CN113654773A - Near-physiological pulsating flow loading device for fatigue test of intravascular stent - Google Patents
Near-physiological pulsating flow loading device for fatigue test of intravascular stent Download PDFInfo
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- CN113654773A CN113654773A CN202110738322.6A CN202110738322A CN113654773A CN 113654773 A CN113654773 A CN 113654773A CN 202110738322 A CN202110738322 A CN 202110738322A CN 113654773 A CN113654773 A CN 113654773A
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Abstract
本发明提供的一种血管支架疲劳测试的近生理脉动流加载装置，属于医疗器械技术领域，血管支架疲劳测试的近生理脉动流加载装置包括：模拟血管，具有用于放置待测支架的检测段；所述模拟血管内适于流通有模拟液；加载装置，内部具有多段模拟血管；所述模拟血管的检测段设置在所述加载装置内；本发明的血管支架疲劳测试的近生理脉动流加载装置，提供了与支架植入人体后所收到的生理状态类似的压力和流量。其中脉动的压力使模拟血管发生周期性扩张和收缩变形，为支架提供压缩作用力；脉动流为支架提供脉动流体剪切力。该装置更加精确的模拟了血管支架在人体血管内的真实状态，解决了血管支架疲劳测试近生理的脉动加载难题。
The invention provides a near-physiological pulsating flow loading device for fatigue testing of vascular stents, belonging to the technical field of medical devices. The near-physiological pulsating flow loading device for fatigue testing of vascular stents comprises: a simulated blood vessel, and a detection section for placing the stent to be tested. ; the simulated blood vessel is suitable for circulating a simulated liquid; the loading device has multiple sections of simulated blood vessels inside; the detection section of the simulated blood vessel is set in the loading device; the near-physiological pulsating flow loading of the vascular stent fatigue test of the present invention A device that provides pressure and flow similar to the physiological state received by the stent after implantation in the human body. The pulsating pressure causes the simulated blood vessel to undergo periodic expansion and contraction deformation, which provides compressive force for the stent; the pulsating flow provides pulsating fluid shear force for the stent. The device more accurately simulates the real state of the blood vessel stent in the human blood vessel, and solves the near-physiological pulsation loading problem of the blood vessel stent fatigue test.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a near-physiological pulsating flow loading device for a vascular stent fatigue test.
Background
The vascular stent is implanted as a common means for interventional therapy of cardiovascular diseases, and has the advantages of small wound, quick postoperative recovery, stable treatment effect and the like.
After being implanted into a human body, the vascular stent is subjected to shear force generated by blood flow in blood vessels and tensile and compressive stress generated by vasodilation and contraction for a long time, so that the vascular stent can fail due to fatigue.
At present, the fatigue testing device of the blood vessel stent can only simulate the relaxation of the blood vessel stent, and ignores the shearing force action of the blood flow after the blood vessel stent is implanted into a blood vessel, thereby causing the inaccuracy of the fatigue performance test of the blood vessel stent.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to overcome the defect that the fatigue test device of the blood vessel stent in the prior art can only simulate the relaxation of the blood vessel stent, and neglects the shearing force action of blood flow after the blood vessel stent is implanted into a blood vessel, so that the test on the fatigue performance of the blood vessel stent is inaccurate, thereby providing a near-physiological pulsating flow loading device for the fatigue test of the blood vessel stent.
In order to solve the technical problem, the invention provides a near-physiological pulsating flow loading device for a fatigue test of a vascular stent, which comprises:
the simulated blood vessel is provided with a detection section for placing a stent to be detected; the inside of the simulated blood vessel is suitable for circulating simulated liquid;
the loading device is internally provided with a plurality of sections of simulated blood vessels; the detection section of the simulated blood vessel is arranged in the loading device.
Preferably, the method further comprises the following steps:
the pressure monitoring module is provided with pressure sensors arranged on two sides of the loading device; the pressure sensor is used for monitoring the pressure of the inlet and the outlet of the simulated blood vessel.
Preferably, the method further comprises the following steps:
a caliper module having a caliper sensor disposed outside the simulated blood vessel; the diameter measuring sensor is used for monitoring the change of the pipe diameter of the simulated blood vessel; the diameter measuring sensor is connected with the acquisition and control system;
the acquisition and control system is provided with a flow sensor arranged in the pipeline; the flow sensor is used for monitoring the flow in the circulating pipeline; the acquisition and control system is connected with the driving device; and the pressure sensor is connected with the acquisition and control system.
Preferably, the method further comprises the following steps:
a liquid cavity for containing the simulation liquid; the liquid containing cavity is communicated with the simulated blood vessel.
Preferably, the method further comprises the following steps:
the damper is communicated with the liquid containing cavity; the damper is adapted to adjust the flow resistance.
Preferably, the simulated blood vessel has a plurality of blood vessels; a plurality of simulated blood vessels are arranged in the loading device side by side; one end of each of the plurality of simulated blood vessels is communicated with the liquid containing cavity.
The technical scheme of the invention has the following advantages:
1. the invention provides a near-physiological pulsating flow loading device for a vascular stent fatigue test, which comprises: the device comprises a liquid containing cavity, a damper, a loading device, a collecting and controlling system and a driving device; the invention changes the flow in the simulated blood vessel through the liquid containing cavity and the damper; the simulated blood vessel flows with simulated liquid to simulate the shearing force action generated by the blood flow after the blood vessel stent is implanted into the blood vessel; and the real state of the blood vessel stent in the blood vessel of the human body is simulated more accurately, and the problem of pulse loading close to physiology in the fatigue test of the blood vessel stent is solved, so that the fatigue test of the blood vessel stent is more scientific and reliable.
2. According to the near-physiological pulsating flow loading device for the fatigue test of the vascular stent, the pressure sensor can read the wall surface pressure in the liquid cavity in real time; the diameter measuring sensor can monitor the movement displacement of the bracket to be measured in the simulated blood vessel in real time; the flow sensor can monitor the flow in the circulating pipeline in real time; reading and processing the signals by an acquisition and control system, and displaying pressure, flow and displacement waveforms; the system is driven to operate by the driving device.
3. The near-physiological pulsating flow loading device for the fatigue test of the vascular stent provided by the invention can adjust the pressure in the simulated blood vessel and change the flow of the simulated liquid in the simulated blood vessel by injecting and sucking gas into the liquid containing cavity, thereby creating a near-physiological flow environment for the fatigue test of the vascular stent.
4. The near-physiological pulsating flow loading device for the fatigue test of the vascular stent provided by the invention adjusts the resistance in the flow pipeline through the damper, changes the flow of simulation liquid in the simulated blood vessel, and creates a near-physiological flow environment for the fatigue test of the vascular stent.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic structural diagram of a near-physiological pulsating flow loading device for a fatigue test of a vascular stent of the present invention.
Fig. 2 is a schematic structural diagram of the loading device of the present invention.
Description of reference numerals:
1. a loading device; 2. simulating a blood vessel; 3. a collection and control system; 4. a drive device; 5. a detection section; 6. a liquid containing cavity; 7. a damper; 8. a caliper module; 9. and a pressure monitoring module.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The near-physiological pulsating flow loading device for the fatigue test of the intravascular stent provided by the embodiment comprises a loading device 1, wherein a simulation blood vessel 2 with simulation liquid flowing inside is arranged in the loading device 1 in a penetrating manner; the simulated liquid flows in the simulated blood vessel 2 to simulate the shearing force action generated by the blood flow after the blood vessel stent is implanted into the blood vessel; and the real state of the blood vessel support in the blood vessel of the human body is simulated more accurately, and the pulse loading problem of the fatigue detection of the blood vessel support close to physiology is solved, so that the fatigue detection of the blood vessel support is more scientific and reliable.
As shown in fig. 2, a simulated blood vessel 2 is arranged in a loading device 1, simulated liquid flows through the inside of the simulated blood vessel 2, a detection section 5 is arranged on the simulated blood vessel 2, and a stent to be detected is placed in the detection section 5; during installation, the detection section 5 simulating the blood vessel 2 is arranged inside the loading device 1;
a pressure monitoring module 9 is arranged on the loading device 1; the pressure monitoring module 9 is provided with pressure sensors arranged in an inlet and an outlet of the loading device 1, and can read pressure data in the loading device in real time in the testing process, store, display and feed back and adjust the loading device 1 through the acquisition and control system 3 in real time;
in a loading device 1, a plurality of simulated blood vessels 2 are arranged side by side, and 2-4 to-be-tested stents can be placed in each simulated blood vessel 2, so that a plurality of to-be-tested stents can be simultaneously measured at one time, and high-flux simulation of accelerated fatigue of the to-be-tested stents can be realized.
A diameter measuring instrument module 8 is also arranged on the pulsation loading device; the diameter measuring instrument module 8 is provided with a diameter measuring sensor which is arranged in the loading device 1, the diameter measuring sensor measures the diameter change of the to-be-measured support during movement in real time, and the loading device 1 is fed back and adjusted by acquiring and storing the measurement data of a probe of the diameter measuring sensor through an acquisition and control system.
The pulse loading device is also provided with a collecting and controlling system 3; the acquisition and control system 3 is provided with a flow sensor, the flow sensor is arranged in the circulating pipeline, the flow sensor measures the flow change in the circulating pipeline in real time, and the acquisition and control system acquires the measurement data of the flow sensor.
In the data processing process, after a computer reads data, the 16-system data is converted into the 10-system diameter according to a communication protocol, and related parameters of the data in a certain range can be calculated; displaying a waveform: the converted diameter is displayed in a waveform display window, the change of the diameter can be observed through a waveform curve, and data are stored.
Specifically, the simulation liquid is contained in the liquid containing cavity 6, the pressure in the liquid containing cavity 6 is changed through the process of introducing gas or exhausting gas into the liquid containing cavity 6, so that the pressure in the simulated blood vessel 2 is close to the physiological environment, the flow resistance of the pipeline can be changed by adjusting the damper 7, and the flowing in the simulated blood vessel is close to the physiological condition.
Method of use and principles
When the fatigue test is carried out on the stent to be tested, the near-physiological pulsating flow loading device for the fatigue test of the vascular stent is connected to fatigue test equipment, an operator firstly exhausts bubbles in the simulated blood vessel 2 to prevent influencing the monitoring of the flow pressure, then the stent to be tested is implanted into the simulated blood vessel 2, and then the simulated blood vessel 2 is installed in the loading device 1;
after the normal start, the pressure monitoring module reads in the pressure waveform generated when the simulation liquid flows and the standard arterial pressure waveform to be compared, and the volume of the gas in the liquid accommodating cavity 6 and the damper 7 are adjusted to be close to each other, namely, a near-physiological flowing environment is created for the fatigue detection of the to-be-detected support.
The motion amplitude of the support to be detected is obtained in real time through the diameter measuring instrument module 8, and the loading device 1 is controlled through the acquisition and control system 3, so that the motion amplitude is matched with the fatigue detection requirement. The acquisition and control system 3 is also provided with a flow monitoring module for monitoring the flow change condition in the circulating pipeline in real time.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (6)
1. A vascular stent fatigue test's nearly physiology pulsating flow loading device which characterized in that includes:
the simulated blood vessel (2) is provided with a detection section (5) for placing a stent to be detected; the inside of the simulated blood vessel (2) is suitable for flowing simulated liquid;
a loading device (1) having a plurality of sections of simulated blood vessels (2) therein; the detection section (5) of the simulated blood vessel (2) is arranged in the loading device (1).
2. The stent fatigue testing near-physiologic pulsatile flow loading device of claim 1, further comprising:
the pressure monitoring module (9) is provided with pressure sensors arranged on two sides of the loading device (1); the pressure sensor is used for monitoring the pressure at the inlet and the outlet of the simulated blood vessel (2).
3. The stent fatigue testing near-physiologic pulsatile flow loading device of claim 2, further comprising:
a caliper module (8) having a caliper sensor disposed outside the simulated blood vessel (2); the diameter measuring sensor is used for monitoring the change of the pipe diameter of the simulated blood vessel (2); the diameter measuring sensor is connected with the acquisition and control system;
a collection and control system (3) having a flow sensor arranged in the pipeline; the flow sensor is used for monitoring the flow in the circulating pipeline; the acquisition and control system (3) is connected with the driving device (4); the pressure sensor is connected with the acquisition and control system (3).
4. The stent fatigue testing near-physiologic pulsatile flow loading device of claim 3, further comprising:
a liquid cavity (6) for containing the simulation liquid; the liquid containing cavity (6) is communicated with the simulated blood vessel (2).
5. The stent fatigue testing near-physiologic pulsatile flow loading device of claim 4, further comprising:
the damper (7) is communicated with the liquid containing cavity (6); the damper (7) is adapted to adjust the flow resistance.
6. The near-physiologic pulsatile flow loading device for vascular stent fatigue testing according to claim 5, wherein the simulated blood vessel (2) has a plurality of; a plurality of simulated blood vessels (2) are arranged in the loading device (1) side by side; one ends of the plurality of simulated blood vessels (2) are communicated with the liquid containing cavity (6).
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| CN202110738322.6A CN113654773A (en) | 2021-06-30 | 2021-06-30 | Near-physiological pulsating flow loading device for fatigue test of intravascular stent |
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| CN116718494A (en) * | 2023-08-10 | 2023-09-08 | 天津大学 | A high-frequency pulse artificial implant fatigue tester |
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