CN102919260B - Insecticidal composition containing ZJ3757 and neonicotinoid insecticides - Google Patents

Abstract

An insecticidal composition containing ZJ3757 and neonicotinoid insecticides. The invention discloses an agricultural insecticidal composition, which contains two active components. The first active component is N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-1 -(3-chloropyridin-2-yl)-3-fluoromethoxy-1H-pyrazole-5-carboxamide, the second active ingredient is selected from imidacloprid, nitenpyram, thiamethoxam, pyridine Combination of one, two or more of tamiprid, thiacloprid and clothianidin, the weight ratio of the first active component to the second active component is 50:1～1:50 . The insecticide composition of the present invention has the effect of synergizing and expanding the prevention and control spectrum, and is especially suitable for preventing and controlling Lepidoptera Chilo suppressalis, Rice leaf roller, Homoptera rice planthopper and Coleoptera rice water weevil .

Description

Insecticidal composition containing ZJ3757 and neonicotinoid insecticides

technical field

The invention belongs to the field of agricultural insecticide and relates to an insecticidal composition containing ZJ3757 and neonicotinoid insecticides.

Background technique

In agricultural production practice, we often face the phenomenon of mixed occurrence of multiple pests on one crop. For example, when rice planthoppers, rice thrips, and rice water weevil harm rice, they are often accompanied by rice leaf rollers, rice stem borers, and three pests. The mixed occurrence of the stem borer, whitefly, aphids and diamondback moth, Spodoptera litura, beet armyworm, etc. also occur mixedly on vegetables.

ZJ3757 belongs to o-formamidobenzamide insecticides, chemical name: N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-1-(3-chloropyridine-2 -yl)-3-fluoromethoxy-1H-pyrazole-5-carboxamide, molecular formula: C ₂₂ H ₂₂ C ₁₂ FN ₅ O ₃ , relative molecular mass: 494.35, has the following structural formula (I):

ZJ3757 belongs to o-formamidobenzamide insecticides. The insecticidal activity of this compound is basically the same as that of DuPont’s chlorantraniliprole. It belongs to the insecticides acting on ryanodine receptors. This type of compound It can bind to ryanodine receptors, leading to uncontrolled and loss of Ca2+ release, paralyzing the contraction function of muscle cells, and it is a compound with a new mechanism of action. The pests treated with the pesticide showed rapid cessation of feeding, fatigue, nausea and muscle paralysis, until death. This type of insecticide has a wide insecticidal spectrum, a long residual effect period, low toxicity, is environmentally friendly, and has no cross-resistance with existing various insecticides. It can effectively control various Lepidoptera pests and some Coleoptera larvae and adults, and can also be used to control pests such as ants and termites.

The prominent features of neonicotinoid insecticides such as imidacloprid, nitenpyram, thiamethoxam, acetamiprid, thiacloprid, clothianidin, etc. are: high efficiency, broad spectrum, low toxicity, no side effects, long-term Long, can be widely used in the control of planthoppers, whiteflies, aphids, leafhoppers, leafhoppers, leaf beetles, scales and other pests.

Contents of the invention

The object of the present invention is to provide a composition containing insecticide ZJ3757 and neonicotinoid insecticides, which can make full use of the synergistic effect produced by mixing the two active components, expand the control spectrum, and improve Control efficiency, reduce agricultural costs, delay the emergence of pest resistance, and solve the inconvenience caused by repeated application of pesticides when various pests occur at the same time, as well as the adverse effects that may be caused by repeated application of pesticides.

For achieving the purpose of the invention, the technical scheme adopted by the present invention is:

An agricultural insecticidal composition, containing two active components, the first active component is N-(2-(tert-butylcarbamoyl)-4-chloro-6-methyl with the above structural formula (I) Phenyl)-1-(3-chloropyridin-2-yl)-3-fluoromethoxy-1H-pyrazole-5-carboxamide, the second active ingredient is selected from imidacloprid, nitenpyram, One, two or more combinations of thiamethoxam, acetamiprid, thiacloprid and clothianidin, the weight ratio of the first active component to the second active component is 50: 1～1:50.

Imidacloprid, English name: imidacloprid, chemical name: 1-(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylamine, molecular formula: C ₉ H ₁₀ ClN ₅ O ₂ , relatively Molecular mass: 255.7, with the following structural formula (II):

Nitenpyram, English name: nitenpyram, chemical name: (E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-N'-methyl-2-nitrovinyl-1 ,1-diamine, molecular formula: C ₁₁ H ₁₅ ClN ₄ O ₂ , relative molecular mass: 270.7, has the following structural formula (Ⅲ):

Thiamethoxam, English name: thiamethoxam, chemical name: N-3-(2-chloro-1,3-thiazol-5-ylmethyl)-5-methyl-1,3,5-oxadiazine-4 -Nitroamine, molecular formula: C ₈ H ₁₀ ClN ₅ O ₃ S, relative molecular mass: 291.7, has the following structural formula (IV):

Acetamiprid, English name: acetamiprid, chemical name: (E)-N ¹ -[(6-chloro-3-pyridyl)methyl]-N ² -cyano-N ¹ -methylacetamide, molecular formula: C ₁₀ H ₁₁ ClN ₄ , relative molecular mass: 222.7, has the following structural formula (Ⅴ):

Thiacloprid, English name: thiacloprid, chemical name: [3-[(6-chloro-3-pyridyl)methyl]-1,3-thiazoline-2-ylidene]cyanamide, molecular formula: C ₁₀ H ₉ ClN ₄ S, relative molecular mass: 252.7, has the following structural formula (Ⅵ):

Clothianidin, English name: clothianidin, chemical name: (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine, molecular formula: C ₆ H ₈ ClN ₅ O ₂ S, relative molecular mass: 249.7, has the following structural formula (Ⅶ):

In the agricultural pesticidal composition of the present invention, the amount of the active ingredient depends on the application rate of the compound when used alone, and also depends on the ratio of one compound to another compound and the degree of synergistic effect. In the insecticidal composition of the present invention, the weight ratio of the first active component to the second active component is preferably 20:1-1:20, more preferably 4:1-1:4, especially Preferably it is 2:1 to 1:2.

The second active ingredient in the present invention is preferably nitenpyram and/or thiamethoxam.

The agricultural insecticidal composition of the present invention may further contain a carrier, which may be solid or liquid, and any carrier commonly used for preparing insecticidal compositions can be used.

Suitable solid carriers include: minerals, plants, synthetic fillers and inorganic salts. The minerals include silicates, carbonates, sulfates and oxides. Silicates such as kaolin, sepiolite, nacrite, montmorillonite, mica, vermiculite, pyrophyllite, talc. Carbonates such as: calcium carbonate, dolomite. Sulfates such as ammonium sulfate, sodium sulfate, calcium sulfate. Oxides such as quicklime, magnesium lime, diatomaceous earth. Vegetables such as: citrus pomace, corn cob, chaff powder, rice husk, soybean straw powder, tobacco powder, walnut shell, sawdust. Synthetic fillers such as precipitated calcium carbonate hydrate, precipitated calcium carbonate, white carbon black. Inorganic salts such as potassium chloride, sodium chloride.

Liquid carriers include water and organic solvents. When the preparation is emulsifiable concentrate, microemulsion, water emulsion or suspoemulsion, the organic solvent plays the role of solubilization and antifreeze. Suitable organic solvents include aromatics such as benzene, xylene, toluene, alkylbenzenes, alkylnaphthalenes, and chlorinated aromatics; chlorinated aliphatics such as vinyl chloride, chloroform, methylene chloride, chloroform, carbon tetrachloride and polychloroethanes; aliphatic hydrocarbons such as petroleum distillates, cyclohexane, light mineral oils and paraffins. Alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, fatty alcohols, etc.; ethers such as methyl glycol ether, ethyl glycol ether, petroleum ether. Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone and isophorone, N-methyl-pyrrolidone; special solvents also include dimethylformamide, dimethyl sulfoxide, polyethylene glycol Alcohols, nitriles; vegetable oils and methylated vegetable oils. The above-mentioned organic solvents may be used alone, or in combination, or in combination with water.

The auxiliary agent of the present invention may include one or more of surfactants, defoamers, thickeners, suspending agents and antifreezing agents as required, and may also include other auxiliary agents commonly used in this industry as required.

Surfactants can be emulsifiers, dispersants, stabilizers or wetting agents; can be ionic or nonionic. Suitable surfactants include: sodium and calcium salts of polyacrylic acid and lignosulfonic acid; polycondensation products of fatty acids or fatty amines having at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide; glycerol, Fatty acid esters of 1-lauryl alcohol, 1-myristyl alcohol, sorbitol, sucrose or pentaerythritol; and their polycondensation products with ethylene oxide and/or propylene oxide; sulfate salts or Sulfonates; alkali or alkaline earth metal salts, preferably sodium, of sulfuric or sulfonic acids containing at least 10 carbon atoms in the molecule, such as sodium lauryl sulfate, sodium secondary alkyl sulfate, ricinium sulfonate Sodium salt of sesame oil, sodium alkylarylsulfonate and sodium dodecylbenzenesulfonate; polymer of ethylene oxide, copolymer of ethylene oxide and propylene oxide.

Emulsifiers include nonionic emulsifiers and commercially available emulsifiers. Non-ionic emulsifiers are preferably polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers and polyoxyethylene fatty ammonia, such as ethoxylated castor oil, polyoxyethylene (n ₂₀ ) phenylethylphenol ether oleate, Alkylaryl polyoxyethylene polyoxypropylene ether, alkylaryl formaldehyde resin polyoxyethylene ether, tristyrylphenol polyoxyethylene (n ₂₀ ), ether phosphorylated triethanolamine salt, diphenylethylphenol polyoxyethylene Oxyethylene ether (n ₁₈ ) formaldehyde condensate, diphenylphenol polyoxyethylene (n ₁₈ ) polyoxypropylene ether (n ₂₀ ), etc. Commercially available emulsifiers include: Agricultural Milk 0201B, Agricultural Milk 0203B, Agricultural Milk 100 ^# , Agricultural Milk 500 ^# , Agricultural Milk 600 ^# , Agricultural Milk 600-2 ^# , Agricultural Milk 1601, Agricultural Milk 2201, Agricultural Milk NP-10 , Nongru NP-15, Nongru 507 ^# , Nongru OX-635, Nongru OX-622, Nongru OX-653, Nongru OX-667, Nongru CS-7, Ningru 36 ^# .

The dispersant of the present invention includes: sodium lignosulfonate, pull-open powder, calcium lignosulfonate, methylnaphthalenesulfonic acid formaldehyde condensate, naphthalenesulfonic acid formaldehyde condensate, sodium methylenenaphthalenesulfonate, oil Sodium acid methyl amino ethyl sulfonate, epoxy polyether, p-tert-butyl ether, dibutyl naphthalene sulfonic acid formaldehyde condensate, phosphates such as sodium hexametaphosphate, alkylphenol polyoxyethylene phosphate, alkanes Alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, N-methyl-fatty acyl-taurine sodium alkylphenol polyoxyethylene ether formaldehyde condensate, aralkylphenol polyoxyethylene ether phosphate ester alkylphenol poly Oxyethylene ether, castor oil ethylene oxide adduct, ethylene oxide-propylene oxide block copolymer alkylphenol polyoxyethylene ether formaldehyde condensate, alkylphenol polyoxyethylene polyoxypropylene ether and methyl cellulose.

The wetting agent of the present invention includes: sodium lauryl sulfate, sodium alkyl alcohol polyoxyethylene ether sulfate, octylphenol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, Sodium Alkyl Sulfonate, Sodium Dodecyl Benzene Sulfonate, Sodium Alkyl Naphthalene Sulfonate, Alkyl Succinate Sulfonate, Sodium Lauryl Polyoxyethylene Ether Sulfonate, Sodium Alkylamide Taurate, Fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene block polymer, sorbitan fatty acid ester polyoxyethylene ether, etc.

The thickener of the present invention can be artificially synthesized, such as carboxymethyl alcohol, polyvinyl alcohol or polyvinyl acetate; it can also be a natural water-soluble polymer, such as xanthan gum, gelatin, gum arabic , polyvinylpyrrolidone, aluminum magnesium silicate, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac, carboxymethyl cellulose and sodium alginate, etc.

The defoaming agent described in the present invention is preferably: foam enemy, silicones, C _{8 ~ 10} fatty alcohols, C _{10 ~ 20} saturated fatty acids and amides, etc.

The pesticidal composition of the present invention can be formulated into emulsifiable concentrates, suspensions, suspoemulsions, microemulsions, aqueous emulsions, powders, granules or capsules. When formulated into preparations, the emulsifiable oil, suspension, suspoemulsion, microemulsion, water emulsion, powder, granule or capsule contains 0.5-95% by weight of the insecticidal composition.

The above-mentioned powder is preferably a wettable powder, and when formulated into a wettable powder, the wettable powder preferably contains 30% to 40% by weight of the insecticidal composition; the above-mentioned granules are preferably water-dispersible granules, when It is formulated into water-dispersible granules, and the water-dispersible granules preferably contain 30% to 50% by weight of the insecticidal composition. When formulated as emulsifiable concentrate, the insecticidal composition preferably contains 30% to 40% by weight of the emulsifiable concentrate; when formulated as a suspension, the suspension preferably contains 25% to 40% by weight insecticidal composition.

The agricultural insecticidal composition of the present invention can be directly made into a finished preparation form, that is, each material in the composition has been mixed, and is directly used for insecticide; the components of the composition can also be provided by separate preparations, which are stored in a bucket ( tank) mixed directly. The concentrates of the present invention are generally mixed with water to obtain the desired concentration of active substance.

The agricultural insecticidal composition of the present invention is particularly suitable for controlling Lepidoptera, Homoptera and Coleoptera pests; it is suitable for various plants, such as rice, wheat, apple, grape, strawberry, cucumber, zucchini, pepper, Sweet pepper, eggplant, tomato, kidney bean, cowpea, leek, lettuce, cabbage, sunflower, lychee, tobacco, rubber, flowers, Chinese medicinal materials and lawn, etc.

The agricultural insecticide application site of the present invention is farmland, orchard or warehouse. The dosage of the insecticidal composition of the present invention in the field is 30g ai/hm ² -40g ai/hm ² .

The agricultural insecticidal composition of the present invention can be applied by common methods, such as pouring, seed dressing, spraying and spraying. The amount of application varies with climatic conditions or crop status, and the application time can be before or after pest damage. The duration of the protective effect is usually related to the content of the individual compounds in the composition, but also to external factors, such as climate, which can be mitigated by using appropriate formulations.

The agricultural insecticidal composition of the present invention can also be used in combination with other compounds with herbicide and bactericidal properties, and can also be used in combination with nematicides, protective agents, growth regulators, plant nutrients or soil regulators.

Compared with the prior art, the agricultural insecticidal composition of the present invention has the following advantages:

(1) The two insecticidal compounds in the composition show a strong synergistic effect within a certain ratio range, and the insecticidal effect of the mixed composition is significantly improved compared with its single agent, thereby reducing the dosage , while reducing the cost of pesticides for farmers, it also reduces the impact on the environment;

(2) It can control the pests of Lepidoptera, Homoptera and Coleoptera that occur at the same time, providing users with an extremely convenient and effective means of prevention and control.

Detailed ways

The present invention will be further described below in conjunction with specific examples, but the present invention is not limited to these specific implementations. Those skilled in the art will realize that the present invention covers all alternatives, modifications and equivalents as may be included within the scope of the claims.

The percentages in the proportioning of all solid preparations in the invention are percentages by weight, and the percentages in the proportioning ratios of liquid preparations are percentages in volume; the treatment doses of biologically active parts are all effective content.

1. Preparation

1. Preparation of EC

According to the formula requirements, add the solvent, the original drug and the emulsifier respectively, mix evenly, and if necessary, heat and dissolve in a water bath to obtain a transparent emulsifiable oil.

Embodiment 1 (30% emulsifiable concentrate)

ZJ375720%, imidacloprid 10%, Nongru 2201 ^# 7.5%, Nongru 600 ^# 4.5%, dimethylformamide 8%, solvent naphtha 150 to 100% (S-150# (the main component is durene, Jiangsu Hualun Chemical Co., Ltd.)).

Embodiment 2 (40% emulsifiable concentrate)

ZJ375730%, acetamiprid 10%, Nongru 500 ^# 5%, Nongru 0201B 10%, dimethylformamide 12%, solvent oil 150 to 100% (S-150# (the main component is durene, Jiangsu Hualun Chemical Co., Ltd.)).

Embodiment 3 (40% emulsifiable concentrate)

ZJ3757 20%, nitenpyram 20%, Nongru 0203B 6%, Nongru 0201B 9%, cyclohexanone 8%, solvent oil 150 to 100% (S-150# (the main component is durene, Jiangsu Hua Lun Chemical Co., Ltd.)).

2. Preparation of wettable powder

According to the requirements of the formula, the original drug, various additives and fillers are fully mixed, and the processed product is obtained after being pulverized by an ultra-fine pulverizer.

Embodiment 4 (30% wettable powder)

ZJ375720%, imidacloprid 10%, sodium dodecylbenzene sulfonate 2.0%, white carbon black 5%, sodium lignosulfonate 10%, light calcium carbonate to 100%.

Embodiment 5 (40% wettable powder)

ZJ375730%, Nitenpyram 10%, Sodium Lauryl Sulfate 1.5%, Naphthalene Sulfonate Formaldehyde Condensate 5%, Sodium Lignosulfonate 3%, White Carbon Black 8%, Light Calcium Carbonate to 100% .

Embodiment 6 (40% wettable powder)

ZJ375720%, nitenpyram 20%, sodium dodecylbenzene sulfonate 1.8%, p-tert-butyl ether 2%, white carbon black 10%, sodium lignosulfonate 10%, light calcium carbonate to 100% %.

3. Preparation of water dispersible granules

Mix and pulverize the original drug, powdery carrier, wetting and spreading agent, binder, etc., add water and knead, then add to a granulator equipped with a certain size screen for granulation. Then dry and sieve (according to the range of the sieve) to obtain granular products.

Embodiment 7 (30% water dispersible granule)

ZJ3757 20%, Nitenpyram 10%, Sodium Lignosulfonate 15%, Sodium Naphthalene Sulfonate Formaldehyde Condensate 5%, Epoxy Polyether 5%, Bentonite 10%, Kaolin to 100%.

Embodiment 8 (40% water dispersible granule)

ZJ3757 20%, thiamethoxam 20%, N-methyl-oleoyl-sodium taurate 8%, naphtholsulfonic acid formaldehyde condensate 10%, soluble starch 8%, sodium sulfate 10%, kaolin supplemented to 100% .

Embodiment 9 (30% water dispersible granule)

ZJ3757 20%, Thiamethoxam 10%, N-Methyl-Oleoyl-Taurine Sodium 8%, Naphtholsulfonic Acid Formaldehyde Condensate 10%, Soluble Starch 8%, Sodium Sulfate 10%, Kaolin Supplemented to 100% .

Embodiment 10 (50% water dispersible granule)

ZJ3757 40%, Thiamethoxam 10%, Sodium Lignosulfonate 15%, Sodium Naphthalene Sulfonate Formaldehyde Condensate 5%, Epoxy Polyether 5%, Bentonite 10%, Kaolin to 100%.

4. Preparation of suspending agent

According to the requirements of the formula, use water as the medium, mix the original drug, dispersant, wetting agent, suspending agent and antifreeze evenly, then add it to the sand mill, perform sand grinding to a certain particle size and filter, then add the thickener Shear and mix well.

Embodiment 11 (30% suspending agent)

ZJ3757 20%, Nitenpyram 10%, Open Powder 1.5%, Soproplot SC 3%, Xanthan Gum 0.15%, Magnesium Aluminum Silicate 1.5%, 418G 0.3%, BIT 0.05%, Ethylene Glycol 3%, Water Supplement to 100%.

Embodiment 12 (40% suspending agent)

ZJ375720%, Nitenpyram 20%, Sodium Lignosulfonate 5%, White Carbon Black 0.3%, Attapulgite 1.0%, Potassium Dihydrogen Phosphate 0.2%, Ethylene Glycol 4%, Tributyl Phosphate 0.2%, Water was made up to 100%.

Embodiment 13 (30% suspending agent)

ZJ3757 20%, thiamethoxam 10%, sodium methylnaphthalene sulfonate formaldehyde condensate 2.5%, bentonite 1.0%, agricultural milk OX-656 5.0%, glycerin 4%, tributyl phosphate 0.2%, water to make up to 100%.

Embodiment 14 (40% suspending agent)

ZJ3757 20%, thiamethoxam 20%, phenethylphenol polyoxyethylene polyoxypropylene ether 3%, aluminum magnesium silicate 1.0%, xanthan gum 0.1%, propylene glycol polyoxyethylene polyoxypropylene ether 1.0%, water supplement to 100%.

Embodiment 15 (25% suspending agent)

ZJ3757 20%, thiamethoxam 5%, emulsifier 1601# (styrylphenol polyoxyethylene polyoxypropylene ether) 10%, dispersant SOPA-2704, bentonite 2%, xanthan gum 0.1%, silicone defoaming Agent 0.4%, glycerol 5%, water to make up to 100%.

Embodiment 16 (25% suspending agent)

ZJ3757 20%, Thiacloprid 2%, Opening Powder 1.5%, Soproplot SC 3%, Xanthan Gum 0.15%, Magnesium Aluminum Silicate 1.5%, 418G 0.3%, BIT 0.05%, Ethylene Glycol 3%, Water Supplement to 100%.

2. Determination of biological activity

In order to further understand the toxicity of the combination of ZJ3757 and neonicotinoids to pests, a large number of formulation screening tests were carried out. The test refers to the Indoor Bioassay Test Guidelines for Pesticides and Pesticides (Agricultural Industry Standard NY/T1154.7-2006) and the SOP for the Evaluation of Bioactivity of Pesticides (Insecticide Volume), and the rice planthopper was sprayed.

Theoretical mixture toxicity index (TTI) = toxicity index of A × content of A in the mixture (%)

Toxicity index of +B × B content in the mixture (%)

If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if it is less than 80, it indicates an antagonistic effect; if it is greater than 80 but less than 120, it indicates an additive effect.

The results show that: test results: ZJ3757·nitenpyram and ZJ3757·thiamethoxam have high activity on the tested targets, ZJ3757 mixed with nitenpyram and thiamethoxam showed a significant synergistic effect , the activity of the mixture is much higher than that of the control single agent. The results are detailed in Examples 17-18.

Example 17

The combined synergistic effect of ZJ3757 and nitenpyram is shown in Table 1, and the test object is rice planthopper (Nilaparvata lugens).

Table 1 Synergistic effect of ZJ3757 combined with nitenpyram

deal with Proportion _LC50 (mg/L) measured toxicity index theoretical virulence index co-toxicity coefficient ZJ3757: Nitenpyram 50:1 10.943 142.40 118.06 120.62 ZJ3757: Nitenpyram 20:1 8.609 181.01 143.87 125.82 ZJ3757: Nitenpyram 4:1 3.943 395.21 284.23 139.04 ZJ3757: Nitenpyram 2:1 2.448 636.56 407.06 156.38 ZJ3757: Nitenpyram 1:1 1.871 832.87 560.58 148.57 ZJ3757: Nitenpyram 1:2 1.398 1114.66 714.11 156.09 ZJ3757: Nitenpyram 1:4 1.303 1195.93 836.93 142.89 ZJ3757: Nitenpyram 1:20 1.209 1288.92 977.30 131.89 ZJ3757: Nitenpyram 1:50 1.202 1296.42 1003.10 129.24 Nitenpyram - 1.526 1021.17 - - ZJ3757 - 15.583 100.0 - -

Example 18

The synergistic effect of ZJ3757 combined with thiamethoxam is shown in Table 2, and the test object is rice planthopper (N.lugens).

Table 2 Synergistic effect of ZJ3757 combined with thiamethoxam

deal with Proportion _LC50 (mg/L) measured toxicity index theoretical virulence index co-toxicity coefficient ZJ3757: Thiamethoxam 50:1 9.985 148.62 119.48 124.39 ZJ3757: Thiamethoxam 20:1 7.767 191.06 147.31 129.70 ZJ3757: Thiamethoxam 8:1 4.951 299.74 210.40 142.46 ZJ3757: Thiamethoxam 4:1 3.199 463.89 298.72 155.30

[0103] ZJ3757: Thiamethoxam 2:1 2.205 673.02 431.20 156.08 ZJ3757: Thiamethoxam 1:1 1.693 876.55 596.79 146.88 ZJ3757: Thiamethoxam 1:2 1.436 1033.43 762.39 135.55 ZJ3757: Thiamethoxam 1:4 1.232 1204.55 894.87 134.61 ZJ3757: Thiamethoxam 1:20 1.105 1342.99 1046.28 128.36 ZJ3757: Thiamethoxam 1:50 1.024 1449.22 1074.11 134.92 Thiamethoxam - 1.357 1093.59 - - ZJ3757 - 14.840 100.0 - -

3. The effect of field plot control

Example 19 Field efficacy test of Nitenpyram ZJ3757 mixture against rice planthopper and rice leaf roller

Determination of preparation example 7 (30% nitenpyram ZJ3757 water dispersible granule), embodiment 11 (30% nitenpyram ZJ3757 suspension concentrate), embodiment 12 (40% nitenpyram · ZJ3757 suspension concentrate) on the control effect of rice planthopper and rice leaf roller. The experimental site is located in Shaoxing, Zhejiang Province, and it is a single-season hybrid rice. The application rate is 750kg/hm ² . 20% ZJ3757 suspension: 35g ai/hm ² ; 10% nitenpyram soluble liquid: 30g ai/hm ² . Use the "Hemei" HM-16A knapsack electric sprayer to spray evenly on the leaves of the plants. Plot area: 25m ² , repeated 4 times, arranged in random blocks. The survey of rice leaf rollers was carried out by jumping at 5 points in each plot, surveying 5 clumps in each row, and surveying 25 clumps of rice in total. The number of rolled leaves and the total number of leaves in each clump were investigated; Jumping method, investigate the population base of insects before spraying, and investigate the amount of residual insects after spraying.

Test results: using formulation Example 7 (30% Nitenpyram ZJ3757 water-dispersible granules), Example 10 (40% Thiamethoxam ZJ3757 water-dispersible granules), Example 11 (30% Nitenpyram ZJ3757 suspension concentrate), Example 12 (40% Nitenpyram ZJ3757 suspension concentrate), the control effects on rice planthopper and rice leaf roller were 95.6%-98.5% and 90.6%-93.3% respectively 7 days after application 15 days after application, the control effect on rice planthopper and rice leaf roller still reached 76.7%-84.2% and 81.4%-84.8%, and the control effect on brown planthopper was better than 10% nitenpyram soluble liquid 30g ai/hm ² , the control effect on rice leaf roller is better than or equivalent to 20% ZJ3757 SC 35g ai/hm ² , nitenpyram·ZJ3757 can control rice planthopper and rice leaf roller at the same time, and has a long lasting effect.

Table 3 Results of field efficacy tests of nitenpyram·ZJ3757 mixture against rice planthopper and rice leaf roller

Example 18 Field efficacy test of thiamethoxam and ZJ3757 mixture against rice planthopper and rice leaf roller

Determination of formulation Example 8 (40% Thiamethoxam ZJ3757 water-dispersible granules), Example 9 (30% Thiamethoxam ZJ3757 water-dispersible granules), Example 10 (50% Thiamethoxam ZJ3757 water-dispersible granules) under field conditions ZJ3757 water dispersible granules), Example 13 (30% Thiamethoxam ZJ3757 suspension), Example 14 (40% Thiamethoxam ZJ3757 suspension), Example 15 (25% Thiamethoxam ZJ3757 suspension ) against rice planthopper and rice leaf roller. The experimental site is located in Ningbo City, Zhejiang Province, and it is a single-season hybrid rice. The application rate is 750kg/hm ² . 20% ZJ3757 suspension: 35g ai/hm ² ; 25% thiamethoxam water dispersible granule: 16g ai/hm ² . Use the "Hemei" HM-16A knapsack electric sprayer to spray evenly on the leaves of the plants. Plot area: 25m ² , repeated 4 times, arranged in random blocks. The survey of rice leaf rollers was carried out by jumping at 5 points in each plot, surveying 5 clumps in each row, and surveying 25 clumps of rice in total. The number of rolled leaves and the total number of leaves in each clump were investigated; Jumping method, investigate the population base of insects before spraying, and investigate the amount of residual insects after spraying.

Test results: Example 8 (40% thiamethoxam ZJ3757 water-dispersible granules), Example 9 (30% thiamethoxam ZJ3757 water-dispersible granules), and Example 10 (50% thiamethoxam ZJ3757 water-dispersible granules) were used. Water dispersible granules), Example 13 (30% Thiamethoxam ZJ3757 suspension), Example 14 (40% Thiamethoxam ZJ3757 suspension), Example 15 (25% Thiamethoxam ZJ3757 suspension) 3 days after application, the control effect on rice planthopper was 70.4%-85.2%, the control effect on rice leaf roller was 45.2%-50.3%, and the control effect on rice planthopper and rice leaf roller was 93.5% on 7 days after application. %-98.7% and 88.4%-95.5%, 15 days after application, the control effect on rice planthopper and rice leaf roller still reached 80.7%-91.3% and 74.2%-83.1%, and the control effect on rice planthopper was better than or equivalent to With 16g ai/hm ² of 25% thiamethoxam water dispersible granules, the control effect on rice leaf roller is better than or equivalent to 35g ai/hm ² of 20% ZJ3757 suspension concentrate, and thiamethoxam·ZJ3757 can control rice fly Lice and rice leaf roller, and long-lasting.

Table 4 Field efficacy test of thiamethoxam·ZJ3757 mixture against rice planthopper and rice leaf roller

Example 19 Field efficacy test of mixture of thiamethoxam and ZJ3757 on rice stem borer and rice water weevil

Determination of formulation Example 8 (40% Thiamethoxam ZJ3757 water-dispersible granules), Example 9 (30% Thiamethoxam ZJ3757 water-dispersible granules), Example 13 (30% Thiamethoxam ZJ3757 water-dispersible granules) under field conditions ZJ3757 suspension concentrate), Example 14 (40% thiamethoxam · ZJ3757 suspension concentrate) on the control effect of Chilo suppressalis and rice water weevil. The experimental site is located in Yingkou City, Liaoning Province, and the rice variety is Yanfeng 47. The application rate is 750kg/hm ² . 20% ZJ3757 suspension: 40g ai/hm ² ; 25% thiamethoxam water dispersible granule: 25g ai/hm ² . Use the "Hemei" HM-16A knapsack electric sprayer to spray evenly on the leaves of the plants. Plot area: 25m ² , repeated 4 times, arranged in random blocks. The investigation of Chilorrhizae adopts 5-point sampling in every plot, and 5 clumps are surveyed in each row. A total of 25 clumps of rice are investigated, and the number of dead seedlings and the total number of plants in each clump are investigated; the rice water weevil uses 5-point sampling in parallel jumps. Investigate the population base of insects, and investigate the amount of residual adults after treatment.

Test results: Example 8 (40% thiamethoxam ZJ3757 water-dispersible granules), Example 9 (30% thiamethoxam ZJ3757 water-dispersible granules), and Example 13 (30% thiamethoxam ZJ3757 water-dispersible granules) were used. Suspension concentrate), Example 14 (40% thiamethoxam ZJ3757 suspension concentrate), 7 days after the drug, the control effect on rice water weevil was 91.6%-94.1%, and the control effect on rice borer was 89.5%-92.7%. After 15 days, the control effect on rice water weevil and rice stem borer still reached 89.3%-93.4% and 92.7%-93.7%, and the control effect on rice water weevil and stem borer was better than 25% thiamethoxam water dispersible granule 25g ai/hm ² and 20% ZJ3757 SC 40g ai/hm ² , thiamethoxam·ZJ3757 can control rice water weevil and stem borer at the same time.

Table 5 Field efficacy test of thiamethoxam·ZJ3757 mixture on rice water weevil and Chilo borer

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Claims (8)

1. An agricultural insecticidal composition is characterized in that containing two kinds of active components, the first active component is N-(2-(tert-butylcarbamoyl)-4-chlorine with the following structural formula (I) -6-methylphenyl)-1-(3-chloropyridin-2-yl)-3-fluoromethoxy-1H-pyrazole-5-carboxamide, The second active component is selected from nitenpyram and/or thiamethoxam, and the weight ratio of the first active component to the second active component is 20:1˜1:20. 2. The agricultural insecticidal composition according to claim 1, characterized in that the weight ratio of the first active component to the second active component is 4:1˜1:4. 3. The agricultural insecticidal composition according to claim 2, characterized in that the weight ratio of the first active component to the second active component is 2:1˜1:2. 4. According to the agricultural insecticidal composition described in one of claims 1 to 3, it is characterized in that the insecticidal composition is formulated as emulsifiable concentrate, suspension concentrate, suspoemulsion, microemulsion, water emulsion, powder, granule or Capsules, the emulsifiable concentrate, suspending agent, suspoemulsion, microemulsion, water emulsion, powder, granule or capsule contain the pesticidal composition in an amount of 0.5-95% by weight. 5. according to the described agricultural insecticidal composition of claim 4, it is characterized in that said powder is wettable powder, contains the insecticidal composition of 30%～40% by weight in the wettable powder, and said granule The water dispersible granule contains 30%-50% by weight of the insecticidal composition. 6. According to the agricultural insecticidal composition described in claim 4, it is characterized in that the insecticidal composition contains 30% to 40% by weight in the said emulsifiable concentrate, and contains 25% to 40% by weight in the said suspending agent The percentage content of the insecticidal composition. 7. According to the application of the agricultural insecticidal composition according to claim 1, it is characterized in that said insecticidal composition is used to prevent and control Lepidoptera rice stem borer, rice leaf roller, Homoptera rice planthopper and elytra Purpose Rice water weevil. 8. The application of the agricultural insecticidal composition according to claim 4, characterized in that the application dose of the insecticidal composition in the field is 30g ai/hm ² -40g ai/hm ² .