CN113652349B - Development and preliminary pharmacokinetics experimental equipment for in-vivo analysis method of immediately-readjustment - Google Patents
Development and preliminary pharmacokinetics experimental equipment for in-vivo analysis method of immediately-readjustment Download PDFInfo
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Abstract
The invention discloses a device for developing a vertical re-fit in-vivo analysis method and performing a preliminary pharmacokinetic experiment, which comprises a first shell, a supporting rod, a supporting plate, a main body component, a vibration component and a detection component, wherein the first shell is provided with a first cavity and a second cavity: the water pump is characterized in that a main body assembly is arranged in the first shell and comprises a water pump, a first pipe body, a second shell and a third pipe body; according to the invention, the third tube body is adopted to simulate a human blood vessel, the water pump is adopted to simulate a heart, the second shell body is adopted to simulate each large organ, the vaccinia virus inflammation rabbit skin extract injection is dispersed in a water body, the model generator generates model information and sends signals to the controller to be displayed on the display screen, the movement track which is suitable for standing in vivo and the reaction with pathological tissues are simulated, the standing in vivo analysis is carried out, the preliminary pharmacokinetics is realized, the reaction which is suitable for standing in vivo is analyzed, and the experiment is carried out without using expensive instruments or adopting experimental bodies such as mice, and the cost is low.
Description
Technical Field
The invention relates to the technical field of pharmacokinetic experiment equipment, in particular to a rapid in-vivo analysis method development and preliminary pharmacokinetic experiment equipment.
Background
The extract injection is immediately suitable for vaccinia virus induced inflammation rabbit skin extract injection and is used for cervical, shoulder and wrist syndromes; pain, cold sensation, numbness and other symptoms of the lumbago patients are relieved; symptomatic neuralgia.
Pharmacokinetics is a discipline that quantitatively studies the absorption, distribution, metabolism and excretion of drugs in living organisms and uses mathematical principles and methods to elucidate the law of the change of blood concentration with time.
A large number of experiments are required for any drug before it is put into use, and experimental equipment for in vivo analysis development and use of preliminary pharmacokinetics has not been further developed in the prior art.
For this purpose, a device for the development of a method for in vivo analysis of immediate re-aptamer and for preliminary pharmacokinetic experiments is proposed.
Disclosure of Invention
The invention aims to provide a device for developing a vertical re-aptamer in-vivo analysis method and performing a preliminary pharmacokinetic experiment to solve the problems in the background art.
In order to achieve the above purpose, the present invention provides the following technical solutions: a vertical re-aptamer in-vivo analysis method development and preliminary pharmacokinetic experiment device comprises a first shell, a support rod, a support plate, a main body component, a vibration component and a detection component: the water pump is characterized in that a main body assembly is arranged in the first shell and comprises a water pump, a first pipe body, a second shell and a third pipe body;
four second shells are symmetrically welded in the first shell, the water outlet of the water pump is communicated with one end of the first tube, the other end of the first tube is communicated with one side of one second shell, the water inlet of the water pump is communicated with one end of the second tube, and the other end of the second tube is communicated with one side of the other second shell; the other two second shells and the first two second shells are communicated with each other through a third pipe body;
the vibration component is arranged on the upper surface of the supporting plate and the upper surface of the second shell;
the detection component is arranged on one side of the water pump and the outer side of the second shell.
Preferably: four supporting rods are symmetrically welded on the upper surface of the first shell, and supporting plates are welded on the tops of the four supporting rods.
Preferably: the vibration assembly comprises a vibration motor, a first transmission plate, a transmission rod, a second transmission plate, a fourth pipe body, a fifth pipe body and a valve;
the upper surface welding of backup pad has first drive plate, the upper surface mid-mounting of first drive plate has vibrating motor.
Preferably: four transmission rods are welded on the front surface of the supporting plate in an embedded mode, a second transmission plate is welded at the bottom end of each transmission rod, and the lower surface of each second transmission plate is welded in the middle of the upper surface of the second shell.
Preferably: the upper surface of second casing intercommunication has the fourth body, one side of second casing communicates there is the fifth body.
Preferably: valves are arranged on the outer sides of the fourth pipe body and the fifth pipe body.
Preferably: the detection assembly comprises a viscosity detector, a temperature sensor, a display screen, a controller, a model generator, an electric heating plate and a partition plate;
the viscosity detector is arranged on the upper surface of the second shell, the controller is arranged on one side of the water pump, and the signal output end of the viscosity detector is connected with the signal input end of the controller in a signal mode.
Preferably: the electric heating plate is arranged on the inner bottom wall of the second shell, the temperature sensor is arranged on one side of the second shell, the probe of the temperature sensor penetrates through the inner part of the second shell, and the signal output end of the temperature sensor is in signal connection with the signal input end of the controller.
Preferably: the inside wall welding of second casing has the baffle, the baffle is located the top of electrical heating board.
Preferably: a display screen and a model generator are arranged on one side of the water pump, the signal end of the model generator is in signal connection with the signal end of the controller, and the signal input end of the display screen is in signal connection with the signal output end of the controller;
the model generator is configured to generate model information.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, a third tube body is adopted to simulate a human blood vessel, a water pump is adopted to simulate a heart, a second shell body is adopted to simulate each large organ, vaccinia virus inflammation-causing rabbit skin extract injection is dispersed in a water body, a model generator generates model information and sends signals to a controller to be displayed on a display screen, a movement track which is immediately suitable for the human body and a reaction with pathological tissues are simulated, and in-vivo analysis is carried out on the immediately suitable body, so that preliminary pharmacokinetics is realized, and the reaction which is immediately suitable for the human body is analyzed without using expensive instruments or adopting experimental bodies such as mice for experiments, and the cost is low;
2. according to the invention, the electric heating plate is started to heat water in the second shell, the temperature sensor detects the temperature of the water in the second shell, when the temperature of the water reaches the normal body temperature of a human body, the electric heating plate is closed, the temperature sensor always detects the temperature of the water, and when the temperature of the water is lower than the normal body temperature by 0.5 ℃, the electric heating plate is started to ensure accurate experimental data;
3. according to the invention, the tackifier is injected into the second shell, the vibration motor is started, the vibration excitation rod of the vibration motor expands the transmission area through the first transmission plate to drive the support plate to vibrate, when the support plate vibrates, the four transmission rods are matched with the second transmission plate to expand the vibration area to drive the second shell to vibrate, so that the tackifier injected into the second shell can be rapidly dispersed in a plurality of second shells and third tubes, at the moment, the viscosity is detected by the viscosity detector, the low-speed interval injection is kept in the tackifier injection process, and the tackifier is diffused by the vibration assembly during the interval period, so that the viscosity cannot deviate from the viscosity of human blood.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic view of the bottom view of the present invention;
FIG. 3 is a schematic top view of the present invention;
FIG. 4 is a schematic view of a second housing according to the present invention;
FIG. 5 is a schematic view of the cross-sectional structure A-A of FIG. 4 in the present invention.
In the figure: 1. a first housing; 2. a support rod; 3. a support plate; 10. a body assembly; 11. a water pump; 12. a first tube body; 13. a second tube body; 14. a second housing; 15. a third tube body; 20. a vibration assembly; 21. a vibration motor; 22. a first drive plate; 23. a transmission rod; 24. a second drive plate; 25. a fourth pipe body; 26. a fifth pipe body; 27. a valve; 30. a detection assembly; 31. a viscosity detector; 32. a temperature sensor; 33. a display screen; 34. a controller; 35. a model generator; 36. an electric heating plate; 37. a partition board.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Examples
Referring to fig. 1-5, the present invention provides a technical solution: a vertical re-aptamer in-vivo analysis method development and preliminary pharmacokinetic experiment apparatus comprising a first housing 1, a support bar 2, a support plate 3, a body assembly 10, a vibration assembly 20 and a detection assembly 30: the main body assembly 10 is installed inside the first housing 1, and the main body assembly 10 comprises a water pump 11, a first pipe body 12, a second pipe body 13, a second housing 14 and a third pipe body 15;
four second shells 14 are symmetrically welded in the first shell 1, the water outlet of the water pump 11 is communicated with one end of the first tube body 12, the other end of the first tube body 12 is communicated with one side of one second shell 14, the water inlet of the water pump 11 is communicated with one end of the second tube body 13, and the other end of the second tube body 13 is communicated with one side of the other second shell 14; the other two second shells 14 and the first two second shells 14 are communicated with each other through a third pipe body 15;
the vibration assembly 20 is mounted to the upper surface of the support plate 3 and the upper surface of the second housing 14;
the sensing assembly 30 is installed at one side of the water pump 11 and at the outer side of the second housing 14.
In this embodiment, specific: four support rods 2 are symmetrically welded on the upper surface of the first shell 1, and support plates 3 are welded on the tops of the four support rods 2; the support bar 2 provides support for the support plate 3, and the support plate 3 provides support for the vibration motor 21 and the first transmission plate 22.
In this embodiment, specific: the vibration assembly 20 includes a vibration motor 21, a first driving plate 22, a driving rod 23, a second driving plate 24, a fourth pipe 25, a fifth pipe 26, and a valve 27;
the upper surface of the supporting plate 3 is welded with a first transmission plate 22, and a vibrating motor 21 is arranged in the middle of the upper surface of the first transmission plate 22; the vibration motor 21 is started, and the excitation rod expands the transmission area through the first transmission plate 22 to drive the support plate 3 to vibrate.
In this embodiment, specific: four transmission rods 23 are welded on the front surface of the support plate 3 in an embedded mode, a second transmission plate 24 is welded at the bottom end of each transmission rod 23, and the lower surface of each second transmission plate 24 is welded in the middle of the upper surface of the second shell 14; when the supporting plate 3 vibrates, the four transmission rods 23 are matched with the second transmission plate 24 to enlarge the vibration area, so that the second shell 14 is driven to vibrate, and the tackifier injected into the second shell 14 can be rapidly dispersed in the second shells 14 and the third pipe body 15.
In this embodiment, specific: the upper surface of the second shell 14 is communicated with a fourth pipe body 25, and one side of the second shell 14 is communicated with a fifth pipe body 26; the fourth tube 25 is used to inject tackifier, vaccinia virus-induced inflammatory rabbit skin extract injection and bacteria instead of human pathological cells.
In this embodiment, specific: the outer sides of the fourth pipe body 25 and the fifth pipe body 26 are respectively provided with a valve 27; the valve 27 controls whether the fourth pipe 25 and the fifth pipe 26 flow.
In this embodiment, specific: the detection assembly 30 includes a viscosity detector 31, a temperature sensor 32, a display screen 33, a controller 34, a model generator 35, an electric heating plate 36, and a partition 37;
the viscosity detector 31 is arranged on the upper surface of the second shell 14, the controller 34 is arranged on one side of the water pump 11, and the signal output end of the viscosity detector 31 is in signal connection with the signal input end of the controller 34; the viscosity detector 31 is used for detecting the viscosity of the water in the second housing 14, so as to achieve the purpose of optimally simulating the viscosity of the blood of the human body.
In this embodiment, specific: the electric heating plate 36 is mounted on the inner bottom wall of the second shell 14, the temperature sensor 32 is mounted on one side of the second shell 14, a probe of the temperature sensor 32 penetrates through the inside of the second shell 14, and a signal output end of the temperature sensor 32 is in signal connection with a signal input end of the controller 34; with the above arrangement, the electric heating plate 36 heats the water inside the second housing 14, the temperature sensor 32 detects the temperature of the water inside the second housing 14, and when the temperature of the water reaches the normal body temperature of the human body, the electric heating plate 36 is turned off.
In this embodiment, specific: a partition plate 37 is welded on the inner side wall of the second shell 14, and the partition plate 37 is positioned above the electric heating plate 36; the partition 37 isolates the water electric heating plate 36.
In this embodiment, specific: a display screen 33 and a model generator 35 are arranged on one side of the water pump 11, a signal end of the model generator 35 is in signal connection with a signal end of the controller 34, and a signal input end of the display screen 33 is in signal connection with a signal output end of the controller 34;
the model generator 35 is configured to generate model information for display on the display screen 33.
Principle of operation or principle of structure: firstly, a large amount of water source is injected into the second shell 14 through the fourth tube body 25, after the water source is filled in each second shell 14 and each third tube body 15, tackifier is injected into the second shell 14, the vibration motor 21 is started, the vibration rod of the vibration motor 21 expands the transmission area through the first transmission plate 22 to drive the support plate 3 to vibrate, when the support plate 3 vibrates, the four transmission rods 23 are matched with the second transmission plate 24 to expand the vibration area to drive the second shell 14 to vibrate, so that the tackifier injected into the second shell 14 can be rapidly dispersed in a plurality of second shells 14 and the third tube bodies 15, at the moment, the viscosity is detected by the viscosity detector 31, the tackifier is injected at a low speed in the tackifier injection process, and the vibration assembly 20 is used for diffusing the tackifier during the interval period to ensure that the viscosity cannot deviate from the viscosity of human blood;
starting an electric heating plate 36, wherein the electric heating plate 36 heats water in the second shell 14, the temperature sensor 32 detects the temperature of the water in the second shell 14, when the temperature of the water reaches the normal body temperature of a human body, the electric heating plate 36 is closed, the temperature sensor 32 always detects the temperature of the water, and when the temperature of the water is lower than the normal body temperature by 0.5 ℃, the electric heating plate 36 is started, so that accurate experimental data is ensured;
when the water viscosity reaches the standard, bacteria are replaced by injection, pathological tissues are simulated, the vibration motor 21 is started again, and the pathological tissues are diffused;
the vaccinia virus-induced inflammation rabbit skin extract injection is injected, the water pump 11 is started to simulate heart beating, the vaccinia virus-induced inflammation rabbit skin extract injection is dispersed in a water body through the cooperation of the first pipe body 12, the second pipe body 13 and the third pipe body 15, the model generator 35 generates model information and sends signals to the controller 34 to be displayed on the display screen 33, the movement track which is suitable for the human body immediately and the reaction with pathological tissues are simulated, the in-vivo analysis is performed immediately, the preliminary pharmacokinetics is realized, the reaction which is suitable for the human body immediately is analyzed, and the experiment is performed by adopting an experiment body such as a white mouse or the like without expensive instruments, so that the cost is low.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The utility model provides a three-dimensional and fit in-vivo analysis method development and preliminary pharmacokinetic experiment equipment, includes first casing (1), bracing piece (2), backup pad (3), main part subassembly (10), vibration subassembly (20) and detection component (30), its characterized in that: the water pump is characterized in that a main body assembly (10) is arranged in the first shell (1), and the main body assembly (10) comprises a water pump (11), a first pipe body (12), a second pipe body (13), a second shell (14) and a third pipe body (15);
four second shells (14) are symmetrically welded in the first shell (1), the water outlet of the water pump (11) is communicated with one end of the first pipe body (12), the other end of the first pipe body (12) is communicated with one side of one second shell (14), the water inlet of the water pump (11) is communicated with one end of the second pipe body (13), and the other end of the second pipe body (13) is communicated with one side of the other second shell (14); the other two second shells (14) and the first two second shells (14) are communicated with each other through a third pipe body (15);
the vibration assembly (20) is arranged on the upper surface of the supporting plate (3) and the upper surface of the second shell (14);
the detection assembly (30) is mounted on one side of the water pump (11) and on the outer side of the second shell (14).
2. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 1, wherein: four supporting rods (2) are symmetrically welded on the upper surface of the first shell (1), and supporting plates (3) are welded on the tops of the four supporting rods (2).
3. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 1, wherein: the vibration assembly (20) comprises a vibration motor (21), a first transmission plate (22), a transmission rod (23), a second transmission plate (24), a fourth pipe body (25), a fifth pipe body (26) and a valve (27);
the upper surface welding of backup pad (3) has first drive plate (22), the upper surface mid-mounting of first drive plate (22) has vibrating motor (21).
4. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 3, wherein: four transmission rods (23) are welded on the front surface of the supporting plate (3) in an embedded mode, a second transmission plate (24) is welded at the bottom end of each transmission rod (23), and the lower surface of each second transmission plate (24) is welded in the middle of the upper surface of the second shell (14).
5. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 3, wherein: the upper surface of second casing (14) communicates there is fourth body (25), one side of second casing (14) communicates there is fifth body (26).
6. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 3, wherein: valves (27) are arranged on the outer sides of the fourth pipe body (25) and the fifth pipe body (26).
7. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 1, wherein: the detection assembly (30) comprises a viscosity detector (31), a temperature sensor (32), a display screen (33), a controller (34), a model generator (35), an electric heating plate (36) and a partition plate (37);
the viscosity detector (31) is arranged on the upper surface of the second shell (14), the controller (34) is arranged on one side of the water pump (11), and the signal output end of the viscosity detector (31) is connected with the signal input end of the controller (34) in a signal mode.
8. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 7, wherein: the electric heating plate (36) is arranged on the inner bottom wall of the second shell (14), the temperature sensor (32) is arranged on one side of the second shell (14), a probe of the temperature sensor (32) penetrates through the inside of the second shell (14), and a signal output end of the temperature sensor (32) is in signal connection with a signal input end of the controller (34).
9. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 8, wherein: a partition plate (37) is welded on the inner side wall of the second shell (14), and the partition plate (37) is positioned above the electric heating plate (36).
10. The apparatus for in vivo analysis method development and preliminary pharmacokinetic experiments according to claim 7, wherein: one side of the water pump (11) is provided with a display screen (33) and a model generator (35), a signal end of the model generator (35) is in signal connection with a signal end of the controller (34), and a signal input end of the display screen (33) is in signal connection with a signal output end of the controller (34).
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008066525A2 (en) * | 2006-11-30 | 2008-06-05 | Dancu Michael B | System and method for producing dynamic conditions including in vivo hemodynamic conditions in a three dimensional tubular structure |
| CN102097026A (en) * | 2009-12-14 | 2011-06-15 | 中国科学院上海药物研究所 | Device and method for simulating pharmacokinetics characteristics in vitro |
| CN111819442A (en) * | 2017-11-29 | 2020-10-23 | 再心生物科技有限公司 | Bioreactor Screening Platform for Simulating Human Systems Biology and Screening for Inotropic Effects of Agents on the Heart |
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| GB2467645B (en) * | 2007-07-06 | 2011-12-21 | Univ London | A method of proliferating human hepatocyte cells |
| EP3050027A4 (en) * | 2013-09-27 | 2017-05-31 | Commonwealth Scientific and Industrial Research Organisation | Manifold diffusion of solutions for kinetic analysis of pharmacokinetic data |
| WO2016036532A1 (en) * | 2014-09-05 | 2016-03-10 | Icahn School Of Medicine At Mount Sinai | Automated, multifunctional, engineered cardiac tissue culture and testing bioreactor system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2008066525A2 (en) * | 2006-11-30 | 2008-06-05 | Dancu Michael B | System and method for producing dynamic conditions including in vivo hemodynamic conditions in a three dimensional tubular structure |
| CN102097026A (en) * | 2009-12-14 | 2011-06-15 | 中国科学院上海药物研究所 | Device and method for simulating pharmacokinetics characteristics in vitro |
| CN111819442A (en) * | 2017-11-29 | 2020-10-23 | 再心生物科技有限公司 | Bioreactor Screening Platform for Simulating Human Systems Biology and Screening for Inotropic Effects of Agents on the Heart |
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