DK1157037T3 - GCSF-konjugater - Google Patents

GCSF-konjugater

Info

Publication number: DK1157037T3
Authority: DK; Denmark
Prior art keywords: conjugates; csf; mixture; formula; composition
Prior art date: 1999-01-29

Application number

DK00904422T

Other languages

Danish (da)

English (en)

Inventor

Pascal Sebastian Bailon

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-29

Filing date

2000-01-19

Publication date

2003-11-24

2000-01-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-11-24 Application granted granted Critical

2003-11-24 Publication of DK1157037T3 publication Critical patent/DK1157037T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Zoology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polyethers (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK00904422T 1999-01-29 2000-01-19 GCSF-konjugater DK1157037T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11791799P	1999-01-29	1999-01-29
PCT/US2000/001264 WO2000044785A1 (en)	1999-01-29	2000-01-19	Gcsf conjugates

Publications (1)

Publication Number	Publication Date
DK1157037T3 true DK1157037T3 (da)	2003-11-24

Family

ID=22375505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00904422T DK1157037T3 (da)	1999-01-29	2000-01-19	GCSF-konjugater

Country Status (26)

Country	Link
US (4)	US20030130193A1 (sk)
EP (1)	EP1157037B1 (sk)
JP (1)	JP2002540065A (sk)
KR (1)	KR100689212B1 (sk)
CN (1)	CN1376164A (sk)
AT (1)	ATE246202T1 (sk)
AU (1)	AU2618500A (sk)
BG (1)	BG65213B1 (sk)
BR (1)	BR0007781A (sk)
CA (1)	CA2361766C (sk)
CZ (1)	CZ300546B6 (sk)
DE (1)	DE60004172T2 (sk)
DK (1)	DK1157037T3 (sk)
EA (2)	EA004685B1 (sk)
ES (1)	ES2204509T3 (sk)
HK (1)	HK1049673A1 (sk)
HU (1)	HU228488B1 (sk)
IL (1)	IL144361A0 (sk)
MX (1)	MXPA01007609A (sk)
NO (1)	NO331787B1 (sk)
NZ (1)	NZ513113A (sk)
PT (1)	PT1157037E (sk)
RS (1)	RS50928B (sk)
SK (1)	SK286898B6 (sk)
WO (1)	WO2000044785A1 (sk)
ZA (1)	ZA200105932B (sk)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE246202T1 (de) *	1999-01-29	2003-08-15	Hoffmann La Roche	Gcsf konjugate
US6646110B2 (en)	2000-01-10	2003-11-11	Maxygen Holdings Ltd.	G-CSF polypeptides and conjugates
US6831158B2 (en)	2000-01-10	2004-12-14	Maxygen Holdings Ltd.	G-CSF conjugates
US6555660B2 (en)	2000-01-10	2003-04-29	Maxygen Holdings Ltd.	G-CSF conjugates
ATE421535T1 (de)	2000-10-16	2009-02-15	Chugai Pharmaceutical Co Ltd	Peg-modifiziertes erythropoietin
MXPA04000231A (es)	2001-07-11	2004-05-04	Maxygen Holdings Ltd	Conjugados del factor de estimulacion de colonias de granulocitos.
US7214660B2 (en)	2001-10-10	2007-05-08	Neose Technologies, Inc.	Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en)	2001-10-10	2007-02-06	Neose Technologies, Inc.	Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
CA2462930C (en) *	2001-10-10	2012-07-10	Shawn De Frees	Remodeling and glycoconjugation of peptides
WO2004099231A2 (en)	2003-04-09	2004-11-18	Neose Technologies, Inc.	Glycopegylation methods and proteins/peptides produced by the methods
MXPA04004809A (es) *	2001-11-20	2004-08-11	Pharmacia Corp	Conjugados de hormona de crecimiento humana modificada quimicamente.
CN100337689C (zh)	2002-07-24	2007-09-19	弗·哈夫曼-拉罗切有限公司	聚亚烷基二醇酸加合物
US7695723B2 (en)	2002-12-31	2010-04-13	Sygnis Bioscience Gmbh & Co. Kg	Methods of treating neurological conditions with hematopoietic growth factors
US7785601B2 (en)	2002-12-31	2010-08-31	Sygnis Bioscience Gmbh & Co. Kg	Methods of treating neurological conditions with hematopoietic growth factors
WO2005012484A2 (en)	2003-07-25	2005-02-10	Neose Technologies, Inc.	Antibody-toxin conjugates
EP1667706A4 (en) *	2003-08-22	2009-06-24	Queensland Inst Med Res	G-CSF DERIVATIVE FOR INDUCING IMMUNOLOGICAL TOLERANCE
US20080305992A1 (en)	2003-11-24	2008-12-11	Neose Technologies, Inc.	Glycopegylated erythropoietin
CA2585758C (en)	2004-10-29	2017-08-01	Neose Technologies, Inc.	Remodeling and glycopegylation of fibroblast growth factor (fgf)
NZ556436A (en)	2005-01-10	2010-11-26	Biogenerix Ag	Glycopegylated granulocyte colony stimulating factor
US20060174362A1 (en) *	2005-02-01	2006-08-03	Origen Therapeutics, Inc.	Long-term culture of avian primordial germ cells (PGCs)
WO2006121569A2 (en)	2005-04-08	2006-11-16	Neose Technologies, Inc.	Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US7381805B2 (en)	2005-06-01	2008-06-03	Maxygen Holdings, Ltd.	Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
WO2006138572A2 (en)	2005-06-16	2006-12-28	Nektar Therapeutics Al, Corporation	Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
CA2617064A1 (en) *	2005-08-04	2007-02-15	Nektar Therapeutics Al, Corporation	Conjugates of a g-csf moiety and a polymer
US20070105755A1 (en)	2005-10-26	2007-05-10	Neose Technologies, Inc.	One pot desialylation and glycopegylation of therapeutic peptides
JP2007112924A (ja) *	2005-10-21	2007-05-10	National Institute For Materials Science	高分子架橋剤及びこの架橋剤を用いたリポソーム又は細胞の架橋体
WO2007056191A2 (en)	2005-11-03	2007-05-18	Neose Technologies, Inc.	Nucleotide sugar purification using membranes
CN101002943B (zh) *	2006-01-17	2012-02-01	中国科学院过程工程研究所	支链peg-gcsf和peg-gmcsf结合物及其制备方法
CN101516388B (zh)	2006-07-21	2012-10-31	诺和诺德公司	通过o-联糖基化序列的肽的糖基化
ITMI20061624A1 (it)	2006-08-11	2008-02-12	Bioker Srl	Mono-coniugati sito-specifici di g-csf
US8969532B2 (en)	2006-10-03	2015-03-03	Novo Nordisk A/S	Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
US20100316631A1 (en) *	2006-10-19	2010-12-16	The Uab Research Foundation	Water Soluble Curcumin-Based Compounds
KR101079993B1 (ko) *	2006-11-17	2011-11-04	동아제약주식회사	폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체
JP2008125952A (ja) *	2006-11-24	2008-06-05	National Institute For Materials Science	複合架橋体
CN101245109B (zh) *	2007-02-12	2011-12-14	杭州九源基因工程有限公司	一种聚乙二醇单修饰的重组人粒细胞集落刺激因子突变体及其制备方法
NZ580030A (en)	2007-04-03	2012-06-29	Biogenerix Ag	Methods of treatment using glycopegylated g-csf
WO2008154639A2 (en)	2007-06-12	2008-12-18	Neose Technologies, Inc.	Improved process for the production of nucleotide sugars
AR067537A1 (es)	2007-07-17	2009-10-14	Hoffmann La Roche	Purificacion de polipeptidos pegilados
AR067536A1 (es)	2007-07-17	2009-10-14	Hoffmann La Roche	Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
CN101352573B (zh) *	2007-07-27	2011-02-09	杭州九源基因工程有限公司	聚乙二醇单修饰的重组人集落细胞刺激因子赖氨酸缺陷体
WO2009103199A1 (zh)	2008-02-18	2009-08-27	江苏恒瑞医药股份有限公司	水溶性聚合物修饰的g-csf偶联物
EP2626079A3 (en)	2008-02-27	2014-03-05	Novo Nordisk A/S	Conjungated factor VIII molecules
RU2409669C9 (ru)	2008-08-18	2012-05-27	ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM")	Способ иммобилизации биологически активного вещества (бав) на носитель (варианты) и конъюгат бав-носитель, полученный данными способами
JP5632376B2 (ja)	2008-09-23	2014-11-26	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	エリスロポエチンの精製
KR101485646B1 (ko)	2010-02-11	2015-01-22	에프. 호프만-라 로슈 아게	Ｉｇｆ―ⅰ 폴리(에틸렌 글리콜) 컨쥬게이트
WO2012035037A1 (en)	2010-09-14	2012-03-22	F. Hoffmann-La Roche Ag	Method for purifying pegylated erythropoietin
US8889630B2 (en)	2011-12-23	2014-11-18	Carlos Lopez	Method for hair regrowth using Granulocyte-Colony Stimulating Factor
EP3484911B1 (en)	2016-07-15	2020-11-04	H. Hoffnabb-La Roche Ag	Method for purifying pegylated erythropoietin
BR112020007037A2 (pt)	2017-10-11	2020-11-17	Elanco Us Inc.	variantes de g-csf porcino e seus usos
SI3731872T1 (sl)	2017-12-29	2022-04-29	F. Hoffmann-La Roche Ag	Postopek za zagotavljanje sestavka PEGiliranih beljakovin
US20200362002A1 (en)	2017-12-29	2020-11-19	Hoffmann-La Roche Inc.	Process for providing pegylated protein composition
US12208142B2 (en)	2017-12-29	2025-01-28	Hoffmann-La Roche Inc.	Process for providing PEGylated protein composition
JP2024500974A (ja) *	2020-12-23	2024-01-10	ジャズファーマシューティカルズアイルランドリミテッド	電荷遮蔽された融合タンパク質を精製する方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1609546A (en) *	1925-11-19	1926-12-07	Petroleum Rectifying Co	Process of separating water from emulsions
US4179337A (en) *	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
US4002531A (en) *	1976-01-22	1977-01-11	Pierce Chemical Company	Modifying enzymes with polyethylene glycol and product produced thereby
US6936694B1 (en) *	1982-05-06	2005-08-30	Intermune, Inc.	Manufacture and expression of large structural genes
DE3380726D1 (en) *	1982-06-24	1989-11-23	Japan Chem Res	Long-acting composition
US4514497B1 (en) *	1983-12-30	1998-02-24	Novagene Inc	Modified live pseudorabies viruses
JPS61227526A (ja) *	1984-07-25	1986-10-09	Chugai Pharmaceut Co Ltd	新規なコロニー刺激因子
US5532341A (en) *	1985-03-28	1996-07-02	Sloan-Kettering Institute For Cancer Research	Human pluripotent hematopoietic colony stimulating factor
US4766106A (en) *	1985-06-26	1988-08-23	Cetus Corporation	Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4810643A (en) *	1985-08-23	1989-03-07	Kirin- Amgen Inc.	Production of pluripotent granulocyte colony-stimulating factor
US4791192A (en) *	1986-06-26	1988-12-13	Takeda Chemical Industries, Ltd.	Chemically modified protein with polyethyleneglycol
US4894226A (en) *	1986-11-14	1990-01-16	Cetus Corporation	Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
US5362853A (en) *	1986-12-23	1994-11-08	Kyowa Hakko Kogyo Co., Ltd.	Polypeptide derivatives of human granulocyte colony stimulating factor
US5214132A (en) *	1986-12-23	1993-05-25	Kyowa Hakko Kogyo Co., Ltd.	Polypeptide derivatives of human granulocyte colony stimulating factor
US5194592A (en) *	1986-12-23	1993-03-16	Kyowa Hakko Kogyo Co. Ltd.	Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor
US4904584A (en) *	1987-12-23	1990-02-27	Genetics Institute, Inc.	Site-specific homogeneous modification of polypeptides
US4847325A (en) *	1988-01-20	1989-07-11	Cetus Corporation	Conjugation of polymer to colony stimulating factor-1
CA1340810C (en) *	1988-03-31	1999-11-02	Motoo Yamasaki	Polypeptide derivatives of human granulocyte colony stimulating factor
US5218092A (en) *	1988-09-29	1993-06-08	Kyowa Hakko Kogyo Co., Ltd.	Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
US5349052A (en) *	1988-10-20	1994-09-20	Royal Free Hospital School Of Medicine	Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
JP2989002B2 (ja) *	1988-12-22	1999-12-13	キリン―アムジエン・インコーポレーテツド	化学修飾顆粒球コロニー刺激因子
US6166183A (en) *	1992-11-30	2000-12-26	Kirin-Amgen, Inc.	Chemically-modified G-CSF
US5166322A (en) *	1989-04-21	1992-11-24	Genetics Institute	Cysteine added variants of interleukin-3 and chemical modifications thereof
US5372808A (en) *	1990-10-17	1994-12-13	Amgen Inc.	Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US5252714A (en) *	1990-11-28	1993-10-12	The University Of Alabama In Huntsville	Preparation and use of polyethylene glycol propionaldehyde
US5281698A (en) *	1991-07-23	1994-01-25	Cetus Oncology Corporation	Preparation of an activated polymer ester for protein conjugation
US5382657A (en) *	1992-08-26	1995-01-17	Hoffmann-La Roche Inc.	Peg-interferon conjugates
US5581476A (en) *	1993-01-28	1996-12-03	Amgen Inc.	Computer-based methods and articles of manufacture for preparing G-CSF analogs
US5824784A (en) *	1994-10-12	1998-10-20	Amgen Inc.	N-terminally chemically modified protein compositions and methods
JP3708151B2 (ja) *	1994-12-15	2005-10-19	協和醗酵工業株式会社	Ｐｅｇ化したヒト顆粒球コロニー刺激因子の定量法
US5672662A (en) *	1995-07-07	1997-09-30	Shearwater Polymers, Inc.	Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
KR0176625B1 (ko) *	1996-11-05	1999-04-01	삼성전자주식회사	적외선 물체검출장치
ATE246202T1 (de) *	1999-01-29	2003-08-15	Hoffmann La Roche	Gcsf konjugate

2000
- 2000-01-19 AT AT00904422T patent/ATE246202T1/de active
- 2000-01-19 JP JP2000596041A patent/JP2002540065A/ja active Pending
- 2000-01-19 DK DK00904422T patent/DK1157037T3/da active
- 2000-01-19 EP EP00904422A patent/EP1157037B1/en not_active Expired - Lifetime
- 2000-01-19 CN CN00809241A patent/CN1376164A/zh active Pending
- 2000-01-19 HU HU0203652A patent/HU228488B1/hu unknown
- 2000-01-19 KR KR1020017009533A patent/KR100689212B1/ko active IP Right Grant
- 2000-01-19 AU AU26185/00A patent/AU2618500A/en not_active Abandoned
- 2000-01-19 NZ NZ513113A patent/NZ513113A/xx not_active IP Right Cessation
- 2000-01-19 SK SK1035-2001A patent/SK286898B6/sk not_active IP Right Cessation
- 2000-01-19 MX MXPA01007609A patent/MXPA01007609A/es active IP Right Grant
- 2000-01-19 ES ES00904422T patent/ES2204509T3/es not_active Expired - Lifetime
- 2000-01-19 EA EA200100838A patent/EA004685B1/ru not_active IP Right Cessation
- 2000-01-19 WO PCT/US2000/001264 patent/WO2000044785A1/en active IP Right Grant
- 2000-01-19 CA CA2361766A patent/CA2361766C/en not_active Expired - Lifetime
- 2000-01-19 DE DE60004172T patent/DE60004172T2/de not_active Expired - Lifetime
- 2000-01-19 BR BR0007781-0A patent/BR0007781A/pt not_active Application Discontinuation
- 2000-01-19 PT PT00904422T patent/PT1157037E/pt unknown
- 2000-01-19 EA EA200400067A patent/EA200400067A1/ru unknown
- 2000-01-19 IL IL14436100A patent/IL144361A0/xx not_active IP Right Cessation
- 2000-01-19 RS YUP-543/01A patent/RS50928B/sr unknown
- 2000-01-19 CZ CZ20012654A patent/CZ300546B6/cs not_active IP Right Cessation
2001
- 2001-07-18 ZA ZA200105932A patent/ZA200105932B/en unknown
- 2001-07-27 NO NO20013700A patent/NO331787B1/no not_active IP Right Cessation
- 2001-08-29 BG BG105851A patent/BG65213B1/bg unknown
2002
- 2002-12-30 US US10/331,434 patent/US20030130193A1/en not_active Abandoned
2003
- 2003-03-13 HK HK03101820.1A patent/HK1049673A1/zh unknown
2005
- 2005-04-26 US US11/114,576 patent/US20050196378A1/en not_active Abandoned
2007
- 2007-03-12 US US11/717,536 patent/US20070219356A1/en not_active Abandoned
2008
- 2008-06-27 US US12/163,283 patent/US20080287659A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HK1049673A1 (zh)	2003-05-23
YU54301A (sh)	2003-10-31
DE60004172T2 (de)	2004-04-22
PT1157037E (pt)	2003-12-31
HU228488B1 (en)	2013-03-28
MXPA01007609A (es)	2003-06-24
NO331787B1 (no)	2012-04-02
CA2361766C (en)	2011-12-06
DE60004172D1 (de)	2003-09-04
CN1376164A (zh)	2002-10-23
NO20013700L (no)	2001-09-25
US20050196378A1 (en)	2005-09-08
HUP0203652A3 (en)	2005-01-28
RS50928B (sr)	2010-08-31
PL363117A1 (en)	2004-11-15
US20080287659A1 (en)	2008-11-20
EA004685B1 (ru)	2004-06-24
US20070219356A1 (en)	2007-09-20
ES2204509T3 (es)	2004-05-01
KR100689212B1 (ko)	2007-03-09
EP1157037A1 (en)	2001-11-28
KR20020007296A (ko)	2002-01-26
BR0007781A (pt)	2002-02-05
ATE246202T1 (de)	2003-08-15
CA2361766A1 (en)	2000-08-03
CZ20012654A3 (cs)	2002-05-15
JP2002540065A (ja)	2002-11-26
BG105851A (en)	2002-06-28
WO2000044785A1 (en)	2000-08-03
SK286898B6 (sk)	2009-07-06
NO20013700D0 (no)	2001-07-27
SK10352001A3 (sk)	2002-06-04
IL144361A0 (en)	2002-05-23
EA200100838A1 (ru)	2002-04-25
HUP0203652A2 (hu)	2003-03-28
NZ513113A (en)	2004-03-26
ZA200105932B (en)	2002-10-18
EP1157037B1 (en)	2003-07-30
CZ300546B6 (cs)	2009-06-10
US20030130193A1 (en)	2003-07-10
AU2618500A (en)	2000-08-18
EA200400067A1 (ru)	2004-04-29
BG65213B1 (bg)	2007-07-31

Publication	Publication Date	Title
DK1157037T3 (da)	2003-11-24	GCSF-konjugater
IL140710A0 (en)	2002-02-10	Pulmonary delivery of active agents
DK1299348T3 (da)	2008-07-28	Forbindelser og sammensætninger til levering af aktive midler
SE0001899D0 (sv)	2000-05-22	New compounds
ATE286500T1 (de)	2005-01-15	1,2,3,4-tetrahydroisochinolin-derivate
BG66093B1 (bg)	2011-04-29	Състави с контролирано освобождаване, съдържащи нимесулид
AP9801169A0 (en)	1999-08-05	N-hydroxy-B-sulfonyl propionamide derivatives.
DE60038183D1 (de)	2008-04-10	Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe
IS6658A (is)	2002-12-17	Ný efnasambönd
IT1312115B1 (it)	2002-04-04	Composti amorfi e relative composizioni farmaceutiche
ATE268175T1 (de)	2004-06-15	Decursin-enthaltende pharmazeutische zusammensetzungen
ATE280588T1 (de)	2004-11-15	Dextran-leptin konjugate, pharmazeutische zusammentsetzungen und verbundene verfahren
EA200701172A1 (ru)	2007-10-26	2-алкокси-3,4,5-тригидроксиалкиламиды, их получение, композиции, их содержащие, и применение
DK1204659T3 (da)	2004-04-05	Serotonerge benzofuraner
ES2159260A1 (es)	2001-09-16	Nueva composicion de metanosulfonato de paroxetina
TR200401462T4 (tr)	2004-08-23	Torsemid modifikasyonu II' yi içeren dengeli bir farmasötik formülasyonu
YU5302A (sh)	2006-05-25	Derivati streptogramina, njihovo dobivanje i smeše koje ih sadrže
NO20021429D0 (no)	2002-03-21	1,4-dioksacykloalkan-2-oner og 1,4-dioksacykloalken-2-oner
SE0004780D0 (sv)	2000-12-22	Novel compunds
HRP20070054T3 (en)	2007-07-31	Fungicidal mixtures
PL365687A1 (en)	2005-01-10	Novel trioxepan compounds
ECSP003412A (es)	2000-05-25	Derivados de 3- amino -3-arilpropan - 1 - ol, su preparacion y su uso