CN107509735B - Synergistic acaricidal composition and use thereof - Google Patents

Abstract

The invention discloses a synergistic acaricidal composition. The synergistic acaricidal composition is composed of tevermectin and fenpyroximate; the mass ratio of tevermectin and fenfenib is 1:50～ 50:1. The present invention also provides an acaricide prepared by using the above-mentioned synergistic acaricidal composition, wherein the acaricide contains a mass percentage of ≥0.1% of the synergistic acaricidal composition. The present invention also provides the use of the above-mentioned synergistic acaricidal composition: controlling agricultural pest mites.

Description

Synergistic acaricidal composition and use thereof

technical field

The present invention relates to an acaricidal composition, in particular to a synergistic acaricidal composition containing trovemectin and fenpyroxifen and its application.

Background technique

Tenvermectin (tenvermectin) is a new biological source of insecticidal and acaricidal compounds. Tianvermectin has good control effect on lepidopteran pests such as leaf miner, diamondback moth, cotton bollworm and mites such as spider mites and panclaw mites on fruit trees and vegetables.

Cyenopymfen is a new type of pyrazole acaricide developed by Nissan Chemical Co., Ltd. It has a novel mechanism of action. The agent is converted into hydroxyl compounds through metabolism and acts on the electron transport chain of the respiratory system. By disturbing the dehydrogenation of succinate Enzyme, inhibit the normal function of mitochondria to achieve preventive effect. It has no cross-resistance with the acaricides used today, and can effectively control various harmful mites on fruits, citrus, tea, and vegetables.

At present, some old acaricide varieties in China (such as dicofol and fenamidine, etc.) have been banned from use due to their safety and resistance issues, while acaricides with relatively high safety and better control effects (such as pyridine) Varieties such as pyrimidine, pyridaben and tetramizine) have also become increasingly prominent due to long-term use. In recent years, although new acaricides have been developed and produced (such as spirodiclofen, diflufenac, etc.), because mites are easily resistant pests, long-term use of a single variety of acaricides is easy to cause. The rapid development of resistance requires the alternating use of acaricides with different mechanisms of action. As acaricides with novel mechanism of action and biological acaricides with excellent activity, pyraclostrobin and vermectin can provide new options for the alternate use of acaricides.

SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide a novel low-toxicity, high-efficiency and long-lasting effect, delaying the generation of drug resistance of harmful mites, and can effectively prevent and control agricultural mites (especially for propargite and abamectin that have been produced Acaricidal composition for resistant mites).

In order to solve the above-mentioned technical problems, the present invention provides a synergistic acaricidal composition, the synergistic acaricidal composition is composed of tevermectin and fenpyroximate; 1:50～50:1.

As an improvement of the synergistic acaricidal composition of the present invention: the mass ratio of tevermectin and fenpyroxifen is 1:20-20:1.

As a further improvement of the synergistic acaricidal composition of the present invention: the mass ratio of tevermectin and fenpyroxifen is 1:10-5:1; more preferably: 0.1-5:1.

The present invention also provides an acaricide prepared from the above-mentioned synergistic acaricidal composition, wherein the acaricide contains a mass percentage of ≥0.1% of the synergistic acaricidal composition.

As an improvement of the acaricide of the present invention: the acaricide contains a synergistic acaricidal composition with a mass percentage of 1% to 80%.

As a further improvement of the acaricide of the present invention: the acaricide is an emulsifiable concentrate, a suspending agent, a microemulsion, a water emulsion, a wettable powder, a water dispersible granule, and a dispersible oil suspension.

The present invention also provides the use of the above-mentioned synergistic acaricidal composition: controlling agricultural pest mites.

As an improvement of the use of the synergistic acaricidal composition of the present invention: it is used to control the harmful mites that have developed resistance to propargite and abamectin.

The acaricidal composition of the present invention contains two active ingredients, one active ingredient is tevemectin, and the other active ingredient is fenpyroxifen. The invention combines the two, which can effectively prevent and control the harm of resistant mites. It can reduce the dosage of pesticides, significantly improve the effect of killing mites, reduce environmental pollution, solve the problem that harmful mites are prone to resistance to a single agent, and prolong the service life of the agents. It is an important means of comprehensive pest management. There is no report or application of the combination of tevemectin and fenpyroxifen to control agricultural pest mites.

In addition to the above-mentioned composition, the acaricide provided by the present invention may further include carriers and adjuvants that are acceptable for pesticides and are usually used to formulate insecticidal and acaricidal compositions. The carrier can be solid or liquid.

Suitable solid carriers include: minerals, plants, synthetic fillers and inorganic salts. The minerals include silicates, carbonates, sulfates and oxides. Silicates such as kaolin, sepiolite, nacre, montmorillonite, mica, vermiculite, pyrophyllite, talc. Carbonates such as: calcium carbonate, dolomite. Sulfates such as ammonium sulfate, sodium sulfate, calcium sulfate. Oxides such as quicklime, magnesia lime, diatomaceous earth. Plants such as: citrus pulp, corn cob, rice husk meal, rice husk, soybean straw meal, tobacco meal, walnut shell, sawdust meal. Synthetic fillers such as precipitated calcium carbonate hydrate, precipitated calcium carbonate, silica. Inorganic salts such as potassium chloride, sodium chloride.

Liquid carriers include water and organic solvents. When the active ingredient is an aqueous emulsion or a suspoemulsion, the organic solvent plays the role of solubilization and antifreeze. Suitable organic solvents include aromatic hydrocarbons such as benzene, xylenes, toluene, alkylbenzenes, alkylnaphthalenes and chlorinated aromatic hydrocarbons; chlorinated aliphatic hydrocarbons such as vinyl chloride, chloroform, dichloromethane, chloroform, carbon tetrachloride and polychlorinated ethanes; aliphatic hydrocarbons such as petroleum distillates, cyclohexane, light mineral oils and paraffins. Alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, fatty alcohols, etc.; ethers such as methyl glycol ether, ethyl glycol ether, petroleum ether. Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone and isophorone, N-methyl-pyrrolidone; specialty solvents also include dimethylformamide, dimethyl sulfoxide, polyethylene glycol , has nitrile; vegetable oil and methylated vegetable oil and other oil phase carriers. The above-mentioned carriers can be used alone, or in combination, and can also be used in combination with water.

The adjuvants of the present invention may include one or more of surfactants, defoaming agents, thickeners, suspending agents and antifreeze agents as required, and may also include other adjuvants commonly used in the industry as needed.

Surfactants may be emulsifying agents, dispersing agents or wetting agents; may be ionic or non-ionic. Suitable surfactants include: sodium and calcium salts of polyacrylic acid and lignosulfonic acid; polycondensation products of fatty acids or fatty amines containing at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide; glycerol, Fatty acid esters of dodecanol-1, tetradecanol-1, sorbitol, sucrose or pentaerythritol; and their polycondensation products with ethylene oxide and/or propylene oxide; sulfate salts of their polycondensation products or Sulfonates; alkali metal or alkaline earth metal salts of sulfuric acid or sulfonic acid containing at least 10 carbon atoms in the molecule, preferably sodium salts, such as sodium lauryl sulfate, sodium secondary alkyl sulfate, sulfonated castor Sodium salt of sesame oil, sodium alkylarylsulfonate and sodium dodecylbenzenesulfonate; polymer of ethylene oxide, copolymer of ethylene oxide and propylene oxide.

Emulsifiers include nonionic emulsifiers and commercially available emulsifiers. Nonionic emulsifiers are preferably polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers and polyoxyethylene fatty ammonia, such as ethoxylated castor oil, polyoxyethylene (n ₂₀ ) phenethyl phenol ether oleate, Alkyl aryl polyoxyethylene polyoxypropylene ether, alkyl aryl formaldehyde resin polyoxyethylene ether, tristyryl phenol polyoxyethylene (n ₂₀ ), ether phosphorylated triethanolamine salt, diphenylethylphenol-based polyoxyethylene Oxyethylene ether (n ₁₈ ) formaldehyde condensate, diphenylphenol polyoxyethylene (n ₁₈ ) polyoxypropylene ether (n ₂₀ ), and the like. Commercially available emulsifiers include: Agricultural Milk 0201B, Agricultural Milk 0203B, Agricultural Milk 100 ^# , Agricultural Milk 500 ^# , Agricultural Milk 600 ^# , Agricultural Milk 600-2 ^# , Agricultural Milk 1601, Agricultural Milk 2201, Agricultural Milk NP-10 , Agricultural Milk NP-15, Agricultural Milk 507 ^# , Agricultural Milk OX-635, Agricultural Milk OX-622, Agricultural Milk OX-653, Agricultural Milk OX-667, Agricultural Milk CS-7, Ning Ru 36 ^# .

The dispersing agent of the present invention includes: sodium lignosulfonate, pulling powder, calcium lignosulfonate, methylnaphthalenesulfonate formaldehyde condensate, naphthalenesulfonate formaldehyde condensate, sodium methylenenaphthalenesulfonate, oil Sodium methyl aminoethyl sulfonate, epoxy polyether, p-tert-butyl ether, dibutylnaphthalenesulfonic acid formaldehyde condensate, phosphate such as sodium hexametaphosphate, alkylphenol polyoxyethylene phosphate, alkane Alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, N-methyl-fatty acyl-sodium taurate alkylphenol polyoxyethylene ether formaldehyde condensate, aralkylphenol polyoxyethylene ether phosphate alkylphenol poly Oxyethylene ether, castor oil ethylene oxide adduct, ethylene oxide-propylene oxide block copolymer alkylphenol polyoxyethylene ether formaldehyde condensate, alkylphenol polyoxyethylene polyoxypropylene ether and methyl cellulose.

The wetting agent of the present invention includes: sodium lauryl sulfate, sodium alkyl alcohol polyoxyethylene ether sulfate, octylphenol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate , Sodium Alkyl Sulfonate, Sodium Dodecylbenzene Sulfonate, Sodium Alkyl Naphthalene Sulfonate, Sodium Alkyl Succinic Acid Sulfonate, Sodium Lauryl Polyoxyethylene Ether Sulfonate, Sodium Alkamide Taurine , fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene block polymer, sorbitan fatty acid ester polyoxyethylene ether, etc.

The thickener described in the present invention can be either synthetic, such as carboxymethyl alcohol, polyvinyl alcohol or polyvinyl acetate; it can also be a natural water-soluble polymer, such as xanthan gum, gelatin, gum arabic , polyvinylpyrrolidone, aluminum magnesium silicate, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac, carboxymethyl cellulose and sodium alginate, etc.

The defoaming agent of the present invention is preferably: foam enemies, silicones, C _8-10 fatty alcohols, C _10-20 saturated fatty acids, amides, and the like.

The acaricidal composition of the present invention can be formulated into emulsifiable concentrate, suspending agent, microemulsion, water emulsion, wettable powder, water dispersible granule, dispersible oil suspension and the like. When formulated into formulations, the emulsifiable concentrates, suspending agents, microemulsions, aqueous emulsions, wettable powders, water dispersible granules, dispersible oil suspensions, containing acaricidal compositions contain more than 0.1% by mass of the composition (The following percentages are all mass percentages).

When it is a wettable powder, the active ingredient is 0.1% to 80%, the wetting agent is 2% to 10%, the dispersant is 5% to 10%, and the filler is 8% to 90%.

When it is an emulsifiable concentrate, the active ingredient is 0.1% to 60%, the emulsifier is 1% to 10%, and the solvent is supplemented to 100%.

When it is a suspending agent, the active ingredients are 0.1% to 60%, the wetting agent is 1% to 5%, the dispersant is 1% to 8%, the thickener is 0.1% to 1%, and the antifreeze is 2% to 5%. to 100%.

When it is a microemulsion, the active ingredient is 0.1% to 40%, the emulsifier is 1% to 12%, the cosolvent is 0% to 10%, the stabilizer is 0% to 5%, the solvent is 0% to 40%, and the water is filled to 100% .

When it is a water emulsion, the active ingredient is 0.1% to 40%, the emulsifier is 1% to 20%, the cosolvent is 0% to 15%, the stabilizer is 0% to 5%, the solvent is 10% to 40%, and the water is filled to 100%. .

In the case of water dispersible granules, 0.1% to 80% of active ingredients, 0% to 2% of surfactant, 1% to 15% of wetting agent, 1% to 15% of dispersant, 1% to 10% of disintegrant, The stabilizer is 0% to 5%, and the filler is filled to 100%.

When it is a dispersible oil suspension, the active ingredients are 0.1% to 60%, the wetting agent is 1% to 5%, the dispersant is 1% to 8%, the thickener is 0.1% to 1%, and the antifreeze agent is 1% to 3%. The oil phase carrier is made up to 100%.

The agricultural acaricidal composition of the present invention can be directly prepared in the form of a finished preparation, that is, the substances in the composition have been mixed and are directly used for killing acaricide; the components of the composition can also be provided by separate preparations, which are placed in a barrel (tank) before use. ) directly mixed. The concentrates of the present invention are generally mixed with water to obtain the desired concentration of active substance.

The present invention also includes the use of the composition of the present invention to prepare an acaricidal preparation to control agricultural and forestry pests. It is especially suitable for controlling a variety of important agricultural pests such as cotton spider mites, vegetable spider mites, hawthorn spider mites, citrus spider mites, citrus rust mites, apple spider mites, apple spider mites, two-spotted spider mites, and gall mites , powder mites, etc. For fruit trees such as apples, pears, citrus, lychees, etc., cereals such as wheat, rice, etc., beans such as soybeans, kidney beans, etc., cotton, tea trees, vegetables such as cabbage, cauliflower, cabbage, rape, tomato, pepper, flowers such as Moon, etc.

The agricultural acaricide application site of the present invention is farmland, orchard or warehouse and the like.

The agricultural acaricidal composition of the present invention can be applied by common methods, such as pouring, spraying, and spraying. The application rate varies with climatic conditions or crop status (about 450-750L/ha), and the application time can be before or after the mites damage. The duration of protective action is generally related to the content of individual compounds in the composition, as well as to external factors such as climate, but the effects of climate can be mitigated by the use of appropriate dosage forms.

The agricultural acaricidal composition of the present invention can also be mixed with other compounds with insecticidal, herbicidal and bactericidal properties, and can also be mixed with nematicides, protective agents, growth regulators, plant nutrients or soil conditioners.

Compared with the prior art, the composition containing two active ingredients provided by the present invention has the following advantages:

(1) The combination of the two active ingredients in the composition has a strong synergistic effect on the harmful mite Tetranychus cinnabarinus within a certain ratio range, and the mixed composition has a more obvious acaricidal effect than its single agent. improvement;

(2) The two active ingredients in the composition have obvious quick-acting and long-lasting effects on harmful mites such as Panonychus citri and Panonychus ulmi within a certain ratio range. higher than a single dose;

(3) The composition is composed of active ingredients with different action mechanisms, and the action sites are increased, which is conducive to overcoming and delaying the generation of drug resistance of harmful mites and prolonging the service life of pesticides. The composition preparation is used for preventing and treating Panclaw citrus mites that have developed resistance to common medicaments such as propargite and abamectin, and has excellent control effect.

Detailed ways

The present invention will be further described below with reference to specific embodiments, but the present invention is not limited to these specific embodiments. Those skilled in the art should realize that the present invention covers all alternatives, modifications and equivalents that may be included within the scope of the claims.

1. Determination of indoor biological activity

In order to understand the virulence of tevemectin, fenpyroxifen and their combinations against mites, the indoor biological activity assay was carried out. The test refers to the indoor bioassay test guidelines for pesticides and pesticides (agricultural industry standard NY/T1154.7-2006) and the creation of the SOP for pesticide biological activity evaluation (Pesticide Volume), and the spray method is used. The test target was Tetranychus cinnabarinus. Cut off the leaf with handle, insert it into a glass bottle with water, and connect a certain number of adult Tetranychus cinnabarinus mites. After the adult mites lay eggs for 24 hours, the adult mites are removed. After all the eggs hatched for 48 hours, spray treatment was carried out, and they were naturally air-dried. Cultured in an observation room (25±2°C, humidity 70%-80%, 16h light/d). The experiment was repeated 3 times, and a blank control was set, and the investigation was carried out after 48 hours. During the investigation, it was regarded as dead insects that could not crawl normally. The survey data was analyzed and counted with "DPS Data Processing System" V14.50 Professional Edition, and the regression line and LC50 value were obtained. The virulence index was calculated using the Sun Yunpei method (Sun et al., 1960), and the co-toxicity coefficient was calculated (Table 1).

Theoretical Mixed Toxicity Index (TTI)=Toxicity Index of A×A Content in Mixed Use (%)

+B toxicity index×B content in mixed use (%)

If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if it is less than 80, it indicates an antagonistic effect; if it is greater than 80 and less than 120, it indicates an additive effect.

Table 1. Determination results of indoor toxicity of Tianvermectin, fenpyroxifen and their mixture to Tetranychus cinnabarinus

medicine LC₅₀(mg/L) Measured virulence index Theoretical virulence index Co-toxicity factor Tianvermectin (A) 0.0212 3920.28 - - Pyridoxine (B) 0.8311 100.00 - - A:B(1:100) 0.4920 168.92 137.82 122.56 A:B (1:50) 0.3450 240.90 174.91 137.73 A:B(1:20) 0.1881 441.84 281.92 156.73 A:B(1:10) 0.1105 752.13 447.30 168.15 A:B(1:5) 0.0662 1255.44 736.71 170.41 A:B(1:1) 0.0231 3597.84 2010.14 178.98 A:B(5:1) 0.0143 5811.89 3283.57 177.00 A:B (10:1) 0.0147 5653.74 3572.98 158.24 A:B (20:1) 0.0135 6156.30 3738.36 164.68 A:B (50:1) 0.0151 5503.97 3845.38 143.13 A:B (100:1) 0.0162 5130.25 3882.46 132.14

The results of the indoor toxicity test showed that the mixture of tevermectin and fenpyroxifen showed a synergistic effect on Tetranychus cinnabarinus in the mass ratio of 1:100～100:1. It has obvious synergistic effect in the range of 1:20～20:1, and the synergistic effect is the most significant in the range of mass ratio of 1:10～5:1. It is scientific and reasonable to mix tevemectin and fenpyroxifen to control the above-mentioned pests.

2. Preparation of the composition

The percentages in the proportions of all formulations in the invention are mass percentages.

1) Preparation of EC:

According to the requirements of the formula, the solvent, the original drug and the emulsifier are added respectively, mixed evenly, and if necessary, heated and dissolved in a water bath to obtain a transparent emulsifiable concentrate.

Example 1 10% EC

Tianvermectin 5%, fenpyroximate 5%, agricultural milk 0203B 6%, agricultural milk 0201B 9%, cyclohexanone 8%, solvent oil 150 to make up to 100%.

Example 2 20% EC

Tianvermectin 15%, nitrilofenac 5%, agricultural milk 2201# 6%, agricultural milk 0201B 8%, cyclohexanone 8%, solvent oil 150 to make up to 100%.

2), the preparation of wettable powder

According to the requirements of the formula, the original drug, various additives and fillers are fully mixed, and the processed product is obtained after being pulverized by an ultra-fine pulverizer.

Example 3 60% wettable powder

Vermectin 30%, Pyridoxine 30%, Sodium Dodecylbenzene Sulfonate 1.8%, p-tert-butyl ether 2%, White Carbon Black 10%, Sodium Lignin Sulfonate 10%, Light Carbonic Acid Calcium supplement to 100%.

Example 4 60% wettable powder

Tianvermectin 50%, fenpyroximate 10%, sodium dodecylbenzene sulfonate 2%, p-tert-butyl ether 2%, white carbon black 5%, sodium lignosulfonate 10%, light carbonic acid Calcium supplement to 100%.

Three), the preparation of water dispersible granules

Mix and pulverize the original drug, powder carrier, wetting and spreading agent and binder, add water and knead, and then add it to a granulator equipped with a certain size of screen for granulation. Then it is dried and sieved (according to the screen range) to obtain granular products.

Example 5 40% water dispersible granules

Tianvermectin 10%, Pyridoxine 30%, N-Methyl-Oleoyl-Sodium Taurate 8%, Naphthol Sulfonate Formaldehyde Condensate 10%, Soluble Starch 8%, Sodium Sulfate 10%, Kaolin Clay Top up to 100%.

Example 6 50% water dispersible granules

Tianvermectin 25%, fenpyroximate 25%, sodium lignosulfonate 15%, sodium methylnaphthalene sulfonate formaldehyde condensate 5%, epoxy polyether 5%, bentonite 10%, kaolin to make up to 100% .

Four), the preparation of suspending agent

According to the requirements of the formula, using water as the medium, mix the original drug, dispersant, wetting agent, suspending agent and antifreeze evenly, then add it to the sand mill, sand to a certain particle size and filter, and then add the thickener Cut and mix well.

Example 7 30% suspending agent

Tianvermectin 5%, fenpyroximate 25%, sodium lignosulfonate 5%, white carbon black 0.3%, EFW (mixture of alkylnaphthalene sulfonate and anionic wetting agent) 2.0%, dihydrogen phosphate Potassium 0.2%, ethylene glycol 4%, tributyl phosphate 0.2%, water to make up to 100%.

Example 8 55% suspending agent

Tianvermectin 50%, nitrilofenac 5%, sodium methylnaphthalene sulfonate formaldehyde condensate 2.5%, EFW (mixture of alkyl naphthalene sulfonate and anionic wetting agent) 2.0%, agricultural milk OX-656 3.0%, glycerol 4%, tributyl phosphate 0.2%, water to make up to 100%.

Five), the preparation of water emulsion

Mix and stir the original drug, solvent and emulsifier to form a homogeneous oil phase, mix and stir water and ethylene glycol to form a water phase, and under high shear conditions, slowly add the oil phase to the water phase, namely Aqueous emulsions are available.

Example 9 15% water emulsion

Tianvermectin 5%, nitrile fenpyroximate 10%, mineral spirits S-150 30%, triphenylethylphenol polyoxyethylene ether phosphate 3%, styrylphenol formaldehyde resin polyoxyethylene polyoxypropylene ether 5 %, propylene glycol 3%, water to 100%.

Example 10 25% water emulsion

Tianvermectin 15%, fenpyroximate 10%, mineral spirits S-150 30%, triphenylethylphenol polyoxyethylene ether phosphate 4%, hydroxyl terminated polyoxyethylene polyoxypropylene ether block copolymer 5 %, ethylene glycol 3%, water to 100%.

6) Preparation of microemulsion

Mix and stir the original drug, solvent and emulsifier to form a homogeneous oil phase, gradually add water into the oil phase, and stir until uniform and transparent.

Example 11 8% Microemulsion

Tianvermectin 2%, fenpyroximate 6%, isopropyl alcohol 10%, mineral spirits S-150 15%, calcium dodecylbenzenesulfonate 2%, styryl phenyl polyoxyethylene ether 18% , water to 100%.

Example 12 15% Microemulsion

Tianvermectin 5%, Pyridoxine 10%, N-Octylpyrrolidone 6%, Mineral spirit S-150 15%, Calcium dodecylbenzenesulfonate 2%, Alkylphenol formaldehyde resin polyoxyethylene ether 15%, water to 100%.

Seven), the preparation of dispersible oil suspension agent

After mixing the original drug, dispersant, emulsifier, thickener and oil phase carrier evenly, add it to a sand mill and grind it to a certain particle size.

Example 13 10% Dispersible Oil Suspension

Tianvermectin 5%, nitrilofenac 5%, alkylphenol polyoxyethylene ether phosphate 2%, castor oil polyoxyethylene ether 13%, organic bentonite 2%, and methyl oleate to make up to 100%.

Example 14 30% Dispersible Oil Suspension

Tianvermectin 10%, nitrilofenac 20%, triphenylethyl phenol polyoxyethylene ether phosphate 3%, fatty alcohol polyoxyethylene ether 14%, organic bentonite 1.5%, methyl oleate to make up to 100 %.

3. Efficacy test in field plot

Test 1. Field efficacy test on Panonychus citri

The control effect against Panonychus citrus was determined under field conditions. The test was carried out in accordance with the regulations of "Pesticide Field Efficacy Test Guidelines (1) - Acaricides for the Control of Panonychus citrifolia GB/T 17980.11-2000", and 5 fixed points were used for citrus leaves in each experimental plot to move east, south and west. , 5 orientation marks in the north, 2 plants were investigated in each plot, and the number of all live insects on each plant was investigated. The quick-acting effect of the drug was investigated 1 day after the drug, and the persistence of the drug was investigated 7 days, 14 days, and 21 days after the drug. The application rate was 750L/ha.

Test results: The control effects of different proportions of the composition preparations against Panonychus citrus are all better than that of fenpyroximate and tevermectin. In terms of quick-acting properties, one day after the drug, the control effect of the composition in the range of 1:10 to 5:1 is 76.8% to 80.1%, while the control effect of other compositions is 71.5% to 72.2%. The control efficacy of single agent was 67.2% and 62.8%, respectively. In terms of lasting effect, the lasting effect of the composition in the ratio of 1:10 to 5:1 is 14 to 21 days, and the control effect 21 days after the drug is 93.8% to 95.0%. The lasting period of the other formulations is 7-14 days, and the control effect after 14 days is lower than 83.1%-88.3%, see Table 2 for details.

The results showed that when the composition ratio was in the range of 1:10 to 5:1, the quick-acting and lasting effect of the chemical on Panonychus citrus were significantly higher than those of the two single-agents and other compositions.

Table 2. Results of field efficacy test on Panonychus citrus

Remarks: Change the mass ratio relationship between Tianvermectin and Pyridoxine (as described in Table 2), and the rest can be obtained according to the corresponding preparation method of the suspending agent in the embodiment, and each suspending agent as described in Table 2 can be obtained. .

Experiment 2. Field efficacy test on apple Panonychus ulmi

The control effect against Panonychus apple was determined under field conditions. The test was carried out according to the regulations of "Pesticide Field Efficacy Test Guidelines (1) - Acaricides for the Control of Apple Tetranychus GB/T 17980.7-2000". Apple leaves in each experimental plot were marked with 5 fixed points and 5 orientations of east, south, west and north, and 2 plants were investigated in each plot to investigate the number of all live insects on each plant. The quick-acting effect of the drug was investigated 1 day after the drug, and the persistence of the drug was investigated 7 days, 14 days, and 21 days after the drug. The application rate was 750L/ha.

Test results: The control effects of different proportions of the composition preparations against Panonychus apple are better than that of fenpyroximate and tevemectin. In terms of quick-acting properties, one day after the drug, the control effect of the composition in the range of 1:10 to 5:1 is 75.9% to 82.9%, while the control effect of other compositions is 71.7% to 72.1%. The control efficacy of single agent was 66.3% and 63.5%, respectively. In terms of lasting effect, the duration of the composition in the ratio of 1:10 to 5:1 is 14 to 21 days, and the control effect of 21 days after the drug is 93.1% to 94.4%, while the two single doses and other The lasting period of the formulation composition is 7-14 days, and the preventive effect 14 days after the medicine is 83.6%-89.6%. See Table 3 for details.

The results showed that when the composition ratio was in the range of 1:10 to 5:1, the quick-acting and lasting effects of the drug on Panonychus apple were significantly higher than those of the two single-dose and other proportioning compositions.

Table 3 Results of field efficacy test on Panonychus apple

Test 3. Field efficacy test of Panonychus citrus that has developed resistance to both propargite and abamectin

Taking the composition preparation as the test agent, the citrus Panonychus mites, which have developed resistance to propargite and abamectin, were selected as the control objects. The commonly used agents propargite and abamectin were used as control agents. The test method and investigation method are the same as those of Test 1.

Test results: The control effect of the composition preparation on Panonychus citrus in the range of 1:10～5:1 is higher than that of other ratios, and the control effect is 1 day, 7 days, 14 days and 21 days after the treatment 76.0%-81.7%, 92.1%-94.3%, 94.2%-98.7%, 91.8%-94.1% respectively, which are much higher than the super-dose of commonly used citrus panclaw mites such as propargite and abamectin below the prevention effect. The results show that the composition preparation has excellent control effect on the control of Panonychus citrus citrus mites that have developed resistance to common chemicals such as propargite and abamectin. See Table 4 for details.

Table 4 Results of field efficacy test of resistant Panclaw citrus mites

Remarks: Change the mass ratio relationship between Tianvermectin and Pyridoxine (as described in Table 4), according to the preparation method of the corresponding composition preparation in the above-mentioned embodiment, the test medicament as described in Table 4 can be obtained. .

The conventional effective concentration of propargite used in the field is about 250 mg/L, and the conventional effective concentration of abamectin used in the field is about 10 mg/L. Therefore, the above-mentioned Table 4 has been greatly overused.

The above data show that the mixture of tevemectin and fenpyroxifen has obvious synergistic effect on the control of Panonychus citrus and Panonychus apple under a specific ratio range. efficacy) was better than the use of tevermectin and fenpyroximate alone.

The above-mentioned indoor detection and field efficacy test results show that the beneficial effects produced by the acaricidal composition of the present invention are:

(1) Compared with a single agent, the composition has a significant synergistic effect on harmful mites, and significantly improves the quick-acting and lasting effect on harmful mites;

(2) After the lasting effect is improved, the frequency of medication can be reduced, the cost of medication can be reduced, and environmental pollution and pesticide residues can be reduced;

(3) The composition is composed of active ingredients with different action mechanisms, and the action sites are increased, which is conducive to overcoming and delaying the generation of pest resistance. The specific composition preparation is used to control commonly used drugs such as propargite and abamectin The citrus mites that have developed resistance have excellent control effect. The composition of the invention has no obvious adverse effect on fruit trees, and the leaf color and growth are normal, and the composition is safe and meets the safety requirements of pesticide preparations.

Finally, it should also be noted that the above enumeration is only a few specific embodiments of the present invention. Obviously, the present invention is not limited to the above embodiments, and many modifications are possible. All deformations that those of ordinary skill in the art can directly derive or associate from the disclosure of the present invention shall be considered as the protection scope of the present invention.

Claims (4)

1. the synergistic acaricidal composition for preventing and treating the harmful mites that have produced drug resistance to propargite and abamectin, it is characterized in that: the synergistic acaricidal composition is composed of Tianvermectin and nitrile pyrimethamine. Ester composition; the mass ratio of tevemectin and fenpyroxifen is 1:1～5:1. 2 . The acaricide prepared by using the synergistic acaricidal composition according to claim 1 , wherein the acaricide contains the synergistic acaricidal composition with a mass percentage of ≥ 0.1%. 3 . 3 . The acaricide according to claim 2 , wherein the acaricide contains a synergistic acaricidal composition with a mass percentage of 1% to 80%. 4 . 4. The acaricide according to claim 3, wherein the acaricide is an emulsifiable concentrate, a suspending agent, a microemulsion, a water emulsion, a wettable powder, a water dispersible granule, and a dispersible oil suspension.