DK2041123T3 - Kondenserede cykliske forbindelser. - Google Patents

Kondenserede cykliske forbindelser.

Info

Publication number: DK2041123T3
Authority: DK; Denmark
Prior art keywords: cyclic compounds; condensed cyclic; condensed; compounds; cyclic
Prior art date: 2006-06-27

Application number

DK07767983.5T

Other languages

English (en)

Inventor

Tsuneo Yasuma

Nobuyuki Negoro

Masayuki Yamashita

Masahiro Itou

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-27

Filing date

2007-06-26

Publication date

2012-05-07

2007-06-26 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2012-05-07 Application granted granted Critical

2012-05-07 Publication of DK2041123T3 publication Critical patent/DK2041123T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Immunology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Vascular Medicine (AREA)

DK07767983.5T 2006-06-27 2007-06-26 Kondenserede cykliske forbindelser. DK2041123T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2006177099		2006-06-27
PCT/JP2007/063208 WO2008001931A2 (en)	2006-06-27	2007-06-26	Fused cyclic compounds

Publications (1)

Publication Number	Publication Date
DK2041123T3 true DK2041123T3 (da)	2012-05-07

Family

ID=38656568

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK10172951.5T DK2248812T5 (da)	2006-06-27	2007-06-26	Kondenserede cykliske forbindelser som GPR40-receptormodulatorer
DK07767983.5T DK2041123T3 (da)	2006-06-27	2007-06-26	Kondenserede cykliske forbindelser.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK10172951.5T DK2248812T5 (da)	2006-06-27	2007-06-26	Kondenserede cykliske forbindelser som GPR40-receptormodulatorer

Country Status (36)

Country	Link
US (5)	US7732626B2 (da)
EP (4)	EP2431367A3 (da)
JP (3)	JP4401428B2 (da)
KR (1)	KR101058772B1 (da)
CN (4)	CN102731451B (da)
AR (1)	AR061644A1 (da)
AT (1)	ATE543815T1 (da)
AU (1)	AU2007265966B2 (da)
BR (1)	BRPI0713378A8 (da)
CA (2)	CA2838448A1 (da)
CL (1)	CL2007001873A1 (da)
CO (1)	CO6160234A2 (da)
CR (1)	CR10564A (da)
CY (2)	CY1112705T1 (da)
DK (2)	DK2248812T5 (da)
ES (2)	ES2379661T3 (da)
GE (1)	GEP20115359B (da)
HR (2)	HRP20120333T1 (da)
IL (1)	IL195947A (da)
JO (1)	JO2969B1 (da)
MA (1)	MA30537B1 (da)
ME (1)	ME00535B (da)
MX (1)	MX2008016274A (da)
MY (1)	MY154798A (da)
NO (1)	NO20090235L (da)
NZ (1)	NZ574038A (da)
PE (1)	PE20080993A1 (da)
PL (2)	PL2041123T3 (da)
PT (2)	PT2248812E (da)
RS (2)	RS52307B (da)
RU (1)	RU2444521C2 (da)
SI (2)	SI2041123T1 (da)
TW (1)	TWI354668B (da)
UA (1)	UA95296C2 (da)
WO (1)	WO2008001931A2 (da)
ZA (1)	ZA200900154B (da)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
BRPI0818253A2 (pt)	2007-10-10	2015-04-07	Amgen Inc	Moduladores de gpr40 bifenil substituídos
US8450522B2 (en) *	2008-03-06	2013-05-28	Amgen Inc.	Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
WO2009117421A2 (en) *	2008-03-17	2009-09-24	Kalypsys, Inc.	Heterocyclic modulators of gpr119 for treatment of disease
JP2012503595A (ja)	2008-07-28	2012-02-09	シダンスクユニバーシティ	代謝病の治療用の化合物
TW201014850A (en)	2008-09-25	2010-04-16	Takeda Pharmaceutical	Solid pharmaceutical composition
ES2450567T3 (es)	2008-10-15	2014-03-25	Amgen, Inc	Moduladores de GPR40 espirocíclicos
EP2351743A4 (en)	2008-10-27	2012-05-09	Takeda Pharmaceutical	BICYCLIC COMPOUND
AR074760A1 (es) *	2008-12-18	2011-02-09	Metabolex Inc	Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
EP2371826A4 (en)	2008-12-29	2012-06-27	Takeda Pharmaceutical	NEW CONNECTION WITH CONDENSED RINGS AND ITS USE
WO2010087467A1 (en)	2009-01-27	2010-08-05	Takeda Pharmaceutical Company Limited	Delta-5-desaturase inhibitors
EP2423176A4 (en)	2009-04-22	2012-11-07	Astellas Pharma Inc	CARBOXYLIC ACID COMPOUND
WO2010143733A1 (en)	2009-06-09	2010-12-16	Takeda Pharmaceutical Company Limited	Novel fused cyclic compound and use thereof
SG178062A1 (en)	2009-07-28	2012-03-29	Takeda Pharmaceutical	Tablet
CA2779398A1 (en)	2009-10-30	2011-05-05	Mochida Phamaceutical Co., Ltd.	Novel 3-hydroxy-5-arylisoxazole derivative
MX2012007474A (es)	2009-12-25	2012-08-01	Mochida Pharm Co Ltd	Derivados de 3-hidroxi-5-arilisotiazol novedosos.
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
PH12012502347A1 (en)	2010-04-27	2014-10-14	Takeda Pharmaceuticals Co	Bicyclic compound derivatives and their use as acc inhibitors
AU2011266099B2 (en)	2010-06-16	2014-09-11	Takeda Pharmaceutical Company Limited	Crystal of amide compound
US8299117B2 (en)	2010-06-16	2012-10-30	Metabolex Inc.	GPR120 receptor agonists and uses thereof
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
US20130184272A1 (en)	2010-09-17	2013-07-18	Takeda Pharmaceutical Company Limited	Diabetes therapeutic agent
US9040525B2 (en)	2010-10-08	2015-05-26	Mochida Pharmaceutical Co., Ltd.	Cyclic amide derivative
AU2011337565A1 (en)	2010-11-30	2013-07-11	Takeda Pharmaceutical Company Limited	Bicyclic compound
ES2546154T3 (es)	2010-12-01	2015-09-21	Boehringer Ingelheim International Gmbh	Ácidos indaniloxidihidrobenzofuranilacéticos, útiles para el tratamiento del síndrome metabólico
WO2012111849A1 (en) *	2011-02-17	2012-08-23	Takeda Pharmaceutical Company Limited	Production method of optically active dihydrobenzofuran derivative
CN104470886A (zh)	2011-04-08	2015-03-25	赛丹思科大学	用于治疗代谢疾病的邻-氟取代的化合物
WO2012147518A1 (ja)	2011-04-27	2012-11-01	持田製薬株式会社	新規３－ヒドロキシイソチアゾール１－オキシド誘導体
JPWO2012147516A1 (ja)	2011-04-28	2014-07-28	持田製薬株式会社	環状アミド誘導体
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103012343B (zh) *	2011-09-26	2015-04-08	上海恒瑞医药有限公司	稠合环类衍生物、其制备方法及其在医药上的应用
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9133129B2 (en)	2011-10-24	2015-09-15	Takeda Pharmaceutical Company Limited	Bicyclic compound
US9365540B2 (en)	2012-01-12	2016-06-14	Takeda Pharmaceutical Company Limited	Benzimidazole derivatives as MCH receptor antagonists
UA115975C2 (uk) *	2012-01-12	2018-01-25	Джянгсу Хенгруй Медісін Ко., Лтд.	Поліциклічні похідні як агоністи gpr40 для лікування діабету та метаболічного синдрому та спосіб їх отримання
GB2498968A (en) *	2012-02-01	2013-08-07	Prosidion Ltd	Pharmaceutical combination of a GPR119 agonist and a GPR40 agonist
US9181186B2 (en)	2012-02-13	2015-11-10	Takeda Pharmaceutical Company Limited	Aromatic ring compound
US9382188B2 (en)	2012-02-13	2016-07-05	Takeda Pharmaceutical Company Limited	Aromatic ring compound
US20150011549A1 (en)	2012-02-15	2015-01-08	Takeda Pharmaceutical Company Limited	Tablet
US9238639B2 (en)	2012-02-24	2016-01-19	Takeda Pharmaceutical Company Limited	Aromatic ring compound
AU2013227266A1 (en)	2012-02-28	2014-10-02	Piramal Enterprises Limited	Phenyl alkanoic acid derivatives as GPR agonists
US8642585B2 (en) *	2012-03-26	2014-02-04	Boehringer Ingelheim International Gmbh	Indanyloxydihydrobenzofuranylacetic acids
US9073864B2 (en)	2012-03-29	2015-07-07	Takeda Pharmaceutical Company Limted	Aromatic ring compound
US8809376B2 (en) *	2012-04-30	2014-08-19	Boehringer Ingelheim International Gmbh	Indanyloxydihydrobenzofuranylacetic acids
JPWO2013168760A1 (ja)	2012-05-10	2016-01-07	武田薬品工業株式会社	芳香環化合物
EP2848621A4 (en)	2012-05-10	2016-06-01	Takeda Pharmaceutical	AROMATIC RING CONNECTION
US9486411B2 (en)	2012-06-05	2016-11-08	Takeda Pharmaceutical Company Limited	Solid preparation
EP2872127A1 (en)	2012-07-11	2015-05-20	Elcelyx Therapeutics, Inc.	Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
JP2015127299A (ja)	2012-07-19	2015-07-09	武田薬品工業株式会社	固形製剤
RU2015106909A (ru)	2012-08-02	2016-09-27	Мерк Шарп И Доум Корп.	Антидиабетические трициклические соединения
SI2894151T1 (sl)	2012-09-04	2021-01-29	Shanghai Hengrui Pharmaceutical Co. Ltd.	Imidazolinski derivati, postopki za njihovo pripravo in njihove uporabe v medicini
US20150297573A1 (en)	2012-10-24	2015-10-22	INSERM (Institut National de la Santé et de la Recherche Médicale)	TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
TWI692469B (zh) *	2012-11-09	2020-05-01	南韓商Ｌｇ化學股份有限公司	Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物
CA2891574A1 (en)	2012-11-16	2014-05-22	Bristol-Myers Squibb Company	Dihydropyrazole gpr40 modulators
CN104822675A (zh)	2012-11-28	2015-08-05	勃林格殷格翰国际有限公司	新的茚满基氧基二氢苯并呋喃乙酸
US20140163025A1 (en)	2012-12-07	2014-06-12	Boehringer Ingelheim International Gmbh	Indanyloxydihydrobenzofuranylacetic acids
JP6314335B2 (ja)	2013-02-06	2018-04-25	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新しいインダニルオキシジヒドロベンゾフラニル酢酸
US9840512B2 (en)	2013-02-22	2017-12-12	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
AU2014221489B2 (en) *	2013-02-28	2018-03-08	Tiumbio Co., Ltd.	Tricyclic compound and use thereof
CN103145663B (zh) *	2013-03-01	2016-03-23	上海高准医药有限公司	(s)-2-(2,3-二氢苯并呋喃-3-基)乙酸衍生物，其制备方法及其在医药上的应用
US9605000B2 (en)	2013-03-14	2017-03-28	Takeda Pharmaceutical Company Limited	Spiro azetidine isoxazole derivatives and their use as SSTR antagonists
CN104059039B (zh) *	2013-03-22	2017-03-15	正大天晴药业集团股份有限公司	具有gpr40受体功能调节作用的稠环化合物
WO2014165816A1 (en)	2013-04-05	2014-10-09	North Carolina Central University	Compounds useful for the treatment of metabolic disorders and synthesis of the same
WO2014170842A2 (en)	2013-04-17	2014-10-23	Piramal Enterprises Limited	Substituted alkyl carboxylic acid derivatives as gpr agonists
CN104870429B (zh) *	2013-05-22	2017-05-03	四川海思科制药有限公司	苯并呋喃衍生物、其制备方法及其在医药上的应用
CN104250238B (zh) *	2013-06-25	2017-12-26	南京圣和药业股份有限公司	Gpr40激动剂及其应用
CN104250239B (zh) *	2013-06-29	2016-09-07	山东轩竹医药科技有限公司	芳香多环羧酸衍生物
CN104507921B (zh) *	2013-07-02	2017-02-22	四川海思科制药有限公司	苯并环丁烯类衍生物、其制备方法及其在医药上的应用
CA2917490A1 (en)	2013-07-09	2015-01-15	Takeda Pharmaceutical Company Limited	Heterocyclic compound
HUE039259T2 (hu)	2013-08-09	2018-12-28	Takeda Pharmaceuticals Co	Aromás vegyület
CN104370864B (zh) *	2013-08-14	2016-04-13	成都苑东生物制药股份有限公司	一种2-(6-羟基-2,3-二氢苯并呋喃-3-基)乙腈化合物和以该化合物制备tak-875药物的方法
CN105246875A (zh) *	2013-09-03	2016-01-13	四川海思科制药有限公司	茚满衍生物及其制备方法和在医药上的应用
JO3442B1 (ar)	2013-10-07	2019-10-20	Takeda Pharmaceuticals Co	مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
WO2015051496A1 (en)	2013-10-08	2015-04-16	Merck Sharp & Dohme Corp.	Antidiabetic tricyclic compounds
WO2015062486A1 (en) *	2013-10-31	2015-05-07	Sunshine Lake Pharma Co., Ltd.	Biphenyl compounds and uses thereof
WO2015097713A1 (en)	2013-11-14	2015-07-02	Cadila Healthcare Limited	Novel heterocyclic compounds
ES2747973T3 (es)	2013-11-15	2020-03-12	Merck Sharp & Dohme	Compuestos tricíclicos antidiabéticos
CN104650055A (zh) *	2013-11-22	2015-05-27	山东轩竹医药科技有限公司	芳香多环羧酸衍生物
WO2015084692A1 (en)	2013-12-04	2015-06-11	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
WO2015089809A1 (en)	2013-12-19	2015-06-25	Merck Sharp & Dohme Corp.	Antidiabetic substituted heteroaryl compounds
EP3102198B1 (en)	2014-02-06	2020-08-26	Merck Sharp & Dohme Corp.	Antidiabetic compounds
US9428470B2 (en)	2014-02-13	2016-08-30	Takeda Pharmaceutical Company Limited	Heterocyclic compound
US9346776B2 (en)	2014-02-13	2016-05-24	Takeda Pharmaceutical Company Limited	Fused heterocyclic compound
CN105001212B (zh) *	2014-04-16	2018-01-16	江苏柯菲平医药股份有限公司	稠环化合物及其制备方法和应用
WO2015176267A1 (en)	2014-05-22	2015-11-26	Merck Sharp & Dohme Corp.	Antidiabetic tricyclic compounds
US10100042B2 (en)	2014-08-08	2018-10-16	Merck Sharp & Dohme Corp.	[5,6]—fused bicyclic antidiabetic compounds
WO2016019587A1 (en)	2014-08-08	2016-02-11	Merck Sharp & Dohme Corp.	[7, 6]-fused bicyclic antidiabetic compounds
US10662171B2 (en)	2014-08-08	2020-05-26	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
EP3177287B1 (en)	2014-08-08	2022-02-23	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
CN104193731B (zh) *	2014-08-27	2017-03-15	广东东阳光药业有限公司	一种脲取代联苯类化合物及其组合物及用途
CN104177320B (zh) *	2014-08-27	2016-03-02	广东东阳光药业有限公司	一种脲取代联苯类化合物及其组合物及用途
CA2960944C (en) *	2014-10-17	2019-09-10	Hyundai Pharm Co., Ltd.	Use of 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivatives in combination with a secondary active ingredient for the treatment of metabolic diseases
ES2805743T3 (es)	2015-03-24	2021-02-15	Inst Nat Sante Rech Med	Método y composición farmacéutica para uso en el tratamiento de la diabetes
CN105418563B (zh) *	2015-12-28	2017-11-10	山东大学	Tak‑875类似物及其制备方法与应用
US10676458B2 (en)	2016-03-29	2020-06-09	Merch Sharp & Dohne Corp. Rahway	Antidiabetic bicyclic compounds
EP3551176A4 (en)	2016-12-06	2020-06-24	Merck Sharp & Dohme Corp.	Antidiabetic heterocyclic compounds
WO2018118670A1 (en)	2016-12-20	2018-06-28	Merck Sharp & Dohme Corp.	Antidiabetic spirochroman compounds
CN110248929B (zh)	2017-01-26	2023-05-12	勃林格殷格翰国际有限公司	苄基氨基吡嗪基环丙烷甲酸、其药物组合物和用途
EP3573953A1 (en)	2017-01-26	2019-12-04	Boehringer Ingelheim International GmbH	Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
WO2018138027A1 (en)	2017-01-26	2018-08-02	Boehringer Ingelheim International Gmbh	Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceuticalcompositions and uses thereof
JP7050792B2 (ja)	2017-01-26	2022-04-08	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ベンジルオキシピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用
WO2018146008A1 (en)	2017-02-08	2018-08-16	Boehringer Ingelheim International Gmbh	Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
JOP20180029A1 (ar)	2017-03-30	2019-01-30	Takeda Pharmaceuticals Co	مركب حلقي غير متجانس
JOP20180028A1 (ar)	2017-03-31	2019-01-30	Takeda Pharmaceuticals Co	مركب ببتيد
AR111199A1 (es)	2017-03-31	2019-06-12	Takeda Pharmaceuticals Co	Compuesto aromático agonista de gpr40
WO2018181847A1 (ja)	2017-03-31	2018-10-04	武田薬品工業株式会社	芳香環化合物
EP3709995A4 (en)	2017-11-16	2021-04-14	Merck Sharp & Dohme Corp.	BICYCLIC ANTIDIABETIC COMPOUNDS
DK3737470T5 (da)	2018-01-08	2024-05-27	Celon Pharma Sa	3-phenyl-4-hexynsyrederivater som gpr40-agonister
PL3752501T3 (pl)	2018-02-13	2023-08-21	Gilead Sciences, Inc.	Inhibitory pd-1/pd-l1
CN110294744A (zh) *	2018-03-21	2019-10-01	中国医学科学院药物研究所	Gpr40受体激动剂、其制法和其药物组合物与用途
KR20210008834A (ko)	2018-03-23	2021-01-25	카모트 테라퓨틱스, 인크.	G-단백질 결합 수용체의 조절제
TWI712412B (zh)	2018-04-19	2020-12-11	美商基利科學股份有限公司	Pd‐1/pd‐l1抑制劑
US10774071B2 (en)	2018-07-13	2020-09-15	Gilead Sciences, Inc.	PD-1/PD-L1 inhibitors
JP6773938B2 (ja)	2018-08-27	2020-10-21	株式会社スコヒアファーマ	安息香酸エステル化合物
JP2022503793A (ja)	2018-09-24	2022-01-12	武田薬品工業株式会社	Ｇｉｐ受容体アゴニストペプチド化合物及びその使用
JP7511548B2 (ja)	2018-09-24	2024-07-05	武田薬品工業株式会社	Ｇｉｐ受容体アゴニストペプチド化合物及びその使用
CN112955435B (zh)	2018-10-24	2024-09-06	吉利德科学公司	Pd-1/pd-l1抑制剂
US20220071925A1 (en) *	2019-02-13	2022-03-10	Gexval Inc.	Medicinal composition for preventing or treating bone diseases
WO2020166662A1 (ja) *	2019-02-13	2020-08-20	株式会社ジェクスヴァル	骨疾患の予防または治療用の医薬組成物
EP4458834A3 (en)	2020-02-07	2025-01-15	Gasherbrum Bio, Inc.	Heterocyclic glp-1 agonists
MX2022011816A (es)	2020-03-25	2022-10-10	Takeda Pharmaceuticals Co	Dosificacion qd de compuestos peptidicos agonistas del receptor de gip y sus usos.
US20230143604A1 (en)	2020-03-25	2023-05-11	Takeda Pharmaceutical Company Limited	Qw dosing of gip receptor agonist peptide compounds and uses thereof
JPWO2022034664A1 (da) *	2020-08-12	2022-02-17
WO2022133111A1 (en) *	2020-12-16	2022-06-23	Regents Of The University Of Minnesota	Cubanyl biguanide compounds
KR20240007251A (ko)	2021-05-13	2024-01-16	카모트 테라퓨틱스, 인크.	G-단백질 결합 수용체의 조절제
WO2023169456A1 (en)	2022-03-09	2023-09-14	Gasherbrum Bio , Inc.	Heterocyclic glp-1 agonists
WO2023179542A1 (en)	2022-03-21	2023-09-28	Gasherbrum Bio , Inc.	5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
JP2025513071A (ja)	2022-04-14	2025-04-22	ガシャーブラム・バイオ・インコーポレイテッド	ヘテロ環式ｇｌｐ－１アゴニスト
TW202435857A (zh)	2022-12-15	2024-09-16	美商迦舒布魯姆生物有限公司	具有glp-1促效劑活性之化合物之鹽及固體形式
WO2024138048A1 (en)	2022-12-22	2024-06-27	Gasherbrum Bio, Inc.	Heterocyclic glp-1 agonists
WO2024131869A1 (en)	2022-12-22	2024-06-27	Gasherbrum Bio, Inc.	Heterocyclic glp-1 agonists
WO2024169952A1 (en)	2023-02-16	2024-08-22	Gasherbrum Bio, Inc.	Heterocyclic glp-1 agonists
WO2025006921A1 (en)	2023-06-30	2025-01-02	Gasherbrum Bio, Inc.	Heterocyclic glp-1 agonists
WO2025015269A1 (en)	2023-07-13	2025-01-16	Aconcagua Bio, Inc.	Compounds, compositions, and methods
WO2025015268A1 (en)	2023-07-13	2025-01-16	Aconcagua Bio, Inc.	Modulators of calcitonin receptor and/or amylin receptor activity
WO2025045208A1 (en)	2023-08-31	2025-03-06	Gasherbrum Bio, Inc.	Heteroaryl-heterocycloalkyl-based glp-1 agonists
WO2025137307A1 (en)	2023-12-20	2025-06-26	Gasherbrum Bio, Inc.	Heterocyclic glp-1 agonists
CN117865851A (zh) *	2024-01-10	2024-04-12	上海吉奉生物科技有限公司	一种Fmoc-2,6-二甲基酪氨酸的合成方法

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9309324D0 (en) *	1993-05-06	1993-06-16	Bayer Ag	Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
US5489586A (en)	1994-03-07	1996-02-06	Warner-Lambert Company	Method for treating inflammatory disease in humans
US5612330A (en)	1994-03-07	1997-03-18	Warner-Lambert Company	Methods for inhibiting and controlling viral growth
WO1997010224A1 (en)	1995-09-13	1997-03-20	Takeda Chemical Industries, Ltd.	Benzoxazepine compounds, their production and use as lipid lowering agents
US5807876A (en) *	1996-04-23	1998-09-15	Vertex Pharmaceuticals Incorporated	Inhibitors of IMPDH enzyme
RU6023U1 (ru)	1997-01-20	1998-02-16	АО "Автоэлектроника"	Устройство управления для экономайзера принудительного холостого хода
US6025372A (en)	1997-04-04	2000-02-15	Merck & Co., Inc.	Somatostatin agonists
US6057338A (en)	1997-04-04	2000-05-02	Merck & Co., Inc.	Somatostatin agonists
AU1285499A (en)	1997-10-30	1999-05-24	Merck & Co., Inc.	Somatostatin agonists
JP2002543065A (ja)	1999-04-28	2002-12-17	アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	Ｐｐａｐ受容体リガンドとしてのトリアリール酸誘導体
RU11297U1 (ru)	1999-06-16	1999-09-16	Курзанов Евгений Владимирович	Установка для выборочного измерения производительности нефтяных источников при групповом учете
AR035016A1 (es)	1999-08-25	2004-04-14	Takeda Chemical Industries Ltd	Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
EP1222182B1 (en)	1999-08-26	2005-11-16	Aventis Pharmaceuticals Inc.	Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benozopyrans
WO2001025228A1 (fr)	1999-10-07	2001-04-12	Tadeka Chemical Industries, Ltd.	Derives d'amines
ES2225252T3 (es)	1999-11-10	2005-03-16	Takeda Chemical Industries, Ltd.	Compuestos n-heterociclicos de 5 miembros con actividad hipoglucemica e hipolipidemica.
AU2223501A (en) *	1999-12-24	2001-07-09	Kyowa Hakko Kogyo Co. Ltd.	Fused purine derivatives
AU2001252596A1 (en)	2000-04-28	2001-11-12	Takeda Chemical Industries Ltd.	Melanin concentrating hormone antagonists
WO2001087834A1 (fr)	2000-05-16	2001-11-22	Takeda Chemical Industries, Ltd.	Antagoniste de l'hormone de concentration de la melanine
US6429223B1 (en) *	2000-06-23	2002-08-06	Medinox, Inc.	Modified forms of pharmacologically active agents and uses therefor
US6610677B2 (en) *	2000-09-15	2003-08-26	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
JP4105947B2 (ja) *	2000-09-15	2008-06-25	バーテックスファーマシューティカルズインコーポレイテッド	プロテインキナーゼインヒビターとして有用なトリアゾール化合物
RU2340611C2 (ru)	2000-09-15	2008-12-10	Вертекс Фармасьютикалз Инкорпорейтед	Производные пиразола, используемые в качестве ингибиторов протеинкиназы
US6660731B2 (en) *	2000-09-15	2003-12-09	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
US6613776B2 (en) *	2000-09-15	2003-09-02	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) *	2000-09-15	2009-01-06	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
MXPA03005609A (es) *	2000-12-21	2003-10-06	Vertex Pharma	Compuestos de pirazol utiles como inhibidores de la proteina cinasa.
WO2002068471A2 (en) *	2000-12-21	2002-09-06	Bristol-Myers Squibb Company	Nucleic acid molecules and polypeptides for a human cation channel polypeptide
EP1491540B1 (en) *	2001-03-30	2006-12-13	Pfizer Products Inc.	Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors
TWI311133B (en)	2001-04-20	2009-06-21	Eisai R&D Man Co Ltd	Carboxylic acid derivativeand the salt thereof
TW522326B (en) *	2001-08-03	2003-03-01	Inventec Corp	Real-time data customer service system and method thereof
US6701066B2 (en) *	2001-10-11	2004-03-02	Micron Technology, Inc.	Delivery of solid chemical precursors
US20050245571A1 (en)	2001-10-19	2005-11-03	Hidenori Abe	Amine derivative
JP4166024B2 (ja)	2002-03-07	2008-10-15	独立行政法人科学技術振興機構	２環式化合物およびその製造方法
RS93604A (en) *	2002-04-26	2007-02-05	F. Hoffmann-La Roche Ag.,	Substituted phenylacetamides and their use as glucokinase activators
WO2004011469A1 (ja) *	2002-07-26	2004-02-05	Kyowa Hakko Kogyo Co., Ltd.	細胞分化誘導剤
AU2003277576A1 (en) *	2002-11-08	2004-06-07	Takeda Pharmaceutical Company Limited	Receptor function controlling agent
US7572910B2 (en) *	2003-02-20	2009-08-11	Pfizer, Inc.	Pyridazinone aldose reductase inhibitors
US20070105959A1 (en)	2003-03-11	2007-05-10	Shinya Kusuda	Cynnamyl alcohol derivative compounds and drugs containing the compounds as active ingredient
US7244763B2 (en)	2003-04-17	2007-07-17	Warner Lambert Company Llc	Compounds that modulate PPAR activity and methods of preparation
JP4805552B2 (ja) *	2003-05-30	2011-11-02	武田薬品工業株式会社	縮合環化合物
US7820837B2 (en)	2003-05-30	2010-10-26	Takeda Pharmaceutical Company Limited	Condensed ring compound
RU2353617C2 (ru)	2003-10-31	2009-04-27	Такеда Фармасьютикал Компани Лимитед	Производные пиридина в качестве ингибиторов дипептидилпептидазы iv
TW200523252A (en) *	2003-10-31	2005-07-16	Takeda Pharmaceutical	Pyridine compounds
WO2005051890A1 (en)	2003-11-19	2005-06-09	Smithkline Beecham Corporation	Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40
AU2004309271A1 (en)	2003-12-25	2005-07-14	Takeda Pharmaceutical Company Limited	3-(4-benzyloxyphenyl)propanoic acid derivatives
JP4074616B2 (ja) *	2003-12-25	2008-04-09	武田薬品工業株式会社	３−（４−ベンジルオキシフェニル）プロパン酸誘導体
JP4855777B2 (ja) *	2003-12-26	2012-01-18	武田薬品工業株式会社	フェニルプロパン酸誘導体
CA2560111A1 (en)	2004-03-15	2005-09-22	Takeda Pharmaceutical Company Limited	Aminophenylpropanoic acid derivative
EP2253315A1 (en) *	2004-03-30	2010-11-24	Takeda Pharmaceutical Company Limited	Alkoxyphenylpropanoic acid derivatives
UA90269C2 (ru) *	2004-04-02	2010-04-26	Мицубиси Танабе Фарма Корпорейшн	Тетрагидрохинолиновые производные и способ их получения
TW200609219A (en) *	2004-06-17	2006-03-16	Neurogen Corp	Aryl-substituted piperazine derivatives
JP3689711B1 (ja)	2004-12-24	2005-08-31	極東鋼弦コンクリート振興株式会社	真空グラウト注入方法
TW200637839A (en) *	2005-01-07	2006-11-01	Taisho Pharmaceutical Co Ltd	1-thio-d-glucitol derivatives
BRPI0607433A2 (pt) *	2005-02-25	2009-09-08	Takeda Pharmaceutical	composto ou um sal do mesmo, pró-droga, agente farmacêutico, inibidor de peptidase, uso de um composto ou de uma pró-droga do mesmo, e, métodos de prevenção ou tratamento de doenças, de inibição de peptidase em um mamìfero, e de produção de um composto
TW200815418A (en)	2006-06-27	2008-04-01	Astrazeneca Ab	New compounds I
PE20080344A1 (es)	2006-06-27	2008-06-09	Sanofi Aventis	Compuestos 8-azabiciclo[3.2.1]oct-8-il-1,2,3,4-tetrahidroquinolina sustituidos como inhibidores 11b-hsd1
PE20080212A1 (es)	2006-06-27	2008-04-25	Sanofi Aventis	Derivados de ureas de piperidina o pirrolidina como moduladores de la 11b-hidroxiesteroide deshidrogenasa tipo 1 (11bhsd1)

2007
- 2007-06-26 NZ NZ574038A patent/NZ574038A/en not_active IP Right Cessation
- 2007-06-26 JP JP2008554357A patent/JP4401428B2/ja not_active Expired - Fee Related
- 2007-06-26 DK DK10172951.5T patent/DK2248812T5/da active
- 2007-06-26 CN CN201210241482.0A patent/CN102731451B/zh not_active Expired - Fee Related
- 2007-06-26 CL CL2007001873A patent/CL2007001873A1/es unknown
- 2007-06-26 MX MX2008016274A patent/MX2008016274A/es active IP Right Grant
- 2007-06-26 PL PL07767983T patent/PL2041123T3/pl unknown
- 2007-06-26 ZA ZA200900154A patent/ZA200900154B/xx unknown
- 2007-06-26 SI SI200730892T patent/SI2041123T1/sl unknown
- 2007-06-26 RU RU2009102515/04A patent/RU2444521C2/ru active
- 2007-06-26 ES ES07767983T patent/ES2379661T3/es active Active
- 2007-06-26 RS RS20120169A patent/RS52307B/en unknown
- 2007-06-26 HR HRP20120333TT patent/HRP20120333T1/hr unknown
- 2007-06-26 CN CN2012105303764A patent/CN103083307A/zh active Pending
- 2007-06-26 TW TW096122999A patent/TWI354668B/zh not_active IP Right Cessation
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- 2007-06-26 DK DK07767983.5T patent/DK2041123T3/da active
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- 2007-06-26 PE PE2007000827A patent/PE20080993A1/es not_active Application Discontinuation
- 2007-06-26 CN CN2012105303389A patent/CN103070854A/zh active Pending
- 2007-06-26 CA CA2838448A patent/CA2838448A1/en not_active Abandoned
- 2007-06-26 GE GEAP200711077A patent/GEP20115359B/en unknown
- 2007-06-26 KR KR1020097001696A patent/KR101058772B1/ko not_active Expired - Fee Related
- 2007-06-26 EP EP13190005.2A patent/EP2743268A3/en not_active Withdrawn
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2008
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2009
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2010
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2012
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Also Published As

Publication number	Publication date
PL2248812T3 (pl)	2014-07-31
CN101616913B (zh)	2013-01-23
JP4917634B2 (ja)	2012-04-18
MA30537B1 (fr)	2009-06-01
EP2041123B1 (en)	2012-02-01
NO20090235L (no)	2009-02-16
EP2248812A3 (en)	2011-03-16
US20120046338A1 (en)	2012-02-23
CA2838448A1 (en)	2008-01-03
ATE543815T1 (de)	2012-02-15
SI2248812T1 (sl)	2014-04-30
CA2656003C (en)	2014-03-25
ZA200900154B (en)	2010-03-31
US8492430B2 (en)	2013-07-23
ES2450081T3 (es)	2014-03-21
UA95296C2 (uk)	2011-07-25
JP5409757B2 (ja)	2014-02-05
AR061644A1 (es)	2008-09-10
BRPI0713378A2 (pt)	2012-04-03
CY1114978T1 (el)	2016-12-14
EP2041123A2 (en)	2009-04-01
CR10564A (es)	2012-06-18
CN103070854A (zh)	2013-05-01
IL195947A (en)	2013-07-31
JO2969B1 (en)	2016-03-15
AU2007265966A1 (en)	2008-01-03
GEP20115359B (en)	2011-12-26
CN103083307A (zh)	2013-05-08
RU2444521C2 (ru)	2012-03-10
TW200811125A (en)	2008-03-01
US20100004312A1 (en)	2010-01-07
HRP20140201T1 (hr)	2014-04-11
US8598226B2 (en)	2013-12-03
HRP20120333T1 (hr)	2012-05-31
RS53230B (en)	2014-08-29
EP2041123B9 (en)	2013-01-02
PL2041123T3 (pl)	2012-09-28
RS52307B (en)	2012-12-31
IL195947A0 (en)	2009-09-01
SI2041123T1 (sl)	2012-05-31
EP2248812B1 (en)	2013-12-25
CO6160234A2 (es)	2010-05-20
JP2009542580A (ja)	2009-12-03
US7732626B2 (en)	2010-06-08
DK2248812T3 (da)	2014-03-10
CY1112705T1 (el)	2016-02-10
JP2012062320A (ja)	2012-03-29
CA2656003A1 (en)	2008-01-03
US20140080891A1 (en)	2014-03-20
EP2431367A2 (en)	2012-03-21
PT2041123E (pt)	2012-04-09
BRPI0713378A8 (pt)	2018-01-02
KR20090027743A (ko)	2009-03-17
MX2008016274A (es)	2009-01-15
EP2248812A2 (en)	2010-11-10
EP2743268A2 (en)	2014-06-18
US8088821B2 (en)	2012-01-03
US20130267589A1 (en)	2013-10-10
US20100197761A1 (en)	2010-08-05
JP2009280595A (ja)	2009-12-03
CN102731451B (zh)	2015-07-29
RU2009102515A (ru)	2010-08-10
PE20080993A1 (es)	2008-10-06
WO2008001931A2 (en)	2008-01-03
ES2379661T3 (es)	2012-04-30
AU2007265966B2 (en)	2012-05-17
EP2431367A3 (en)	2012-07-04
NZ574038A (en)	2011-12-22
TWI354668B (en)	2011-12-21
MY154798A (en)	2015-07-31
KR101058772B1 (ko)	2011-08-24
JP4401428B2 (ja)	2010-01-20
CN101616913A (zh)	2009-12-30
HK1131126A1 (en)	2010-01-15
CL2007001873A1 (es)	2008-01-04
ME00535B (me)	2011-10-10
EP2743268A3 (en)	2014-10-08
DK2248812T5 (da)	2015-01-26
WO2008001931A3 (en)	2009-09-11
PT2248812E (pt)	2014-03-12
CN102731451A (zh)	2012-10-17

Publication	Publication Date	Title
DK2041123T3 (da)	2012-05-07	Kondenserede cykliske forbindelser.
NL2000581A1 (nl)	2007-10-23	Aangecondenseerde fenylamidoheterocyclische verbindingen.
BRPI0815717A2 (pt)	2015-02-10	Compostos de imidazopirazina.
ATE513831T1 (de)	2011-07-15	Pyridinä3,4-büpyrazinone
FR2909857B1 (fr)	2009-03-06	Endovalve.
BRPI0923786A2 (pt)	2016-07-26	compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos
CL2007002263S1 (es)	2008-02-08	Motoneta.
CR10353A (es)	2009-01-09	Nuevos compuestos.
CL2008000457S1 (es)	2008-07-18	Motoneta.
BRPI0810203A2 (pt)	2014-10-14	Compostos peptídeos cíclicos.
CL2007003097S1 (es)	2008-05-16	Motocicleta.
EP2257171A4 (en)	2011-08-31	FUSED TETRAHYDRO-1H-PYRROLO PYRIDONES
BRPI0912716A2 (pt)	2015-10-13	composto.
BRPI0916395A2 (pt)	2016-02-16	compostos de 1,6-di-hidro-2h-3-oxa-6-aza-as-indaceno
EP2098523A4 (en)	2011-09-21	NOVEL COMPOUNDS WITH AFFINITY FOR THE AMYLOID SUBSTANCE
DK2097400T3 (da)	2013-10-14	Kondenseret, substitueret aminopyrrolidinderivat
BRPI0812460A2 (pt)	2014-12-02	" compostos orgânicos ".
DK2221296T3 (da)	2012-09-24	Kondenserede indanforbindelser
BRPI0818848A2 (pt)	2015-04-14	Compostos de 2,3-di-idro-benzofurano
ITCE20060002A1 (it)	2007-09-11	Patok.
FR2914850B1 (fr)	2010-11-12	Deambulateur.
ES1061980Y (es)	2006-08-01	Contenedor-palet.
ES1062074Y (es)	2006-08-01	Autorefrigerante solar-ecologico.
ITPA20060005A1 (it)	2007-08-15	Calciocards.
ITRA20060010A1 (it)	2007-08-11	Espositore.