CN110192985A - A kind of care agent and preparation method thereof for skin moisture-keeping reparation - Google Patents

Abstract

The invention discloses a care agent for skin moisturizing and repairing, which consists of the following components in mass percentage: disodium EDTA: 0.05-0.15%, nicotinamide: 0.5-3.0%, glycerin: 2.0-5.5%, propylene glycol: 2.5‑5.5%, Xanthan Gum: 0.05‑0.35%, Sodium Hyaluronate: 0.05‑0.5%, Paraben: 0.15‑0.5%, Caprylic/Capric Triglycerides: 1.0‑5.0%, Polymeric Methylsiloxane: 1.0‑3.0%, Isononyl Isononanoate: 1.0‑5.0%, Jojoba Seed Oil: 0.5‑5.0%, Shea Butter Oil: 0.5‑2.5%, Repairing Essential Oil: 1.75‑ 10.5%, Fullerene: 0.05‑0.5%, Restorin: 0.35‑2%, Cetearyl Alcohol: 0.2‑3.5%, Cetearyl Olivate: 1.0‑2.5%, Sorbitan Olive Oleate 1.0‑2.5%, Lecithin: 0.1‑1.0%, Oligopeptide‑1: 0.5‑5.0%, D‑Panthenol: 0.1‑0.5%, Centella Asiatica Extract: 0.5‑2.5%, 1,2 ‑Hexylene glycol: 0.5‑2.5%, deionized water: balance. The product of the invention can rapidly improve the water retention capacity of the skin, obviously improve the dryness of the skin, increase the water content in the skin, and make the skin appear youthful.

Description

A kind of care agent for skin moisturizing repair and preparation method thereof

technical field

The invention relates to the technical field of cosmetics, in particular to a care agent for skin moisturizing and repairing and a preparation method thereof.

Background technique

With the continuous update and iteration of international big-name skin care technology, the continuous development of biotechnology and medical beauty technology, people's requirements for the quality of skin care products are constantly improving, and the voice of safety, effectiveness, innovation, mildness and economy is getting higher and higher; from a national perspective , to encourage innovation, enterprises should continue to make breakthroughs in their respective industries, conduct further research on advanced achievements discovered in practical applications, and form their own technical achievements and barriers. How to use cutting-edge science in the field, unique application design and natural It is the development trend of the domestic cosmetics industry to combine forces to achieve 1+1>2 effects, and combine it with the concept of healthy overall beauty, research and compound high-efficiency and all-round mixtures to help domestic brands. Based on this, how to screen traditional natural green plant extracts, combine their respective functional characteristics, and combine strong forces to develop a new multi-effect synergistically promoted compound is the direction of technological development. Human skin is poor in smoothness, low in hydration capacity, and dull due to air pollution, sun damage, free radical damage, decline in its own metabolic vitality, slow synthesis of collagen or hyaluronic acid, and improper skin care factors; so from these perspectives Start by choosing the right raw materials, linking effects, complementing and promoting each other to brighten the skin and increase the skin's water holding capacity.

Chinese patent CN102018652B discloses a dual-component moisturizing system skin care product, which is composed of Snowflower bulb extract, sponge extract, sodium lactate and pentylene glycol. This moisturizing skin care product can lock water on the surface of the skin and replenish water on the bottom layer, forming a dual moisturizing system. However, the extracts of Snowflower Bulbs and Sponge are easily oxidized, and the moisturizing effect is poor, which cannot meet the requirements of modern people for moisturizing and hydrating effects. It is unfavorable for the application and popularization of this dual moisturizing system skin care product.

Contents of the invention

Aiming at the defects in the prior art, the present invention provides a skin care agent for moisturizing and repairing the skin and a preparation method thereof, which has better moisturizing effect.

The present invention realizes through following technical scheme:

A care agent for skin moisturizing and repairing, which consists of the following components in mass percentage: disodium EDTA: 0.05-0.15%, nicotinamide: 0.5-3.0%, glycerin: 2.0-5.5%, propylene glycol: 2.5-5.5% , Xanthan Gum: 0.05-0.35%, Sodium Hyaluronate: 0.05-0.5%, Paraben: 0.15-0.5%, Caprylic/Capric Triglycerides: 1.0-5.0%, Dimethicone Alkane: 1.0-3.0%, Isononyl Isononanoate: 1.0-5.0%, Jojoba Seed Oil: 0.5-5.0%, Shea Butter Oil: 0.5-2.5%, Repair Essential Oil: 1.75-10.5%, Rich Lexene: 0.05-0.5%, Restorative: 0.35-2%, Cetearyl Alcohol: 0.2-3.5%, Cetearyl Olivate: 1.0-2.5%, Sorbitan Olivate 1.0 -2.5%, Lecithin: 0.1-1.0%, Oligopeptide-1: 0.5-5.0%, D-Panthenol: 0.1-0.5%, Centella Asiatica Extract: 0.5-2.5%, 1,2-Hexanediol : 0.5-2.5%, deionized water: balance.

In some of these embodiments, the repairing essential oil is sunflower (HELIANTHUS ANNUUS) seed oil, safflower flower extract, gardenia flower extract, chrysanthemum flower extract, plum flower extract, peony extract, grape seed oil, The mixture of perilla seed extract and tocopherol, the specific addition amount is sunflower (HELIANTHUSANNUUS) seed oil: 0.05-1.0%, safflower flower extract: 0.1-1.0%, gardenia flower extract: 0.1-1.0%, Chrysanthemum Flower Extract: 0.1-1.0%, Plum Blossom Extract: 0.1-1.0%, Peony Extract: 0.1-1.0%, Grape Seed Oil: 1.0-3.0%, Perilla Seed Extract: 0.1-1.0%, Tocopherol: 0.1-0.5%.

The above-mentioned repairing essence oil is a combination of sunflower (HELIANTHUS ANNUUS) seed oil, safflower flower extract, gardenia flower extract, chrysanthemum flower extract, plum blossom extract, peony extract, grape seed oil, perilla seed extract and fertility Phenols are mixed in a reasonable ratio, and the repairing essence oil obtained has good moisturizing and whitening effects. Among them, sunflower (HELIANTHUS ANNUUS) seed oil and grape seed oil are used as base materials, which are rich in nutrients and natural minerals, which are conducive to transporting water across the membrane to the stratum corneum, thereby increasing the moisture content of the skin and achieving a moisturizing effect. In the environment rich in mineral ions provided by sunflower (HELIANTHUS ANNUUS) seed oil and grape seed oil, it is beneficial to extract safflower flower extract, gardenia flower extract, chrysanthemum flower extract, plum flower extract, peony extract, The nutrients in perilla seed extract and tocopherol are transported to the stratum corneum through transmembrane transport. These nutrients not only have moisturizing effect, but also have whitening effect. In addition, tocopherol can also improve the skin barrier function, so it cooperates with sunflower (HELIANTHUS ANNUUS) seed oil and grape seed oil to regulate the microenvironment of the skin surface, facilitate water transportation, and play a moisturizing role.

In some of these embodiments, the safflower extract, gardenia extract, chrysanthemum extract, plum extract, peony extract and perilla seed extract are all prepared by alcohol extraction, specifically the dried The plant is added to ethanol with a mass ratio of 95%, extracted under reflux and soaking for 10-15 hours, and then the extract is filtered with a filter cloth, and then centrifuged to obtain the plant extract, and the plant is safflower Or gardenias or chrysanthemums or plum blossoms or peonies or perilla seeds.

In the present invention, safflower flower extract, gardenia flower extract, chrysanthemum flower extract, plum blossom extract, peony extract and perilla seed extract are all prepared by alcohol extraction, and sunflower (HELIANTHUSANNUUS) seed oil and tocopherol The compatibility of the compound is stronger, and the repairing essence oil compounded is more mild, and has obvious effects on repairing skin itching, redness, swelling, heat, pain, etc. long-lasting moisturizing effect.

In some of these embodiments, the repair element is a mixture of ceramide 1, ceramide 2, ceramide 3 and ceramide 4, and the addition amount is specifically ceramide 1: 0.1-0.5%, ceramide 2: 0.1% -0.5%, Ceramide 3: 0.1-0.5%, Ceramide 4: 0.05-0.5%.

In the present invention, multiple ceramides are used in combination, so that the absorption effect of the skin is good, the dry skin can be significantly improved, the water content in the skin can be increased, and a good moisturizing effect can be achieved.

In some of these embodiments, the fullerene is a modified water-based fullerene, and the preparation method of the modified water-based fullerene is as follows: water-based fullerene, polyester polyol, concentrated hydrochloric acid and a volume concentration of Add 80-95% ethanol into the reaction kettle, and carry out the reaction at 55-65°C for 10-15 hours. After the reaction is complete, add sodium bicarbonate to adjust its pH value to 7-8, and then take the material out. The substance is modified water-based fullerene.

In some of the embodiments, the mass ratio of the aqueous fullerene, polyester polyol, concentrated hydrochloric acid and ethanol with a volume concentration of 95% is 30:7:1:(4-7).

In the present invention, after the fullerene is modified to prepare the modified water-based fullerene, its water holding capacity is enhanced. It has high biocompatibility, and cooperates with other ingredients to have moisturizing, softening, anti-wrinkle, whitening and refreshing effects.

In some of the embodiments, the centella asiatica extract contains 50-90% by weight of total flavonoids.

In some of these embodiments, the centella asiatica extract contains 75.4% by weight of total flavonoids.

The present invention also provides a preparation method of a care agent for skin moisturizing repair, comprising the following steps: 1) weighing deionized water, disodium EDTA, glycerin, propylene glycol, nicotinamide, xanthan gum, sodium hyaluronate, Add p-hydroxyacetophenone into the emulsification pot, stir and heat at 30r/min to 83-85°C; 2) Weigh caprylic/capric triglyceride, polydimethylsiloxane, isononyl isononanoate, Add bacon seed oil, shea butter oil, repairing essence oil, repairing essence, cetearyl alcohol, cetearyl olive oleate, and sorbitan olive oil into the emulsified oil pan, at a speed of 30r/min Stir and heat to 78-83°C, then add the raw materials of the emulsification oil pot into the emulsification pot, stir at a speed of 30r/min, 3) Weigh the lecithin and add it to the emulsification pot, homogenize for 5 minutes, vacuumize to -0.03MPa, and keep the temperature constant After 20 minutes, stir at a speed of 30r/min and start to cool down; 4) Cool down to below 45°C, weigh oligopeptide-1, D-panthenol, Centella asiatica extract, and 1,2-hexanediol into the emulsification pot , stirring at a speed of 30r/min for 20 minutes, vacuuming to -0.05mpa, and controlling the pH to 4.5-6.5; 5) Store it in a storage tank after passing the inspection, and put it in a tank after standing still for 24 hours.

The beneficial effects of the present invention are reflected in:

The skin moisturizing and repairing care agent of the present invention has good skin permeability, can quickly and effectively moisturize dry skin, and is not sticky. The repairing essence oil and the repairing element of the present invention are added to the care agent system according to a specific ratio, which can increase the penetration speed of the skin, give the skin a moist feeling, and feel smooth, so that the skin has a lustrous and refreshing moisturizing effect; fullerene Compounded with Centella asiatica extract into the care agent, it can eliminate the active oxygen produced by various conditions, the anti-oxidation duration is long, the moisturizing effect is more obvious, and it has good skin compatibility; the product of the present invention can quickly improve The moisture retention of the skin stimulates the vitality of the cells, and has obvious effects on the repair of skin itching, redness, swelling, heat, pain, etc. It can significantly improve dry skin, increase the moisture content in the skin, and make the skin look younger .

Detailed ways

Embodiments of the technical solution of the present invention will be described in detail below. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and therefore are only examples, rather than limiting the protection scope of the present invention.

It should be noted that, unless otherwise specified, the technical terms or scientific terms used in this application shall have the usual meanings understood by those skilled in the art to which the present invention belongs.

Example 1

A care agent for skin moisturizing and repairing, consisting of the following components by mass percentage: disodium EDTA: 0.05%, nicotinamide: 0.5%, glycerin: 2.0%, propylene glycol: 2.5%, xanthan gum: 0.05% , Sodium Hyaluronate: 0.05%, Para-Hydroxyacetophenone: 0.15%, Caprylic/Capric Triglyceride: 1.0%, Dimethicone: 1.0%, Isononyl Isononanoate: 1.0%, Jojoba Seed Oil: 0.5%, Shea Butter Oil: 0.5%, Sunflower (HELIANTHUSANNUUS) Seed Oil: 0.05%, Safflower Flower Extract: 0.1%, Gardenia Flower Extract: 1.0%, Chrysanthemum Flower Extract: 1.0% , Plum Blossom Extract: 1.0%, Peony Extract: 1.0%, Grape Seed Oil: 3.0%, Perilla Seed Extract: 1.0%, Tocopherol: 0.5%, Fullerene: 0.5%, Ceramide 1: 0.5% , Ceramide 2: 0.5%, Ceramide 3: 0.5%, Ceramide 4: 0.5%, Cetearyl Alcohol: 3.5%, Cetearyl Olivate: 2.5%, Sorbitan Olivate 2.5%, Lecithin: 1.0%, Oligopeptide-1: 5.0%, D-Panthenol: 0.5%, Centella Asiatica Extract: 2.5%, 1,2-Hexanediol: 2.5%, Deionized Water: I The centella asiatica extract contains 90% by weight of total flavonoids.

The preparation method of the modified water-based fullerene is: adding water-based fullerene with a mass ratio of 30:7:1:4, polyester polyol, concentrated hydrochloric acid and ethanol with a volume concentration of 95% into the reactor, The reaction is carried out at 55° C. for 10 hours. After the reaction is complete, sodium bicarbonate is added to adjust its pH value to 7-8, and then the material is taken out, which is the modified water-based fullerene.

The preparation method of the above-mentioned embodiment comprises the following steps: 1) Weighing deionized water, disodium EDTA, glycerin, propylene glycol, nicotinamide, xanthan gum, sodium hyaluronate, and p-hydroxyacetophenone into an emulsifying pot, 30r 2) Weigh caprylic/capric triglyceride, polydimethylsiloxane, isononyl isononanoate, jojoba seed oil, shea butter oil, sunflower (HELIANTHUS ANNUUS ) seed oil, safflower flower extract, gardenia flower extract, chrysanthemum flower extract, plum blossom extract, peony extract, grape seed oil, perilla seed extract, tocopherol, ceramide 1, ceramide 2, neuro Add amide 3 and ceramide 4, cetearyl alcohol, cetearyl olive oleate, and sorbitan olive oil into the emulsified oil pan, stir at 30r/min and heat to 78°C, then put the emulsified oil into the emulsified oil pan 3) Weigh the lecithin and add it into the emulsification pot, homogenize for 5 minutes, vacuumize to -0.03MPa, keep the temperature for 20 minutes, stir at a speed of 30r/min and start to cool down; 4) Lower the temperature to below 45°C, weigh oligopeptide-1, D-panthenol, Centella asiatica extract, and 1,2-hexanediol into the emulsification pot, stir at 30r/min for 20 minutes, and vacuum to - 0.05mpa, PH to control 4.5-6.5; 5) After passing the inspection, store it in a storage tank, and put it in a tank after standing still for 24 hours.

Example 2

A care agent for skin moisturizing and repairing, which consists of the following components in mass percentage: disodium EDTA: 0.15%, nicotinamide: 3.0%, glycerin: 5.5%, propylene glycol: 5.5%, xanthan gum: 0.35%, Sodium Hyaluronate: 0.5%, Para-Hydroxyacetophenone: 0.5%, Caprylic/Capric Triglycerides: 5.0%, Dimethicone: 3.0%, Isononyl Isononanoate: 5.0%, Hojo Bacon Seed Oil: 5.0%, Shea Butter Oil: 2.5%, Sunflower (HELIANTHUS ANNUUS) Seed Oil: 1.0%, Safflower Flower Extract: 1.0%, Gardenia Flower Extract: 0.1%, Chrysanthemum Flower Extract: 0.1% , Plum Blossom Extract: 0.1%, Peony Extract: 0.1%, Grape Seed Oil: 1.0%, Perilla Seed Extract: 0.1%, Tocopherol: 0.1%, Fullerene: 0.05%, Ceramide 1: 0.1% , Ceramide 2: 0.1%, Ceramide 3: 0.1%, Ceramide 4: 0.05%, Cetearyl Alcohol: 0.2%, Cetearyl Olivate: 1.0%, Sorbitan Olivate 1.0%, Lecithin: 0.1%, Oligopeptide-1: 0.5%, D-Panthenol: 0.1%, Centella Asiatica Extract: 0.5%, 1,2-Hexanediol: 0.5%, Deionized Water: I Amount, the centella asiatica extract contains 50% by weight of total flavonoids.

The preparation method of the modified water-based fullerene is: adding water-based fullerene with a mass ratio of 30:7:1:7, polyester polyol, concentrated hydrochloric acid and ethanol with a volume concentration of 80% into the reactor, The reaction is carried out at 65° C. for 15 hours. After the reaction is complete, sodium bicarbonate is added to adjust its pH value to 7-8, and then the material is taken out, which is the modified water-based fullerene.

The preparation method of the above-mentioned embodiment comprises the following steps: 1) Weighing deionized water, disodium EDTA, glycerin, propylene glycol, nicotinamide, xanthan gum, sodium hyaluronate, and p-hydroxyacetophenone into an emulsifying pot, 30r 2) Weigh caprylic/capric triglyceride, polydimethylsiloxane, isononyl isononanoate, jojoba seed oil, shea butter oil, sunflower (HELIANTHUS ANNUUS ) seed oil, safflower flower extract, gardenia flower extract, chrysanthemum flower extract, plum blossom extract, peony extract, grape seed oil, perilla seed extract, tocopherol, ceramide 1, ceramide 2, neuro Add amide 3 and ceramide 4, cetearyl alcohol, cetearyl olive oleate, and sorbitan olive oil into the emulsified oil pan, stir at 30r/min and heat to 83°C, then put the emulsified oil into the emulsified oil pan 3) Weigh the lecithin and add it into the emulsification pot, homogenize for 5 minutes, vacuumize to -0.03MPa, keep the temperature for 20 minutes, stir at a speed of 30r/min and start to cool down; 4) Lower the temperature to below 45°C, weigh oligopeptide-1, D-panthenol, Centella asiatica extract, and 1,2-hexanediol into the emulsification pot, stir at 30r/min for 20 minutes, and vacuum to - 0.05mpa, PH to control 4.5-6.5; 5) After passing the inspection, store it in a storage tank, and put it in a tank after standing still for 24 hours.

Example 3

A care agent for skin moisturizing and repairing, consisting of the following components in mass percentage: disodium EDTA: 0.1%, nicotinamide: 2%, glycerin: 4%, propylene glycol: 3.5%, xanthan gum: 0.25%, Sodium Hyaluronate: 0.2%, Para-Hydroxyacetophenone: 0.2%, Caprylic/Capric Triglyceride: 3%, Dimethicone: 2%, Isononyl Isononanoate: 3%, Huohuo Palma Seed Oil: 2.5%, Shea Butter Oil: 2%, Sunflower (HELIANTHUS ANNUUS) Seed Oil: 0.5%, Safflower Flower Extract: 0.5%, Gardenia Flower Extract: 0.5%, Chrysanthemum Flower Extract: 0.5% , Plum Blossom Extract: 0.5%, Peony Extract: 0.5%, Grape Seed Oil: 2%, Perilla Seed Extract: 0.5%, Tocopherol: 0.3%, Fullerene: 0.2%, Ceramide 1: 0.3% , Ceramide 2: 0.3%, Ceramide 3: 0.4%, Ceramide 4: 0.2%, Cetearyl Alcohol: 2%, Cetearyl Olivate: 2%, Sorbitan Olivate 2%, Lecithin: 0.5%, Oligopeptide-1: 3%, D-Panthenol: 0.3%, Centella Asiatica Extract: 2%, 1,2-Hexanediol: 2%, Deionized Water: I The centella asiatica extract contains 75.4% by weight of total flavonoids.

The preparation method of the modified water-based fullerene is: adding water-based fullerene with a mass ratio of 30:7:1:6, polyester polyol, concentrated hydrochloric acid and ethanol with a volume concentration of 90% into the reactor, The reaction is carried out at 60° C. for 13 hours. After the reaction is complete, sodium bicarbonate is added to adjust its pH value to 7-8, and then the material is taken out, which is the modified water-based fullerene.

The preparation method of the above-mentioned embodiment comprises the following steps: 1) Weighing deionized water, disodium EDTA, glycerin, propylene glycol, nicotinamide, xanthan gum, sodium hyaluronate, and p-hydroxyacetophenone into an emulsifying pot, 30r 2) Weigh caprylic/capric triglyceride, polydimethylsiloxane, isononyl isononanoate, jojoba seed oil, shea butter oil, sunflower (HELIANTHUS ANNUUS ) seed oil, safflower flower extract, gardenia flower extract, chrysanthemum flower extract, plum blossom extract, peony extract, grape seed oil, perilla seed extract, tocopherol, ceramide 1, ceramide 2, neuro Add amide 3 and ceramide 4, cetearyl alcohol, cetearyl olive oleate, and sorbitan olive oil into the emulsified oil pan, stir at a speed of 30r/min and heat to 80°C, then put the emulsified oil into the emulsified oil pan 3) Weigh the lecithin and add it into the emulsification pot, homogenize for 5 minutes, vacuumize to -0.03MPa, keep the temperature for 20 minutes, stir at a speed of 30r/min and start to cool down; 4) Lower the temperature to below 45°C, weigh oligopeptide-1, D-panthenol, Centella asiatica extract, and 1,2-hexanediol into the emulsification pot, stir at 30r/min for 20 minutes, and vacuum to - 0.05mpa, PH to control 4.5-6.5; 5) After passing the inspection, store it in a storage tank, and put it in a tank after standing still for 24 hours.

Comparative example 1

The difference from Example 3 is that no repair essence oil is added in Comparative Example 1.

Comparative example 2

The difference from Example 3 is that no repair element is added in Comparative Example 2.

Comparative example 3

The difference from Example 3 is that no fullerene was added in Comparative Example 3.

Comparative example 4

The difference from Example 3 is that no Centella asiatica extract was added in Comparative Example 4.

Comparative example 5

The difference from Example 3 is that no safflower flower extract is added to the repairing essence oil in Comparative Example 5.

Comparative example 6

The difference from Example 3 is that no ceramide 1 is added to the repair element in Comparative Example 6.

Comparative example 7

The difference from Example 3 is that the fullerene in Comparative Example 7 is not modified.

Efficacy evaluation

1 test instrument

Germany CK company multifunctional skin tester, model CUTOMETERDUALMPA580, this patent selects the skin water content test probe and the skin water loss TEWL test probe.

2 test method

2.1 MMV test method of skin moisture content

2.1.1 Test Principle

This method uses the capacitance method to test the water content of the stratum corneum of human skin. Its principle is based on the significant difference in the dielectric constant of water and other substances. According to the different water content of the skin, the measured capacitance value of the skin is different, and the observed parameters can represent the skin. Moisture value.

2.1.2 Test conditions and volunteer requirements

Test environment conditions: The test environment temperature is 22±1°C, the humidity is 50±5%, and real-time dynamic detection is carried out;

Volunteer requirements: At least 30 valid volunteers, aged between 16-65 (except pregnant or breastfeeding women): Forearm test area The basic value of capacitance method skin moisture measurement is between 15-100: no serious Systemic diseases, no immunodeficiency or autoimmune diseases; no active allergic diseases; no previous history of severe allergies to skin care cosmetics; no use of hormone drugs and immunosuppressants within the past month: for participating in other clinical trials The experimenter; the test drug was used according to the regulations and the information was complete; all volunteers should fill out the informed consent form before the test;

2.1.3 Preparation before the test

Do not use any products (cosmetic or topical) for 2-3 days prior to the test site. Before the experiment, the subjects were required to agree to clean their hands on the inside of their forearms and wipe them clean with a dry facial tissue. After cleaning, the subject measured the inner forearm of both hands and marked the measurement area. Before the formal test, you should sit quietly in a standard room for at least 30 minutes, without drinking water, with your forearm exposed, placed in the test state, and kept relaxed.

2.1.4 Test steps

In the experiment, a 3*3cm ² test area is marked on the inner side of the left and right arms, and multiple areas can be marked on the same arm, with an interval of 1 cm. Both the test product and the placebo were randomly distributed on the left and right arms. Measurements on the test and control areas were performed using a capacitive dermatometer. Each area was measured 15 times in parallel. First measure the blank paper in each test area, and then use latex finger cots to spread the test evenly in the test area at an amount of 2.0±0.1mg sample/cm ² . Smear to measure 0 hour, 0.5 hour, 1 hour, 2 hours, the skin moisture content of the test area and the blank control area (measured according to this time during verification), and the test of the same volunteer is completed by the same measuring person.

2.1.5 Test data

The MMV value of each time period was measured in decibels according to the design of the experiment.

The calculation formula is:

W%=(W1-W0)/W0×100%

Note: w% = percentage increase in skin moisture content (MMV)

W0 = moisture content of the skin before using the sample

W1 = water content of the skin after using the sample

The results are shown in Table 1:

Table 1 MMV values in each time period

2.2 Transdermal water loss TEWL test method

2.2.1 Test Principle

The measurement principle of the test instrument comes from FICK's diffusion law: dm/dt=D.A.dp/dx. Two sets of temperature and humidity sensors are used to measure the water vapor pressure gradient near the epidermis (within about 1cm) formed by the water loss of the stratum corneum in different bright spots, and directly measure the amount of moisture emitted through the skin. The TEWL value is an important indicator of the quality of the skin barrier. The lower the TEWL value of the skin, the better the barrier function of the skin, and vice versa. 2.2.2 Test conditions and volunteer requirements

Test environment conditions: The test environment temperature is 22±1°C, the humidity is 50±5%, and real-time dynamic detection is carried out;

Volunteer requirements: At least 30 valid volunteers, aged between 16-65 (except pregnant or breastfeeding women): Forearm test area The basic value of capacitance method skin moisture measurement is between 15-100: no serious Systemic diseases, no immunodeficiency or autoimmune diseases; no active allergic diseases; no previous history of severe allergies to skin care cosmetics; no use of hormone drugs and immunosuppressants within the past month: for participating in other clinical trials The experimenter; the test drug was used according to the regulations and the information was complete; all volunteers should fill out the informed consent form before the test;

2.2.3 Preparation before the test

Do not use any products (cosmetic or topical) for 2-3 days prior to the test site. Before the experiment, the subjects were required to agree to clean their hands on the inside of their forearms and wipe them clean with a dry facial tissue. After cleaning, the subject measured the inner forearm of both hands and marked the measurement area. Before the formal test, you should sit quietly in a standard room for at least 30 minutes, without drinking water, with your forearm exposed, placed in the test state, and kept relaxed.

2.2.4 Test steps

In the experiment, a 3*3cm ² test area is marked on the inner side of the left and right arms, and multiple areas can be marked on the same arm, with an interval of 1 cm. Both the test product and the placebo were randomly distributed on the left and right arms. Measurements on the test and control areas were performed using a capacitive dermatometer. Each area was measured 15 times in parallel. First measure the blank paper in each test area, and then use latex finger cots to spread the test evenly in the test area at an amount of 2.0±0.1mg sample/cm ² . Smear to measure 0 hour, 0.5 hour, 1 hour, 2 hours, the skin moisture content of the test area and the blank control area (measured according to this time during verification), and the test of the same volunteer is completed by the same measuring person.

2.2.5 Test data

According to the experimental design, the TEWL values of each period were measured respectively.

The calculation formula is:

T%=(T1-T0)/T0×100%

Note: T% = percent reduction in transepidermal water loss (TEWL);

T0 = transdermal water loss value of skin samples;

T1 = value of water loss through the skin after using the sample on the skin;

The results are shown in Table 2:

Table 2 TEWL values in each time period

Combined with Tables 1-2, the skin moisturizing and repairing care agent provided by the present invention has a scientific distribution ratio of each component, and the skin moisture content increases by 164.31% in time, and the skin moisture content can also maintain a 78.65% increase in 2 hours. Its ability to reduce skin water loss TEWL is greatly improved, which is conducive to the full moisturizing of the skin. Compared with Comparative Examples 1 to 7, the prescriptions provided by Examples 1 to 3 all showed a significant improvement (p<0.05) in terms of increasing the water content and inhibiting water loss, indicating that the compounding of each component played a significant role. synergistic effect.

Enhanced penetration evaluation experiment

Test sample: embodiment 3, comparative example 1, comparative example 2

Experimental object: female mice

Experimental method: the three samples were divided into three groups, 10 female mice were selected respectively, and marked separately, 15g of the sample was applied to the mammary glands of each mouse every day, and the samples were applied three times for 15 consecutive days, and the mammary glands of each mouse were observed The results are shown in Table 3.

table 3

It can be seen from Table 3 that after 15 days of continuous observation, the mammary glands of mice coated with Comparative Example 1 increased by an average of 8.062%, the mammary glands of mice coated with Comparative Example 2 increased by an average of 10.184%, and the mammary glands of mice coated with Example 3 increased on average. 11.186%, it can be seen that repairing essence oil and repairing element have the effect of promoting penetration.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than limiting them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: It is still possible to modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the technical solutions of the various embodiments of the present invention. All of them should be covered by the scope of the claims and description of the present invention.

Claims (9)

1. a kind of care agent for skin moisture-keeping reparation, it is characterised in that: consist of the following components in percentage by mass: EDTA Disodium: 0.05-0.15%, niacinamide: 0.5-3.0%, glycerol: 2.0-5.5%, propylene glycol: 2.5-5.5%, xanthan gum: 0.05-0.35%, Sodium Hyaluronate: 0.05-0.5%, parahydroxyacet-ophenone: 0.15-0.5%, caprylic/capric triglyceride: 1.0-5.0%, dimethyl silicone polymer: 1.0-3.0%, isononyl isononanoate: 1.0-5.0%, jojoba seed oil: 0.5- 5.0%, Butyrospermum parkii fruit fatty oil: 0.5-2.5%, maintenance essential oils: 1.75-10.5%, fullerene: 0.05-0.5%, maintenance Element: 0.35-2%, cetostearyl alcohol: 0.2-3.5%, cetostearyl alcohol olive oleate: 1.0-2.5%, the smooth olive oil of sorb Acid esters 1.0-2.5%, lecithin: 0.1-1.0%, oligopeptides -1:0.5-5.0%, D-pantothenyl aleohol: 0.1-0.5%, centella are extracted Object: 0.5-2.5%, 1,2- hexylene glycol: 0.5-2.5%, deionized water: surplus.

2. the care agent according to claim 1 for skin moisture-keeping reparation, it is characterised in that: the maintenance essential oils are Sunflower (HELIANTHUS ANNUUS) seed oil, safflower flower extract, cape jasmine flower extract, chrysanthemum extract, plum blossom are extracted The mixing of object, peony extract, grape seed oil, purple common perilla seed and tocopherol, additive amount are specially sunflower (HELIANTHUS ANNUUS) seed oil: 0.05-1.0%, safflower flower extract: 0.1-1.0%, cape jasmine flower extract: 0.1- 1.0%, chrysanthemum extract: 0.1-1.0%, Flos Mume extract: 0.1-1.0%, peony extract: 0.1-1.0%, grape pip Oil: 1.0-3.0%, purple common perilla seed: 0.1-1.0%, tocopherol: 0.1-0.5%.

3. the care agent according to claim 2 for skin moisture-keeping reparation, it is characterised in that: the safflower flower extracts Object, cape jasmine flower extract, chrysanthemum extract, Flos Mume extract, peony extract and purple common perilla seed are all made of alcohol extracting method Preparation, specially by dry plant be added to mass ratio be 95% ethyl alcohol in, carry out under reflux and impregnation extraction 10~ 15h is then filtered extracting solution with filter cloth, then be centrifugated and obtain plant extracts, the plant be safflower flower or Gardenia or chrysanthemum or plum blossom or tree peony or purple perilla seed.

4. the care agent according to claim 1 for skin moisture-keeping reparation, it is characterised in that: the maintenance element is nerve The mixing of amide 1, Cer NS, Cer NP and ceramide 4, additive amount are specially Cer EOS: 0.1-0.5%, Cer NS: 0.1-0.5%, Cer NP: 0.1-0.5%, ceramide 4:0.05-0.5%.

5. the care agent according to claim 1 for skin moisture-keeping reparation, it is characterised in that: the fullerene is to be modified Aqueous fullerene, the modified water-soluble fullerene the preparation method comprises the following steps: by aqueous fullerene, polyester polyol, concentrated hydrochloric acid and body The ethyl alcohol that product concentration is 80-95% is added in reaction kettle, and reaction 10-15 hours is carried out under 55-65 DEG C of Conditions Condition, has been reacted Quan Hou is added sodium bicarbonate, adjusts its pH value in 7-8, then take out material, which is exactly modified water-soluble fullerene.

6. the care agent according to claim 4 for skin moisture-keeping reparation, it is characterised in that: the aqueous fullerene, The mass ratio for the ethyl alcohol that polyester polyol, concentrated hydrochloric acid and volumetric concentration are 95% is 30:7:1:(4-7).

7. the care agent according to claim 1 for skin moisture-keeping reparation, it is characterised in that: the Gotu Kola P.E The general flavone of the % of weight containing 50-90.

8. the care agent according to claim 7 for skin moisture-keeping reparation, it is characterised in that: the Gotu Kola P.E General flavone containing 75.4 weight %.

9. a kind of prepare the method such as the described in any item care agents for skin moisture-keeping reparation of claim 1-8, feature It is, includes the following steps: 1) to weigh deionized water, EDETATE SODIUM, glycerol, propylene glycol, niacinamide, xanthan gum, hyaluronic acid Sodium, parahydroxyacet-ophenone are added in emulsion pot, and 30r/min speed is heated with stirring to 83-85 DEG C；2) caprylic/capric glycerol is weighed Three esters, dimethyl silicone polymer, isononyl isononanoate, jojoba seed oil, Butyrospermum parkii fruit fatty oil, maintenance essential oils, maintenance element, The smooth olive oleate of cetostearyl alcohol, cetostearyl alcohol olive oleate, sorb is added in emulsification oil cauldron, and 30r/min speed is stirred Mix and be heated to 78-83 DEG C, then the raw material for emulsifying oil cauldron is added in emulsion pot, 30r/min speed stirring, 3) it weighs lecithin and adds Enter in emulsion pot, homogeneous 5 minutes, is evacuated to -0.03MPa, after twenty minutes, the stirring of 30r/min speed begins to cool drop to constant temperature Temperature；4) 45 DEG C are cooled to be added in emulsion pot hereinafter, weighing oligopeptides -1, D-pantothenyl aleohol, Gotu Kola P.E, 1,2- hexylene glycol, 30r/min speed stirs 20 minutes, is evacuated to -0.05mpa, and PH is to controlling 4.5-6.5；5) it is stored in storage tank after the assay was approved In, it is canned after static 24 hours.