CN106236313B - Burn and scald experimental provision for animal - Google Patents

Abstract

The present invention relates to the burn and scald experimental provision for animal, block is scalded, for burn and scald animal；Drive rod, it is threadedly coupled with scald block, for driving scald block to move back and forth, the side of drive rod is provided with spur gear；Spacing pair, for limiting drive rod；Drive gear, drive gear engages with the spur gear of drive rod side, for driving drive rod to move；Motor, for driving drive gear to move；Driver, for controlling motor to act；Controller, for controlling driver, receive the signal of weighing sensor；Support plate, the animal of burn and scald is treated for placing；Weighing sensor is located at below support plate, for detecting the change of power in support plate.The present invention can record time of contact to the effective control of contact area, control the animal burn and scald experimental facilities of contact force.

Description

Burn and scald experimental device for animals

technical field

The invention relates to the field of medical experimental equipment, in particular to a burn and scald experimental device for animals.

Background technique

The occurrence and development of human diseases are very complicated. Due to the time and space limitations of accumulated clinical experience, as well as various moral and methodological restrictions, many experiments cannot fully explore the pathogenesis and curative effect of diseases. Nor should patients be used as experimental subjects. The attractiveness of animal models lies precisely in the fact that they overcome the aforementioned deficiencies and play a unique role in biomedical research. The establishment of animal models of burns and scalds is an extremely important experimental method and means in basic and applied research in the field of modern burn surgery. An ideal model will help to understand more scientifically and accurately the effects of various body systems and local wounds after burns and scalds. Develop and evolve laws, and explore targeted prevention and control measures.

Pigs, dogs, sheep, rats, mice, and guinea pigs are often used as animal models of burns. The selection of experimental animals is mainly based on the anatomical and physiological characteristics of the animals, and the principle is to satisfy the purpose of the experiment to the greatest extent. Rats and mice are often used in the study of burn wound sepsis and wound medication; pigs, dogs and guinea pigs, which are similar in structure to human skin tissue, are often used to observe the effect of scab-removing drugs and wound healing, and they are also suitable for research on burn shock. research; pigs, sheep and rats were used for the research on the changes of nutrient metabolism after burns.

The degree of burn injury depends on the temperature, pressure and time of injury, and its depth is mainly determined by the histological examination of the case, which is basically consistent with the clinical "three degrees and four divisions". Laser Doppler flowmeter, infrared thermal imaging camera, high-sensitivity skin interrogator, ultrasonic instrument, proton magnetic resonance imaging instrument, light reflection measuring instrument, and current measuring instrument modified from meridian measuring instrument can be used to measure the burning of experimental animals respectively. Changes in microcirculation, local temperature, deformed collagen content, water content, spectral characteristics, and blood flow in the scalded area.

The burn stasis area refers to the middle part of the three-layer concentric structure of the burn wound. Within 48 hours, irreversible coagulation necrosis occurs with vascular embolism, and timely and effective prevention of this progressive change is helpful for reducing damage and reducing complications. , shorten the treatment cycle, reduce disability, has important clinical significance. An ideal burn model is helpful for a more scientific and accurate understanding of the development and evolution of burn wounds, and to explore targeted prevention and treatment measures.

In the prior art, when conducting animal burn experiments, the burn contact area is not easy to control, it is easy to produce large errors, the contact time cannot be effectively quantified, and the contact force for burn and scald is difficult to obtain, all of which hinder the effective burn and scald mechanism in the later stage analyze. Need a kind of animal burn and scald experimental equipment that can effectively control the contact area, record the contact time, and control the contact force.

Contents of the invention

The object of the present invention is to provide an animal burn and scald experimental equipment capable of effectively controlling the contact area, recording the contact time and controlling the contact force.

Burn and scald experimental devices for animals, including:

Scalding blocks for burning and scalding animals;

The driving rod is threadedly connected with the scalding block, and is used to drive the scalding block to reciprocate, and the side of the driving rod is provided with a spur gear;

Limiting pair, used to limit the driving rod;

a driving gear, the driving gear meshes with the spur gear on the side of the driving rod, and is used to drive the driving rod to move;

The drive motor is used to drive the drive gear to move;

The driver is used to control the action of the drive motor;

The controller is used to control the driver and receive the signal from the load cell;

Support tray for placing animals to be burned;

a load cell, the load cell is located under the support plate and is used to detect the change of the force on the support plate.

The controller is connected to a liquid crystal screen, and the liquid crystal screen is an interactive interface for modifying or displaying parameters, and realizes two-way communication with the controller.

The inside of the scalding block is provided with a heater, and after the heater is connected with the heater switch, it is connected to a controller, and the side of the scalding block is provided with a temperature sensor.

The temperature sensor is fixed on the burn block or the driving rod.

The temperature of the scalding block, the controller, the temperature sensor, the heater and the heater switch are a closed-loop feedback system.

The heater switch is an electromagnetic switch.

The driving motor is a stepping motor, and the driver is a stepping motor controller.

The scalding surface of the scalding block is comb-shaped, or planar, or triangular, or circular.

When the scald block is circular, the diameter is 1cm-4cm. When the scald block is point-shaped, 4 or 6 points are evenly arranged, and each point is a circle with a diameter of 1cm-2cm.

Described scalding block, driving rod, limit pair, driving gear, driving motor, driver, controller, support plate, load cell, liquid crystal screen, temperature sensor, heater and heater switch are fixed on the integral frame.

The upper end of the scalding block is provided with a threaded column, and the two ends of the threaded column are respectively provided with threads, and the threads at both ends are respectively connected to the scalding block and the driving rod.

The scald block of the present invention is used to burn and scald animals; the driving rod is threadedly connected with the scald block, and is used to drive the scald block to reciprocate, and the side of the driving rod is provided with a spur gear; the limit pair is used to limit the driving rod; the driving gear, The driving gear meshes with the spur gear on the side of the driving rod to drive the driving rod to move; the driving motor is used to drive the driving gear to move; the driver is used to control the action of the driving motor; the controller is used to control the driver and receive the load cell signal; a support plate for placing the animal to be burned; a load cell located below the support plate for detecting changes in force on the support plate. The controller controls the drive motor through the driver, and the drive gear drives the drive rod to move, so that the scald block acts on the animal, and the load cell feeds back the detected force to the controller, and the controller records the feedback information and control information for Experiments provide reference. The invention can effectively control the contact area, record the contact time, and control the contact force of the animal burn and scald experimental equipment.

Description of drawings

Fig. 1 is a schematic diagram of the present invention;

Fig. 2 is the bottom view of spot burn block;

In the figure: 1, scalding block, 2, driving rod, 3, limit pair, 4, driving gear, 5, driving motor, 6, driver, 7, controller, 8, support plate, 9, load cell, 10 , LCD screen, 11, temperature sensor, 12, heater, 13, heater switch.

detailed description

The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

Example 1:

A burn and scald experimental device for animals, including: a scalding block 1, used to burn and scald animals; a driving rod 2, threaded with the scalding block 1, used to drive the scalding block 1 to reciprocate, and a spur gear is provided on the side of the driving rod 2 The limit pair 3 is used to limit the driving rod 2; the driving gear 4, the driving gear 4 meshes with the spur gear on the side of the driving rod 2, and is used to drive the driving rod 2 to move; the driving motor 5 is used to drive the driving gear 4 to move; The driver 6 is used to control the action of the drive motor 5; the controller 7 is used to control the driver 6 and receives the signal from the load cell 9; the support plate 8 is used to place the animal to be burned; the load cell 9 is the load cell 9 is located below the support disc 8 and is used to detect the change of force on the support disc 8 .

The controller 7 is connected to a liquid crystal screen 10, which is an interactive interface for modifying or displaying parameters, and realizes two-way communication with the controller 7. The driving motor 5 is a stepping motor, and the driver 6 is a stepping motor controller. The scalding surface of the scalding block 1 is comb-shaped, or plane-shaped, or triangular-shaped, or circular, with controllable force, area, and depth, and high operation accuracy, and is suitable for scald experiments in various situations. Scalding block 1, drive rod 2, limit pair 3, drive gear 4, drive motor 5, drive 6, controller 7, support plate 8, load cell 9, LCD screen 10, temperature sensor 11, heater 12 and heating The switch 13 is fixed on the integral frame.

The scald block 1 is point-shaped, and 4 points are evenly arranged, and each point is a circle with a diameter of 2 cm. The upper end of the scald block 1 is provided with a threaded post, and the two ends of the threaded post are respectively provided with threads, and the threads at both ends are respectively connected with the scald block 1 and the driving rod 2 .

The experimental animals were rats. Before the experiment, the backs of the animals were depilated by electric push, and then depilated by Nair, anesthetized by intraperitoneal injection of 1% pentobarbital sodium (40 mg/kg), and fixed on the experimental table in a prone position.

The controller 7 controls the driving motor 5 through the driver 6, and the driving gear 4 drives the driving rod 2 to move, so that the scalding block 1 acts on the animal, and the load cell 9 feeds back the detected force situation to the controller, and the controller 7 feeds back Information and control information are recorded to provide reference for experiments.

Example 2:

A burn and scald experimental device for animals, including: a scalding block 1, used to burn and scald animals; a driving rod 2, threaded with the scalding block 1, used to drive the scalding block 1 to reciprocate, and a spur gear is provided on the side of the driving rod 2 The limit pair 3 is used to limit the driving rod 2; the driving gear 4, the driving gear 4 meshes with the spur gear on the side of the driving rod 2, and is used to drive the driving rod 2 to move; the driving motor 5 is used to drive the driving gear 4 to move; The driver 6 is used to control the action of the drive motor 5; the controller 7 is used to control the driver 6 and receives the signal from the load cell 9; the support plate 8 is used to place the animal to be burned; the load cell 9 is the load cell 9 is located below the support disc 8 and is used to detect the change of force on the support disc 8 .

The controller 7 is connected to a liquid crystal screen 10, which is an interactive interface for modifying or displaying parameters, and realizes two-way communication with the controller 7. The driving motor 5 is a stepping motor, and the driver 6 is a stepping motor controller. The scalding surface of the scalding block 1 is comb-shaped, or planar, or triangular, or circular. Scalding block 1, drive rod 2, limit pair 3, drive gear 4, drive motor 5, drive 6, controller 7, support plate 8, load cell 9, LCD screen 10, temperature sensor 11, heater 12 and heating The switch 13 is fixed on the integral frame.

The inside of scalding block 1 is provided with heater 12, after heater 12 is connected with heater switch 13, connects controller 7 again, and scalding block 1 side is provided with temperature sensor 11. The temperature sensor 11 is fixed on the burn block 1 or the driving rod 2 . The temperature of the scalding block 1, the controller 7, the temperature sensor 11, the heater 12 and the heater switch 13 are closed-loop feedback systems. The heater switch 13 is an electromagnetic switch.

The basic principles, main features and advantages of the present invention have been shown and described above. Those skilled in the industry should understand that the present invention is not limited by the above-mentioned embodiments, and that described in the above-mentioned embodiments and the description only illustrates the principles of the present invention, and the present invention also has various aspects without departing from the spirit and scope of the present invention. Variations and improvements all fall within the scope of the claimed invention. The protection scope of the present invention is defined by the appended claims and their equivalents.

Claims (10)

1. The burn and scald experimental device for animals is characterized in that, comprising: Scalding block (1), used for burning and scalding animals; The drive rod (2) is threadedly connected with the scald block (1), and is used to drive the scald block (1) to reciprocate in the vertical direction, and the side of the drive rod (2) is provided with a spur gear; The limit pair (3) is used to limit the driving rod (2); Drive gear (4), the drive gear (4) meshes with the spur gear on the side of the drive rod (2) to drive the drive rod (2) to move; The drive motor (5) is used to drive the drive gear (4) to move; The driver (6) is used to control the action of the drive motor (5); A controller (7), used to control the driver (6) and receive a signal from the load cell (9); Support plate (8), is used for placing the animal to be burned; A load cell (9), the load cell (9) is located below the support plate (8), and is used to detect changes in force on the support plate (8). 2. The burn and scald experimental device for animals according to claim 1, characterized in that, the controller (7) is connected to a liquid crystal screen (10), and the liquid crystal screen (10) is an interactive method for modifying or displaying parameters. The interface realizes two-way communication with the controller (7). 3. the burn experiment device for animal according to claim 1, is characterized in that, the inside of described scald block (1) is provided with heater (12), and described heater (12) and heater switch (13) After connecting, connect the controller (7), and the side of the scalding block (1) is provided with a temperature sensor (11). 4. The burn and scald experimental device for animals according to claim 3, characterized in that the temperature sensor (11) is fixed on the scald block (1) or the driving rod (2). 5. the burn and scald experiment device for animal according to claim 3, is characterized in that, the temperature of described scald block (1), controller (7), temperature sensor (11), heater (12) and The heater switch (13) is a closed-loop feedback system. 6. The burn and scald experimental device for animals according to claim 3, characterized in that, the heater switch (13) is an electromagnetic switch. 7. The burn and scald experimental device for animals according to claim 1, characterized in that, the drive motor (5) is a stepper motor, and the driver (6) is a stepper motor controller. 8. The burn and scald experimental device for animals according to claim 1, characterized in that, the scald surface of the scald block (1) is comb-shaped, or triangular, or circular, or point-shaped. 9. The burn and scald experimental device for animals according to claim 8, characterized in that, when the scald block (1) is circular, the diameter is 1 cm to 4 cm, and the scald block (1) is point-shaped 4 or 6 points are evenly arranged, and each point is a circle with a diameter of 1cm to 2cm. 10. according to the arbitrary described burn and scald experiment device that is used for animal from claim 1 to 9, it is characterized in that, described scald block (1), drive rod (2), limit pair (3), drive gear ( 4), drive motor (5), driver (6), controller (7), support plate (8), load cell (9), LCD screen (10), temperature sensor (11), heater (12) Be fixed on the integral frame with heater switch (13).