Automatic filling formula cholelithiasis therapeutic instrument
Technical field
The present invention relates to a kind of medical apparatus and instruments, especially treat a kind of automatic filling formula therapy equipment of cholelithiasis.
Background technology
Gallstone disease is global frequently-occurring disease, very harmful to human health.Along with the trend enhancing of aged tendency of population, the quickening and the growth in the living standard of people's rhythm of life, the sickness rate of gallstone disease constantly raises.Gallstone disease is the general name of cholelithiasis, calculus of intrahepatic duct, extrahepatic bile ducts calculus.According to statistics, cholelithiasis accounts for gallstone disease and always sends out more than 80% of case load.The sickness rate of China adult cholelithiasis is about 10%, middle-aged women even up to 15%.Therefore probing into method efficient, the safe treatment cholelithiasis is very important.
The Therapeutic Method of cholelithiasis has a variety of, mainly is divided into operative therapy and non-operative treatment.Current prevailing treatment means is the excision gallbladder.Open the extensive wound property that abdomen is got the gallbladder operation although its small incision cholecystectomy has reduced tradition, because it still belongs to traumatic means, many patients are reluctant to accept; Laparoscopic cholecystectomy has obviously reduced the health wound; But this scheme needs general anesthesia; Patient's danger such as severe cardiac lung disease, diabetes are very big for suffering from, and the expensive high-end instrument and equipment of these scheme needs, make treatment be difficult to carry out in the general hospital; The most important thing is gallbladder as a part of human body organ, bring infringement can for after the excision people's physiology and psychology, therefore, Most patients more is ready to accept non-operative treatment.
Non-operative treatment mainly comprises oral dissolved stone medicine treatment, ESWL and perfusion lithodialysis method.The most effective in the present oral dissolved stone medicine therapy for taking ursodesoxycholic acid.This medicine toleration is better, is applicable to the cholelithiasis of diameter less than 10mm.Though these therapy oral drugs are convenient, and certain lithodialysis curative effect is arranged, easy for patients to accept, its treatment time is long, and expensive has certain ill effect and toxic reaction, and relapse rate is higher after the drug withdrawal.
ESWL is to utilize liquid electricity, piezoelectricity or magnetoelectric effect to produce shock wave, through medium conduction and focusing, pulverizes a kind of technology of calculi in vivo behind the entering human body.Wherein ultrasonic rubble therapy is to utilize the ultrasound wave of high frequency, high energy, focusing, imports in the body through tissue calculus is produced stress and cavitation, makes the cracked purpose that reaches treatment of calculus.The advantage of this therapy is Noninvasive treatment, simple to operate, painless waiting bitterly for, and shortcoming is very big to the tissue injury around the calculus.If ultransonic intensity is at 0.1W/cm
2When following, do not cause tangible biological effect, if ultrasound intensity is at 0.1W/cm
2Can cause tissue generation functional character and organic variation when above, the part patient biliary colic can occur after implementing this therapy simultaneously.
Perfusion lithodialysis method; Be on master's the basis mainly promptly with the cholesterol type calculus at cholelithiasis; Perfusion a kind of safe and effective cholesterol solvent-methyl tert-butyl ether (MTBE) in gallbladder; Cholelithiasis directly contacts the lithodialysis agent, and drug level is high relatively, thereby reaches the purpose of dissolving calculus fully, rapidly.In addition, in the process of dissolving calculus fast, can not damage gallbladder mucosa.Be applicable to patient such as older, high-risk adhesion of gallbladder that should not operative treatment and hope to keep gallbladder and the patient that selects non-operative treatment.
What mainly adopt in early days is manual directly infusion therapy, by clinical department of internal medicine doctor completion hand-manipulated.Be specially the doctor and through liver puncture conduit inserted patient's gallbladder, use glass syringe perfusion and suction lithodialysis agent such as MTBE through percutaneous, each 5-10ml, branch was extracted out in several minutes, so repeated multiple times.But still there is potential safety hazard in this process, flows into bile duct and intestinal if the MTBE in the gallbladder too much causes it to overflow gallbladder, can be absorbed by the body, and is prone to produce nausea and vomiting, side effect such as haemolysis.Because the gallbladder size there are differences, the calculus amount is different, and the self-constriction property of gallbladder, and these factors all make the people for being difficult to accurately control quantity of solvent, in case solvent is leaked to inside of human body branches such as intestinal, then can cause poisoning, the infringement health.Operation easier is big, efficient is low so manual perfusion lithodialysis method still exists, and the lithodialysis agent is prone to leak and cause easily operator's problems such as fatigue.
CN2875449; A kind of " cholelithiasis dissolving appearance " that is used to treat cholelithiasis disclosed; A kind of computer controlled automatic lithodialysis agent circulation dissolution therapy appearance has been proposed; Owing to adopted the closed loop pressure control model, made the treatment operation of under computer control, accomplishing perfusion dissolving cholelithiasis automatically to have overcome the big shortcoming of poor stability, operation easier that perfusion lithodialysis agent treatment cholelithiasis hand-manipulated exists.But this instrument adopts pressure transducer is placed outside the human gall bladder, transmits pressure application through sealing air and measures IBP power.This pressure testing method precision is low, and instrument reply emergency case response speed is slow, causes instrument safety in operation and poor stability, has treatment hidden danger, so press for a kind of safer, sensitive, therapeutic equipments efficiently.
Summary of the invention
The object of the invention just is the deficiency to above-mentioned prior art, and a kind of automatic filling formula cholelithiasis therapeutic instrument that adopts the built-in pressure transducer of conduit is provided.
The objective of the invention is to realize through following technical scheme:
Automatic filling formula cholelithiasis therapeutic instrument; Be to connect keyboard 3 by touch screen 1 through PC 2, PC 2 connects microcontroller 4 through the USB mouth, and pressure transducer 5 is connected with microcontroller 4 through ADC module 6; Temperature sensor 9 is connected with microcontroller 4 through modulate circuit 10; Heater strip 12 is connected with microcontroller 4 through solid-state relay 11, and suction pump 13 connects microcontroller 4 through ADC module 7, and charge pump 14 connects microcontroller 4 through ADC module 8 and constitutes.
Pressure transducer 5 places external catheter 20 Inner Front Ends; Suction tube 16 and intrusion pipe 17 also are housed in the external catheter 20, and suction tube 16 is in the sealing of external catheter 20 Inner Front Ends, and sidewall is provided with pump orifice 18; Intrusion pipe 17 is provided with perfusing hole 22 at external catheter 20 Inner Front Ends, and sidewall also is provided with perfusing hole 19.
Suction tube 16 is connected with solvent cell 23 through suction pump 13, and intrusion pipe 17 connects and composes through charge pump 14 solvent cells 23.
Automatic filling formula cholelithiasis therapeutic instrument is made up of touch screen, PC, keyboard, microcontroller, pressure transducer, ADC module, DAC module, suction pump, charge pump, temperature sensor, temperature sensor modulate circuit, solid-state relay and heater strip etc.Comprise suction tube 16, intrusion pipe 17 and pressure sensor signal line 21 in the external catheter 20, an end of conduit links to each other with patient's gallbladder, and an end of other end intrusion pipe 17 and suction tube 16 links to each other.Intrusion pipe 17 is independently controlled by charge pump and suction pump respectively with suction tube 16, and the other end is connected to solvent cell, has the cholelithiasis solvent in the solvent cell.Pressure transducer is in the end that external catheter contacts with human gall bladder, is used to measure the human gall bladder internal pressure, and the pressure signal of measurement exports the ADC module to through lead, sends into microcontroller through becoming digital quantity after the conversion.Microcontroller is analyzed force value, through the rotating speed and the rotating of suction pump of DAC module controls and charge pump, realizes the automatic filling of solvent, and keeps IBP power to be in the pressure limit that is provided with in advance.Microcontroller heats the solvent in the solvent cell through solid-state relay control heater strip simultaneously, and through its temperature value of temperature sensor measurement, realizes automatic heating and insulation to solvent, and its temperature is in the temperature range that is provided with in advance.Carry out communication through usb bus between microcontroller and the PC, the parameters of measuring is transferred on the PC shows, and receive the instruction of PC transmission in real time.Operation instrument TT&C software is provided with the instrument operational factor through keyboard or touch screen on the PC.
During the instrument operation, microcontroller is measured the human gall bladder internal pressure in real time, if pressure increases; Then improve the speed of service of suction pump, reduce charge pump speed, to quicken to extract the gallbladder internal solvent; Otherwise, then reduce the speed of service of suction pump, improve charge pump speed; To quicken in gallbladder, to pour into solvent, realize that IBP power was in normal range.When outer connecting duct stopped up, pressure occurred unusual, and the cholelithiasis fragment that stops up conduit is washed away in microprocessor controls suction pump and charge pump counter-rotating, guaranteed that the operation of conduit internal solvent is unobstructed.
Beneficial effect: because pressure transducer is placed catheter tip, it is directly contacted with the interior liquid of gallbladder, detect patient's IBP power in real time; And serve as the rotating speed according to two peristaltic pumps of control with it, therefore it is higher to measure sensitivity, and solvent perfusion control is more accurate; Therapeutic process accuracy, stability and reliability have been guaranteed; Treatment time shortens, and operating difficulty reduces, thereby alleviates the patient suffering.The present invention adopts the combination of computer, microcontroller and virtual instrument software, makes this instrument have modularity, standardized hardware configuration and visual, patterned operation interface.
Description of drawings
Accompanying drawing 1 is an automatic filling formula cholelithiasis therapeutic instrument structured flowchart
Accompanying drawing 2 is an automatic filling formula cholelithiasis therapeutic instrument connection layout
Attached 3 is Fig. 2 external catheter cut-away view
Accompanying drawing 4 is Fig. 2 A-A sectional view
1 touch screen, 2PC machine, 3 keyboards, 4 microcontrollers, 5 pressure transducers, 6ADC module, 7DAC module, 8DAC module, 9 temperature sensors, 10 modulate circuits, 11 solid-state relays, 12 heater strips, 13 suction pumps, 14 charge pumps, 16 suction tubes, 17 intrusion pipes, 18 pump orifices, 19 perfusing holes, 20 external catheters, 21 pressure sensor signal lines, 22 intrusion pipe front end perfusing holes, 23 solvent cells.
The specific embodiment
Do further detailed description below in conjunction with accompanying drawing and embodiment:
Automatic filling formula cholelithiasis therapeutic instrument; Be to connect keyboard 3 by touch screen 1 through PC 2, PC 2 connects microcontroller 4 through the USB mouth, and pressure transducer 5 is connected with microcontroller 4 through ADC module 6; Temperature sensor 9 is connected with microcontroller 4 through modulate circuit 10; Heater strip 12 is connected with microcontroller 4 through solid-state relay 11, and suction pump 13 connects microcontroller 4 through ADC module 7, and charge pump 14 connects microcontroller 4 through ADC module 8 and constitutes.
Pressure transducer 5 places external catheter 20 Inner Front Ends; Suction tube 16 and intrusion pipe 17 also are housed in the external catheter 20, and suction tube 16 is in the sealing of external catheter 20 Inner Front Ends, and sidewall is provided with pump orifice 18; Intrusion pipe 17 is provided with perfusing hole 22 at external catheter 20 Inner Front Ends, and sidewall also is provided with perfusing hole 19.
Suction tube 16 is connected with solvent cell 23 through suction pump 13, and intrusion pipe 17 connects and composes through charge pump 14 solvent cells 23.
Automatic filling formula cholelithiasis therapeutic instrument is made up of touch screen, PC, keyboard, microcontroller, pressure transducer, ADC module, DAC module, suction pump, charge pump, temperature sensor, temperature sensor modulate circuit, solid-state relay and heater strip etc.Comprise suction tube 16, intrusion pipe 17 and pressure sensor signal line 21 in the external catheter 20, an end of conduit links to each other with patient's gallbladder, and an end of other end intrusion pipe 17 and suction tube 16 links to each other.Intrusion pipe 17 is independently controlled by charge pump and suction pump respectively with suction tube 16, and the other end is connected to solvent cell, has the cholelithiasis solvent in the solvent cell.Pressure transducer is in the end that external catheter contacts with human gall bladder, is used to measure the human gall bladder internal pressure, and the pressure signal of measurement exports the ADC module to through lead, sends into microcontroller through becoming digital quantity after the conversion.Microcontroller is analyzed force value, through the rotating speed and the rotating of suction pump of DAC module controls and charge pump, realizes the automatic filling of solvent, and keeps IBP power to be in the pressure limit that is provided with in advance.Microcontroller heats the solvent in the solvent cell through solid-state relay control heater strip simultaneously, and through its temperature value of temperature sensor measurement, realizes automatic heating and insulation to solvent, and its temperature is in the temperature range that is provided with in advance.Carry out communication through usb bus between microcontroller and the PC, the parameters of measuring is transferred on the PC shows, and receive the instruction of PC transmission in real time.Operation instrument TT&C software is provided with the instrument operational factor through keyboard or touch screen on the PC.
During the instrument operation, microcontroller is measured the human gall bladder internal pressure in real time, if pressure increases; Then improve the speed of service of suction pump, reduce charge pump speed, to quicken to extract the gallbladder internal solvent; Otherwise, then reduce the speed of service of suction pump, improve charge pump speed; To quicken in gallbladder, to pour into solvent, realize that IBP power was in normal range.When outer connecting duct stopped up, pressure occurred unusual, and the cholelithiasis fragment that stops up conduit is washed away in microprocessor controls suction pump and charge pump counter-rotating, guaranteed that the operation of conduit internal solvent is unobstructed.