DK2274297T3 - Pyrrolidinon-glucokinase-aktivatorer - Google Patents
Pyrrolidinon-glucokinase-aktivatorerInfo
- Publication number
- DK2274297T3 DK2274297T3 DK09732665.6T DK09732665T DK2274297T3 DK 2274297 T3 DK2274297 T3 DK 2274297T3 DK 09732665 T DK09732665 T DK 09732665T DK 2274297 T3 DK2274297 T3 DK 2274297T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrrolidinone
- glucokinase activators
- glucokinase
- activators
- pyrrolidinone glucokinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4537008P | 2008-04-16 | 2008-04-16 | |
| US14576109P | 2009-01-20 | 2009-01-20 | |
| PCT/EP2009/054067 WO2009127546A1 (en) | 2008-04-16 | 2009-04-06 | Pyrrolidinone glucokinase activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2274297T3 true DK2274297T3 (da) | 2012-07-16 |
Family
ID=40785354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09732665.6T DK2274297T3 (da) | 2008-04-16 | 2009-04-06 | Pyrrolidinon-glucokinase-aktivatorer |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7741327B2 (da) |
| EP (1) | EP2274297B1 (da) |
| JP (1) | JP5518838B2 (da) |
| KR (1) | KR101259249B1 (da) |
| CN (1) | CN102007118B (da) |
| AR (1) | AR071474A1 (da) |
| AT (1) | ATE557017T1 (da) |
| AU (1) | AU2009237794B2 (da) |
| BR (1) | BRPI0911035B8 (da) |
| CA (1) | CA2720524C (da) |
| CL (1) | CL2009000889A1 (da) |
| CY (1) | CY1112921T1 (da) |
| DK (1) | DK2274297T3 (da) |
| ES (1) | ES2386192T3 (da) |
| HR (1) | HRP20120589T1 (da) |
| IL (1) | IL207503A (da) |
| MX (1) | MX2010011226A (da) |
| PE (1) | PE20091842A1 (da) |
| PL (1) | PL2274297T3 (da) |
| PT (1) | PT2274297E (da) |
| RU (1) | RU2010146384A (da) |
| SI (1) | SI2274297T1 (da) |
| TW (1) | TW200944519A (da) |
| WO (1) | WO2009127546A1 (da) |
| ZA (1) | ZA201006159B (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110021570A1 (en) * | 2009-07-23 | 2011-01-27 | Nancy-Ellen Haynes | Pyridone glucokinase activators |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2553086B1 (en) | 2010-03-31 | 2017-04-19 | The Scripps Research Institute | Reprogramming cells |
| US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
| US20120142705A1 (en) * | 2010-12-06 | 2012-06-07 | Robert Francis Kester | Isatin and oxindole compounds |
| US8470866B2 (en) * | 2011-05-03 | 2013-06-25 | Hoffmann-La Roche Inc. | Isoindolinone derivatives |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| RU2621725C2 (ru) * | 2012-12-25 | 2017-06-07 | Хуа Медисин | Способ получения 1-([1,3]диоксолан-4-илметил)-1н-пиразол-3-иламина |
| US10604541B2 (en) | 2016-07-22 | 2020-03-31 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
| CA3046861A1 (en) * | 2016-12-15 | 2018-06-21 | Hua Medicine (Shanghai) Ltd. | Oral preparation of glucokinase activator and preparation method therefor |
| BR112019012584A2 (pt) | 2016-12-22 | 2019-11-19 | Bayer Ag | heteroarilpirrolonas substituídas e sais das mesmas e uso das mesmas como substâncias ativas herbicidas |
| WO2018114662A1 (de) | 2016-12-22 | 2018-06-28 | Bayer Cropscience Aktiengesellschaft | Substituierte 1,2,4-thiadiazolylpyrrolone und 1,2,4-thiadiazolylhydantoine sowie deren salze und ihre verwendung als herbizide wirkstoffe |
| BR112020012166A2 (pt) | 2017-12-19 | 2020-11-24 | Bayer Aktiengesellschaft | n-heterociclil- e n-heteroaril-tetra-hidropirimidinonas substituídas e os sais das mesmas, e o uso das mesmas como substâncias ativas herbicidas |
| CN114246950A (zh) * | 2018-05-31 | 2022-03-29 | 华领医药技术（上海）有限公司 | 含葡萄糖激酶激活剂和α-葡萄糖苷酶抑制剂的药物组合及其制备方法和用途 |
| CN113493442B (zh) * | 2020-04-03 | 2024-11-08 | 天津药物研究院有限公司 | 作为葡萄糖激酶活化剂的吡咯烷酮衍生物及其制备方法和用途 |
| US11813274B2 (en) | 2020-04-22 | 2023-11-14 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| WO2021212360A1 (en) * | 2020-04-22 | 2021-10-28 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| JP7595985B2 (ja) | 2020-08-24 | 2024-12-09 | 華領医薬技術（上海）有限公司 | 置換アクリレート化合物の製造 |
| TWI817307B (zh) * | 2021-01-04 | 2023-10-01 | 大陸商華領醫藥技術（上海）有限公司 | 多扎格列艾汀（ｄｏｒｚａｇｌｉａｔｉｎ）和胰高血糖素樣肽-１類似物的藥物組成物 |
| CN113527265B9 (zh) * | 2021-02-02 | 2022-07-19 | 湖南南新制药股份有限公司 | 一种氘代吡咯烷酮衍生物、药物组合物及其用途 |
| CN113750100B (zh) * | 2021-08-31 | 2022-12-30 | 海南中济医药科技有限公司 | 一种含有多扎格列艾汀与西格列汀的药物组合物及其制备方法 |
| AR127064A1 (es) | 2021-09-15 | 2023-12-13 | Hua Medicine Shanghai Ltd | Prodroga de derivados de pirrolidona como activador de glucoquinasa |
| KR20250006204A (ko) | 2022-04-25 | 2025-01-10 | 니뽄 신야쿠 가부시키가이샤 | Ddr1 키나아제 저해제로서의 화합물 및 의약 |
| WO2024188273A1 (zh) * | 2023-03-13 | 2024-09-19 | 华领医药技术（上海）有限公司 | 作为葡萄糖激酶激活剂的吡咯烷酮衍生物的固体形式 |
| CN118812408A (zh) * | 2024-09-18 | 2024-10-22 | 潍坊市海欣药业有限公司 | 一种多格列艾汀关键中间体的合成方法 |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE842346C (de) | 1950-10-14 | 1952-06-26 | Joachim Dipl-Chem Dr Goerdeler | Verfahren zur Darstellung von 5-Amino-1, 2, 4-thiodiazolen |
| NO844147L (no) | 1983-10-18 | 1985-04-19 | Du Pont | Nye 8-substituerte pyrazolopentathiepiner og beslektede forbindelser og deres anvendelse som fungicider og som svovelsensitiviseringsmidler i fotografiske emulsjoner |
| JPS6284064A (ja) | 1985-10-09 | 1987-04-17 | Shionogi & Co Ltd | ３−パ−フルオロアルキル−５−ヒドロキシイソオキサゾ−ル類 |
| CH668422A5 (de) | 1986-06-26 | 1988-12-30 | Lonza Ag | 4-benzyloxy-3-pyrrolin-2-on, dessen herstellung und verwendung zur synthese von tetramsaeure. |
| GB9103454D0 (en) | 1991-02-19 | 1991-04-03 | Pfizer Ltd | Therapeutic agents |
| IL116507A (en) | 1991-11-13 | 1997-08-14 | Schering Ag | Pyrazole derivatives |
| US5498190A (en) | 1994-06-27 | 1996-03-12 | Handsontoys, Inc. | Flexible foam construction toy and method of manufacturing same |
| JPH08151386A (ja) | 1994-09-27 | 1996-06-11 | Takeda Chem Ind Ltd | 複素環エチルチオセフェム化合物、その製造法および抗菌組成物 |
| US6114541A (en) | 1997-03-10 | 2000-09-05 | Hoffmann-La Roche Inc. | Method for the preparation of α-Bromo-Lactam derivatives |
| ES2205760T3 (es) | 1998-04-30 | 2004-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos antipicornavirales, su preparacion y su utilizacion. |
| GB9812523D0 (en) | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
| RU2242469C2 (ru) * | 1999-03-29 | 2004-12-20 | Ф.Хоффманн-Ля Рош Аг | Активаторы глюкокиназы |
| US6610846B1 (en) | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
| ES2226811T3 (es) | 1999-03-29 | 2005-04-01 | F. Hoffmann-La Roche Ag | Activadores de glucoquinasa. |
| WO2001005783A1 (en) | 1999-07-15 | 2001-01-25 | Pharmacopeia, Inc. | Bradykinin b1 receptor antagonists |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| KR100502033B1 (ko) | 2000-05-03 | 2005-07-25 | 에프. 호프만-라 로슈 아게 | 알키닐 페닐 헤테로방향족 글루코키나제 활성제 |
| AU6591401A (en) | 2000-05-08 | 2001-11-20 | Hoffmann La Roche | Para-amine substituted phenylamide glucokinase activators |
| AU778036B2 (en) | 2000-05-08 | 2004-11-11 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
| BR0115999A (pt) | 2000-12-06 | 2003-09-30 | Hoffmann La Roche | Composto, composição farmacêutica que compreende o mesmo, sua utilização, processo para o tratamento profilático ou terapêutico de diabetes do tipo ii e processo para a preparação do composto |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| WO2003095438A1 (en) | 2002-04-26 | 2003-11-20 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
| JP4881559B2 (ja) | 2002-06-27 | 2012-02-22 | ノボ・ノルデイスク・エー／エス | 治療薬としてのアリールカルボニル誘導体 |
| CA2498089A1 (en) | 2002-10-03 | 2004-06-17 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
| AU2003287038A1 (en) | 2002-10-09 | 2004-05-04 | The Board Of Trustees Of The University Of Illinois | METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO (2, 3-b) FURAN AND RELATED COMPOUNDS |
| MY141521A (en) | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| US7262196B2 (en) | 2003-02-11 | 2007-08-28 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
| PE20050194A1 (es) * | 2003-02-13 | 2005-04-23 | Banyu Pharma Co Ltd | Derivados de piridina-2-carboxamida como activadores de glucoquinasa |
| AU2004215514B2 (en) | 2003-02-26 | 2010-03-04 | Msd K.K. | Heteroarylcarbamoylbenzene derivative |
| CA2547591C (en) | 2003-10-24 | 2010-08-17 | Aventis Pharmaceuticals Inc. | Novel compounds and compositions as cathepsin inhibitors |
| US7473696B2 (en) | 2003-10-27 | 2009-01-06 | Merck & Co., Inc. | CCR-2 antagonist salt |
| RU2386622C9 (ru) | 2004-01-06 | 2021-04-21 | Ново Нордиск А/С | Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы |
| WO2005080359A1 (en) | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
| BRPI0507734A (pt) | 2004-02-18 | 2007-07-10 | Astrazeneca Ab | composto ou um sal, pró-droga ou solvato do mesmo, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto |
| WO2005090332A1 (ja) | 2004-03-23 | 2005-09-29 | Banyu Pharmaceutical Co., Ltd | 置換キナゾリン又はピリドピリミジン誘導体 |
| EP1737870A1 (en) | 2004-04-02 | 2007-01-03 | Novartis AG | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
| US7750020B2 (en) | 2004-04-02 | 2010-07-06 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of Type 2 diabetes |
| WO2005103021A1 (en) | 2004-04-21 | 2005-11-03 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
| TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| GB0418046D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Eantioselective process |
| GB0418058D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Fluorination process |
| US7745491B2 (en) | 2004-08-12 | 2010-06-29 | Prosidion Limited | Substituted phenylacetamides and their use as glucokinase activators |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| GB0423044D0 (en) | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| WO2006058923A1 (en) | 2004-12-03 | 2006-06-08 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
| WO2006064286A1 (en) | 2004-12-13 | 2006-06-22 | Medivir Uk Ltd | Cathepsin s inhibitors |
| WO2006094770A2 (en) | 2005-03-08 | 2006-09-14 | Ludwig-Maximilians-Universitaet Muenchen | Apparatus and method for the final processing of a forming tool for a sheet-metal body part |
| TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| JP2009500377A (ja) | 2005-07-08 | 2009-01-08 | ノボ・ノルデイスク・エー／エス | ジシクロアルキルウレア型グルコキナーゼ活性化剤 |
| US20080234273A1 (en) | 2005-07-09 | 2008-09-25 | Mckerrecher Darren | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes |
| NZ575512A (en) | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| US20110053910A1 (en) | 2005-07-09 | 2011-03-03 | Mckerrecher Darren | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
| MX2008000560A (es) | 2005-07-11 | 2008-03-10 | Mitsubishi Tanabe Pharma Corp | Un derivado de oxima y sus preparaciones. |
| EP1904467B1 (en) | 2005-07-14 | 2013-05-01 | Novo Nordisk A/S | Urea glucokinase activators |
| JP2009504621A (ja) | 2005-08-09 | 2009-02-05 | アストラゼネカ アクチボラグ | 糖尿病の処置のためのヘテロアリールカルバモイルベンゼン誘導体 |
| WO2007026761A1 (ja) | 2005-08-31 | 2007-03-08 | Astellas Pharma Inc. | チアゾール誘導体 |
| GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
| WO2007053503A1 (en) | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Substituted dihydroisoindolones as allosteric modulators of glucokinase |
| EP1948645A1 (en) | 2005-11-03 | 2008-07-30 | Prosidion Limited | Tricyclo substituted amides |
| US20080293741A1 (en) | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
| WO2007051845A1 (en) | 2005-11-03 | 2007-05-10 | Prosidion Ltd | Tricyclo substituted amides |
| TWI411607B (zh) | 2005-11-14 | 2013-10-11 | Vitae Pharmaceuticals Inc | 天門冬胺酸蛋白酶抑制劑 |
| WO2007061923A2 (en) | 2005-11-18 | 2007-05-31 | Takeda San Diego, Inc. | Glucokinase activators |
| CN101437512A (zh) | 2006-01-27 | 2009-05-20 | 阿雷生物药品公司 | 葡萄糖激酶活化剂 |
| EP2001875A2 (en) | 2006-03-08 | 2008-12-17 | Takeda San Diego, Inc. | Glucokinase activators |
| EP2543667B1 (en) | 2006-03-24 | 2015-01-28 | Array Biopharma, Inc. | A method of preparing 2-aminopyridine analogs as glucokinase activators |
| WO2007115968A2 (en) | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Process for the preparation of a glucokinase activator |
| JP5190448B2 (ja) | 2006-04-20 | 2013-04-24 | ファイザー・プロダクツ・インク | グルコキナーゼ仲介疾患を予防および治療するための縮合フェニルアミド複素環化合物 |
| CA2649577A1 (en) | 2006-04-28 | 2007-11-08 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
| US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
| US7888504B2 (en) | 2006-07-06 | 2011-02-15 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
| MX2009000688A (es) | 2006-07-24 | 2009-01-30 | Hoffmann La Roche | Pirazoles como activadores de glucocinasa. |
| KR20090034395A (ko) * | 2006-07-26 | 2009-04-07 | 노파르티스 아게 | 운데카프레닐 피로포스페이트 합성효소의 억제제 |
| MX2009009525A (es) | 2007-03-07 | 2009-09-16 | Kyorin Seiyaku Kk | Activador de glucocinasa. |
| US20100222326A1 (en) | 2007-04-27 | 2010-09-02 | Ucb Pharma, S.A. | New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders |
| CN101121688A (zh) | 2007-09-14 | 2008-02-13 | 南开大学 | 合成奥拉西坦的改进方法 |
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