CN107349128A - A kind of sorbefacient facial mask - Google Patents
A kind of sorbefacient facial mask Download PDFInfo
- Publication number
- CN107349128A CN107349128A CN201710722874.1A CN201710722874A CN107349128A CN 107349128 A CN107349128 A CN 107349128A CN 201710722874 A CN201710722874 A CN 201710722874A CN 107349128 A CN107349128 A CN 107349128A
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- CN
- China
- Prior art keywords
- parts
- facial mask
- water
- sorbefacient
- parithenolide
- Prior art date
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- 230000001815 facial effect Effects 0.000 title claims abstract description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 240000008320 Veronica anagallis aquatica Species 0.000 claims abstract description 21
- 235000000758 Veronica anagallis aquatica Nutrition 0.000 claims abstract description 21
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 229930182432 Polygalasaponin Natural products 0.000 claims abstract description 18
- 235000011187 glycerol Nutrition 0.000 claims abstract description 14
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 7
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 7
- 239000011570 nicotinamide Substances 0.000 claims abstract description 7
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 6
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims abstract description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- 241000196324 Embryophyta Species 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 10
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 10
- 229920000193 polymethacrylate Polymers 0.000 claims description 8
- 241000208966 Polygala Species 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000003208 petroleum Substances 0.000 claims description 6
- 238000002137 ultrasound extraction Methods 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 5
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 5
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- 229960000458 allantoin Drugs 0.000 claims description 5
- 229960001631 carbomer Drugs 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 229940051250 hexylene glycol Drugs 0.000 claims description 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
- 229940101267 panthenol Drugs 0.000 claims description 5
- 235000020957 pantothenol Nutrition 0.000 claims description 5
- 239000011619 pantothenol Substances 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 230000007062 hydrolysis Effects 0.000 claims description 4
- 238000006460 hydrolysis reaction Methods 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 3
- 229920002498 Beta-glucan Polymers 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 229920000570 polyether Polymers 0.000 claims description 2
- VQPABOFQLUBEIQ-UHFFFAOYSA-N C(C)O.[O].C1=CC=CC=C1 Chemical compound C(C)O.[O].C1=CC=CC=C1 VQPABOFQLUBEIQ-UHFFFAOYSA-N 0.000 claims 2
- 241000221095 Simmondsia Species 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 238000010521 absorption reaction Methods 0.000 abstract description 14
- 239000003963 antioxidant agent Substances 0.000 abstract description 7
- 230000003078 antioxidant effect Effects 0.000 abstract description 7
- 238000007254 oxidation reaction Methods 0.000 abstract description 6
- 230000003647 oxidation Effects 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 235000006708 antioxidants Nutrition 0.000 abstract description 4
- 230000019522 cellular metabolic process Effects 0.000 abstract description 4
- 150000003254 radicals Chemical class 0.000 abstract description 4
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract description 3
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract description 3
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract description 3
- 102000004190 Enzymes Human genes 0.000 abstract description 3
- 108090000790 Enzymes Proteins 0.000 abstract description 3
- 235000008384 feverfew Nutrition 0.000 abstract description 3
- 230000001771 impaired effect Effects 0.000 abstract description 3
- 230000001603 reducing effect Effects 0.000 abstract description 3
- 230000003834 intracellular effect Effects 0.000 abstract description 2
- 230000005808 skin problem Effects 0.000 abstract description 2
- 230000002087 whitening effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 7
- 210000005075 mammary gland Anatomy 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000693 micelle Substances 0.000 description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 3
- 244000044822 Simmondsia californica Species 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 229960005323 phenoxyethanol Drugs 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N Butanol Natural products CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 235000007516 Chrysanthemum Nutrition 0.000 description 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 239000005456 alcohol based solvent Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000002242 deionisation method Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- OCZVHBZNPVABKX-UHFFFAOYSA-N 1,1-diphenyl-2-(2,4,6-trinitrophenyl)hydrazine;ethanol Chemical compound CCO.[O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NN(C=1C=CC=CC=1)C1=CC=CC=C1 OCZVHBZNPVABKX-UHFFFAOYSA-N 0.000 description 1
- 244000296912 Ageratum conyzoides Species 0.000 description 1
- 235000004405 Ageratum conyzoides Nutrition 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000016535 Capraria biflora Nutrition 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 102000034573 Channels Human genes 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 108010063907 Glutathione Reductase Proteins 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- -1 Propane diols Chemical class 0.000 description 1
- 241001128140 Reseda Species 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 241000196245 Ulva intestinalis Species 0.000 description 1
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- 230000003064 anti-oxidating effect Effects 0.000 description 1
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- 239000011203 carbon fibre reinforced carbon Chemical group 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N dimethylmethane Natural products CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000000852 hydrogen donor Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000008798 inflammatory stress Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000011506 response to oxidative stress Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical group 0.000 description 1
- RXHIKAIVEMAPRU-JRIGQVHBSA-N sequiterpene Natural products C1=C(C)[C@@H](OC(C)=O)[C@H](O)[C@@]2(O)[C@H](C)CC[C@@H](C(C)=C)[C@H]21 RXHIKAIVEMAPRU-JRIGQVHBSA-N 0.000 description 1
- 230000037067 skin hydration Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of sorbefacient facial mask, including the composition such as water speedwell cyanidenon, Japanese polygala saponin, parithenolide, propane diols, niacinamide, glycerine, glycosylglycerol, butanediol.Water speedwell cyanidenon in facial mask has strong reducing property, can reduce intracellular unnecessary free radical, recovers impaired activities of antioxidant enzymes, and repair the cell impaired because of oxidation；Japanese polygala saponin can reduce cell metabolism loss, strengthen the activity of polyphenoils, the reparation of further assisted oxidation damaged cell；Feverfew can effectively adjust cell metabolism, promote the absorption of other active components.Several composition synergies, have the function that anti-oxidant, promotion skin reparation and promote active ingredient to absorb；In addition, the facial mask of strong replenishing water and preserving moisture effect can significantly improve skin pattern, while skin whitening, the skin problems such as dark yellow, color spot are reduced.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of sorbefacient facial mask.
Background technology
Modern likes carrying out skin nursing using cosmetics, and moisturizing water lock is and thin so the premise of effect nursing
The number of born of the same parents' moisture, is related to the absorption of functional component.When skin absorbs large quantity of moisture, barrier function will decline, effectively into
Point just easily from corneocyte penetrate into.Because it is the outermost barrier for protecting our bodies that skin day, which is born, very
More materials are all not easy to be less readily available for absorption by the skin.The absorbability of skin is by the thickness of many skins, the integrality of skin, age, portion
The influence of the factors such as position, water content, the physicochemical property of material (whether being fat-soluble etc.), temperature, allow skin to drink sufficient water and be equal to increasing
Add the water content of skin, and the increase of water content can increase the absorption of material.The facial mask of quality better be can yet be regarded as excellent shield
Skin product, the package treatment of dept. of dermatology is equivalent to during face mask film, the evaporation of moisture of skin can be hindered, increase the aqueous of skin
Amount, so as to increase absorption of the skin to skin care item.Absorption of the facial mask to active component has facilitation.It closes local skin
Get up, increase skin hydration degree.Skin temperature rises simultaneously, is advantageous to molecular motion (infiltration), to a certain extent
Promote the absorption of active component.
But facial mask broad categories on the market, the excitant of the more skins of chemical solvent of many facial mask additions is big, or
Ethanol isoconcentration is excessive, is not only unable to skin care, on the contrary falls the original moisture absorption of skin；Or addition forbidden amphetamine, damage
Skin.
The content of the invention
Based on this, it is an object of the invention to provide a kind of sorbefacient facial mask, can effectively facilitate metabolism and face is micro-
Circulation, and promote the absorption of active ingredient.
In order to achieve the above object, the present invention provides following technical scheme：
A kind of sorbefacient facial mask includes following plant composition by weight：Water speedwell cyanidenon 1-10 parts,
Japanese polygala saponin 1-8 parts, parithenolide 1-8 parts.
Preferably, water speedwell cyanidenon 2-8 parts, Japanese polygala saponin 2-6 parts, parithenolide 2-6 parts.
Optimally, 5 parts of water speedwell cyanidenon, 3 parts of Japanese polygala saponin, 3 parts of parithenolide.
The preparation method of the water speedwell cyanidenon comprises the following steps：Dry water speedwell is crushed, crosses 40-60 mesh
Sieve, by solid-liquid ratio 1:10-20 adds petroleum ether, at 60-90 DEG C, is ultrasonically treated 30-60min, ultrasonic power 400-500W, frequency
Rate 300-400KHZ, filtering, discards filtrate, and residue after petroleum ether again with volatilizing；By solid-liquid ratio 1:10-20 adds methanol,
Ultrasonic extraction 30-60min, ultrasonic power 400-500W, frequency 300-400KHZ, filtering, concentrating filter liquor is collected, obtain water hardship
Mai cyanidenons.
The preparation method of the Japanese polygala saponin comprises the following steps：By Japanese polygala clean dry, 40-60 mesh crushed
Sieve, by solid-liquid ratio 1:10-20 adds 70-95% ethanol, refluxing extraction 2-3h at 70-90 DEG C, filtering, collects concentrating filter liquor,
Obtain Japanese polygala saponin.
The preparation method of the parithenolide comprises the following steps：By dry parithenolide, 40-60 mesh crushed
Sieve, by solid-liquid ratio 1:10-20 adds 100% methanol, after standing liquid, normal temperature ultrasonic extraction 15-30min, filtering, collects filtrate
It is concentrated, obtain parithenolide.
The facial mask also includes following component：Propane diols 5-15 parts, niacinamide 0.01-0.05 parts, glycerine 5-10 parts, glycerine
Polymethacrylates 0.1-0.5 parts, hydrolysis Jojoba esters 0.2-0.8 parts, glycosylglycerol 1-5 parts, butanediol 10-20
Part, beta glucan 1-5 parts, Sodium Hyaluronate 0.05-0.1 parts, panthenol 0.02-0.1 parts, allantoin 0.1-0.5 parts, hexylene glycol
0.1-1 parts, EDETATE SODIUM 0.1-0.5 parts, methyl hydroxybenzoate 0.02-0.1 parts, hydroxyethyl cellulose 0.1-0.5 parts, carbomer 0.1-
0.3 part, triethanolamine 0.1-0.3 parts, Phenoxyethanol 0.3-1 parts, Cremophor RH40/PPG-26- butylol polyethers -26/
Water 0.1-0.5 parts, deionized water are to 100 parts.
The present invention also provides a kind of preparation method of sorbefacient facial mask, comprises the following steps：
(1) propane diols, niacinamide, glycerine, glycerine polymethacrylates, glycosylglycerol, butanediol, β-Portugal are gathered
Sugar, Sodium Hyaluronate, panthenol, allantoin, hexylene glycol, EDETATE SODIUM, methyl hydroxybenzoate, hydroxyethyl cellulose, carbomer, deionization
Water, add in agitated kettle and be heated with stirring to 80-85 DEG C, stirring and dissolving is complete, and A phases are made；
(2) glycerine polymethacrylates, hydrolysis Jojoba esters, Cremophor RH40/PPG-26- butanol are gathered
The water of ether -26/ adds in agitated kettle and is heated with stirring to 80-85 DEG C, and B phases are made；
(3) under stirring, B is added to A phases, stirred；
(4) 45-55 DEG C is cooled to, triethanolamine is added, stirs, add above-mentioned plant composition, Phenoxyethanol, fill
Divide cooling discharging after stirring.
Following introduce is made to the plant component of the present invention：
Water speedwell is the drying herb of goatweed north water speedwell or water speedwell, contains abundant cyanidenon.Sweet-scented osmanthus
The effect of grass is plain is mainly manifested in occurs oxidation reaction own as reducing agent, strengthens the activity of organism antioxidant system,
The reason for this is that the material, which contains 2 hydroxyls, one carbonyl, carbon-carbon double bond, strong reducing property is embodied, hydrogen donor can be used as,
It is easy for that hydrogen atom can be provided to be used to reduce free radical.In addition, cyanidenon can also strengthen the work of intracellular antioxidase
Property, the activity for the superoxide dismutase and catalase being damaged can be recovered, while dimension A, Vc, the storage capacity for tieing up E are improved,
Improve oxidative damage, can also finally strengthen glutathione peroxidase and glutathione reductase activity, strengthen glutathione
Content so that improve oxidation resistance.
Japanese polygala is Polygalaceae polygala, or the herb or root of ovum leaf polygala.Main component is saponin(e in Japanese polygala
Class compound and flavonoid drugs, wherein Japanese polygala saponin can effectively reduce loss of the antioxidase in metabolic process, together
Shi Zengqiang activities of antioxidant enzymes, the removing of free radical can be accelerated and reduce the generation and accumulation of metabolite and peroxide, dropped
The inflammatory Cytokines Expression that lower metabolic production induces, and then the reaction protection cell region of interest that reduces inflammation.
Feverfew, alias button chrysanthemum is composite family, chrysanthemum purpose biennial herb flowers, perennial herb.Mainly contain sequiterpene
The compositions such as lactone, Yellow ketones, wherein parithenolide can be by controlling the activity of transcription factor and channel protein, and then adjust
The accretion rate of cell, sick cell growth can be suppressed, increase normal cell viability.Meanwhile parithenolide can various mediators
Expression quantity, control inflammation and response to oxidative stress degree, reduce the generation of inflammation and peroxidating.
Compared with prior art, it is the device have the advantages that as follows：(1) water speedwell reseda in facial mask of the invention
Element has strong reducing property, can reduce unnecessary free radical into the cell, recover impaired activities of antioxidant enzymes, and reparation because of oxidation and by
The cell of damage；Japanese polygala saponin can reduce cell metabolism loss, strengthen the activity of polyphenoils, further assisted oxidation by
Damage the reparation of cell；Feverfew can effectively adjust cell metabolism, promote the absorption of other active components.Several composition collaborations are made
With, have the function that it is anti-oxidant, promote skin reparation and promote active ingredient absorb；(2) facial mask of the invention contains niacinamide
And Sodium Hyaluronate, strong replenishing water and preserving moisture effect can significantly improve skin pattern, while skin whitening, reduce dark yellow, color spot etc.
Skin problem；(3) solvent that the present invention uses is mostly the composition that small molecule promotees infiltration, and active component can be made preferably to play its work(
Effect, reaches best skin effect；(4) facial mask composition of the invention safety, gently, and preparation technology is simple, there is very big city
Field prospect.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
1-5 of the embodiment of the present invention present invention promotes absorption face pack prescription to be shown in Table 1
Table 1
The preparation method of above-mentioned water speedwell cyanidenon comprises the following steps：
Dry water speedwell is crushed, 40 mesh sieves are crossed, by solid-liquid ratio 1:15 add petroleum ether, at 70 DEG C, are ultrasonically treated
50min, ultrasonic power 450W, frequency 350KHZ, filtering, discard filtrate, residue after petroleum ether again with volatilizing；By solid-liquid ratio
1:15 add methanol, ultrasonic extraction 60min, ultrasonic power 450W, frequency 350KHZ, filtering, collect concentrating filter liquor, obtain water
Gutweed cyanidenon.
The preparation method of above-mentioned Japanese polygala saponin comprises the following steps：
By Japanese polygala clean dry, 40 mesh sieves are crushed, by solid-liquid ratio 1:15 add 80% ethanol, refluxing extraction at 90 DEG C
2.5h, filtering, concentrating filter liquor is collected, obtains Japanese polygala saponin.
The preparation method of above-mentioned parithenolide comprises the following steps：
By dry parithenolide, 40 mesh sieves are crushed, by solid-liquid ratio 1:15 add 100% methanol, after standing liquid,
Normal temperature ultrasonic extraction 20min, filtering, concentrating filter liquor is collected, obtains parithenolide.
The preparation method of the sorbefacient facial masks of embodiment 1-5 comprises the following steps：
(1) propane diols, niacinamide, glycerine, glycerine polymethacrylates, glycosylglycerol, butanediol, β-Portugal are gathered
Sugar, Sodium Hyaluronate, panthenol, allantoin, hexylene glycol, EDETATE SODIUM, methyl hydroxybenzoate, hydroxyethyl cellulose, carbomer, deionization
Water, add in agitated kettle and be heated with stirring to 85 DEG C, stirring and dissolving is complete, and A phases are made；
(2) glycerine polymethacrylates, hydrolysis Jojoba esters, Cremophor RH40/PPG-26- butanol are gathered
The water of ether -26/ adds in agitated kettle and is heated with stirring to 85 DEG C, and B phases are made；
(3) under stirring, B is added to A phases, stirred；
(4) 50 DEG C are cooled to, triethanolamine is added, stirs, add above-mentioned plant composition, Phenoxyethanol, fully
Cooling discharging after stirring.
Comparative example 1
Difference with embodiment 1 is not add water speedwell cyanidenon, other preparation conditions and method and the phase of embodiment 1
Together.
Comparative example 2
Difference with embodiment 1 is not add Japanese polygala saponin, and other preparation conditions and method are same as Example 1.
Comparative example 3
Difference with embodiment 1 is not add parithenolide, and other preparation conditions and method are same as Example 1.
Comparative example 4
Difference with embodiment 1 is not add plant composition, and other preparation conditions and method are same as Example 1.
Anti-oxidant measure
Compound concentration is 1 × 10-4Mol/L DPPH ethanol solutions.It will be obtained in embodiment -5 and comparative example 1-4
Sorbefacient facial mask, with 80% ethanol be configured to concentration be respectively 0.01,0.04,0.08,0.10,0.12,0.16,
0.20th, 0.24,0.26 testing sample solution.5mL sample solutions and DPPH solution are taken respectively, and is well mixed, and lucifuge is put
30min is put, is returned to zero with 80% ethanol, absorbance A i is determined at 517BITI；Same method, 5mL80% alcohol solvents are taken respectively
It is mutually mixed uniformly with sample solution, absorbance A j is determined after avoid light place 30min；5mL80% alcohol solvents add 5mLDPPH
Solution mixes, avoid light place 30min, measure absorbance A c.Finally free radical scavenging activity is calculated according to below equation：IP%=[1
One (Ai-Aj)/Ac] × 100, Ai is sample and the absorption values after DPPH effects in formula；Aj is sample itself to extinction
The contribution of degree；Ac is DPPH itself absorption.
The ability measurement result that DPPH is removed to embodiment 1-5 and comparative example 1-4 facial mask is shown in Table 2
Table 2
As shown in Table 2, it is removed DPPH ability and increased with the increase of each extraction moiety concentrations.
Data above shows sorbefacient facial mask antioxidation activity made from embodiment 1-5 apparently higher than comparative example 1-4,
It can be seen that in facial mask of the present invention, water speedwell cyanidenon, Japanese polygala saponin and parithenolide Synergistic, effectively remove freely
Base.
Promote to absorb efficacy validation
Test specimen：The mixing of above-mentioned plant composition, small-micelle water, above-mentioned plant composition and small-micelle water
Liquid, deionized water
Experimental subjects：Female small white mouse
Experimental method：Four kinds of samples are divided into four groups, choose 10 female small white mouses respectively, carry out separating label, at every
15g samples are smeared at small white mouse mammary gland position daily, are smeared in three times, continuous to smear 15 days, observe each small white mouse mammary gland increase
Situation, it the results are shown in Table 3
Table 3
As known from Table 3, by 15 days Continuous Observations, the small white mouse mammary gland for smearing plant composition averagely increases 8.062%,
The small white mouse mammary gland for smearing small-micelle water averagely increases 10.184%, smears plant composition and subset water mixed liquid
Small white mouse mammary gland averagely increases 11.186%, and the small white mouse mammary gland for smearing deionized water averagely increases 2.039%, it is seen that small molecule
Group's water capacity is easily absorbed by the skin, and plant composition plays the role of to promote infiltration, and small-micelle water can be aided in transport nutriment, promotees
Enter the absorption of active ingredient.
Above example only illustrates embodiment of the present invention, does not have any formal limitation to the present invention；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes or modification using the technology contents disclosed, turns into equivalent
The equivalent embodiment of change, according to the technology of the present invention essence, simple modification, equivalent change and modification is carried out to the present invention, belonged to
In the range of technical solution of the present invention.
Claims (8)
1. a kind of sorbefacient facial mask, it is characterised in that the facial mask includes following plant composition by weight：
Water speedwell cyanidenon 1-10 parts, Japanese polygala saponin 1-8 parts, parithenolide 1-8 parts.
2. a kind of sorbefacient facial mask according to claim 1, it is characterised in that the facial mask includes by weight
Following plant composition：
Water speedwell cyanidenon 2-8 parts, Japanese polygala saponin 2-6 parts, parithenolide 2-6 parts.
3. a kind of sorbefacient facial mask according to claim 1, it is characterised in that the facial mask includes by weight
Following plant composition：
5 parts of water speedwell cyanidenon, 3 parts of Japanese polygala saponin, 3 parts of parithenolide.
A kind of 4. sorbefacient facial mask according to claim 1, it is characterised in that the system of the water speedwell cyanidenon
Preparation Method comprises the following steps：
Dry water speedwell is crushed, 40-60 mesh sieves are crossed, by solid-liquid ratio 1:10-20 adds petroleum ether, at 60-90 DEG C, ultrasound
30-60min, ultrasonic power 400-500W, frequency 300-400KHZ are handled, filtering, discards filtrate, residue uses petroleum ether again
After volatilize；By solid-liquid ratio 1:10-20 adds methanol, ultrasonic extraction 30-60min, ultrasonic power 400-500W, frequency 300-
400KHZ, filtering, concentrating filter liquor is collected, obtains water speedwell cyanidenon.
A kind of 5. sorbefacient facial mask according to claim 1, it is characterised in that the preparation side of the Japanese polygala saponin
Method comprises the following steps：
By Japanese polygala clean dry, 40-60 mesh sieves are crushed, by solid-liquid ratio 1:10-20 adds 70-95% ethanol, at 70-90 DEG C
Refluxing extraction 2-3h, filtering, concentrating filter liquor is collected, obtains Japanese polygala saponin.
A kind of 6. sorbefacient facial mask according to claim 1, it is characterised in that the preparation side of the parithenolide
Method comprises the following steps：
By dry parithenolide, 40-60 mesh sieves are crushed, by solid-liquid ratio 1:10-20 adds 100% methanol, stands liquid
Afterwards, normal temperature ultrasonic extraction 15-30min, filtering, concentrating filter liquor is collected, obtains parithenolide.
A kind of 7. sorbefacient facial mask according to claim 1, it is characterised in that the facial mask also include below into
Point：
Propane diols 5-15 parts, niacinamide 0.01-0.05 parts, glycerine 5-10 parts, glycerine polymethacrylates 0.1-0.5 parts, water
Solve Jojoba esters 0.2-0.8 parts, glycosylglycerol 1-5 parts, butanediol 10-20 parts, beta glucan 1-5 parts, Sodium Hyaluronate
0.05-0.1 parts, panthenol 0.02-0.1 parts, allantoin 0.1-0.5 parts, hexylene glycol 0.1-1 parts, EDETATE SODIUM 0.1-0.5 parts, hydroxyl
Benzene methyl 0.02-0.1 parts, hydroxyethyl cellulose 0.1-0.5 parts, carbomer 0.1-0.3 parts, triethanolamine 0.1-0.3 parts, benzene oxygen
Ethanol 0.3-1 parts, the water 0.1-0.5 parts of Cremophor RH40/PPG-26- butylol polyethers -26/, deionized water are to 100 parts.
8. a kind of preparation method of the sorbefacient facial mask as described in claim any one of 1-7, it is characterised in that including following
Step：
(1) by propane diols, niacinamide, glycerine, glycerine polymethacrylates, glycosylglycerol, butanediol, beta glucan, thoroughly
Bright matter acid sodium, panthenol, allantoin, hexylene glycol, EDETATE SODIUM, methyl hydroxybenzoate, hydroxyethyl cellulose, carbomer, deionized water, add
Enter to be heated with stirring to 80-85 DEG C in agitated kettle, stirring and dissolving is complete, and A phases are made；
(2) by glycerine polymethacrylates, hydrolysis Jojoba esters, Cremophor RH40/PPG-26- butylol polyethers-
26/ water adds in agitated kettle and is heated with stirring to 80-85 DEG C, and B phases are made；
(3) under stirring, B is added to A phases, stirred；
(4) it is cooled to 45-55 DEG C, adds triethanolamine, stir, adds plant composition as claimed in claim 1, benzene oxygen
Ethanol, stir rear cooling discharging.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110101652A (en) * | 2019-06-14 | 2019-08-09 | 芳香世家化妆品(广州)有限公司 | A kind of maintenance essence dew |
| CN110192985A (en) * | 2019-06-26 | 2019-09-03 | 广州市百爱神生物科技有限公司 | A kind of care agent and preparation method thereof for skin moisture-keeping reparation |
| CN110642867A (en) * | 2019-06-21 | 2020-01-03 | 上海澄穆生物科技有限公司 | 8-ethylenimine-parthenolide hydrochloride and preparation method and application thereof |
| CN111658554A (en) * | 2019-11-19 | 2020-09-15 | 深圳市婵小君化妆品有限公司 | Cosmetic based on small molecular group water and preparation method thereof |
| CN114569480A (en) * | 2022-02-25 | 2022-06-03 | 上海澄穆生物科技有限公司 | Application of luteolin and pharmaceutically acceptable salt thereof as dopamine receptor agonist in cosmetics |
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2017
- 2017-08-21 CN CN201710722874.1A patent/CN107349128A/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101652A (en) * | 2019-06-14 | 2019-08-09 | 芳香世家化妆品(广州)有限公司 | A kind of maintenance essence dew |
| CN110642867A (en) * | 2019-06-21 | 2020-01-03 | 上海澄穆生物科技有限公司 | 8-ethylenimine-parthenolide hydrochloride and preparation method and application thereof |
| CN110642867B (en) * | 2019-06-21 | 2020-07-21 | 上海澄穆生物科技有限公司 | 8-ethylenimine-parthenolide hydrochloride and preparation method and application thereof |
| CN110192985A (en) * | 2019-06-26 | 2019-09-03 | 广州市百爱神生物科技有限公司 | A kind of care agent and preparation method thereof for skin moisture-keeping reparation |
| CN111658554A (en) * | 2019-11-19 | 2020-09-15 | 深圳市婵小君化妆品有限公司 | Cosmetic based on small molecular group water and preparation method thereof |
| CN114569480A (en) * | 2022-02-25 | 2022-06-03 | 上海澄穆生物科技有限公司 | Application of luteolin and pharmaceutically acceptable salt thereof as dopamine receptor agonist in cosmetics |
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