CY1119103T1 - Διενυδρο συμπλεγμα ενωσης βενζοθειοφαινιου και διεργασια για την παραγωγη αυτου - Google Patents
Διενυδρο συμπλεγμα ενωσης βενζοθειοφαινιου και διεργασια για την παραγωγη αυτουInfo
- Publication number
- CY1119103T1 CY1119103T1 CY20171100293T CY171100293T CY1119103T1 CY 1119103 T1 CY1119103 T1 CY 1119103T1 CY 20171100293 T CY20171100293 T CY 20171100293T CY 171100293 T CY171100293 T CY 171100293T CY 1119103 T1 CY1119103 T1 CY 1119103T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dihydrate
- producing
- compound complex
- sulfate compound
- benzene sulfate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Σκοπός της παρούσας εφεύρεσης είναι να παράσχει ένωση η οποία να μπορεί να χρησιμοποιηθεί ως ανώτερος θεραπευτικός παράγοντας για παθήσεις του κεντρικού νευρικού συστήματος. Η παρούσα εφεύρεση παρέχει διένυδρο σύμπλεγμα της 7-[4-(4-βενζο[b]θειοφαιν-4-υλο-πιπεραζιν-1-υλο)βουτοξυ]-1Η-κινολιν-2-όνης ή άλατος αυτής, και διεργασία για την παραγωγή αυτού.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261636920P | 2012-04-23 | 2012-04-23 | |
| US201361791378P | 2013-03-15 | 2013-03-15 | |
| PCT/JP2013/062681 WO2013162046A1 (en) | 2012-04-23 | 2013-04-23 | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119103T1 true CY1119103T1 (el) | 2018-02-14 |
Family
ID=48428584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100293T CY1119103T1 (el) | 2012-04-23 | 2017-03-07 | Διενυδρο συμπλεγμα ενωσης βενζοθειοφαινιου και διεργασια για την παραγωγη αυτου |
Country Status (37)
| Country | Link |
|---|---|
| US (5) | US9499525B2 (el) |
| EP (1) | EP2841431B2 (el) |
| JP (1) | JP5952917B2 (el) |
| KR (1) | KR102160395B1 (el) |
| CN (1) | CN104254530B (el) |
| AR (1) | AR090774A1 (el) |
| AU (1) | AU2013253372B2 (el) |
| BR (1) | BR112014026424B1 (el) |
| CA (1) | CA2870000C (el) |
| CO (1) | CO7111315A2 (el) |
| CY (1) | CY1119103T1 (el) |
| DK (1) | DK2841431T4 (el) |
| EA (1) | EA026541B1 (el) |
| ES (1) | ES2617881T5 (el) |
| FI (1) | FI2841431T4 (el) |
| HK (1) | HK1203073A1 (el) |
| HR (1) | HRP20170242T4 (el) |
| HU (1) | HUE031997T2 (el) |
| IL (1) | IL235044B (el) |
| IN (1) | IN2014DN08867A (el) |
| JO (1) | JO3325B1 (el) |
| LT (1) | LT2841431T (el) |
| ME (1) | ME02619B (el) |
| MX (1) | MX361723B (el) |
| MY (1) | MY170220A (el) |
| NZ (1) | NZ630260A (el) |
| PH (1) | PH12014502324B1 (el) |
| PL (1) | PL2841431T5 (el) |
| PT (1) | PT2841431T (el) |
| RS (1) | RS55742B2 (el) |
| SG (1) | SG11201406790VA (el) |
| SI (1) | SI2841431T2 (el) |
| SM (2) | SMT201700130T1 (el) |
| TW (1) | TWI562991B (el) |
| UA (1) | UA117456C2 (el) |
| WO (1) | WO2013162046A1 (el) |
| ZA (1) | ZA201407477B (el) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| AR090775A1 (es) | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| JOP20210047A1 (ar) * | 2012-10-25 | 2017-06-16 | Otsuka Pharma Co Ltd | عامل وقائي و/أو علاجي للأعراض السلوكية والنفسية المصحوبة بمرض تنكسي عصبي أو الأعراض الإندفاعية المصحوبة بمرض ذهني، يحتوي على بريكسبيرازول أو ملحه |
| KR20160138301A (ko) | 2014-04-22 | 2016-12-02 | 오쓰까 세이야꾸 가부시키가이샤 | 브렉스피프라졸과 날메펜의 병용제 및 물질-관련 장애의 치료를 위한 이의 용도 |
| CN104447723A (zh) * | 2014-11-28 | 2015-03-25 | 瑞阳制药有限公司 | 7-(4-(4-(苯并[b]噻吩基)-1-哌嗪基)丁氧基)-2(1H)-喹啉酮的制备方法 |
| CN104829603A (zh) * | 2015-05-19 | 2015-08-12 | 杭州新博思生物医药有限公司 | A晶型依匹唑派盐酸盐及其制备方法 |
| CN106883223B (zh) * | 2015-12-16 | 2021-11-23 | 北京福元医药股份有限公司 | 一种Brexpiprazole盐酸盐的纯化方法 |
| WO2017106641A1 (en) | 2015-12-17 | 2017-06-22 | Assia Chemical Industries Ltd. | Solid state forms of brexpiprazole |
| JP2019059672A (ja) * | 2015-12-28 | 2019-04-18 | 大日本住友製薬株式会社 | 治療抵抗性うつ病等の治療薬 |
| US10464931B2 (en) | 2015-12-28 | 2019-11-05 | Honour (R&D) | Process for the preparation of Quinolin-2(1H)-one derivatives |
| WO2017134038A1 (en) | 2016-02-01 | 2017-08-10 | Hexal Ag | Anhydrate-free polymorphically pure micronized crystalline brexpiprazole dihydrate for use in intramuscular injectable sustained release formulations |
| US20170320862A1 (en) | 2016-05-03 | 2017-11-09 | Cadila Healthcare Limited | Process for the preparation of brexpiprazole and intermediates thereof |
| CN107365305A (zh) | 2016-05-12 | 2017-11-21 | 上海奥博生物医药技术有限公司 | 一种依匹哌唑新晶型及其制备方法 |
| WO2017208251A1 (en) * | 2016-05-31 | 2017-12-07 | Cipla Limited | A new stable polymorph of brexpiprazole and process for preparation thereof |
| CN106188023A (zh) * | 2016-07-04 | 2016-12-07 | 山东川成医药股份有限公司 | 一种依匹唑派的精制方法 |
| PL233778B1 (pl) | 2016-07-19 | 2019-11-29 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu |
| US20200093821A1 (en) | 2016-08-16 | 2020-03-26 | Hexal Ag | Pharmaceutical Compositions of a Benzothiophene Compound |
| EP3500247B1 (en) | 2016-08-16 | 2020-05-27 | H e x a l Aktiengesellschaft | Immediate release tablet of a benzothiophene compound |
| CN107936005A (zh) * | 2016-10-13 | 2018-04-20 | 上海科胜药物研发有限公司 | 一种依匹哌唑新晶型ii及其制备方法 |
| CN111233848A (zh) * | 2016-12-14 | 2020-06-05 | 上海博志研新药物技术有限公司 | 一种依匹哌唑甲醇合物、晶型a、及其制备方法和应用 |
| US11072605B2 (en) | 2017-02-02 | 2021-07-27 | Hexal Ag | Crystalline brexpiprazole |
| EP3501506B1 (en) | 2017-12-19 | 2019-10-09 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising brexpiprazole |
| CN111440158A (zh) * | 2020-03-24 | 2020-07-24 | 石药集团中奇制药技术（石家庄）有限公司 | 一种盐酸依匹哌唑新晶型及其制备方法 |
| US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
| WO2022176017A1 (ja) * | 2021-02-16 | 2022-08-25 | 大塚製薬株式会社 | 非晶質体及び当該非晶質体を含む組成物 |
| WO2023067664A1 (ja) * | 2021-10-18 | 2023-04-27 | 大塚製薬株式会社 | ベンゾチオフェン化合物の新規結晶形及びその製造方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| SI1675573T2 (sl) † | 2003-10-23 | 2012-08-31 | Otsuka Pharma Co Ltd | Sterilna injektibilna aripiprazolna formulacija z nadzorovanim sproščanjem in postopek |
| WO2006030446A1 (en) | 2004-09-13 | 2006-03-23 | Matrix Laboratories Ltd | Process for the preparation of polymorphs, solvates of aripiprazole using aripiprazole acid salts |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| JP4315393B2 (ja) | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| AR066677A1 (es) * | 2007-05-24 | 2009-09-02 | Novartis Ag | Formulacion de pasireotida. composicion farmaceutica para liberacion prolongada. microparticulas. |
| CA2703742A1 (en) * | 2007-10-26 | 2009-04-30 | Repligen Corporation | Methods of identifying histone deacetylase inhibitors useful for neurological disorders |
| CN101917969A (zh) * | 2008-01-30 | 2010-12-15 | 诺瓦提斯公司 | 包含奥曲肽和三种线形聚丙交酯-共-乙交酯聚合物的缓释制剂 |
| US9511022B2 (en) † | 2010-08-24 | 2016-12-06 | Otsuka Pharmaceutical Co., Ltd. | Suspension and cake composition containing carbostyryl derivative and silicone oil and/or silicone oil derivative |
| JP2012232958A (ja) * | 2011-05-09 | 2012-11-29 | Otsuka Pharmaceut Co Ltd | 注射製剤 |
| TWI546299B (zh) * | 2011-07-28 | 2016-08-21 | 大塚製藥股份有限公司 | 用於製造苯并［ｂ］噻吩之方法 |
| JO3227B1 (ar) * | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
| JOP20200109A1 (ar) * | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| AR090775A1 (es) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
-
2013
- 2013-04-19 TW TW102114005A patent/TWI562991B/zh active
- 2013-04-22 AR ARP130101319A patent/AR090774A1/es unknown
- 2013-04-23 IN IN8867DEN2014 patent/IN2014DN08867A/en unknown
- 2013-04-23 WO PCT/JP2013/062681 patent/WO2013162046A1/en active Application Filing
- 2013-04-23 UA UAA201412555A patent/UA117456C2/uk unknown
- 2013-04-23 HR HRP20170242TT patent/HRP20170242T4/hr unknown
- 2013-04-23 PL PL13722129.7T patent/PL2841431T5/pl unknown
- 2013-04-23 LT LTEP13722129.7T patent/LT2841431T/lt unknown
- 2013-04-23 KR KR1020147032745A patent/KR102160395B1/ko active Active
- 2013-04-23 MY MYPI2014703139A patent/MY170220A/en unknown
- 2013-04-23 US US14/396,224 patent/US9499525B2/en active Active
- 2013-04-23 MX MX2014012527A patent/MX361723B/es active IP Right Grant
- 2013-04-23 ES ES13722129T patent/ES2617881T5/es active Active
- 2013-04-23 AU AU2013253372A patent/AU2013253372B2/en active Active
- 2013-04-23 JO JOP/2013/0114A patent/JO3325B1/ar active
- 2013-04-23 HU HUE13722129A patent/HUE031997T2/en unknown
- 2013-04-23 CA CA2870000A patent/CA2870000C/en active Active
- 2013-04-23 JP JP2014550214A patent/JP5952917B2/ja active Active
- 2013-04-23 SG SG11201406790VA patent/SG11201406790VA/en unknown
- 2013-04-23 FI FIEP13722129.7T patent/FI2841431T4/fi active
- 2013-04-23 BR BR112014026424-4A patent/BR112014026424B1/pt active IP Right Grant
- 2013-04-23 SM SM20170130T patent/SMT201700130T1/it unknown
- 2013-04-23 DK DK13722129.7T patent/DK2841431T4/da active
- 2013-04-23 NZ NZ630260A patent/NZ630260A/en unknown
- 2013-04-23 RS RS20170214A patent/RS55742B2/sr unknown
- 2013-04-23 CN CN201380021622.6A patent/CN104254530B/zh active Active
- 2013-04-23 EP EP13722129.7A patent/EP2841431B2/en active Active
- 2013-04-23 PT PT137221297T patent/PT2841431T/pt unknown
- 2013-04-23 SI SI201330538T patent/SI2841431T2/sl unknown
- 2013-04-23 EA EA201491933A patent/EA026541B1/ru not_active IP Right Cessation
- 2013-04-23 ME MEP-2017-56A patent/ME02619B/me unknown
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2014
- 2014-10-07 IL IL235044A patent/IL235044B/en active IP Right Grant
- 2014-10-14 CO CO14226629A patent/CO7111315A2/es unknown
- 2014-10-15 ZA ZA2014/07477A patent/ZA201407477B/en unknown
- 2014-10-17 PH PH12014502324A patent/PH12014502324B1/en unknown
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2015
- 2015-04-13 HK HK15103588.5A patent/HK1203073A1/xx unknown
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2016
- 2016-10-14 US US15/294,644 patent/US10407415B2/en active Active
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2017
- 2017-02-28 SM SM201700130T patent/SMT201700130B/it unknown
- 2017-03-07 CY CY20171100293T patent/CY1119103T1/el unknown
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2019
- 2019-09-09 US US16/564,972 patent/US20200140424A1/en not_active Abandoned
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2020
- 2020-08-04 US US16/985,177 patent/US20210115030A1/en not_active Abandoned
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2022
- 2022-02-14 US US17/651,042 patent/US20230049327A1/en active Pending
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