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CY1116688T1 - Τροποποιητες φαρμακοκινητικων ιδιοτητων θεραπευτικων ειδων - Google Patents

Τροποποιητες φαρμακοκινητικων ιδιοτητων θεραπευτικων ειδων

Info

Publication number
CY1116688T1
CY1116688T1 CY20151100800T CY151100800T CY1116688T1 CY 1116688 T1 CY1116688 T1 CY 1116688T1 CY 20151100800 T CY20151100800 T CY 20151100800T CY 151100800 T CY151100800 T CY 151100800T CY 1116688 T1 CY1116688 T1 CY 1116688T1
Authority
CY
Cyprus
Prior art keywords
modifications
therapeutic products
pharmaceutical properties
compounds
administering
Prior art date
Application number
CY20151100800T
Other languages
English (en)
Inventor
Manoj C Desai
Allen Yu Hong
Hongtao Liu
Lianhong Xu
Randall W Vivian
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38729072&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116688(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of CY1116688T1 publication Critical patent/CY1116688T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/78—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton from carbonyl compounds, e.g. from formaldehyde, and amines having amino groups bound to carbon atoms of six-membered aromatic rings, with formation of methylene-diarylamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
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    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
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    • C07—ORGANIC CHEMISTRY
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

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Abstract

Η παρούσα αίτηση κατοχύρωσης ευρεσιτεχνίας προβλέπει ένωση του Χημικού Τύπου I, ή φαρμακευτικώς αποδεκτό άλας, επιδιαλυτωμένο άλας. και/ή έναν εστέρα εξ αυτής, συνθέσεις που περιέχουν τέτοιες ενώσεις, θεραπευτικές μεθόδους που συμπεριλαμβάνουν την χορήγηση τέτοιων ενώσεων και θεραπευτικές μεθόδους που συμπεριλαμβάνουν την χορήγηση τέτοιων ενώσεων με έναν τουλάχιστον επιπρόσθετο θεραπευτικό παράγοντα.
CY20151100800T 2006-07-07 2015-09-14 Τροποποιητες φαρμακοκινητικων ιδιοτητων θεραπευτικων ειδων CY1116688T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81931506P 2006-07-07 2006-07-07
US83237106P 2006-07-21 2006-07-21
US90322807P 2007-02-23 2007-02-23
EP07836007.0A EP2049506B2 (en) 2006-07-07 2007-07-06 Modulators of pharmacokinetic properties of therapeutics

Publications (1)

Publication Number Publication Date
CY1116688T1 true CY1116688T1 (el) 2016-06-22

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CY20151100800T CY1116688T1 (el) 2006-07-07 2015-09-14 Τροποποιητες φαρμακοκινητικων ιδιοτητων θεραπευτικων ειδων
CY2015046C CY2015046I2 (el) 2006-07-07 2015-11-26 Τροποποιητες φαρμακοκινητικων ιδιοτητων θεραπευτικων ειδων

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US (11) US7939553B2 (el)
EP (4) EP3696171B1 (el)
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KR (3) KR101477822B1 (el)
CN (2) CN101490023B (el)
AP (1) AP2985A (el)
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AU (1) AU2007275860C1 (el)
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CY (2) CY1116688T1 (el)
DK (1) DK2049506T4 (el)
EA (2) EA025845B1 (el)
ES (3) ES2611308T3 (el)
FI (2) FIC20150052I1 (el)
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HK (2) HK1232217A1 (el)
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HU (1) HUE025565T4 (el)
IL (2) IL195488A (el)
LT (1) LTC2049506I2 (el)
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PL (1) PL2049506T5 (el)
PT (2) PT2049506E (el)
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TWI411613B (zh) 2006-07-07 2013-10-11 Gilead Sciences Inc 用於改善被細胞色素p450單氧合酶所代謝之治療劑的藥物動力性質之調節劑
CA2661873A1 (en) * 2006-08-31 2008-03-06 Abbott Laboratories Cytochrome p450 oxidase inhibitors and uses thereof
AU2013204815B2 (en) * 2007-02-23 2015-05-07 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
AU2015204378B2 (en) * 2007-02-23 2017-03-09 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
UA101312C2 (ru) 2007-02-23 2013-03-25 Гіліад Сайєнсіз, Інк. Модуляторы фармакокинетических свойств терапевтических препаратов
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JP2012051933A (ja) 2012-03-15
CY2015046I1 (el) 2016-06-22
KR20150042869A (ko) 2015-04-21
HRP20150744T2 (hr) 2016-02-26
HRP20150744T4 (hr) 2024-09-27
RS54237B1 (en) 2015-12-31
FR15C0078I2 (fr) 2016-04-22
PT2487165T (pt) 2016-11-18
CY2015046I2 (el) 2016-06-22
PL2049506T3 (pl) 2015-11-30
FR15C0078I1 (el) 2016-01-08
JP4881433B2 (ja) 2012-02-22
FIC20150052I1 (fi) 2015-11-06
US9139541B2 (en) 2015-09-22
AU2007275860C1 (en) 2014-06-12
US20110212964A1 (en) 2011-09-01
EA020489B1 (ru) 2014-11-28

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