CN109481322A

CN109481322A - A kind of fullerene essence milk

Info

Publication number: CN109481322A
Application number: CN201811180210.8A
Authority: CN
Inventors: 刘建新; 张洪莲
Original assignee: Guangzhou Renault Biotechnology Co ltd
Current assignee: Guangzhou Renault Biotechnology Co ltd
Priority date: 2018-10-10
Filing date: 2018-10-10
Publication date: 2019-03-19

Abstract

The invention discloses fullerene essence milk, which comprises the following raw materials: water, fullerene, glyceryl stearate/PEG-100 stearate, isopropyl palmitate, caprylic/capric triglyceride, isohexadecane, glycerol, propylene glycol, betaine, tara gum, 1, 2-hexanediol, PEG-20 methyl glucose sesquistearate, cetostearyl alcohol, polydimethylsiloxane, methyl glucose sesquistearate, glyceryl polyether-26, tocopherol, allantoin, sodium hyaluronate, carbomer, triethanolamine. According to the fullerene essence emulsion, the prepared essence emulsion can obviously improve the capability of skin cells for synthesizing collagen through reasonable proportioning of various raw materials with different component contents and fullerene, further promotes the effect on the skin structure and function, has excellent acne and acne mark removing effects, and has no stimulation and no damage to the skin in the using process.

Description

A kind of fullerene essence cream

Technical field

The present invention relates to cosmetic technical field more particularly to a kind of fullerene essence creams.

Background technique

Fullerene (Fullerene) is the third allotrope that simple substance carbon is found, be find so far it is unique It is dissolved in the isomer of the carbon of Conventional solvents at room temperature.

Due to fullerene can affine free radical, have extremely strong oxidation resistance, activating skin cells can be played, in advance The effect of anti-skin decline.Have nearly 30,000 papers at present the effect of removing in terms of free radical about fullerene to be published, closely 3000 patents are approved.Just because of this, fullerene starts to be used as cosmetic material since 21 century, has been achieved with Clinical trial result has crease-resistant, whitening, pre- anti-aging, promotion hair growth, improvement pore etc., becomes the tip beauty to attract attention Rongcheng point.Many high-end skin care item brands contain fullerene ingredient, but have excellent anti-acne, anti-acne print effect still without one kind at present Fruit, the fullerene essence cream for being beneficial to skin texture and reconstruction again simultaneously.Based on this, the present invention will provide a kind of fullerene Essence cream and preparation method thereof.

Summary of the invention

Technical problem to be solved by the present invention lies in provide a kind of fullerene essence cream and preparation method thereof.

The present invention a kind of fullerene essence cream to be provided and preparation method thereof, gives reality by following technical solution It is existing:

A kind of fullerene essence cream, the fullerene essence cream, by being prepared comprising following raw material: water 30 ~90 parts, 10~20 parts of fullerene, stearine/0.5~5 part of PEG-100 stearate, isopropyl palmitate 0.1~ 2 parts, 0.5~5 part of caprylic/capric triglyceride, 0.2~2 part of isohexadecane, 0.5~5 part of glycerol, 2~6 parts of propylene glycol, sweet tea 0.2~2 part of dish alkali, 0.3~1.8 part of tara gum, 0.05~5 part of 1,2- hexylene glycol, PEG-20 methyl sesquialter stearic acid 0.1~1 part of ester, 0.05~5 part of cetostearyl alcohol, 0.3~3 part of dimethyl silicone polymer, methyl sesquistearate 0.05~5 part, 0.2~2 part of glycerin polyether -26,0.3~3 part of tocopherol, 0.6~1.5 part of allantoin, Sodium Hyaluronate 0.6 ~1.2 parts, 0.8~1.4 part of carbomer, 0.4~1.4 part of triethanolamine.

As a preferred embodiment, the fullerene essence cream, by being prepared comprising following raw material: water 50 ~70 parts, 13~17 parts of fullerene, stearine/1.5~4 parts of PEG-100 stearate, isopropyl palmitate 0.6~ 1.5 parts, 1.5~4 parts of caprylic/capric triglyceride, 0.8~1.4 part of isohexadecane, 1.5~4 parts of glycerol, propylene glycol 3~5 Part, 0.8~1.4 part of glycine betaine, 0.8~1.3 part of tara gum, 1~4 part of 1,2- hexylene glycol, PEG-20 methyl times semihard 0.4~0.7 part of resin acid ester, 2~3 parts of cetostearyl alcohol, 1~2.3 part of dimethyl silicone polymer, methyl sesquistearate 2~3 parts, 0.8~1.4 part of glycerin polyether -26,1~2.3 part of tocopherol, 0.8~1.3 part of allantoin, Sodium Hyaluronate 0.8 ~1 part, 1~1.2 part of carbomer, 0.6~1.2 part of triethanolamine.

As a kind of optimal case, the fullerene essence cream, by being prepared comprising following raw material: water 70 Part, 18 parts of fullerene, stearine/3 parts of PEG-100 stearate, 1 part of isopropyl palmitate, caprylic/capric glycerol three 2 parts of ester, 1 part of isohexadecane, 2 parts of glycerol, 4 parts of propylene glycol, 1 part of glycine betaine, 1.1 parts of tara gum, 2 parts of 1,2- hexylene glycol, 0.5 part of PEG-20 methyl sesquistearate, 2.5 parts of cetostearyl alcohol, 2.1 parts of dimethyl silicone polymer, methyl 2.3 parts of sesquistearate, 1.1 parts of glycerin polyether -26,1.7 parts of tocopherol, 0.9 part of allantoin, 0.9 part of Sodium Hyaluronate, 1.1 parts of carbomer, 0.8 part of triethanolamine.

As a preferred embodiment, the preparation method of the essence cream comprises the following steps:

S1. water, propylene glycol, glycerol, allantoin, Sodium Hyaluronate, carbomer are sequentially added, is heated, stirring is made mixed Close object 1.

S2. by fullerene, stearine/PEG-100 stearate, isopropyl palmitate, caprylic/capric glycerol three Ester, isohexadecane, glycine betaine, tara gum, 1,2- hexylene glycol, PEG-20 methyl sesquistearate, cetearyl alcohol Alcohol, dimethyl silicone polymer, methyl sesquistearate, glycerin polyether -26, tocopherol, triethanolamine sequentially add, and add Heat, stirring, obtains mixture 2.

S3. mixture 2 is added in mixture 1, keeps the temperature, stir after heating, filtering had both obtained essence cream.

As a preferred embodiment, heating temperature described in S1. is 75~80 DEG C, and speed of agitator is 2000~3000r/ Min, mixing time are 30~50min.

As a preferred embodiment, heating temperature described in S2. is 65~75 DEG C, and speed of agitator is 2500~3000r/ Min, mixing time are 30~40min.

As a preferred embodiment, heating temperature described in S3. is 60~70 DEG C, and soaking time is 30~40min, is stirred Mixing revolving speed is 2000~3500r/min, and mixing time is 20~40min.

The utility model has the advantages that fullerene essence cream of the present invention, passes through the various raw materials and fullerene of different component content Rational proportion, the essence cream being prepared not only be remarkably improved Skin Cell synthesis collagen ability, and then promote To the effect of skin texture and function again, also there is excellent anti-acne and anti-acne to print effect.In use to skin without Fanout free region is stimulated, safety in utilization is good.

Specific embodiment

It is explained further the present invention with reference to embodiments, but embodiment do not do any form to the present invention and limit.

A kind of fullerene essence cream of embodiment 1 and preparation method thereof

Composition of raw materials: 70 parts of water, 18 parts of fullerene, stearine/3 parts of PEG-100 stearate, palmitinic acid isopropyl 1 part of ester, 2 parts of caprylic/capric triglyceride, 1 part of isohexadecane, 2 parts of glycerol, 4 parts of propylene glycol, 1 part of glycine betaine, tara gum 1.1 parts, 2 parts of 1,2- hexylene glycol, 0.5 part of PEG-20 methyl sesquistearate, 2.5 parts of cetostearyl alcohol, poly dimethyl 2.1 parts of siloxanes, 2.3 parts of methyl sesquistearate, 1.1 parts of glycerin polyether -26,1.7 parts of tocopherol, allantoin 0.9 Part, 0.9 part of Sodium Hyaluronate, 1.1 parts of carbomer, 0.8 part of triethanolamine.

Essence cream the preparation method comprises the following steps:

S1. water, propylene glycol, glycerol, allantoin, Sodium Hyaluronate, carbomer are sequentially added, are heated to 78 DEG C, stirred, Speed of agitator is 2900r/min, and mixing time is that mixture 1 is made in 35min；

S2. by fullerene, stearine/PEG-100 stearate, isopropyl palmitate, caprylic/capric glycerol three Ester, isohexadecane, glycine betaine, tara gum, 1,2- hexylene glycol, PEG-20 methyl sesquistearate, cetostearyl alcohol, Dimethyl silicone polymer, methyl sesquistearate, glycerin polyether -26, tocopherol, triethanolamine sequentially add, heating To 70 DEG C, stirring, speed of agitator 3000r/min, mixing time 35min obtain mixture 2；

S3. mixture 2 is added in mixture 1, is heated to 65 DEG C of heat preservation 35min, stirs, speed of agitator 3000r/min, Mixing time is 30min, filtering, both the essence is newborn.

A kind of fullerene essence cream of embodiment 2 and preparation method thereof

Composition of raw materials: 30 parts of water, 10 parts of fullerene, stearine/0.5 part of PEG-100 stearate, palmitinic acid are different 0.1 part of propyl ester, 0.5 part of caprylic/capric triglyceride, 0.2 part of isohexadecane, 0.5 part of glycerol, 2 parts of propylene glycol, glycine betaine 0.2 Part, 0.3 part of tara gum, 0.05 part of 1,2- hexylene glycol, 0.1 part of PEG-20 methyl sesquistearate, cetostearyl alcohol 0.05 part, 0.3 part of dimethyl silicone polymer, 0.05 part of methyl sesquistearate, 0.2 part of glycerin polyether -26, fertility 0.3 part of phenol, 0.6 part of allantoin, 0.6 part of Sodium Hyaluronate, 0.8 part of carbomer, 0.4 part of triethanolamine.

The preparation method of the essence cream of embodiment 2 is same as Example 1.

A kind of fullerene essence cream of embodiment 3 and preparation method thereof

Composition of raw materials: 90 parts of water, 20 parts of fullerene, stearine/5 parts of PEG-100 stearate, palmitinic acid isopropyl 2 parts of ester, 5 parts of caprylic/capric triglyceride, 2 parts of isohexadecane, 5 parts of glycerol, 6 parts of propylene glycol, 2 parts of glycine betaine, tara gum 1.8 parts, 5 parts of 1,2- hexylene glycol, 1 part of PEG-20 methyl sesquistearate, 5 parts of cetostearyl alcohol, poly dimethyl silicon 3 parts of oxygen alkane, 5 parts of methyl sesquistearate, 2 parts of glycerin polyether -26,3 parts of tocopherol, 1.5 parts of allantoin, hyalomitome 1.2 parts of sour sodium, 1.4 parts of carbomer, 1.4 parts of triethanolamine.

The preparation method of the essence cream of embodiment 3 is same as Example 1.

A kind of fullerene essence cream of embodiment 4 and preparation method thereof

The composition of raw materials of embodiment 4 is same as Example 1.

Essence cream the preparation method comprises the following steps:

S1. water, propylene glycol, glycerol, allantoin, Sodium Hyaluronate, carbomer are sequentially added, are heated to 75 DEG C, stirred, Speed of agitator is 2000r/min, and mixing time is that mixture 1 is made in 30min；

S2. by fullerene, stearine/PEG-100 stearate, isopropyl palmitate, caprylic/capric glycerol three Ester, isohexadecane, glycine betaine, tara gum, 1,2- hexylene glycol, PEG-20 methyl sesquistearate, cetearyl alcohol Alcohol, dimethyl silicone polymer, methyl sesquistearate, glycerin polyether -26, tocopherol, triethanolamine sequentially add, and add Heat is to 65 DEG C, and stirring, speed of agitator 2500r/min, mixing time 30min obtain mixture 2；

S3. mixture 2 is added in mixture 1,30min, stirring, speed of agitator 2000r/ are kept the temperature after being heated to 60 DEG C Min, mixing time 20min, filtering, both the essence is newborn.

A kind of fullerene essence cream of embodiment 5 and preparation method thereof

The composition of raw materials of embodiment 5 is same as Example 1.

Essence cream the preparation method comprises the following steps:

S1. water, propylene glycol, glycerol, allantoin, Sodium Hyaluronate, carbomer are sequentially added, are heated to 80 DEG C, stirred, Speed of agitator is 3000r/min, and mixing time is that mixture 1 is made in 50min；

S2. by fullerene, stearine/PEG-100 stearate, isopropyl palmitate, caprylic/capric glycerol three Ester, isohexadecane, glycine betaine, tara gum, 1,2- hexylene glycol, PEG-20 methyl sesquistearate, cetearyl alcohol Alcohol, dimethyl silicone polymer, methyl sesquistearate, glycerin polyether -26, tocopherol, triethanolamine sequentially add, and add Heat is to 75 DEG C, and stirring, speed of agitator 3000r/min, mixing time 40min obtain mixture 2；

S3. mixture 2 is added in mixture 1,40min, stirring, speed of agitator 3500r/ are kept the temperature after being heated to 70 DEG C Min, mixing time 40min, filtering, both the essence is newborn.

Comparative example 1

Comparative example 1 is the difference from embodiment 1 is that the fullerene in composition of raw materials is 5 parts by weight, remaining component and content It is identical；The preparation method of comparative example 1 essence cream is same as Example 1.

Comparative example 2

Comparative example 2 is the difference from embodiment 1 is that the fullerene in composition of raw materials is 25 parts by weight, remaining component and content It is identical；The preparation method of comparative example 2 essence cream is same as Example 1.

Comparative example 3

Comparative example 3 is the difference from embodiment 1 is that the fullerene in composition of raw materials is 35 parts by weight, remaining component and content It is identical；The preparation method of comparative example 2 essence cream is same as Example 1.

Comparative example 4

Comparative example 4 is the difference from embodiment 1 is that be free of fullerene, remaining component and content are identical in composition of raw materials；It is right The preparation method of 4 essence processed cream of ratio is same as Example 1.

Comparative example 5

Certain commercially available brand essence cream.

Effect test:

Facilitation of the 1 essence cream of test case to Skin Cell collagen synthesis

With advancing age, human skin fibroblasts and the synthesis collagen ability decline of people's epidermal keratinocyte, If lacking collagen in skin, connection solidification will occur for collagenous fibres, reduce iuntercellular mucopolysaccharide, skin will lose soft Aging occurs for soft, elastic and gloss, while the fibrous fracture of corium, lipoatrophia, sweat gland and smegma are reduced, and make skin There are a series of aging phenomena such as color spot, wrinkle in skin.Collagen improves cell to collagen egg as dermal matrix index components White rate of growth can be beneficial to skin texture and reconstruction.

Test method: with HDF (human skin fibroblasts) and HEK (people's epidermis spongiocyte) for a system, addition The essence cream dilution of equivalent cultivates cell, after cultivating 72h, measures collagen content with ELISA kit, calculates collagen egg White rate of growth, concrete outcome are shown in Table 1.

The test and evaluation of 2 anti-acne of test case and anti-acne print effect

The test method and evaluation method of anti-acne effect:

Tested crowd: face obviously has small pox

Tested number: 300 people are divided into 10 groups, every group of tested 30 people of number

Position on probation: face, the position of especially long acne

Use the time:, every morning 1 time, continuous 8 weeks

Evaluation method: software is analyzed by skin surface part analyzer VISIACR (Canfield, the U.S.) and face-image Photographic analysis is carried out before Image-Pro Plus (Media Cybernetics, Inc.) is on probation to subject and after use, is calculated Inflammatory papules number or the per capita reduction amount of warts number per capita；It is excellent if reducing 80% or more；If reducing 60%- 80%, then it is good；It is preferable if reducing 40%-60%；If reduce 40% hereinafter, if to be poor.

Anti-acne prints the test method and evaluation method of effect: passing through skin surface part analyzer VISIA CR (Canfield, beauty State) and face-image analysis software I mage-Pro Plus (Media Cybernetics, Inc.) it is on probation to subject before and Photographic analysis is carried out after use, acne print eliminates quantity or desalination degree after visual observations analyze small pox anti-inflammatory, and has acne originally The position of print uses acne print after product to eliminate quantity or desalination degree；If not leaving acne after 80% or more small pox anti-inflammatory Print, or there is the position 80% of acne print or more acne print all to eliminate originally, then it is excellent；If after the small pox anti-inflammatory of 60%-80% all Acne print is not left or leaves behind very shallow acne print, or has the position 60%-80% acne print of acne print all to eliminate or leave behind face originally The very shallow acne print of color is then good；If acne print is not left after the small pox anti-inflammatory of 40%-60% or leaves behind very shallow acne print, Or the acne print that script has the position 40%-60% acne print of acne print all to eliminate or leave behind very slight color, then it is preferable；If 40% with Under small pox anti-inflammatory after do not leave acne print or leave the obvious acne print of color, or have 40% or less the acne print of position of acne print originally The obvious acne print of color is eliminated or leaves, then to be poor, concrete outcome is shown in Table 1.

1 essence cream efficacy assessments of table

From the data in table 1, it can be seen that the embodiment of the present invention 1 is best-of-breed technology scheme；Embodiment 1, can compared with embodiment 4~5 If seeing, operating parameter is different from embodiment 1, and the essence cream effect being prepared is declined；By the present embodiment 1 and comparative example 1, The comparison of comparative example 2~3 is it is found that fullerene additive amount is lower than range of the present invention in essence of the present invention cream, or is higher than this The range is invented, Skin Cell collagen rate of growth, anti-acne and anti-acne print effect can all be caused to reduce；By the present embodiment 1 Comparison with comparative example 4 will will cause the volume increase of Skin Cell collagen it is found that being added to fullerene in essence of the present invention cream less Rate, anti-acne and anti-acne print effect seriously reduce；By the comparison of the present embodiment 1 and comparative example 5 it is found that essence cream of the present invention is improving It all to be got well more than common commercially available Essence in terms of Skin Cell collagen rate of growth, anti-acne and anti-acne print effect.In conclusion Fullerene essence cream of the present invention, by the various raw materials of different component content and the complex role of fullerene, is prepared into To essence cream be not only remarkably improved Skin Cell synthesis collagen ability, and then promote to skin texture and function weight Also there is excellent anti-acne and anti-acne to print effect for new effect, and to the non-stimulated fanout free region of skin in use process.

Claims

1. a fullerene essence milk, it is characterised in that the fullerene essence milk is prepared by comprising the following parts by weight raw materials: 30～90 parts of water, 10～20 parts of fullerenes, glyceryl stearic acid Esters/PEG-100 0.5~5 parts of stearate, 0.1~2 parts of isopropyl palmitate, 0.5~5 parts of caprylic/capric triglyceride, 0.2~2 parts of isohexadecane, 0.5~5 parts of glycerin , 2~6 parts of Propylene Glycol, 0.2~2 parts of Betaine, 0.3~1.8 parts of Acanthopanax Gum, 0.05~5 parts of 1,2-Hexanediol, 0.1~5 parts of PEG-20 Methyl Glucose Sesquistearate 1 part, 0.05-5 parts of cetearyl alcohol, 0.3-3 parts of dimethicone, 0.05-5 parts of methyl glucose sesquistearate, 0.2-2 parts of glycerol polyether-26, Tocopherol 0.3-3 parts, allantoin 0.6-1.5 parts, sodium hyaluronate 0.6-1.2 parts, carbomer 0.8-1.4 parts, triethanolamine 0.4-1.4 parts.

2 . The fullerene essence emulsion according to claim 1 , wherein the fullerene essence emulsion is prepared by comprising the following raw materials in parts by weight: 50 to 70 parts of water, 13 to 17 parts of fullerenes. 3 . , Glyceryl Stearate/PEG-100 Stearate 1.5~4 Parts, Isopropyl Palmitate 0.6~1.5 Parts, Caprylic/Capric Triglyceride 1.5~4 Parts, Isohexadecane 0.8~1.4 Parts, 1.5~4 parts of glycerol, 3~5 parts of propylene glycol, 0.8~1.4 parts of betaine, 0.8~1.3 parts of thorn gum, 1~4 parts of 1,2-hexanediol, PEG-20 methyl glucose sesquihard 0.4~0.7 parts of fatty acid ester, 2~3 parts of cetearyl alcohol, 1~2.3 parts of dimethicone, 2~3 parts of methyl glucose sesquistearate, glyceryl polyether-26 0.8-1.4 parts, tocopherol 1-2.3 parts, allantoin 0.8-1.3 parts, sodium hyaluronate 0.8-1 parts, carbomer 1-1.2 parts, triethanolamine 0.6-1.2 parts.

3. fullerene essence milk according to claim 1, is characterized in that, described fullerene essence milk is prepared by comprising the following raw materials by weight: 70 parts of water, 18 parts of fullerenes, glycerol stearin Ester/PEG-100 Stearate 3 Parts, Isopropyl Palmitate 1 Part, Caprylic/Capric Triglyceride 2 Parts, Isohexadecane 1 Part, Glycerin 2 Parts, Propylene Glycol 4 Parts, Betaine 1 Part , 1.1 parts of Erythrina gum, 2 parts of 1,2-hexanediol, 0.5 parts of PEG-20 methyl glucose sesquistearate, 2.5 parts of cetearyl alcohol, 2.1 parts of polydimethylsiloxane parts, 2.3 parts of methyl glucose sesquistearate, 1.1 parts of glycerol polyether-26, 1.7 parts of tocopherol, 0.9 parts of allantoin, 0.9 parts of sodium hyaluronate, 1.1 parts of carbomer, 0.8 parts of triethanolamine share.

4. the preparation method of the arbitrary described essence milk of claim 1～3, is characterized in that, the preparation method of described essence milk comprises the following steps:

S1. Water, propylene glycol, glycerin, allantoin, sodium hyaluronate, and carbomer are added successively, heated, and stirred to prepare mixture 1;

S2. Combine fullerene, glyceryl stearate/PEG-100 stearate, isopropyl palmitate, caprylic/capric triglyceride, isohexadecane, betaine, echidna gum, 1, 2-Hexanediol, PEG-20 methylglucose sesquistearate, cetearyl alcohol, dimethicone, methylglucose sesquistearate, glyceryl polyether-26 , tocopherol and triethanolamine were added successively, heated and stirred to obtain mixture 2;

S3. Add mixture 2 to mixture 1, keep warm after heating, stir, and filter to obtain essence milk.

5. Essence milk according to claim 4, is characterized in that, the heating temperature described in S1. is 75～80 ℃, the stirring speed is 2000～3000r/min, and the stirring time is 30～50min.

6. Essence milk according to claim 4, is characterized in that, the heating temperature described in S2. is 65～75 ℃, the stirring speed is 2500～3000r/min, and the stirring time is 30～40min.

7. Essence milk according to claim 4, is characterized in that, the heating temperature described in S3. is 60～70 ℃, the holding time is 30～40min, the stirring speed is 2000～3500r/min, and the stirring time is 20 ~40min.