-08-30	Washington University	Treatment for Wolfram syndrome and other endoplasmic reticulum stress disorders
WO2019082940A1 (ja) *	2017-10-25	2019-05-02	学校法人順天堂	リアノジン受容体阻害薬
US11026905B2 (en)	2018-04-19	2021-06-08	Tvardi Therapeutics, Inc.	STAT3 inhibitors
CN112367984B (zh)	2018-04-19	2024-05-10	特维迪疗法公司	Stat3抑制剂
MX2022008914A (es)	2020-01-24	2022-08-16	Tvardi Therapeutics Inc	Compuestos terapeuticos, formulaciones y usos de los mismos.
CN116635378A (zh)	2020-11-06	2023-08-22	赛特凯恩蒂克公司	二环1,4-二氮杂环庚酮和其治疗用途
WO2022150603A1 (en) *	2021-01-08	2022-07-14	Armgo Pharma, Inc.	Crystalline forms of a ryanodine receptor modulator and uses thereof
WO2022246114A2 (en) *	2021-05-20	2022-11-24	Armgo Pharma, Inc.	Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof
EP4433062A1 (en) *	2021-11-16	2024-09-25	Armgo Pharma, Inc.	Therapeutic compounds
US20230302013A1 (en) *	2022-02-09	2023-09-28	The Trustees Of Columbia University In The City Of New York	METHOD OF TREATING VIRAL-INDUCED COGNITIVE DYSFUNCTION BY TARGETING LEAKY RyR2 CHANNELS
EP4230196A1 (en)	2022-02-21	2023-08-23	Som Innovation Biotech, S.A.	Compounds for use in the treatment of dystrophinopathies
WO2023244946A1 (en)	2022-06-15	2023-12-21	Tvardi Therapeutics, Inc.	Prodrugs of stat3 inhibitors

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Publication number	Publication date
GT201400222A (es)	2018-09-28
CU24327B1 (es)	2018-03-13
CR20140476A (es)	2014-12-02
NZ701122A (en)	2016-07-29
US20130281512A1 (en)	2013-10-24
EA201401141A8 (ru)	2015-08-31
US20140378437A1 (en)	2014-12-25
TN2014000424A1 (fr)	2016-03-30
MX350890B (es)	2017-09-25
HK1192537A1 (zh)	2014-08-22
JO3070B1 (ar)	2017-03-15
ES2529890T8 (es)	2015-08-24
WO2013156505A1 (en)	2013-10-24
EP2653466A1 (en)	2013-10-23
MD4489B1 (ro)	2017-06-30
IL235043A (en)	2016-10-31
ECSP14027564A (es)	2015-08-31
PT2653466E (pt)	2014-12-03
AR090712A1 (es)	2014-12-03
MA37525A1 (fr)	2016-05-31
NI201400123A (es)	2015-03-05
MD20140119A2 (ro)	2015-04-30
ME01969B (me)	2015-05-20
US20140088171A1 (en)	2014-03-27
PE20142193A1 (es)	2014-12-31
SG11201406404YA (en)	2014-11-27
MA37525B1 (fr)	2016-12-30
HUE024284T2 (en)	2016-01-28
AP2014008011A0 (en)	2014-10-31
AU2013248313B2 (en)	2016-11-10
PH12014502256B1 (en)	2015-02-09
CU20140119A7 (es)	2015-03-30
EA201401141A1 (ru)	2015-04-30
JP5965542B2 (ja)	2016-08-10
AU2013248313A1 (en)	2014-10-30
PH12014502256A1 (en)	2015-02-09
HRP20141113T8 (hr)	2015-11-06
RU2644350C2 (ru)	2018-02-09
MD4489C1 (ro)	2018-01-31
HK1207073A1 (zh)	2016-01-22
JP2015514736A (ja)	2015-05-21
AP3591A (en)	2016-02-15
CO7091184A2 (es)	2014-10-21
MX2014012575A (es)	2015-07-06
US8853198B2 (en)	2014-10-07
KR20150003347A (ko)	2015-01-08
DK2653466T3 (en)	2015-02-02
TWI507399B (zh)	2015-11-11
MY167783A (en)	2018-09-25
CL2014002756A1 (es)	2015-06-12
CA2870599C (en)	2016-08-16
CA2870599A1 (en)	2013-10-24
RU2014145939A (ru)	2016-06-10
KR101731459B1 (ko)	2017-04-28
CN104350045A (zh)	2015-02-11
TW201345900A (zh)	2013-11-16
PL2653466T3 (pl)	2015-04-30
EP2708535A1 (en)	2014-03-19
EP2653466B1 (en)	2014-10-29
ES2529890T3 (es)	2015-02-25
CN104350045B (zh)	2016-08-24
RS53711B1 (en)	2015-04-30
UA113759C2 (xx)	2017-03-10
DOP2014000230A (es)	2014-12-15
CY1115826T1 (el)	2017-01-25
UY34742A (es)	2013-11-29
ZA201407499B (en)	2015-12-23
HRP20141113T1 (hr)	2015-01-02
BR112014025670B1 (pt)	2020-06-30
SI2653466T1 (sl)	2015-03-31
SA113340479B1 (ar)	2015-09-03

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