CN118471062A - An in vitro dynamic bionic instrument for children's gastrointestinal tract - Google Patents

Abstract

The invention discloses an in-vitro dynamic bionic instrument for gastrointestinal tracts of children, and belongs to the technical field of in-vitro digestion simulation. The bionic instrument comprises a box body (39); gastrointestinal tract model: is used for bionic simulation of the gastrointestinal tract of children; upper filling port (1): is used for injecting gastric juice, bile, pancreatic juice and intestinal juice into the gastrointestinal tract model; and (3) a fluid infusion system: is used for supplementing liquid for the gastrointestinal tract model; physiological index detects integrated module (8): the method is used for detecting physiological indexes of the gastrointestinal tract model; circumferential compressor array: for simulating gastrointestinal motility in children; hydraulic transmission output module (26): for powering the circumferential compressor array. The invention can truly simulate the digestion process of the gastrointestinal tract of children, and can provide accurate experimental data for researching the dissolution and release of oral medicines in children. The method is beneficial to solving the dilemma of developing an accurate experiment model of the oral preparation for children before clinic, and can reduce the use amount of animals in the experiment process, reduce the cost and increase the efficiency.

Description

An in vitro dynamic bionic instrument for children's gastrointestinal tract

Technical Field

The present invention relates to an in vitro dynamic bionic instrument for the gastrointestinal tract of children. Specifically, the present invention relates to a dynamic simulator of the bionic gastrointestinal tract of children made by using 3D printing technology. The instrument can simulate the digestion process of the gastrointestinal tract of children, can be used for in vitro digestion experiments in the fields of pharmacy, and for use in new drug research and development, and belongs to the technical field of in vitro digestion simulation.

Background Art

Children are not smaller versions of adults. They have different physiological and pathological characteristics from adults. Therefore, "tailoring" children's medicines according to children's characteristics has become a consensus in drug research and development. At present, the research and development of children's medicines faces many challenges. The particularity of children's physiological structure and the limitations of clinical trials are the main problems faced in the research and development of children's medicines. Therefore, studying the dissolution and dissolution behavior of drugs in the gastrointestinal tract of children is of great significance for the development of children-specific drugs that fit the physiological and pathological characteristics of children. Under the background of restrictions on clinical trials for children, in vitro simulation of the gastrointestinal environment of children and in vitro simulation of the dissolution and dissolution process of drugs in the gastrointestinal tract have become one of the research strategies for children's drugs.

At present, the simulated gastrointestinal digestion equipment at home and abroad has problems such as poor simulation and complicated operation, and ignores the morphological structure of the gastrointestinal tract of children and the real law of gastrointestinal wall peristalsis. Therefore, an in vitro dynamic bionic instrument for the gastrointestinal tract of children is invented, which uses 3D printing technology to create a highly customized gastrointestinal model to ensure the simulation and functionality of the model, and uses mechanical control technology to simulate gastrointestinal peristalsis. The device can be used for dissolution and dissolution related research in the development of children's drugs, filling the market gap; providing strong support for the development and application of children's drugs, reducing R&D costs, improving the efficiency and success rate of drug development, and helping to improve the safety and effectiveness of children's drugs.

Summary of the invention

The purpose of the present invention is to address the problems existing in the prior art and to provide an in vitro dynamic bionic instrument for the gastrointestinal tract of children, which can simulate the dissolution and dissolution behavior of drugs in the gastrointestinal tract of children under in vitro conditions.

Another purpose of the present invention is to provide a service of simulating the digestion process of drugs in the gastrointestinal tract of children through an in vitro dynamic bionic instrument for the gastrointestinal tract of children.

In order to solve the above technical problems, the technical solution adopted by the present invention is:

An in vitro dynamic bionic instrument for the gastrointestinal tract of children, comprising:

Box;

Gastrointestinal model: used to simulate the gastrointestinal tract of children;

Upper infusion port: used to inject gastric juice, bile, pancreatic juice, and small intestinal juice into the gastrointestinal tract model;

Fluid refilling system: used to refill fluids for the gastrointestinal model;

Physiological index detection integrated module: connected to the gastrointestinal model to detect the physiological indicators of the gastrointestinal model;

Annular compressor array: located on the gastrointestinal tract model, used to simulate the peristalsis of the gastrointestinal tract of children;

Hydraulic transmission output module: used to provide power for the annular compressor array;

Sampling tube automatic sampler: used to sample and test the digestive fluid in the gastrointestinal tract model;

Temperature control system of the whole machine: used to keep the temperature of the gastrointestinal tract model at nearly 37°C;

Human-machine interactive intelligent control screen: used to control the whole machine temperature control system, sampling tube automatic sampler, hydraulic transmission output module, annular compressor array and physiological index detection integrated module;

Power supply: used to power the human-machine interactive intelligent control screen, the whole machine temperature control system, the sampling tube automatic sampler, the hydraulic transmission output module, the annular compressor array and the physiological index detection integrated module.

Preferably, the box includes a visual experiment area and a functional area, the visual experiment area is located in the middle of the box, and the functional area includes an upper functional area located above the visual experiment area and a lower functional area located below the visual experiment area; a human-machine interactive intelligent control screen is arranged on the lower functional area;

A gastrointestinal model is set up in the visual experimental area, which includes a bionic stomach model, duodenum model, jejunum model, ileum model and colon model connected in sequence;

The stomach model includes a stomach body, and three tube ports are arranged on the stomach body: an upper tube port, a middle tube port and a lower tube port. The upper tube port is connected to a gastric juice injection pipe, and the gastric juice injection pipe is connected to an upper perfusion port opened in the upper functional area for injecting gastric juice. The middle tube port is connected to a camera probe, and a physiological index detection integrated module integrating temperature and pH. The lower tube port is a normally closed electromagnetic valve outlet, which is connected to a gastric juice outlet pipe. An automatic sampler for injecting drugs is arranged at the upper pyloric section of the stomach body. The stomach body is disconnected at the pylorus and connected to a normally closed pyloric electromagnetic control valve. A hexagonal flange structure for connecting to the duodenum model is arranged at the end of the stomach body. A gastric hydrochloric acid solution supplement tube is also arranged in the middle of the stomach body.

The duodenal model comprises a duodenal body, the head end of the duodenal body is provided with a hexagonal flange structure and connected to the end of the gastric body, the end of the duodenal body is provided with a hexagonal flange structure for connecting to the jejunum model; an intestinal fluid injection tube port, a pancreatic fluid injection tube port and a bile injection tube port are provided on the duodenal body, the intestinal fluid injection tube port is connected to the intestinal fluid injection tube, the intestinal fluid injection tube is connected to the upper infusion port opened in the upper functional area for injecting intestinal fluid, the pancreatic fluid injection tube port is connected to the pancreatic fluid injection tube, the pancreatic fluid injection tube is connected to the upper infusion port opened in the upper functional area for injecting pancreatic fluid, the bile injection tube port is connected to the bile injection tube, and the bile injection tube is connected to the upper infusion port opened in the upper functional area for injecting bile;

The jejunal model includes a jejunal body, which is divided into multiple sections. The first and last ends of each section are provided with a hexagonal flange structure to assist docking. A liquid normally closed electromagnetic valve outlet is provided on the side wall of the end of the jejunal body to connect with the jejunal liquid outlet tube. The end of the jejunal body is connected to the ileum model.

The ileum model includes an ileum body, which is divided into multiple sections. The first and last ends of each section are provided with a hexagonal flange structure to assist docking. The first end of the ileum body is connected to the jejunum model, and the last end of the ileum body is connected to the colon model. The last end of the ileum body is connected to an adapter flange with an enlarged inner diameter. The side wall of the adapter flange is provided with a liquid second normally closed solenoid valve outlet to connect to the ileum intestinal fluid outlet tube.

The colon model includes a colon body, which is divided into multiple sections. The first and last ends of each section are provided with a hexagonal flange structure to assist docking. The colon body includes an ascending colon section, a transverse colon section and a descending colon section connected in sequence. The end of the descending colon section is closed. The end side wall of the descending colon section is connected with a liquid three-normally closed electromagnetic valve outlet to connect to the colon fluid outlet pipe.

The gastric juice outlet tube, the jejunal juice outlet tube, the ileal intestinal juice outlet tube and the colonic juice outlet tube are respectively connected to the sampling tube automatic sampler, and the sampling tube automatic sampler is connected to the waste liquid drain pipe;

The annular compressor array includes a small six-way compressor-linear array located on the jejunal body, a medium-sized six-way compressor-linear array located on the ileal body, and a large annular compressor fan-shaped array located on the gastric body; the annular compressor arrays all include an openable annular peripheral frame, the annular peripheral frame is connected to two spherical joints, the spherical joints are connected to screws, the screws are fixed to the Teflon metal composite full-hole back plate, and six to eight hydraulic telescopic devices are mounted on the annular peripheral frame, the tail end of each hydraulic telescopic device extends a hydraulic thin tube to the diverter, the diverter extends a hydraulic tube to the hydraulic transmission output module inside the box through a quick connector, and the hydraulic telescopic rod at the head end of the hydraulic telescopic device extends inward to contact the outer surface of the gastric model, the jejunal model, and the ileal model respectively;

The hydraulic transmission output module includes seven hydraulic output devices, which are fixed on the bracket in a ring shape. The head end of the hydraulic output device is connected to the hydraulic pipe through a quick connector, and the tail end push rod of the hydraulic output device is connected to the screw disk. The stepper motor rotates the screw to push the output, and the stepper motor and the screw disk are connected and fixed by an elastic coupling.

Preferably, a children's gastrointestinal tract in vitro dynamic bionic instrument also includes a whole machine temperature control system, the whole machine temperature control system includes a gas temperature active control subsystem and a liquid temperature active control subsystem, including an active heat air inlet device located on the back of the Teflon metal composite full-hole back plate, the Teflon metal composite full-hole back plate is located on the back of the box, and the active heat air inlet device is located at the air outlet on the lower side of the Teflon metal composite full-hole back plate, the gas temperature active control subsystem also includes an active exhaust cleaning device located on the back of the Teflon metal composite full-hole back plate, and the active exhaust cleaning device is located at the air outlet on the left and right sides of the Teflon metal composite full-hole back plate, an activated carbon filter pipeline is arranged in the active exhaust cleaning device, and the gas temperature active control subsystem also includes an in-storage gas temperature control intelligent terminal located above the visual experimental area and automatically controlled by negative feedback through a circuit;

The liquid temperature active control subsystem includes a stainless steel liquid heat exchange pipeline module located above the visual experimental area and a pipeline array electric heating belt wrapped on the outside thereof, a peristaltic pump silicone heat exchange pipeline module located below the visual experimental area and a pipeline electric heating belt wrapped on the outside thereof, and an in-warehouse liquid temperature control intelligent terminal parallel to the in-warehouse gas temperature control intelligent terminal; the in-warehouse gas temperature control intelligent terminal and the in-warehouse liquid temperature control intelligent terminal separate temperature detection heads in the visual experimental area and the pipeline to detect the liquid and gas temperatures in real time and provide feedback. The in-warehouse gas temperature control intelligent terminal and the in-warehouse liquid temperature control intelligent terminal adjust the output power of each subordinate module in real time according to the feedback signal to ensure that the temperature in each place in the visual experimental area is kept at nearly 37°C to simulate the physiological environment of the child's abdominal cavity; the peristaltic pump silicone heat exchange pipeline module is provided with a stepper motor peristaltic pump 2; the in-warehouse gas temperature control intelligent terminal and the in-warehouse liquid temperature control intelligent terminal are respectively connected to the human-computer interaction intelligent control screen;

The stepper motor peristaltic pump located below the box is connected to the stainless steel liquid heat exchange pipe module through a pipe buried in the Teflon metal composite full-hole back plate.

Preferably, the Teflon metal composite full-hole back plate is provided with spare interfaces and spare outlets with various aperture specifications.

Preferably, the box body is made of an aluminum body shell and acid- and alkali-resistant organic glass material.

Preferably, a directional stomach stent is fixed on the Teflon metal composite full-porous back plate to install and fix the gastrointestinal tract model.

Preferably, the stomach model, duodenum model, jejunum model, ileum model and colon model are all manufactured by using 3D printing rapid prototyping technology to make molds and silicone molding technology.

Application of an in vitro dynamic bionic instrument for children's gastrointestinal tract in simulating children's gastrointestinal digestion.

The present invention has the following beneficial effects:

The present invention provides an in vitro dynamic bionic instrument for the gastrointestinal tract of children. Since the sample size of subjects in clinical trials of drugs for children is small, there are few types of drugs designed specifically for children on the market. Therefore, it is very necessary to design an in vitro dynamic bionic instrument for the gastrointestinal tract of children.

The present invention relates to an in vitro dynamic bionic instrument for the gastrointestinal tract of children. The instrument mainly includes a specially designed bionic stomach model, a duodenum model, a jejunum model, an ileum model, a colon model, an automatic sampler, a physiological index detection integrated module, various physiological fluid inlet and outlet pipes, a pyloric electromagnetic control valve, and an annular compressor array arranged on the periphery of the digestive tract to simulate gastrointestinal peristalsis. In addition, there is a whole machine temperature control system inside the box, a sampling tube automatic sampling system, a hydraulic transmission output module, a liquid supply and discharge system, and a matching intelligent control system. Among them, the gastrointestinal tract model adopts a modular design as a whole, and each part is fixedly connected by a hexagonal flange structure, which can be disassembled or assembled as needed. The present invention can truly simulate the digestion process of the gastrointestinal tract of children, and can provide accurate experimental data for studying the dissolution and release of oral drugs in children. It is helpful to solve the dilemma of accurate experimental models for preclinical research and development of oral preparations for children, and at the same time, it can reduce the use of animals in the experimental process, reduce costs and increase efficiency.

BRIEF DESCRIPTION OF THE DRAWINGS

Fig. 1 is a schematic structural diagram of the present invention;

FIG2 is a schematic structural diagram of a stomach model of the present invention;

Fig. 3 is a left side view of Fig. 2;

FIG4 is a top view of FIG2;

FIG5 is a schematic diagram of the structures of the duodenum model, the jejunum model and the ileum model of the present invention;

Fig. 6 is a left side view of Fig. 5;

FIG7 is a top view of FIG5;

FIG8 is a schematic structural diagram of a colon model of the present invention;

FIG9 is a left side view of FIG8;

FIG10 is a top view of FIG8;

FIG11 is a schematic structural diagram of an annular compressor array of the present invention;

FIG12 is a schematic diagram of the structure of FIG11 in an open state;

FIG13 is a schematic structural diagram of the compressed small intestine model of FIG11;

FIG14 is a schematic structural diagram of the compressed small intestine model of FIG13;

15 is a schematic structural diagram of a hydraulic transmission output module of the present invention;

FIG16 is a left side view of FIG15;

FIG17 is a top view of FIG15;

FIG18 is an overall schematic diagram of a hydraulic transmission output module of the present invention;

FIG. 19 is a schematic structural diagram of the automatic sampling machine for sampling tubes of the present invention.

DETAILED DESCRIPTION

The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. The following embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

Example 1

As shown in FIG1 , an in vitro dynamic bionic instrument for the gastrointestinal tract of children can simulate the mechanical process of digestion in the gastrointestinal tract of children. It mainly includes a box 39 with a visual experimental area and a functional area, a specially designed bionic stomach model 32 located in the visual experimental area of the box, a duodenum model 31, a jejunum model 12, an ileum model 14, a colon model 16, an automatic sampler 38, a physiological index detection integrated module 8, an annular compressor array 13, 15, 37 and a hexagonal flange structure 18, in addition, there are a whole machine temperature control system distributed one by one in the functional area rack, an absorption pump module connected to the gastrointestinal tract model and a sampling tube automatic sampling system 28, a hydraulic transmission output module 26 in the lower functional area, and various liquid supply and drainage systems of the entire fuselage and a matching intelligent control system (gas temperature control terminal 2 in the warehouse, liquid temperature control terminal in the warehouse) . 3 and human-computer interaction intelligent control screen 25); after the temperature of the visual experimental area is adjusted in advance to be appropriate, the oral drug is put into the stomach model 32 from the esophagus automatic sampler 38, and mixed with the bionic digestive fluid regulated by the physiological fluid inlet and outlet pipes and the physiological index detection integrated module 8 inside the model, and a preliminary dissolution effect is produced under the peristaltic extrusion of the stomach annular compressor fan array 37; after nearly an hour, it is pushed into the duodenum, jejunum, and ileum in sequence by the annular compressor fan array 37 and a subsequent dissolution effect is produced synchronously (the colon part can be used according to the drug); at the same time, the sampling tube automatic sampling system 28 collects solution samples and physiological data from different parts at different time periods throughout the process, completing the bionic experiment and data collection of the drug dissolution.

The stomach model 32, duodenum model 31, jejunum model 12, ileum model 14 and colon model 16 are all made by using 3D printing rapid prototyping technology to make molds and silicone molding technology. The resulting silicone models are resistant to acid, alkali and most chemical drug components.

The stomach model 32 is provided with three tube openings: an upper tube opening, a middle tube opening and a lower tube opening. The upper tube opening is connected to a gastric juice injection pipe 6 for injecting gastric acid at a fixed time and quantity. A sampling port is also provided for manual sampling using a sampler. The middle tube opening is connected to a physiological index detection integrated module 8 integrating a camera probe, temperature and pH. The lower tube opening is a normally closed electromagnetic valve outlet, connected to a gastric juice outlet tube for sampling and direct discharge of gastric solution. An automatic sampler 38 is placed on the upper pylorus of the stomach model 32, and different dosing components can be assembled according to the dosage form to assist in timed and quantitative sampling. The stomach silicone shell is disconnected at the pylorus and connected to a normally closed pyloric electromagnetic control valve 36. A hexagonal flange structure extends from the end of the other side of the stomach silicone shell.

The duodenum model 31, jejunum model 12, ileum model 14, and colon model 16 are divided into multiple sections according to a certain length, and a hexagonal flange structure extends from the head and tail ends of each section to assist docking; in addition to the outlets 29 and 30 at the ends of each model, the duodenum model 31 is also provided with three inlets, which can be docked with the intestinal fluid injection tube 33, the pancreatic fluid injection tube 34, and the bile injection tube 35 respectively.

Specifically, a children's gastrointestinal tract in vitro dynamic bionic instrument includes a box 39 containing a visual experimental area and a functional area, the visual experimental area is located in the middle of the box 39, and the functional area includes an upper functional area located above the visual experimental area and a lower functional area located below the visual experimental area; a human-machine interactive intelligent control screen 25 is arranged on the lower functional area;

The bionic stomach model 32, duodenum model 31, jejunum model 12, ileum model 14 and colon model 16 are sequentially connected in the visible experimental area;

As shown in Figures 2 to 4, the stomach model 32 includes a stomach body, and three tube ports are arranged on the stomach body: an upper tube port 32-b, a middle tube port 32-c and a lower tube port 32-d. The upper tube port 32-b is connected to a gastric juice injection pipe 6, and the gastric juice injection pipe 6 is connected to an upper infusion port 1 opened in the upper functional area for injecting gastric juice. The middle tube port 32-c is connected to a physiological indicator detection integrated module 8 integrating a camera probe, temperature and pH. The lower tube port 32-d is a normally closed electromagnetic valve outlet, which is connected to a gastric juice outlet pipe; the upper pyloric segment 32-a of the stomach body is provided with an automatic sampler 38 for injecting drugs, the stomach body is disconnected at the pylorus and connected to a normally closed pyloric electromagnetic control valve 36, and the end 32-f of the stomach body is provided with a hexagonal flange structure 18 for connecting to the duodenum model 31; a stomach hydrochloric acid solution replenishment tube 10 is also provided in the middle of the stomach body.

As shown in Figures 5 to 7, the duodenal model 31 includes a duodenal body, a hexagonal flange structure 18 is provided at the head end of the duodenal body and is connected to the end of the gastric body, and a hexagonal flange structure 18 is provided at the end of the duodenal body for connecting to the jejunum model 12; an intestinal fluid injection tube port 31-a, a pancreatic fluid injection tube port 31-b and a bile injection tube port 31-c are provided on the duodenal body, the intestinal fluid injection tube port 31-a is connected to the intestinal fluid injection tube 33, the intestinal fluid injection tube 33 is connected to the upper infusion port 1 opened in the upper functional area for injecting intestinal fluid, the pancreatic fluid injection tube port 31-b is connected to the pancreatic fluid injection tube 34, the pancreatic fluid injection tube 34 is connected to the upper infusion port 1 opened in the upper functional area for injecting pancreatic fluid, and the bile injection tube port 31-c is connected to the bile injection tube 35, and the bile injection tube 35 is connected to the upper infusion port 1 opened in the upper functional area for injecting bile.

The jejunal model 12 includes a jejunal body, which is divided into multiple sections. A hexagonal flange structure 18 extends from the front and rear ends of each section to assist docking. A liquid normally closed solenoid valve outlet 12-a is provided on the side wall at the end of the jejunal body to connect to the jejunal liquid outlet tube. The end of the jejunal body is connected to the ileum model 14.

The ileum model 14 includes an ileum body, which is divided into multiple sections. A hexagonal flange structure 18 extends from the front and rear ends of each section to assist in docking. The front end of the ileum body is connected to the jejunum model 12, and the rear end of the ileum body is connected to the colon model 16. The rear end of the ileum body is connected to an adapter flange 16-a with an enlarged inner diameter. A liquid second normally closed solenoid valve outlet 14-a is provided on the side wall of the adapter flange 16-a, which is connected to the ileum intestinal fluid outlet pipe 29.

In FIGS. 5 to 7 , 12 - b refers to the hexagonal flange structure 18 on the jejunal body; 14 - b refers to the hexagonal flange structure 18 on the ileal body.

As shown in FIGS. 8 to 10 , the colon model 16 includes a colon body, which is divided into multiple sections, and each section has a hexagonal flange structure extending from the head and tail ends to assist docking; the colon body includes an ascending colon section 16-b, a transverse colon section 16-c and a descending colon section 16-d connected in sequence, the end of the descending colon section 16-d is closed, and a liquid three-normally closed electromagnetic valve outlet 16-e is connected to the side wall of the end of the descending colon section 16-d, which is docked with the colon liquid outlet pipe 30;

In FIGS. 8 to 10 , reference numeral 16 - f refers to a hexagonal flange structure 18 on the colon body.

The gastric juice outlet tube, the jejunal juice outlet tube, the ileal intestinal juice outlet tube 29 and the colonic juice outlet tube 30 are respectively connected to the sampling tube automatic sampler 28, and the sampling tube automatic sampler 28 is connected to the waste liquid drain pipe 27;

The temperature control system of the whole machine includes three parts: one is a visualized active closed integral chassis (i.e., the chassis 39); the second is a gas temperature active control subsystem, which includes an active heat inlet device 19 [3D printing customization, including superconducting ptc industrial heater 405mm-1500 watt] located on the back of the Teflon metal composite full-hole back panel 7 [CNC customization], the Teflon metal composite full-hole back panel 7 is located on the back of the visualized active closed integral chassis, and the active heat inlet device 19 is located at the air outlet on the lower side of the Teflon metal composite full-hole back panel 7, and also includes an active exhaust cleaning device 11 [3D printing customization] located on the back of the Teflon metal composite full-hole back panel 7, and the active exhaust cleaning device 11 is located at the air outlet on the left and right sides of the Teflon metal composite full-hole back panel 7, and an activated carbon filter pipe is arranged in the active exhaust cleaning device 11, and also includes an in-warehouse gas temperature control intelligent terminal 2 [Yudian temperature controller AI-20] located above the visual experimental area and automatically controlled by negative feedback through a circuit. 7D1L]; the third is the liquid temperature active control subsystem, including a stainless steel liquid heat exchange pipeline module 5 [CNC customized] located above the visual experimental area and a pipeline array electric heating belt 4 wrapped on the outside, a peristaltic pump silicone heat exchange pipeline module 23 [18# (7.9*11.1mm) silicone pipeline] located below the visual experimental area and a pipeline electric heating belt 22 [small diameter natural coil spiral shaped pipeline heating belt] wrapped on the outside, and an in-warehouse liquid temperature control intelligent terminal 3 [Yudian temperature controller AI-207D1L] parallel to the in-warehouse gas temperature control intelligent terminal 2; the above-mentioned intelligent terminals (in-warehouse gas temperature control intelligent terminal 2 and in-warehouse liquid temperature control intelligent terminal 3) separate temperature detection heads in the visual experimental area and the pipeline to detect the liquid and gas temperatures in real time and provide feedback. The intelligent terminal adjusts the output power of each subordinate module in real time according to the feedback signal, thereby efficiently ensuring that the temperature in the visual experimental area is maintained at nearly 37°C, simulating the physiological environment of the child's abdominal cavity.

The Teflon metal composite full-hole back plate 7 is provided with spare interfaces 9 and spare outlets 17 with various hole diameter specifications.

As shown in FIGS. 11 to 14 , the annular compressor array and the hydraulic transmission output module, the annular compressor array includes a small six-way compressor-linear array 13 located on the jejunal body, a medium-sized six-way compressor-linear array 15 located on the ileal body, and a large annular compressor fan array 37 located on the gastric body; the small six-way compressor-linear array 13, the medium-sized six-way compressor-linear array 15, and the large annular compressor fan array 37 all include an openable and closable annular peripheral frame 28-f, 28-g (the annular peripheral frame includes a left half ring 28-g and a right half ring 28-f, and the left half ring 28-g and the right half ring 28-f are movably connected by a rotating shaft 28-e), and the annular peripheral frame 28-f, 28-g is connected with two spherical joints 28-i [metal spherical The pan/tilt head has a specification of 3/8. The spherical joint 28-i is connected to the screw 28-h [stainless steel threaded screw rod M10mm, pitch 1.5mm]. The screw 28-h is fixed to the Teflon metal composite full-hole back plate 7. Six to eight hydraulic telescopic devices are mounted on the annular peripheral frames 28-f and 28-g. The tail end 28-j of each hydraulic telescopic device extends a hydraulic capillary 28-d [Teflon tube] to the diverter 28-c. The diverter 28-c extends a hydraulic tube 28-a [Teflon tube] to the hydraulic transmission output module 26 inside the box body through a quick connector 28-b. The hydraulic telescopic rod 28-l at the head end 28-k of the hydraulic telescopic device extends inwardly to connect the contact plate with the outer surface of the digestive tract model (respectively, the stomach model 32, the jejunum model 12, and the ileum model 14). During operation: the hydraulic transmission output module 26 inside the box 39 outputs liquid to the hydraulic pipe 28-a, and then to each hydraulic capillary 28-d through the diverter 28-c, and evenly outputs liquid to the hydraulic telescopic device, pushing the hydraulic telescopic rod 28-1 toward the head end, thereby applying pressure to the outer surface of the digestive tract model in all directions, forcing the digestive tract model to contract, completing the physiological behavior simulation of digestive tract muscle contraction, and relaxation in the same way. [All unmarked parts are customized by CNC and 3D printing]; as shown in Figures 15 to 18, the hydraulic transmission output module 26 includes seven hydraulic output devices 22-g, which are fixed in a ring shape on the bracket 22-e. The head end of the hydraulic output device 22-g is connected to the hydraulic pipe 28-a [Teflon tube] through a quick connector 22-i, and the tail end of the hydraulic output device 22-g pushes the rod 22-f connected to the screw disk 22-d, and the stepper motor 22-a [42 stepper motor] rotates the screw 22-c [M8 trapezoidal screw] to push the output, and the stepper motor 22-a and the screw disk 22-d are connected and fixed by an elastic coupling 22-b [elastic coupling M5 to M8].

When working: the stepper motor 22-a is controlled to rotate a certain number of circles, and the rotation is transmitted to the screw disk 22-d through the elastic coupling 22-b [elastic coupling M5 to M8]. The screw disk 22-d cannot rotate, so it moves forward in parallel, and then pushes the tail end push rod 22-f forward in parallel, and transfers the liquid in the internal cavity of the hydraulic output device 22-g to the hydraulic pipe 28-a through the quick adapter 22-i, and then outputs power outward. Multiple groups of hydraulic transmission output modules 26 form an array, and different processes are run at the same time, and the power is output in stages [all unmarked parts are CNC and 3D printed custom].

The fluid supply and drainage system includes several upper infusion ports 1 located in the upper functional area for injecting gastric juice, bile, pancreatic juice, and small intestinal juice, a stainless steel liquid heat exchange pipeline module (upper) 5, a gastric hydrochloric acid solution supplement tube 10, and various physiological fluid injection tubes located in the visualization experimental area: a gastric juice injection connecting pipe 6, an intestinal fluid injection tube 33, a pancreatic juice injection tube 34, and a bile injection tube 35.

The sampling system includes sampling ports located at the stomach model 32, the duodenum model 31, the jejunum model 12, the ileum model 14 and the colon model 16. A sampler such as a syringe can sample the sample solution required at different parts according to experimental requirements.

Specifically, as shown in Figure 19, the sampling tube automatic sampler 28 includes a multi-axis sampling needle table 48-d, a sampling needle 48-b, a flange 48-e, a solenoid valve, an axis screw stepper motor 48-f, a normally open positioning switch 48-g, a sampling tube fixing frame 48-c, and a sampling tube 48-a. The soft pipe 48-h at the upper end of the sampling needle 48-b is connected to the absorption pump module, which can inject the absorbed sample solution into the designated sampling tube 48-a in a timely and quantitative manner to assist sampling. The flange 48-e connects the sampling needle 48-b and the soft pipe 48-h. Specifically, a plurality of injection needles 48-b are placed on the multi-axis injection needle platform 48-d, and a sampling tube fixing rack 48-c is correspondingly arranged below the multi-axis injection needle platform 48-d. A plurality of sampling tubes 48-a are placed on the sampling tube fixing rack 48-c, and the sampling tubes 48-a correspond one to one with the injection needles 48-b. The multi-axis injection needle platform 48-d and the sampling tube fixing rack 48-c are both provided with corresponding normally open positioning switches 48-g, and the normally open positioning switches 48-g are used for the position correspondence between the injection needles 48-b and the sampling tubes 48-a. The multi-axis injection needle platform 48-d is also provided with an axis screw stepper motor 48-f, and the axis screw stepper motor 48-f drives the multi-axis injection needle platform 48-d to move up and down, and then drives the injection needle 48-b to move up and down, so as to facilitate the injection of the sample solution absorbed by the injection needle 48-b into the designated sampling tube 48-a. The solenoid valve is used to control the start or stop of the shaft screw stepper motor 48-f.

The visual active closed integral chassis (i.e., the chassis 39, the body of which is an aluminum shell) has a glass material portion made of acid- and alkali-resistant organic glass material, and the visual experimental area and the metal box are in a completely closed state.

A method for making an in vitro dynamic bionic instrument for the gastrointestinal tract of children, the model includes an in vivo heating and heat preservation device and a stomach model 32, a duodenum model 31, a jejunum model 12, an ileum model 14, and a colon model 16 which are heated and heat-insulated in a box. The models are connected by hexagonal fixing buckles (i.e., hexagonal flange structures 18), and are linked to an annular compressor, as well as a plurality of liquid injection tubes and liquid collection tubes.

The gastrointestinal tract includes a stomach model 32, a duodenum model 31, a jejunum model 12, an ileum model 14, and a colon model 16. These models are made into molds using 3D modeling and printing technology, which can restore the structure of a child's stomach, duodenum, jejunum, ileum, and colon at a 1:1 ratio. The model is then filled with silicone, and the resulting silicone model is acid-resistant, alkali-resistant, and relatively oil-resistant. Each part can be disassembled and connected by a hexagonal fixing buckle (i.e., a hexagonal flange structure 18). If a part fails, it can be replaced in a targeted manner, which is more convenient and quick.

The heating and heat preservation device mainly includes three parts. The first part is three customized tempered glasses located in front of the instrument, on the left and right sides. These three glasses will be used to block the heat exchange between the inside and outside of the instrument to ensure that the temperature inside the instrument will not be lost to the outside. The second part is the active hot air inlet device 19, which blows out hot air from the bottom of the box 39 to heat the lower part. Since the density of hot air is relatively small, the hot air will rise, so the temperature of the entire box will rise, achieving the purpose of heating. The third part is that before the experiment begins, the user should pour an appropriate amount of hot water on the top of the box to make the hot water flow through the stomach model 32, the duodenum model 31, the jejunum model 12, the ileum model 14 and the colon model 16. The hot water will be pumped to the top by the stepper motor peristaltic pump 21 under the box 39 through the pipe 20 buried in the Teflon metal composite full-hole back plate 7, and then enter the gastrointestinal tract model again. Through such a cycle, the temperature inside the silicone model is finally raised to a specific temperature, and the hot water is discharged after the temperature reaches the requirement.

The liquid infusion part includes six liquid infusion ports, which can respectively realize the injection of gastric juice, bile, pancreatic juice, small intestinal juice and other liquids. Before the liquid officially enters the stomach model 32, it will be heated by the pipeline array electric heating belt 4 to simulate the temperature inside the real gastrointestinal tract; and the front end of the duodenum model 12 is provided with three pipe ports, which can realize the injection of small intestinal juice, bile and pancreatic juice.

The drug administration part includes an automatic sample injector 38, through which the drug directly enters the stomach model 32. After the two are fully mixed, the pylorus electromagnetic control valve 36 at the end of the stomach model 32 is opened, and the drug digestive juice enters the intestine. After the drug digestive juice flows into the duodenum model 31, it is further digested.

The simulated peristalsis device includes a linkage six-way compressor structure, which is provided with small, medium and large sizes according to the different diameters and peristaltic bionic requirements of the stomach model 32, the duodenum model 31, the jejunum model 12, the ileum model 14 and the colon model 16. The linkage six-way compressor contains six compression shafts, a front end contact extension shaft, an extension shaft spring, a transmission structure for linking the six compression shafts to move centrifugally and centrifugally at the same time, and a peripheral frame that can be opened and closed into two halves. Through this structure, the silicone model can be compressed inwardly and expanded outwardly from six directions. According to the elasticity of the silicone model itself, a linkage six-way compressor is installed at intervals, and is controlled by a delay control program of a microcomputer, so that multiple linkage six-way compressors can be compressed and stretched in turn according to the gastrointestinal peristalsis law, thereby simulating the real gastrointestinal peristalsis effect of children.

The exhaust device includes an exhaust port on each side of the Teflon metal composite full-hole back plate 7 (i.e., an active exhaust cleaning device 11), and a filter channel along the location of the exhaust port to the rear side of the box body 39, the interior of which will be filled with air filter material to purify and discharge the gas generated by the instrument during use, thereby reducing pollution to the environment.

The intelligent detection part includes a stomach model 32 with an upper and lower tube opening at the greater curvature of the stomach. The upper tube opening is connected to a camera probe, a physiological indicator detection integrated module 8 integrating temperature and pH, and the lower tube opening is used for timed and quantitative injection of gastric acid to simulate the gastric acid secretion process in the body; the stomach model 32 has a sampling port at the lower end of the pylorus, and the duodenum model 31, the jejunum model 12, the ileum model 14 and the colon model 16 are provided with multiple sampling ports for sampling and monitoring the digestion of drugs in the gastrointestinal tract model.

Example 2

A children's gastrointestinal tract in vitro dynamic bionic instrument, the system mainly includes an injection unit, including gastric juice, intestinal juice, bile and pancreatic juice infusion ports (i.e., upper infusion port 1). The stomach model 32, the duodenum model 31, the jejunum model 12, the ileum model 14 and the colon model 16 are connected to each other. In order to realize the bionic movement of the stomach model and the intestinal model, a peristaltic extrusion device is provided in the system, which is respectively installed on the stomach model 32, the jejunum model 12 and the ileum model 14. The digestion and emptying unit includes a gastric juice injection pipe 6 connected to the stomach model 32 and its outlet, a gastric hydrochloric acid solution supplementary pipe 10 and a colon outlet pipe 30. The temperature control system is composed of a closed box 39, a temperature control terminal 2 in the warehouse, a liquid temperature control terminal 3 in the warehouse, a pipeline array electric heating belt 4, a stainless steel liquid heat exchange pipeline module 5, a pipeline electric heating belt 22 and a peristaltic pump silicone heat exchange pipeline module 23. The stomach model and the intestinal model are both silicone models obtained by infusion, which can be detachably fixedly connected to each other. Of course, each model can also be made of other flexible materials.

At the same time, this embodiment adds detection devices in the system, and sets cameras (stainless steel high-definition endoscope cameras for industrial pipeline inspection, etc.), pH measurement modules (tetrafluoro pH electrodes, glass pH electrodes, and matching sensors, 485 signal switching circuits, etc.) and temperature detection modules (thermistor-type stainless steel liquid temperature sensor probes) at various locations in the stomach and intestines. Specifically, the instrument of this embodiment is provided with a stomach camera probe, a pH measurement module, a temperature measurement module, and a liquid pH probe and a liquid temperature probe. The setting of these detection devices is intended to monitor the conditions of the stomach and intestines in real time. The stomach camera probe can be used to obtain image information inside the stomach in order to observe changes during the digestion process. The pH measurement module is used to measure the pH in the liquid to evaluate the acid-base balance of the digestive juice. The temperature measurement module is used to measure the temperature of the liquid to ensure temperature control during the digestion process. The liquid pH probe and the liquid temperature probe are used to accurately measure the pH value and temperature in the liquid, respectively. Through the application of these detection devices, this embodiment can provide comprehensive digestion process monitoring and data recording, providing reliable data support for further research and analysis. At the same time, the setting of these devices also provides a basis for the automated operation and control of the system.

The stomach model 32, duodenum model 31, jejunum model 12, ileum model 14 and colon model 16 are made by replicating the stomach and intestines of real people in a 1:1 scale. The size, shape and internal physiological structure of these models are exactly the same as the stomach and intestines of real children. They are made of soft materials with high elasticity and strong tear resistance. The softness and elasticity of these models enable them to simulate the movement and deformation of the human body, thereby more accurately reflecting the functions and characteristics of the digestive system.

The stomach model 32, duodenum model 31, jejunum model 12, ileum model 14 and colon model 16 in this embodiment are connected in a detachable manner. Specifically, they are connected together by multiple hexagonal flange structures 18. A camera probe, a pH measurement module and a temperature measurement module are installed on the stomach model 32, duodenum model 31, jejunum model 12, ileum model 14 and colon model 16 respectively. A temperature measuring element is installed at the temperature measurement point.

The temperature control function in this embodiment is achieved by heating the injected liquid by the pipe array electric heating belt 4, and the temperature is maintained by the warehouse air temperature control terminal 2, the warehouse liquid temperature control terminal 3, the pipe array electric heating belt 4 and the stainless steel liquid heat energy exchange pipe module 5. After the liquid flows downward, it is insulated and heated by the peristaltic pump silicone heat energy exchange pipe module 23.

This embodiment uses a specially designed peristaltic pump to achieve gastrointestinal peristalsis. A small six-way compressor-linear array 13 located on the jejunal body, a medium-sized six-way compressor-linear array 15 located on the ileal body, and a large annular compressor fan array 37 located on the gastric body are installed on the stomach and intestine parts of different sizes to achieve 360° compression and expansion.

The injection and discharge of this embodiment are composed of a comprehensive pipeline system, which is equipped with a pancreatic juice injection tube 34, a bile injection tube 35, and a gastric juice injection tube 6 to directly inject relevant gastrointestinal fluid, and a drug intelligent injector (i.e., an automatic injector 38) is provided in the stomach, which can automatically inject drugs as needed. Reflux and replenishment tubes are provided at multiple locations in the middle of the intestine, such as an intestinal reflux injection tube, a gastric hydrochloric acid solution replenishment tube 10, and an intestinal fluid replenishment injection tube.

The box body 39 of this embodiment adopts a Teflon metal composite full-hole back plate 7 and an aluminum body shell, wherein a directional stomach bracket is fixed on the Teflon metal composite full-hole back plate 7 to install and fix the gastrointestinal tract mold, and six upper injection ports 1 are arranged separately on the upper part of the box body 39.

It should be understood that in order to streamline the present disclosure and aid in understanding one or more of the various inventive aspects, in the above description of exemplary embodiments of the present invention, various features of the present invention are sometimes grouped together into a single embodiment, figure, or description thereof. However, this disclosed method should not be interpreted as reflecting the intention that the claimed invention requires more features than those expressly recited in each claim. Rather, as reflected in the claims, inventive aspects lie in less than all of the features of the previously disclosed embodiments. Therefore, the claims that follow the detailed description are hereby expressly incorporated into the detailed description, with each claim itself serving as a separate embodiment of the present invention.

Although the present invention has been described according to a limited number of embodiments, it will be apparent to those skilled in the art, with the benefit of the above description, that other embodiments may be envisioned within the scope of the invention thus described. In addition, it should be noted that the language used in this specification is selected primarily for readability and didactic purposes, rather than for explaining or defining the subject matter of the present invention. Therefore, many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the appended claims. The disclosure of the present invention is illustrative, not restrictive, with respect to the scope of the present invention, which is defined by the appended claims.

The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims (8)

1. An in vitro dynamic bionic instrument for gastrointestinal tracts of children, comprising:

A case (39);

gastrointestinal tract model: is used for bionic simulation of the gastrointestinal tract of children;

upper filling port (1): is used for injecting gastric juice, bile, pancreatic juice and intestinal juice into the gastrointestinal tract model;

and (3) a fluid infusion system: is used for supplementing liquid for the gastrointestinal tract model;

Physiological index detects integrated module (8): accessing the physiological index into a gastrointestinal model for detecting the physiological index of the gastrointestinal model;

Circumferential compressor array: is positioned on the gastrointestinal model and used for simulating gastrointestinal peristalsis of children;

hydraulic transmission output module (26): for powering the circumferential compressor array;

sampling tube automatic sampler (28): the method comprises the steps of sampling digestive juice in a gastrointestinal tract model and detecting;

The whole machine temperature regulation and control system comprises: for maintaining the gastrointestinal model at approximately 37 ℃ throughout;

man-machine interaction intelligent control screen (25): the system comprises a temperature regulation system for regulating and controlling the whole machine, an automatic sampling machine (28) for sampling pipes, a hydraulic transmission output module (26), an annular compressor array and a physiological index detection integrated module (8);

And (3) a power supply: the intelligent control system is used for supplying power to a human-computer interaction intelligent control screen (25), a complete machine temperature regulation and control system, an automatic sampling machine (28) for sampling pipes, a hydraulic transmission output module (26), a circumferential compressor array and a physiological index detection integrated module (8).

2. The in vitro dynamic bionic instrument for gastrointestinal tracts of children according to claim 1, wherein the box body (39) comprises a visual experimental area and a functional area, the visual experimental area is positioned in the middle of the box body (39), and the functional area comprises an upper functional area positioned at the upper part of the visual experimental area and a lower functional area positioned at the lower part of the visual experimental area; a man-machine interaction intelligent control screen (25) is arranged on the lower functional area;

A gastrointestinal tract model is arranged in the visual experiment area and comprises a bionic stomach model (32), a duodenum model (31), a jejunum model (12), an ileum model (14) and a colon model (16) which are connected in sequence;

The stomach model (32) comprises a stomach body, and three orifices are arranged on the stomach body: the gastric juice injection device comprises an upper pipe orifice (32-b), a middle pipe orifice (32-c) and a lower pipe orifice (32-d), wherein the upper pipe orifice (32-b) is connected with a gastric juice injection connecting pipe (6), the gastric juice injection connecting pipe (6) is connected with an upper injection port (1) which is opened in an upper functional area and is used for injecting gastric juice, the middle pipe orifice (32-c) is connected with a physiological index detection integrated module (8) which is integrated by a camera probe, temperature and pH, and the lower pipe orifice (32-d) is a normally closed electromagnetic valve outlet and is connected with a gastric juice outlet pipe; the upper section (32-a) of the pylorus of the stomach body is provided with an automatic injector (38) for injecting medicines, the stomach body is disconnected at the pylorus and is connected with a normally closed pylorus electromagnetic control valve (36), and the tail end (32-f) of the stomach body is provided with a hexagonal flange structure (18) for connecting with a duodenal model (31); the middle part of the stomach body is also provided with a stomach hydrochloric acid solution supplementing pipe (10);

The duodenum model (31) comprises a duodenum body, the head end of the duodenum body is provided with a hexagonal flange structure (18) and is connected with the tail end (32-f) of the stomach body, and the tail end of the duodenum body is provided with a hexagonal flange structure (18) which is used for being connected with the jejunum model (12); the duodenum body is provided with an intestinal juice injection pipe orifice (31-a), a pancreatic juice injection pipe orifice (31-b) and a bile injection pipe orifice (31-c), the intestinal juice injection pipe orifice (31-a) is connected with an intestinal juice injection pipe (33), the intestinal juice injection pipe (33) is connected with an upper injection port (1) which is opened in an upper functional area and is used for injecting intestinal juice, the pancreatic juice injection pipe orifice (31-b) is connected with a pancreatic juice injection pipe (34), the pancreatic juice injection pipe (34) is connected with an upper injection port (1) which is opened in the upper functional area and is used for injecting pancreatic juice, the bile injection pipe orifice (31-c) is connected with a bile injection pipe (35), and the bile injection pipe (35) is connected with an upper injection port (1) which is opened in the upper functional area and is used for injecting bile;

The jejunum model (12) comprises a jejunum body which is divided into a plurality of sections, and each section is provided with a hexagonal flange structure (18) at the head end and the tail end for assisting butt joint; a liquid-normally-closed electromagnetic valve outlet (12-a) is arranged on the side wall of the tail end of the jejunum body, the jejunum body is connected with an ileum model (14) in a butt joint way, and the jejunum body is connected with a jejunum liquid outlet pipe;

The ileum model (14) comprises an ileum body which is divided into a plurality of sections, and each section is provided with a hexagonal flange structure (18) at the head end and the tail end for auxiliary butt joint; the head end of the ileum body is connected with a jejunum model (12), the tail end of the ileum body is connected with a colon model (16), the tail end of the ileum body is connected with an adapter flange (16-a) with an enlarged inner diameter, the side wall of the adapter flange (16-a) is provided with a liquid two normally closed electromagnetic valve outlet (14-a), and the two normally closed electromagnetic valve outlets are connected with an ileum intestinal juice outlet pipe (29);

the colon model (16) comprises a colon body which is divided into a plurality of sections, and each section is provided with a hexagonal flange structure (18) at the head and the tail ends for assisting butt joint; the colon body comprises a ascending colon section (16-b), a transverse colon section (16-c) and a descending colon section (16-d) which are sequentially connected, the tail end of the descending colon section (16-d) is closed, the side wall of the tail end of the descending colon section (16-d) is connected with a liquid three-normally-closed electromagnetic valve outlet (16-e), and the liquid three-normally-closed electromagnetic valve outlet is connected with a colon liquid outlet pipe (30);

the gastric juice outlet pipe, the jejunum liquid outlet pipe, the ileum intestinal liquid outlet pipe (29) and the colon liquid outlet pipe (30) are respectively connected with a sampling pipe automatic sampling machine (28), and the sampling pipe automatic sampling machine (28) is connected with a waste liquid sewer pipe (27);

The circumferential compressor array comprises a small six-way compressor-linear array (13) positioned on the jejunum body, a medium six-way compressor-linear array (15) positioned on the ileum body and a large circumferential compressor fan-shaped array (37) positioned on the stomach body; the annular compressor arrays comprise openable annular peripheral frames (28-f, 28-g), two spherical joints (28-i) are connected to the annular peripheral frames (28-f, 28-g), the spherical joints (28-i) are connected with screws (28-h), the screws (28-h) are fixed to a Teflon metal composite full-hole backboard (7), six to eight hydraulic telescopic devices are loaded on the annular peripheral frames (28-f, 28-g), tail ends (28-j) of the hydraulic telescopic devices extend out of the hydraulic tubules (28-d) into the flow divider (28-c), the flow divider (28-c) extends out of the hydraulic pipe (28-a) to a hydraulic transmission output module (26) in the box body (39) through a quick connector (28-b), and hydraulic telescopic rods (28-l) at the head ends (28-k) of the hydraulic telescopic devices are connected with the outer surfaces of the stomach model (32), the jejunum model (12) and the ileum model (14) respectively;

The hydraulic transmission output module (26) comprises seven hydraulic output devices (22-g), the seven hydraulic output devices (22-g) are annularly fixed on the support (22-e), the head end of each hydraulic output device (22-g) is connected with the corresponding hydraulic pipe (28-a) through the corresponding quick connector (22-i), the tail end pushing rod (22-f) of each hydraulic output device (22-g) is connected to the corresponding screw rod screw disc (22-d), the stepping motor (22-a) rotates the screw rod (22-c) to push and output, and the stepping motor (22-a) is connected and fixed with the screw rod screw disc (22-d) through the corresponding elastic coupling (22-b).

3. The in-vitro dynamic bionic instrument for the gastrointestinal tract of the children according to claim 2, further comprising a complete machine temperature regulation and control system, wherein the complete machine temperature regulation and control system comprises a gas temperature active regulation and control subsystem and a liquid temperature active regulation and control subsystem, the complete machine temperature active regulation and control system comprises an active hot air inlet device (19) positioned at the back of a Teflon metal composite full-hole backboard (7), the Teflon metal composite full-hole backboard (7) is positioned at the back of a box body (39), the active hot air inlet device (19) is positioned at an air outlet at the lower side of the Teflon metal composite full-hole backboard (7), the gas temperature active regulation and control subsystem further comprises an active air exhaust cleaning device (11) positioned at the back of the Teflon metal composite full-hole backboard (7), the active air exhaust cleaning device (11) is internally provided with an active carbon filtering pipeline, and the gas temperature active regulation and control subsystem further comprises an in-cabin gas temperature control intelligent terminal (2) which is positioned above a visual experiment area and is automatically controlled by negative feedback through a circuit;

The liquid temperature active control subsystem comprises a stainless steel liquid heat energy exchange pipeline module (5) positioned above the visual experiment area, a pipeline array electric heating belt (4) wrapped outside the stainless steel liquid heat energy exchange pipeline module, a peristaltic pump silica gel heat energy exchange pipeline module (23) positioned below the visual experiment area, a pipeline electric heating belt (22) wrapped outside the peristaltic pump silica gel heat energy exchange pipeline module, and an in-bin liquid temperature control intelligent terminal (3) which is parallel to the in-bin gas temperature control intelligent terminal (2); the in-bin gas temperature control intelligent terminal (2) and the in-bin liquid temperature control intelligent terminal (3) are respectively provided with temperature probes in a visual experiment area and a pipeline, detect the liquid temperature and the gas temperature in real time and feed back the liquid temperature and the gas temperature, and the in-bin gas temperature control intelligent terminal (2) and the in-bin liquid temperature control intelligent terminal (3) adjust the output power of each subordinate module in real time according to feedback signals, so that the temperature of each place in the visual experiment area is kept at approximately 37 ℃, and the physiological environment of the abdominal cavity of a child is simulated; a step motor peristaltic pump II (24) is arranged on the peristaltic pump silica gel heat energy exchange pipeline module (23); the intelligent terminal (2) for controlling the temperature of the gas in the bin and the intelligent terminal (3) for controlling the temperature of the liquid in the bin are respectively connected with the intelligent control screen (25) for man-machine interaction;

The peristaltic pump (21) of the stepping motor positioned below the box body (39) is connected with the stainless steel liquid heat energy exchange pipeline module (5) through a pipeline (20) buried in the Teflon metal composite full-hole backboard (7).

4. The in-vitro dynamic bionic instrument for the gastrointestinal tract of the children according to claim 2 is characterized in that a teflon metal composite full-hole backboard (7) is provided with a standby interface (9) and a standby outlet (17) with various pore sizes.

5. The in vitro dynamic bionic instrument for gastrointestinal tracts of children according to claim 1, wherein the box body (39) is made of an aluminum body shell and an acid and alkali resistant organic glass material.

6. The in vitro dynamic bionic instrument for the gastrointestinal tract of the children according to claim 2, wherein the directional stomach bracket is fixed on the Teflon metal composite full-hole backboard (7) so as to install and fix the gastrointestinal tract model.

7. The in vitro dynamic bionic instrument for the gastrointestinal tract of the child according to claim 2, wherein the stomach model (32), the duodenum model (31), the jejunum model (12), the ileum model (14) and the colon model (16) are manufactured by using a 3D printing rapid prototyping technology to manufacture a mould and using a silica gel turnover mould technology.

8. Use of a dynamic bionic instrument according to any one of claims 1-7 for simulating gastrointestinal digestion in children.