CN112089654A - Acne-removing composition and application thereof - Google Patents
Acne-removing composition and application thereof Download PDFInfo
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- CN112089654A CN112089654A CN202010913348.5A CN202010913348A CN112089654A CN 112089654 A CN112089654 A CN 112089654A CN 202010913348 A CN202010913348 A CN 202010913348A CN 112089654 A CN112089654 A CN 112089654A
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- extract
- cosmetic
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- acne
- inflammatory
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- 206010000496 acne Diseases 0.000 title claims abstract description 83
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- 239000000284 extract Substances 0.000 claims abstract description 42
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- SHOKSIZSCQFIRY-UHFFFAOYSA-N [3-(2-tert-butyl-2-hydroxy-4,4-dimethyl-3-phenylpentanoyl)oxy-2,2-bis[(2-tert-butyl-2-hydroxy-4,4-dimethyl-3-phenylpentanoyl)oxymethyl]propyl] 2-tert-butyl-2-hydroxy-4,4-dimethyl-3-phenylpentanoate Chemical compound C=1C=CC=CC=1C(C(C)(C)C)C(O)(C(C)(C)C)C(=O)OCC(COC(=O)C(O)(C(C=1C=CC=CC=1)C(C)(C)C)C(C)(C)C)(COC(=O)C(O)(C(C=1C=CC=CC=1)C(C)(C)C)C(C)(C)C)COC(=O)C(O)(C(C)(C)C)C(C(C)(C)C)C1=CC=CC=C1 SHOKSIZSCQFIRY-UHFFFAOYSA-N 0.000 claims abstract description 10
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- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 claims description 4
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- DBGSRZSKGVSXRK-UHFFFAOYSA-N 1-[2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]acetyl]-3,6-dihydro-2H-pyridine-4-carboxylic acid Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CCC(=CC1)C(=O)O DBGSRZSKGVSXRK-UHFFFAOYSA-N 0.000 description 1
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an acne-removing composition and application thereof, belonging to the technical field of cosmetics. The anti-acne composition comprises 0.5-3 parts of anti-inflammatory soothing agent, 0.5-5 parts of anti-inflammatory antibacterial agent and 0.5-5 parts of copaiba resin, wherein the anti-inflammatory soothing agent comprises salvia miltiorrhiza extract, clove bud extract, astragalus membranaceus root extract, pyracantha fortuneana fruit extract, hollyhock extract, licorice root extract, caprylic/capric triglyceride and lecithin, the anti-inflammatory antibacterial agent comprises caprylic/capric triglyceride, sunflower seed oil, safflower extract, gardenia extract, chrysanthemum extract, plum blossom extract and pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), and the anti-inflammatory soothing agent, the anti-inflammatory antibacterial agent and the copaiba resin have synergistic effect on acne removal, and can be used for preventing and treating various types of acnes. The cosmetic prepared from the acne-removing composition has multiple-effect functions, good acne-removing effect, pure nature and easy absorption, and is prepared into a stick shape so as to be convenient to carry.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an acne-removing composition and application thereof.
Background
Acne, also known as acne in medicine, is associated with secretion of hormone levels, keratinocyte metabolism, hypersecretion of sebaceous glands, infection by propionibacterium acnes. The effective concentration of the acne-removing medicines in the market at present is not high, so that the acne-removing effect is poor, the acne-removing components comprise chemical compositions, preservatives can be added, side effects such as skin allergy and the like exist, the side effects are not easily absorbed, and bottled or canned acne-removing agents are inconvenient to carry, so that the novel acne-removing composition which is good in acne-removing effect, safe, easy to absorb and convenient to carry is necessary.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides the acne-removing composition which is pure natural, easy to absorb and good in acne-removing effect and the application thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
in a first aspect, the invention provides an acne-removing composition, which comprises the following components in parts by weight: 0.5-3 parts of anti-inflammatory soothing agent, 0.5-5 parts of anti-inflammatory antibacterial agent and 0.5-5 parts of copaiba resin, wherein the anti-inflammatory soothing agent comprises salvia miltiorrhiza extract, clove bud extract, astragalus membranaceus root extract, pyracantha fortuneana fruit extract, marshmallow extract, licorice root extract, caprylic/capric triglyceride and lecithin, and the anti-inflammatory antibacterial agent comprises caprylic/capric triglyceride, sunflower seed oil, safflower extract, gardenia extract, chrysanthemum extract, plum blossom extract and pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate).
The anti-inflammatory soothing agent takes the formulation idea of 'monarch, minister, assistant and guide' in traditional Chinese medicine as guidance, is based on the principle of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis and dredging channels and collaterals, and takes salvia miltiorrhiza as a monarch to avoid excessive vigorous sebaceous glands; clove is used as a minister and has the function of controlling local infection; the pyracantha fortuneana fruit and the marshmallow are used as assistants, and have the effects of promoting blood circulation and stopping bleeding; the liquorice and the astragalus root are used for coordinating the functions of the medicaments, can repair damaged skin, are added with caprylic/capric triglyceride to promote the penetration of functional components and give full play to the functions of the functional components, and are added with lecithin to ensure the regeneration activity of the skin.
According to the concept of 'holism and syndrome differentiation' of the traditional Chinese medicine and the formula principle of 'monarch, minister, assistant and messenger', the anti-inflammatory antibacterial agent is prepared from safflower, gardenia, Hangzhou white chrysanthemum and flos Pruni mume to enhance the function of an active epidermal layer, accelerate the skin barrier repair and prevent the skin from being invaded by the outside, so that the skin is protected, wherein the safflower can remove blood stasis without hurting yin, promote qi circulation and improve the local skin qi and blood circulation; the gardenia has the effects of clearing heat and cooling blood without stasis, can promote skin injury repair, and is used together with the safflower to clear heat and remove stasis without damaging yin; the chrysanthemum morifolium ramat has the functions of promoting the production of body fluid and nourishing yin, is matched with monarch and ministerial medicines to treat complications, and has the functions of dispelling wind and dissipating heat without hurting yang; the flos Pruni mume has effects of moistening skin, promoting skin injury repair, and cooling and moistening without greasiness, and does not obstruct local qi and blood circulation. The anti-inflammatory antibacterial agent has the effects of enhancing the vitality of the active epidermal layer and accelerating the skin barrier repair, so that the skin is not affected by external invasion, and the skin is protected. Meanwhile, the added sunflower seed oil has the anti-inflammatory effect of promoting the healing of skin wounds; pentaerythritol tetra (di-tert-butylhydroxyhydrocinnamate) has antioxidant effect, and can prevent pigmentation caused by acne.
The copaiba balsam resin has the effects of regenerating and healing skin, diminishing inflammation, moisturizing, expelling toxin, nourishing and lubricating skin.
The combination of the specific anti-inflammatory soothing agent and the anti-inflammatory antibacterial agent with the copaiba balsam resin can effectively prevent and treat different types of acnes, endow the skin with new vitality and vitality, simultaneously have a synergistic effect on acne removal, and have better acne removal effect than the combination of only one or two of the anti-inflammatory soothing agent, the anti-inflammatory antibacterial agent and the copaiba balsam resin.
Preferably, in the acne-removing composition, the anti-inflammatory soothing agent accounts for 2.6 parts by weight, the anti-inflammatory antibacterial agent accounts for 4.5 parts by weight, and the copaiba resin accounts for 4.5 parts by weight. When the acne-removing composition contains 2.6 parts by weight of the anti-inflammatory soothing agent, 4.5 parts by weight of the anti-inflammatory antibacterial agent and 4.5 parts by weight of copaiba resin, the acne-removing effect is very remarkable.
Preferably, the anti-inflammatory soothing agent comprises the following components in percentage by weight: 12-16% of salvia miltiorrhiza extract, 4-8% of clove bud extract, 2-6% of astragalus membranaceus root extract, 2-6% of pyracantha fortuneana fruit extract, 2-6% of hollyhock extract, 2-6% of licorice root extract, 47-75.5% of caprylic/capric triglyceride and 0.5-5% of lecithin; the anti-inflammatory antibacterial agent comprises the following components in percentage by weight: 65-75% of caprylic/capric triglyceride, 8-20% of sunflower seed oil, 4-8% of safflower extract, 2-6% of gardenia extract, 2-6% of chrysanthemum extract, 2-6% of plum blossom extract and 0.05-0.2% of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate).
In a second aspect, the invention provides a cosmetic for removing acnes, which contains the acne-removing composition, wherein the anti-inflammatory soothing agent accounts for 0.5-3% of the weight of the cosmetic, the anti-inflammatory antibacterial agent accounts for 0.5-5% of the weight of the cosmetic, and the copaia resin accounts for 0.5-5% of the weight of the cosmetic.
Preferably, the anti-inflammatory soothing agent comprises 2.6% by weight of the cosmetic, the anti-inflammatory antibacterial agent comprises 4.5% by weight of the cosmetic, and the copaiba resin comprises 4.5% by weight of the cosmetic.
When the cosmetic contains 0.5-3 wt% of the anti-inflammatory soothing agent, 0.5-5 wt% of the anti-inflammatory antibacterial agent and 0.5-5 wt%, the cosmetic has a very good acne removing effect, and particularly when the cosmetic contains 2.6 wt% of the anti-inflammatory soothing agent, 4.5 wt% of the anti-inflammatory antibacterial agent and 4.5 wt%, the cosmetic has a better acne removing effect.
Preferably, the cosmetic is in the form of a stick. The cosmetic is in stick form and is convenient for carrying and application.
Preferably, the cosmetic also comprises the following components in percentage by weight: 9-55% of thickening agent, 13-89.4% of emollient and 0.1-1% of antioxidant. Preferably, the cosmetic comprises a thickener comprising, in weight percent: 2-15% of polyethylene, 2-15% of synthetic wax, 1-10% of microcrystalline wax and 4-15% of beeswax; the cosmetic comprises the following emollients in percentage by weight: 2-30% of glycerol tri (ethyl hexanoate), 2-30% of octyl dodecanol, 2-20% of jojoba seed oil, 2-15% of white chinlon oil, 2-15% of castor bean oil, 2-15% of low erucic acid rapeseed oil and 1-10% of C10-30 acid cholesterol/lanosterol mixed ester; the cosmetic comprises the following antioxidants in percentage by weight: 0.1-1% of vitamin E.
Preferably, the cosmetic comprises the following thickeners in percentage by weight: 5% of polyethylene, 6% of synthetic wax, 3% of microcrystalline wax and 8% of beeswax; the cosmetic comprises the following emollients in percentage by weight: 17% of glycerol tri (ethyl hexanoate), 14% of octyl dodecanol, 13% of jojoba seed oil, 9% of white chinlon oil, 5% of castor seed oil, 5% of canola oil and 3% of C10-30 acid cholesterol/lanosterol mixed ester; the cosmetic comprises the following antioxidants in percentage by weight: 0.4 percent of vitamin E.
In a third aspect, the present invention provides a method for preparing the above cosmetic, which comprises the steps of:
(1) heating the thickening agent to 87-92 ℃ until the thickening agent is completely melted;
(2) completely melting the thickening agent, cooling to 78-82 ℃, adding the emollient, melting and uniformly stirring to obtain a thickening agent and emollient mixed reagent;
(3) completely melting the mixed reagent of the thickening agent and the emollient obtained in the step (2), cooling to 68-72 ℃, and adding the anti-inflammatory soothing agent, the anti-inflammatory antibacterial agent, the copaiba resin and the antioxidant to obtain a mixed material;
(4) and (4) cooling to 60-65 ℃ after the mixture obtained in the step (3) is completely melted and uniformly mixed, filtering, taking out of the pot to obtain the cosmetic, and sealing and storing.
Preferably, the heating temperature of the step (1) is 90 ℃.
Preferably, in the step (2), the temperature is reduced to 80 ℃.
Preferably, in the step (3), the temperature is reduced to 70 ℃.
Preferably, in the step (4), the temperature is reduced to 65 ℃.
Compared with the prior art, the invention has the beneficial effects that:
(1) the acne-removing ingredients are guided by the formulation idea of 'monarch, minister, assistant and guide' in the theory of traditional Chinese medicine, have no side effect, are pure plant ingredients, are natural and safe, and are more beneficial to skin absorption;
(2) the acne-removing composition disclosed by the invention has multiple-effect functions and a good acne-removing effect, and can be used for preventing and treating various types of acnes.
(3) The cosmetic for removing the acne contains an effective dose of acne removing components, can effectively remove the acne, is preferably prepared into a full-oil system, does not need to be added with a preservative, and has good adaptability with acne removing raw materials.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific embodiments.
Example 1
This example is an example of an anti-acne composition of the present invention. The acne removing composition comprises the following components in parts by weight: 0.5 part of anti-inflammatory soothing agent, 0.5 part of anti-inflammatory antibacterial agent and 0.5 part of copaiba resin, wherein the anti-inflammatory soothing agent comprises the following components in percentage by weight: 12% of salvia miltiorrhiza extract, 4% of clove bud extract, 2% of astragalus membranaceus root extract, 2% of pyracantha fortuneana fruit extract, 2% of marshmallow extract, 2% of licorice root extract, 75.5% of caprylic/capric triglyceride and 0.5% of lecithin; the anti-inflammatory antibacterial agent comprises the following components in percentage by weight: caprylic/capric triglyceride 75%, sunflower seed oil 14.95%, safflower extract 4%, gardenia extract 2%, chrysanthemum extract 2%, plum blossom extract 2%, pentaerythritol tetrakis (bis-tert-butyl hydroxyhydrocinnamate) 0.05%.
Example 2
This example is an example of an anti-acne composition of the present invention. The acne removing composition comprises the following components in parts by weight: 0.5 part of anti-inflammatory soothing agent, 0.5 part of anti-inflammatory antibacterial agent and 5 parts of copaiba resin, wherein the composition of the anti-inflammatory soothing agent is the same as that of example 1, and the anti-inflammatory antibacterial agent comprises the following components in percentage by weight: 69.9% caprylic/capric triglyceride, 20% sunflower seed oil, 4% safflower extract, 2% gardenia extract, 2% chrysanthemum extract, 2% plum blossom extract and 0.1% pentaerythritol tetrakis (bis-tert-butyl hydroxyhydrocinnamate).
Example 3
This example is an example of an anti-acne composition of the present invention. The acne removing composition comprises the following components in parts by weight: 2.6 parts of anti-inflammatory soothing agent, 4.5 parts of anti-inflammatory antibacterial agent and 4.5 parts of copaiba resin, wherein the anti-inflammatory soothing agent comprises the following components in percentage by weight: 14% of salvia miltiorrhiza extract, 6% of clove bud extract, 4% of astragalus membranaceus root extract, 4% of pyracantha fortuneana fruit extract, 4% of marshmallow extract, 4% of licorice root extract, 61% of caprylic/capric triglyceride and 3% of lecithin; the anti-inflammatory antibacterial agent comprises the following components in percentage by weight: 67.9% caprylic/capric triglyceride, 14% sunflower seed oil, 6% safflower extract, 4% gardenia extract, 4% chrysanthemum extract, 4% plum blossom extract and 0.1% pentaerythritol tetrakis (bis-tert-butyl hydroxyhydrocinnamate).
Example 4
This example is an example of an anti-acne composition of the present invention. The acne removing composition comprises the following components in parts by weight: 3 parts of anti-inflammatory soothing agent, 5 parts of anti-inflammatory antibacterial agent and 5 parts of copaiba resin, wherein the anti-inflammatory soothing agent comprises the following components in percentage by weight: 16% of salvia extract, 8% of clove bud extract, 6% of astragalus membranaceus root extract, 6% of pyracantha fortuneana fruit extract, 6% of marshmallow extract, 6% of licorice root extract, 47% of caprylic/capric triglyceride and 5% of lecithin; the anti-inflammatory antibacterial agent comprises the following components in percentage by weight: caprylic/capric triglyceride 65.8%, sunflower seed oil 8%, safflower extract 8%, gardenia extract 6%, chrysanthemum extract 6%, plum blossom extract 6%, pentaerythritol tetrakis (bis-tert-butyl hydroxyhydrocinnamate) 0.2%.
Example 5
This example is an example of the cosmetic for removing acne according to the present invention. The cosmetic for removing acne in the embodiment is in a stick shape and mainly prepared from the acne-removing composition in the embodiment 1, and the specific composition is shown in table 1.
Example 6
This example is an example of the cosmetic for removing acne according to the present invention. The cosmetic for removing acne in the embodiment is in a stick shape and mainly prepared from the acne-removing composition in the embodiment 2, and the specific composition is shown in table 1.
Example 7
This example is an example of the cosmetic for removing acne according to the present invention. The cosmetic for removing acne in the embodiment is in a stick shape and mainly prepared from the acne-removing composition in the embodiment 3, and the specific composition is shown in table 1.
Example 8
This example is an example of the cosmetic for removing acne according to the present invention. The cosmetic for removing acne in the embodiment is in a stick shape and mainly prepared from the acne-removing composition in the embodiment 4, and the specific composition is shown in table 1.
TABLE 1 compositions/wt.% of cosmetics of examples 5 to 8 and comparative examples 1 to 3%
The preparation method of the cosmetics of examples 5 to 8 includes the steps of:
(1) heating the thickening agent to 87-92 ℃ until the thickening agent is completely melted;
(2) completely melting the thickening agent, cooling to 78-82 ℃, adding the emollient, melting and uniformly stirring to obtain a thickening agent and emollient mixed reagent;
(3) completely melting the mixed reagent of the thickening agent and the emollient obtained in the step (2), cooling to 68-72 ℃, and adding the anti-inflammatory soothing agent, the anti-inflammatory antibacterial agent, the copaiba resin and the antioxidant to obtain a mixed material;
(4) and (4) cooling to 60-65 ℃ after the mixture obtained in the step (3) is completely melted and uniformly mixed, filtering, taking out of the pot to obtain an acne removing stick, and sealing and storing the acne removing stick to obtain the cosmetic.
Comparative examples 1 to 3
Comparative examples 1 to 3 each provide a cosmetic for removing acne. The compositions of these cosmetics are shown in Table 1, and the kinds of the components are the same as in example 7 (the anti-inflammatory soothing agent and the anti-inflammatory antibacterial agent used are the same as in example 7), and the preparation method is also the same as in example 7.
Effect example 1
The cosmetics of examples 5 to 8 were tested according to the test methods in Table 2, and the test results are shown in tables 3 and 4.
TABLE 2 detection methods
Table 3 heavy metal test results
TABLE 4 detection results of microorganisms
| Detecting items | Detecting the index | The result of the detection |
| Total number of colonies | ≤500CFU/g | The acne removing sticks of examples 5 to 8 are all qualified |
| Staphylococcus aureus | ≤100CFU/g | The acne removing sticks of examples 5 to 8 are all qualified |
| Total number of mold and yeast | No detectable value/g | The acne removing sticks of examples 5 to 8 are all qualified |
| Fecal coliform group | No detectable value/g | The acne removing sticks of examples 5 to 8 are all qualified |
| Pseudomonas aeruginosa | No detectable value/g | The acne removing sticks of examples 5 to 8 are all qualified |
Effect example 2
The cosmetics of examples 5 to 8 were subjected to safety tests by the following specific methods:
number of test population: 100, women, between ages 20-50, were divided on average into 4 groups, each group having an average age of 28 ± 3 years, and each group used the same sample.
Health condition: the skin of the subject is healthy, has no skin allergy history, and meets the voluntary selection standard of the subject.
The implementation method comprises the following steps: a spot sticking method comprises the steps of selecting a qualified spot tester, smearing about 0.02g-0.028g of a tested substance in the spot tester in a closed spot sticking test mode, sticking an external special adhesive tape on the back of a tested person, removing the tested substance after 24 hours, observing skin reactions after 0.5 hour, 6 hours, 12 hours, 24 hours and 48 hours after removal, and recording results according to skin reaction grading standards in cosmetic hygiene standards.
And (3) test results: the adverse reactions of the skin of each group were 0 cases at 0.5, 6, 12, 24 and 48 hours after the removal of the test substances, which indicates that the acne removing composition and the acne removing bar of the invention are safe to use and have no irritation.
Effect example 3
The cosmetics of examples 5-8 were subjected to the stability test as follows:
(1) non-cyclic stability test
Test samples: 20 cosmetics of examples 5 to 8 each
And (3) testing period: for 12 weeks
And (3) testing temperature: 50 ℃, 45 ℃, 5 ℃, 18 DEG C
The test method comprises the following steps: the cosmetics of examples 5 to 8 were put into a lipstick package, labeled to indicate information such as product name, formulation number, test conditions, test temperature, etc., and placed in a constant temperature biochemical incubator at 50 ℃, 45 ℃, 5 ℃, to-18 ℃ to test the heat and cold resistance stability of the product, after 24 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 8 weeks, and 12 weeks, respectively, the sample was returned to room temperature, and the presence or absence of undesirable phenomena such as sweating, oil, odor, and the presence or absence of tilt, discoloration, pigment precipitation, whitening, cracking of the contents was observed, and the change in each time period was recorded in a report.
(2)50 ℃ and-18 ℃ Cyclic stability test
Test samples: 20 cosmetics of examples 5 to 8 each
And (3) testing period: for 12 weeks
And (3) testing time: three consecutive cycles of the test (first 24 hours in a constant temperature biochemical incubator at 50 ℃, 24 hours at room temperature, then 24 hours in a constant temperature biochemical incubator at-18 ℃, then returning to room temperature as one cycle and observing the results)
The test method comprises the following steps: the contents of the cosmetics of examples 5 to 8 were put into a lipstick package, labeled with information indicating the product name, formulation number, test conditions, test temperature, etc., and placed in a constant temperature biochemical incubator at 50 ℃ for 24 hours, returned to room temperature for 24 hours, then placed in a constant temperature biochemical incubator at-18 ℃ for 24 hours, and then returned to room temperature. The product was observed for sweating, oil, odor, and the presence of the content in the product under the conditions of alternating heat and cold resistance cycles, and for the adverse phenomena of discoloration, pigment precipitation, whitening, cracking, etc., and the results were recorded in the report.
After the cosmetics of examples 5-8 are subjected to the above tests of non-cyclic and cyclic stability, no abnormality is found, which indicates that the cosmetics have good heat resistance, cold resistance and cold and hot cyclic stability and completely meet the relevant regulatory requirements.
Effect example 4
The cosmetics of examples 5 to 8 and comparative examples 1 to 3 were tested for acne removal efficacy as follows:
(1) propionibacterium acnes bacteriostasis test
The test method comprises the following steps: preparing double-layer plate (the lower layer is 10-15 mL of culture medium, the upper layer is 5mL of culture medium containing propionibacterium acnes) containing propionibacterium acnes (ATCC11827), and the bacterial content of the plate is 104～105CFU/plate; after the plate is cooled, 0.5g of the acne-removing cosmetic samples in the examples 5-8 or the comparative examples 1-3 are accurately weighed respectively, the acne-removing cosmetic samples are uniformly smeared on the bacterium-containing plate by using a sterile cotton swab, the bacterium-containing plate is cultured for 24 hours under the anaerobic condition of 36 +/-1 ℃, then the growth condition of the bacterial colony in the plate is observed, and the area covered by the growth area of the bacterial colony in the plate is recorded.
Evaluation criteria: when the area covered by the colony growing area in the plate is more than 75 percent, the plate is proved to have no acne-removing effect; when the area covered by the colony growing area in the plate is within 50-75%, the plate is proved to have lower acne-removing efficacy; when the area covered by the colony growing area in the plate is within 25-50%, the plate is proved to have moderate acne-removing efficacy; when the colony growing area in the plate covers less than 25 percent of the area, the plate is proved to have high-efficiency acne removing effect. The tests are shown in table 5 for results:
TABLE 5 bacteriostatic efficacy test results of anti-acne cosmetics in examples 5-8 and comparative examples 1-3
As can be seen from Table 5, the anti-acne cosmetics of examples 5-8 all had inhibitory effects on Propionibacterium acnes (ATCC11827), with the examples having the same inhibitory effect and the best effect, and also indicating that example 7 is the most optimal formulation.
(2) Clinical test for acne removal efficacy
The test population: face with acne, age 18-28 years old
Number of human subjects: 40 women and 40 men, and 20 persons in each group
Trial parts: face, especially the region with acne
The effect testing method comprises the following steps: the acne-removing cosmetics of examples 5-8 were applied to the acne-growing part of the patients 2 times a day, and the skin repairing effect was measured after 30 days of maintenance, and the results are shown in Table 6.
Table 6 clinical test results for acne removal efficacy
| Effect | Invalidation | Slight effect | Obvious effect | Complete recovery |
| Example 5 | 16 | 4 | 0 | 0 |
| Example 6 | 15 | 5 | 0 | 0 |
| Example 7 | 0 | 1 | 10 | 9 |
| Example 8 | 0 | 2 | 10 | 8 |
The experimental results are as follows: example 7 is the formulation in which the acne treatment was best, and is also optimal.
In conclusion, the acne removing composition disclosed by the invention is safe to a human body and has a very good acne removing effect; the acne removing stick prepared from the acne removing composition disclosed by the invention is safe and stable, and can effectively remove acnes.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The acne-removing composition is characterized by comprising the following components in parts by weight: 0.5-3 parts of anti-inflammatory soothing agent, 0.5-5 parts of anti-inflammatory antibacterial agent and 0.5-5 parts of copaiba resin, wherein the anti-inflammatory soothing agent comprises salvia miltiorrhiza extract, clove bud extract, astragalus membranaceus root extract, pyracantha fortuneana fruit extract, marshmallow extract, licorice root extract, caprylic/capric triglyceride and lecithin, and the anti-inflammatory antibacterial agent comprises caprylic/capric triglyceride, sunflower seed oil, safflower extract, gardenia extract, chrysanthemum extract, plum blossom extract and pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate).
2. The acne treatment composition according to claim 1, wherein the anti-inflammatory soothing agent is 2.6 parts by weight, the anti-inflammatory antibacterial agent is 4.5 parts by weight, and the copaiba resin is 4.5 parts by weight.
3. The acne-removing composition according to claim 1 or 2, wherein the anti-inflammatory soothing agent comprises the following components in percentage by weight: 12-16% of salvia miltiorrhiza extract, 4-8% of clove bud extract, 2-6% of astragalus membranaceus root extract, 2-6% of pyracantha fortuneana fruit extract, 2-6% of hollyhock extract, 2-6% of licorice root extract, 47-75.5% of caprylic/capric triglyceride and 0.5-5% of lecithin; the anti-inflammatory antibacterial agent comprises the following components in percentage by weight: 65-75% of caprylic/capric triglyceride, 8-20% of sunflower seed oil, 4-8% of safflower extract, 2-6% of gardenia extract, 2-6% of chrysanthemum extract, 2-6% of plum blossom extract and 0.05-0.2% of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate).
4. A cosmetic for removing acne, comprising the composition for removing acne according to any one of claims 1 to 3, wherein the anti-inflammatory soothing agent is 0.5 to 3% by weight of the cosmetic, the anti-inflammatory antibacterial agent is 0.5 to 5% by weight of the cosmetic, and the copaiba resin is 0.5 to 5% by weight of the cosmetic.
5. The cosmetic of claim 4, wherein said anti-inflammatory soothing agent comprises 2.6% by weight of said cosmetic, said anti-inflammatory anti-bacterial agent comprises 4.5% by weight of said cosmetic, and said copaiba resin comprises 4.5% by weight of said cosmetic.
6. The cosmetic according to claim 4 or 5, wherein the cosmetic is in the form of a stick.
7. The cosmetic according to claim 6, further comprising the following components in weight percent: 9-55% of thickening agent, 13-89.4% of emollient and 0.1-1% of antioxidant.
8. The cosmetic according to claim 7, characterized in that it comprises the following thickeners in percentage by weight: 2-15% of polyethylene, 2-15% of synthetic wax, 1-10% of microcrystalline wax and 4-15% of beeswax; the cosmetic comprises the following emollients in percentage by weight: 2-30% of glycerol tri (ethyl hexanoate), 2-30% of octyl dodecanol, 2-20% of jojoba seed oil, 2-15% of white chinlon oil, 2-15% of castor bean oil, 2-15% of low erucic acid rapeseed oil and 1-10% of C10-30 acid cholesterol/lanosterol mixed ester; the cosmetic comprises the following antioxidants in percentage by weight: 0.1-1% of vitamin E.
9. The cosmetic according to claim 8, characterized in that it comprises a thickener comprising, in percentages by weight: 5% of polyethylene, 6% of synthetic wax, 3% of microcrystalline wax and 8% of beeswax; the cosmetic comprises the following emollients in percentage by weight: 17% of glycerol tri (ethyl hexanoate), 14% of octyl dodecanol, 13% of jojoba seed oil, 9% of white chinlon oil, 5% of castor seed oil, 5% of canola oil and 3% of C10-30 acid cholesterol/lanosterol mixed ester; the cosmetic comprises the following antioxidants in percentage by weight: 0.4 percent of vitamin E.
10. A method for preparing a cosmetic product according to any one of claims 4 to 9, comprising the steps of:
(1) heating the thickening agent to 87-92 ℃ until the thickening agent is completely melted;
(2) completely melting the thickening agent, cooling to 78-82 ℃, adding the emollient, melting and uniformly stirring to obtain a thickening agent and emollient mixed reagent;
(3) completely melting the mixed reagent of the thickening agent and the emollient obtained in the step (2), cooling to 68-72 ℃, and adding the anti-inflammatory soothing agent, the anti-inflammatory antibacterial agent, the copaiba resin and the antioxidant to obtain a mixed material;
(4) and (4) cooling to 60-65 ℃ after the mixture obtained in the step (3) is completely melted and uniformly mixed, filtering, taking out of the pot to obtain the cosmetic, and sealing and storing.
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