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JO3512B1 - مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز - Google Patents

مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز

Info

Publication number
JO3512B1
JO3512B1 JOP/2015/0052A JOP20150052A JO3512B1 JO 3512 B1 JO3512 B1 JO 3512B1 JO P20150052 A JOP20150052 A JO P20150052A JO 3512 B1 JO3512 B1 JO 3512B1
Authority
JO
Jordan
Prior art keywords
derivatives useful
quinoxaline derivatives
fgfr kinase
kinase modulators
compounds
Prior art date
Application number
JOP/2015/0052A
Other languages
English (en)
Inventor
Russell Mark Jones
Diego Fernando Domenico Broggini
Wim Vermeulen
Filip Albert Celine Cuyckens
Steven Anna Hostyn
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50389854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3512(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Application granted granted Critical
Publication of JO3512B1 publication Critical patent/JO3512B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات مشتقة جديدة من كوينو أوكسالين، لتركيبات صيدلانية تشتمل على المركبات المذكورة، لعمليات لتحضير المركبات المذكورة ولاستخدام المركبات المذكورة في علاج الأمراض، على سبيل المثال السرطان.
JOP/2015/0052A 2014-03-26 2015-03-23 مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز JO3512B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14161820 2014-03-26

Publications (1)

Publication Number Publication Date
JO3512B1 true JO3512B1 (ar) 2020-07-05

Family

ID=50389854

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2015/0052A JO3512B1 (ar) 2014-03-26 2015-03-23 مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز

Country Status (38)

Country Link
US (2) US9902714B2 (ar)
EP (1) EP3122742B1 (ar)
JP (1) JP6625551B2 (ar)
KR (1) KR102469506B1 (ar)
CN (1) CN106459010B (ar)
AP (1) AP2016009536A0 (ar)
AR (1) AR099854A1 (ar)
AU (1) AU2015238300C1 (ar)
BR (1) BR112016022060B1 (ar)
CA (1) CA2943683A1 (ar)
CL (1) CL2016002382A1 (ar)
CR (1) CR20160501A (ar)
CY (1) CY1120969T1 (ar)
DK (1) DK3122742T3 (ar)
EA (1) EA032145B1 (ar)
ES (1) ES2702450T3 (ar)
HR (1) HRP20182073T1 (ar)
HU (1) HUE041738T2 (ar)
IL (1) IL247658B (ar)
JO (1) JO3512B1 (ar)
LT (1) LT3122742T (ar)
MA (1) MA39783B1 (ar)
MX (1) MX2016012446A (ar)
MY (1) MY194074A (ar)
NI (1) NI201600144A (ar)
NZ (1) NZ724907A (ar)
PH (1) PH12016501898B1 (ar)
PL (1) PL3122742T3 (ar)
PT (1) PT3122742T (ar)
RS (1) RS58088B1 (ar)
SG (1) SG11201607961QA (ar)
SI (1) SI3122742T1 (ar)
SM (1) SMT201800670T1 (ar)
TR (1) TR201819138T4 (ar)
TW (1) TWI686391B (ar)
UA (1) UA117958C2 (ar)
WO (1) WO2015144803A1 (ar)
ZA (1) ZA201606942B (ar)

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