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CO6501182A2 - Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona y su uso como moduladores de pde9a - Google Patents

Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona y su uso como moduladores de pde9a

Info

Publication number
CO6501182A2
CO6501182A2 CO11127673A CO11127673A CO6501182A2 CO 6501182 A2 CO6501182 A2 CO 6501182A2 CO 11127673 A CO11127673 A CO 11127673A CO 11127673 A CO11127673 A CO 11127673A CO 6501182 A2 CO6501182 A2 CO 6501182A2
Authority
CO
Colombia
Prior art keywords
medicaments
heterociclil
pirazolo
pirimidin
dihidro
Prior art date
Application number
CO11127673A
Other languages
English (en)
Inventor
Riccardo Giovannini
Cornelia Dorner-Ciossek
Christian Eickmeier
Dennis Fiegen
Thomas Fox
Klaus Fuchs
Niklas Heine
Holger Rosenbrock
Gerhard Schaenzle
Original Assignee
Boheringer Ingelheim Internat Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2009/053907 external-priority patent/WO2009121919A1/en
Application filed by Boheringer Ingelheim Internat Gmbh filed Critical Boheringer Ingelheim Internat Gmbh
Publication of CO6501182A2 publication Critical patent/CO6501182A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a nuevas pirazolopirimidinonas 1,6-disustituidas de fórmula (I)en que Hc es un grupo tetrahidropiranilo y R1 es el grupo V-W*, en que V y W, independientemente uno de otro, puede ser un grupo arilo o un grupo heteroarilo, que, independientemente uno de otro, puede estar opcionalmente sustituido. De acuerdo con un aspecto de la invención, los nuevos compuestos son para uso como medicamentos o para la fabricación de medicamentos, en particular medicamentos para el tratamiento de estados concernientes a déficits en la percepción, concentración, aprendizaje o memoria. Los nuevos compuestos son también para la fabricación de medicamentos y/o para uso en el tratamiento de la enfermedad de Alzheimer, en particular para la discapacidad cognitiva asociada con la enfermedad de Alzheimer.
CO11127673A 2009-03-31 2011-09-29 Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona y su uso como moduladores de pde9a CO6501182A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
VE57409 2009-03-31
PCT/EP2009/053907 WO2009121919A1 (en) 2008-04-02 2009-04-01 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
EP09171906 2009-09-30

Publications (1)

Publication Number Publication Date
CO6501182A2 true CO6501182A2 (es) 2012-08-15

Family

ID=42174243

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11127673A CO6501182A2 (es) 2009-03-31 2011-09-29 Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona y su uso como moduladores de pde9a

Country Status (34)

Country Link
US (2) US8623901B2 (es)
EP (1) EP2414363B1 (es)
JP (1) JP5542196B2 (es)
KR (1) KR20120003868A (es)
CN (1) CN102365285B (es)
AP (1) AP2011005819A0 (es)
AR (1) AR076171A1 (es)
AU (1) AU2010230290B2 (es)
BR (1) BRPI1011533A2 (es)
CA (1) CA2757231A1 (es)
CL (1) CL2011002454A1 (es)
CO (1) CO6501182A2 (es)
DK (1) DK2414363T3 (es)
EA (1) EA201101395A1 (es)
EC (1) ECSP11011386A (es)
ES (1) ES2460019T3 (es)
GE (1) GEP20146098B (es)
HK (1) HK1163105A1 (es)
HR (1) HRP20140312T1 (es)
IL (1) IL214436A0 (es)
MA (1) MA33152B1 (es)
MX (1) MX2011010184A (es)
MY (1) MY156377A (es)
NZ (1) NZ594567A (es)
PE (1) PE20120505A1 (es)
PL (1) PL2414363T3 (es)
PT (1) PT2414363E (es)
RS (1) RS53167B (es)
SG (1) SG174964A1 (es)
SI (1) SI2414363T1 (es)
TN (1) TN2011000493A1 (es)
TW (1) TW201100426A (es)
UY (1) UY32531A (es)
WO (1) WO2010112437A1 (es)

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