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DK3089994T3 - Fabs-in-tandem-immunglobulin og anvendelser deraf - Google Patents

Fabs-in-tandem-immunglobulin og anvendelser deraf Download PDF

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Publication number
DK3089994T3
DK3089994T3 DK14877308.8T DK14877308T DK3089994T3 DK 3089994 T3 DK3089994 T3 DK 3089994T3 DK 14877308 T DK14877308 T DK 14877308T DK 3089994 T3 DK3089994 T3 DK 3089994T3
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Prior art keywords
fabs
tandem immunoglobulin
immunoglobulin
tandem
Prior art date
Application number
DK14877308.8T
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English (en)
Inventor
Chengbin Wu
Original Assignee
Epimab Biotherapeutics Inc
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Publication of DK3089994T3 publication Critical patent/DK3089994T3/da

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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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DK14877308.8T 2013-12-30 2014-12-24 Fabs-in-tandem-immunglobulin og anvendelser deraf DK3089994T3 (da)

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CN2013090923 2013-12-30
PCT/US2014/072336 WO2015103072A1 (en) 2013-12-30 2014-12-24 Fabs-in-tandem immunoglobulin and uses thereof

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DK3089994T3 true DK3089994T3 (da) 2022-07-04

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US (4) US10519251B2 (da)
EP (2) EP3089994B1 (da)
JP (2) JP6706578B2 (da)
KR (1) KR102056963B1 (da)
CN (1) CN106459182B (da)
AR (1) AR098979A1 (da)
AU (1) AU2014374055B2 (da)
BR (1) BR112016015140A2 (da)
CA (1) CA2931641C (da)
CU (1) CU20160101A7 (da)
DK (1) DK3089994T3 (da)
ES (1) ES2923641T3 (da)
IL (1) IL246287B (da)
MX (1) MX2016008667A (da)
NZ (1) NZ720353A (da)
RU (2) RU2769133C2 (da)
TW (1) TWI672316B (da)
WO (1) WO2015103072A1 (da)

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US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
AU2014205086B2 (en) 2013-01-14 2019-04-18 Xencor, Inc. Novel heterodimeric proteins
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
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