CN102907438A - Insecticidal composite containing ZJ3757 and pymetrozine - Google Patents

Abstract

An insecticidal composition containing ZJ3757 and pymetrozine. The invention discloses an agricultural insecticide composition, which contains two active components. The first active component is N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)- 1-(3-Chloropyridin-2-yl)-3-fluoromethoxy-1H-pyrazole-5-carboxamide, another active ingredient is pymetrozine. The insecticide composition of the invention has the effect of synergizing and expanding the control spectrum, and is especially suitable for controlling Lepidoptera and Homoptera pests.

Description

Insecticidal composition containing ZJ3757 and pymetrozine

technical field

The invention belongs to the field of agricultural insecticides and relates to an insecticidal composition containing ZJ3757 and pymetrozine. the

Background technique

In agricultural production practice, we often face the phenomenon of mixed occurrence of multiple pests on one crop. For example, when rice planthopper harms rice, it is often accompanied by mixed occurrence of rice leaf roller, rice stem borer, and rice stem borer. Vegetables also have Whitefly, aphids and diamondback moth, spodoptera litura, beet armyworm, etc. mixed phenomenon. Due to long-term use, many pests will show resistance to insecticides, so insecticides need to be improved. the

ZJ3757 belongs to o-formamidobenzamide insecticides, and its chemical structure is as follows:

The chemical name is: N-(2-(tert-butylcarbamoyl)-4-chloro-6-methylphenyl)-1-(3-chloropyridin-2-yl)-3-fluoromethoxy-1H-pyridine Azole-5-carboxamide, molecular formula: C ₂₂ H ₂₂ C ₁₂ FN ₅ O ₃ , relative molecular mass: 494.35. ZJ3757 belongs to o-formamidobenzamide insecticides, its insecticidal activity is basically the same as that of chlorantraniliprole developed by DuPont, and it belongs to ryanodine receptor-acting agent insecticides. It can be combined with ryanodine receptors, leading to the uncontrolled and loss of Ca ²⁺ release, paralyzing the contraction function of muscle cells. It is a compound with a new mechanism of action. The pests treated with the pesticide showed rapid cessation of feeding, fatigue, nausea and muscle paralysis, until death. This type of insecticide has a wide insecticidal spectrum, a long residual effect period, low toxicity, is environmentally friendly, and has no cross-resistance with existing various insecticides. It can effectively control various Lepidoptera pests and some Coleoptera larvae and adults, and can also be used to control pests such as ants and termites.

Pymetrozine belongs to pyridine or triazinone insecticides and is a brand new non-biocide insecticide. This product shows excellent control effect on piercing-sucking mouthparts pests of various crops. As long as aphids or planthoppers come into contact with pymetrozine, they will almost immediately produce a stylet blocking effect, stop feeding immediately, and eventually starve to death, and this process is irreversible. Therefore, pymetrozine has an excellent function of blocking insect transmission. Pymetrozine has a contact effect on pests and also has systemic activity. In plants, it can be transported in both xylem and phloem; therefore, it can be used as a foliar spray or as a soil treatment. Thanks to its good transporting properties, new shoots and leaves can also be effectively protected after spraying the stems and leaves. the

Contents of the invention

The object of the present invention is to provide an agricultural insecticide composition containing insecticide ZJ3757 and pymetrozine, which can make full use of the synergistic effect produced by mixing the two active components, expand the control spectrum, improve Control efficiency, reduce agricultural costs, delay the emergence of pest resistance, and solve the inconvenience caused by repeated application of pesticides when various pests occur at the same time, as well as the adverse effects that may be caused by repeated application of pesticides. the

For achieving the purpose of the invention, the technical scheme adopted by the present invention is:

An agricultural insecticide composition, containing two active components, the first active component is ZJ3757 with the above structural formula (I), namely N-(2-(tert-butylcarbamoyl)-4-chloro- 6-methylphenyl)-1-(3-chloropyridin-2-yl)-3-fluoromethoxy-1H-pyrazole-5-carboxamide, the second active ingredient is pymetrozine, so The weight ratio of the first active component to the second active component is 1:50-50:1. the

Chemical name of pymetrozine: 4,5-dihydro-6-methyl-4-(3-pyridinemethyleneamino)-1,2,4-3(2H)-one, molecular formula: C ₁₀ H ₁₁ N ₅ O, molecular weight: 217.23, has the following structural formula (II):

In the agricultural insecticide composition of the present invention, the amount of the active ingredient depends on the application rate of the compound when used alone, and also depends on the ratio of one compound to another compound and the degree of synergistic effect. In the agricultural insecticide composition of the present invention, the weight ratio of the first active component ZJ3757 to the second active component pymetrozine is preferably 1:20 to 20:1, more preferably 1: 3～4:1. the

The agricultural pesticide composition of the present invention may further contain a carrier, which may be solid or liquid, and any carrier usually used for preparing pesticide compositions can be used. the

Suitable solid carriers include: minerals, plants, synthetic fillers and inorganic salts. The minerals include silicates, carbonates, sulfates and oxides. Silicates such as kaolin, sepiolite, nacrite, montmorillonite, mica, vermiculite, pyrophyllite, talc. Carbonates such as: calcium carbonate, dolomite. Sulfates such as ammonium sulfate, sodium sulfate, calcium sulfate. Oxides such as quicklime, magnesium lime, diatomaceous earth. Vegetables such as: citrus pomace, corn cob, chaff powder, rice husk, soybean straw powder, tobacco powder, walnut shell, sawdust. Synthetic fillers such as precipitated calcium carbonate hydrate, precipitated calcium carbonate, white carbon black. Inorganic salts such as potassium chloride, sodium chloride. the

Liquid carriers include water and organic solvents. When the active ingredient is water emulsion or suspoemulsion, the organic solvent plays the role of solubilization and antifreeze. Suitable organic solvents include aromatics such as benzene, xylene, toluene, alkylbenzenes, alkylnaphthalenes, and chlorinated aromatics; chlorinated aliphatics such as vinyl chloride, chloroform, methylene chloride, chloroform, carbon tetrachloride and polychloroethanes; aliphatic hydrocarbons such as petroleum distillates, cyclohexane, light mineral oils and paraffins. Alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, fatty alcohols, etc.; ethers such as methyl glycol ether, ethyl glycol ether, petroleum ether. Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone and isophorone, N-methyl-pyrrolidone; special solvents also include dimethylformamide, dimethyl sulfoxide, polyethylene glycol , Capronitrile; vegetable oil and methylated vegetable oil. The above-mentioned organic solvents may be used alone, or in combination, or in combination with water. the

The auxiliary agent of the present invention may include one or more of surfactants, defoamers, thickeners, suspending agents and antifreezing agents as required, and may also include other auxiliary agents commonly used in this industry as required. the

Surfactants can be emulsifiers, dispersants, stabilizers or wetting agents; can be ionic or nonionic. Suitable surfactants include: sodium and calcium salts of polyacrylic acid and lignosulfonic acid; polycondensation products of fatty acids or fatty amines having at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide; glycerol, Fatty acid esters of 1-lauryl alcohol, 1-myristyl alcohol, sorbitol, sucrose or pentaerythritol; and their polycondensation products with ethylene oxide and/or propylene oxide; sulfate salts or Sulfonates; alkali or alkaline earth metal salts, preferably sodium, of sulfuric or sulfonic acids containing at least 10 carbon atoms in the molecule, such as sodium lauryl sulfate, sodium secondary alkyl sulfate, ricinium sulfonate Sodium salt of sesame oil, sodium alkylarylsulfonate and sodium dodecylbenzenesulfonate; polymer of ethylene oxide, copolymer of ethylene oxide and propylene oxide. the

Emulsifiers include nonionic emulsifiers and commercially available emulsifiers. Non-ionic emulsifiers are preferably polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers and polyoxyethylene fatty ammonia, such as ethoxylated castor oil, polyoxyethylene (n ₂₀ ) phenylethylphenol ether oleate, Alkylaryl polyoxyethylene polyoxypropylene ether, alkylaryl formaldehyde resin polyoxyethylene ether, tristyrylphenol polyoxyethylene (n ₂₀ ), ether phosphorylated triethanolamine salt, diphenylethylphenol polyoxyethylene Oxyethylene ether (n ₁₈ ) formaldehyde condensate, diphenylphenol polyoxyethylene (n ₁₈ ) polyoxypropylene ether (n ₂₀ ), etc. Commercially available emulsifiers include: Agricultural Milk 0201B, Agricultural Milk 0203B, Agricultural Milk 100 ^# , Agricultural Milk 500 ^# , Agricultural Milk 600 ^# , Agricultural Milk 600-2 ^# , Agricultural Milk 1601, Agricultural Milk 2201, Agricultural Milk NP-10 , Nongru NP-15, Nongru 507 ^# , Nongru OX-635, Nongru OX-622, Nongru OX-653, Nongru OX-667, Nongru CS-7, Ningru 36 ^# .

The dispersant of the present invention includes: sodium lignosulfonate, pull-open powder, calcium lignosulfonate, methylnaphthalenesulfonic acid formaldehyde condensate, naphthalenesulfonic acid formaldehyde condensate, sodium methylenenaphthalenesulfonate, oil Sodium acid methyl amino ethyl sulfonate, epoxy polyether, p-tert-butyl ether, dibutyl naphthalene sulfonic acid formaldehyde condensate, phosphates such as sodium hexametaphosphate, alkylphenol polyoxyethylene phosphate, alkanes Alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, N-methyl-fatty acyl-taurine sodium alkylphenol polyoxyethylene ether formaldehyde condensate, aralkylphenol polyoxyethylene ether phosphate ester alkylphenol poly Oxyethylene ether, castor oil ethylene oxide adduct, ethylene oxide propylene oxide block copolymer alkylphenol polyoxyethylene ether formaldehyde condensate, alkylphenol polyoxyethylene polyoxypropylene ether and methyl fiber white. the

The wetting agent of the present invention includes: sodium lauryl sulfate, sodium alkyl alcohol polyoxyethylene ether sulfate, octylphenol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, Sodium Alkyl Sulfonate, Sodium Dodecyl Benzene Sulfonate, Sodium Alkyl Naphthalene Sulfonate, Alkyl Succinate Sulfonate, Sodium Lauryl Polyoxyethylene Ether Sulfonate, Sodium Alkylamide Taurate, Fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene block polymer, sorbitan fatty acid ester polyoxyethylene ether, etc. the

The thickener of the present invention can be artificially synthesized, such as carboxymethyl alcohol, polyvinyl alcohol or polyvinyl acetate; it can also be a natural water-soluble polymer, such as xanthan gum, gelatin, gum arabic , polyvinylpyrrolidone, aluminum magnesium silicate, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac, carboxymethyl cellulose and sodium alginate, etc. the

The defoaming agent described in the present invention is preferably: foam enemy, silicones, C _{8 ~ 10} fatty alcohols, C _{10 ~ 20} saturated fatty acids and amides, etc.

The agricultural insecticide composition of the present invention can be formulated into suspension, suspoemulsion, microemulsion, water emulsion, powder, granule or capsule. When formulated into a preparation, the suspension, suspoemulsion, microemulsion, water emulsion, powder, granule or capsule contains an insecticide composition in an amount of 0.5-95% by weight. the

The above-mentioned granules are preferably water-dispersible granules. When configured as water-dispersible granules, the water-dispersible granules preferably contain 20% to 40% by weight of the insecticide composition. When configured as a suspension, preferably the suspension contains 20% to 40% by weight of the insecticide composition. The above-mentioned powder is preferably a wettable powder, and when formulated into a wettable powder, it is preferable that the wettable powder contains 30% to 40% by weight of the insecticide composition. the

The agricultural insecticide composition of the present invention can be directly made into a finished preparation form, that is, each material in the composition has been mixed and used directly for insecticide; (tank) for direct mixing. The concentrates of the present invention are generally mixed with water to obtain the desired concentration of active substance. the

The agricultural insecticide composition of the present invention is particularly suitable for controlling pests of Lepidoptera, Homoptera and Coleoptera, and is suitable for various plants, such as rice, wheat, apple, grape, strawberry, cucumber, zucchini, pepper , bell pepper, eggplant, tomato, kidney bean, cowpea, leek, lettuce, cabbage, sunflower, lychee, tobacco, rubber, flowers, Chinese medicinal materials and lawn, etc. the

The agricultural insecticide application site of the present invention is farmland, orchard or warehouse. The dosage of the insecticide composition of the present invention in the field is preferably 40g ai/hm ² -60g ai/hm ² .

The agricultural insecticide composition of the present invention can be applied by common methods, such as pouring, spraying and spraying. The amount of application varies with climatic conditions or crop status, and the application time can be before or after pest damage. The duration of the protective effect is usually related to the content of the individual compounds in the composition, but also to external factors, such as climate, which can be mitigated by using appropriate formulations. the

The agricultural insecticide composition of the present invention can also be used in combination with other compounds with herbicidal and bactericidal properties, and can also be used in combination with nematicides, protective agents, growth regulators, plant nutrients or soil regulators. the

Compared with the prior art, the agricultural insecticide composition of the present invention has two significant advantages:

(1) The combination of the two active components in the composition shows a strong synergistic effect within a certain ratio range, and the insecticidal effect of the mixed composition is significantly improved compared with its single agent, thereby reducing the use of Dosage, while reducing the cost of farmers' medication, it also reduces the degree of impact on the environment;

(2) It can prevent and control pests such as Lepidoptera and Homoptera that occur at the same time, providing users with an extremely convenient and effective means of prevention and control. the

Detailed ways

The present invention will be further described below in conjunction with specific examples, but the present invention is not limited to these specific implementations. Those skilled in the art will realize that the present invention covers all alternatives, modifications and equivalents as may be included within the scope of the claims. the

The proportioning percentages of all solid preparations in the present invention are weight percentages, and the proportioning percentages of liquid preparations are volume percentages; the treatment doses of biologically active parts are all effective contents. the

1. Preparation

1. Preparation of wettable powder

According to the requirements of the formula, the original drug, various additives and fillers are fully mixed, and the processed product is obtained after being pulverized by an ultra-fine pulverizer. the

Embodiment 1 (30% wettable powder)

ZJ375710%, 20% pymetrozine, 2.0% sodium dodecylbenzene sulfonate, 5% white carbon black, 10% sodium lignosulfonate, light calcium carbonate supplemented to 100%. the

Embodiment 2 (40% wettable powder)

ZJ375720%, 20% pymetrozine, 1.5% sodium lauryl sulfate, 5% naphthalene sulfonic acid formaldehyde condensate, 3% sodium lignosulfonate, 8% white carbon black, light calcium carbonate supplemented to 100%. the

Embodiment 3 (30% wettable powder)

ZJ375715%, 15% pymetrozine, 1.8% sodium dodecylbenzenesulfonate, 10% white carbon black, 10% sodium lignosulfonate, and light calcium carbonate make up to 100%. the

2. Preparation of water dispersible granules

Mix and pulverize the original drug, powdery carrier, dispersant, wetting agent and filler, add water and knead, then add to a granulator equipped with a certain size screen for granulation. Then dry and sieve (according to the range of the sieve) to obtain granular products. the

Embodiment 4 (20% water dispersible granules)

ZJ375710%, 10% pymetrozine, 15% sodium lignosulfonate, 5% sodium methylnaphthalenesulfonate formaldehyde condensate, 10% bentonite, and 100% kaolin. the

Embodiment 5 (40% water dispersible granules)

ZJ375710%, 30% pymetrozine, 8% sodium N-methyl-oleoyl-taurine, 10% naphtholsulfonic acid formaldehyde condensate, 8% soluble starch, 10% sodium sulfate, kaolin to make up to 100%. the

Embodiment 6 (30% water dispersible granules)

ZJ375720%, 10% pymetrozine, 8% N-methyl-oleoyl-taurine sodium, 10% naphtholsulfonic acid formaldehyde condensate, 8% soluble starch, 10% sodium sulfate, kaolin to make up to 100%. the

Embodiment 7 (30% water dispersible granules)

ZJ375710%, 20% pymetrozine, 15% sodium lignosulfonate, 5% sodium methylnaphthalenesulfonate formaldehyde condensate, 10% bentonite, and 100% kaolin. the

3. Preparation of suspending agent

According to the formula requirements, use water as the medium, mix the original drug, dispersant, wetting agent, suspending agent and antifreeze, and then add it into the sand mill to grind to a certain particle size, filter and add thickener to shear Stir evenly, and prepare the suspending agent of the desired concentration. the

Embodiment 8 (30% suspending agent)

ZJ375710%, 20% pymetrozine, 1.5% open powder, 3% Soproplot SC, 0.15% xanthan gum, 1.5% magnesium aluminum silicate, 0.3% 418G, 0.05% BIT, water to 100%. the

Embodiment 9 (30% suspending agent)

ZJ375720%, pymetrozine 10%, pull open powder 1.5%, Soproplot SC 3%, xanthan gum 0.15%, magnesium aluminum silicate 1.5%, 418G 0.3%, BIT 0.05%, water to 100%. the

Embodiment 10 (40% suspending agent)

ZJ375720%, pymetrozine 20%, polycarboxylate 5%, white carbon black 0.3%, attapulgite 1.0%, potassium dihydrogen phosphate 0.2%, ethylene glycol 4%, tributyl phosphate 0.2%, water supplement to 100%. the

Embodiment 11 (30% suspending agent)

ZJ375715%, pymetrozine 15%, sodium methylnaphthalenesulfonate formaldehyde condensate 2.5%, bentonite 1.0%, Nongru OX-6565.0%, glycerol 4%, tributyl phosphate 0.2%, water to 100% . the

Embodiment 12 (20% suspending agent)

ZJ375710%, 10% pymetrozine, 3% phenylethylphenol polyoxyethylene polyoxypropylene ether, 1.0% aluminum magnesium silicate, 0.1% xanthan gum, 1.0% propylene glycol polyoxyethylene polyoxypropylene ether, water to make up to 100%. the

2. Determination of biological activity

In order to further understand the toxicity of the combination of ZJ3757 and pymetrozine to pests, a large number of formulation screening tests were carried out. The test refers to the Indoor Bioassay Test Guidelines for Insecticides and Pesticides (Agricultural Industry Standard NY/T1154.7-2006) and the SOP for the Evaluation of Bioactivity of Pesticides (Insecticide Volume), and the rice planthopper is sprayed. the

Theoretical mixture toxicity index (TTI) = toxicity index of A × content of A in the mixture (%) + toxicity index of B × content of B in the mixture (%) 

If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if it is less than 80, it indicates an antagonistic effect; if it is greater than 80 but less than 120, it indicates an additive effect. the

The test results show that: ZJ3757·Pymetrozine mixture has very high activity on the tested targets, and ZJ3757 and pymetrozine have a significant synergistic effect, and the activity of the mixture is much higher than that of the control single agent. The results are detailed in Example 13. the

Example 13

The combined synergistic effect of ZJ3757 and pymetrozine is shown in Table 1 below, and the test object is rice planthopper (Nilaparvata lugens). the

Table 1 ZJ3757 and pymetrozine mixed synergistic effect

3. The effect of field plot control

Example 14 ZJ3757 Pymetrozine mixed field efficacy test on rice planthopper and rice leaf roller

Determination of preparation Example 1 (30% ZJ3757·Pymetrozine wettable powder), Example 3 (30% ZJ3757·Pymetrozine wettable powder), Example 4 (30%ZJ3757·Pymetrozine water Dispersible Granules), Example 7 (30% ZJ3757 Pymetrozine Water Dispersible Granules), Example 8 (30% ZJ3757 Pymetrozine Suspension Concentrate), Example 11 (30% ZJ3757 Pymetrozine Suspension Concentrate ) and Example 12 (20% ZJ3757 · pymetrozine suspension concentrate) on the control effect of rice planthopper and rice leaf roller. The experimental site is located in Cangqian Town, Hangzhou, Zhejiang Province, and it is a single-season hybrid rice. The application rate is 750kg/hm ² . The dosage of each preparation example is 40g ai/hm ² or 60g ai/hm ² , 20% ZJ3757 suspension: 35g ai/hm ² , 25% pymetrozine WP: 60g ai/hm ² . Use the "Hemei" HM-16A knapsack electric sprayer to spray evenly on the leaves of the plants. Plot area: 25m ² , repeated 4 times, arranged in random blocks. The survey of rice leaf rollers was carried out by jumping at 5 points in each plot, surveying 5 clumps in each row, and surveying 25 clumps of rice in total. The number of rolled leaves and the total number of leaves in each clump were investigated; Jumping method, investigate the population base of insects before spraying, and investigate the amount of residual insects after spraying.

Test results: Example 1 (30% ZJ3757 Pymetrozine wettable powder), Example 3 (30% ZJ3757 Pymetrozine wettable powder), Example 4 (30% ZJ3757 Pymetrozine water dispersion Granules), Example 7 (30% ZJ3757 Pymetrozine Water-dispersible Granules), Example 8 (30% ZJ3757 Pymetrozine Suspension Concentrate), Example 11 (30% ZJ3757 Pymetrozine Suspension Concentrate) And embodiment 12 (20% ZJ3757 · pymetrozine suspension concentrate), 7 days after the medicine, the control effect on rice planthopper and rice leaf roller is respectively 92.8%-96.6% and 80.3%-92.9%, 15 days after the medicine on rice The control effect of planthopper and rice leaf roller still reaches 79.8%-86.6% and 72.6%-81.9%, and the control effect of rice planthopper is better than or equivalent to 25% pymetrozine WP 60g ai/hm ² . The control effect of leaf roller is better than or equivalent to 20% ZJ3757 SC 35g ai/hm ² , and ZJ3757·pymetrozine can control rice planthopper and rice leaf roller at the same time, and has a long lasting effect.

Table 2 ZJ3757·Pymetrozine mixed field efficacy test results on rice planthopper and rice leaf roller

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Claims (9)

1. An agricultural insecticide composition is characterized in that containing two kinds of active components, the first active component is N-(2-(tert-butylcarbamoyl)-4- Chloro-6-methylphenyl)-1-(3-chloropyridin-2-yl)-3-fluoromethoxy-1H-pyrazole-5-carboxamide,

The second active ingredient is 4,5-dihydro-6-methyl-4-(3-pyridinemethyleneamino)-1,2,4-3(2H) with the following structural formula (II) -ketone,

The weight ratio of the first active component to the second active component is 1:50˜50:1. 2. The agricultural insecticide composition according to claim 1, characterized in that the weight ratio of the first active component to the second active component is 1:20˜20:1. 3. The agricultural insecticide composition according to claim 2, characterized in that the weight ratio of the first active component to the second active component is 1:3˜4:1. 4. According to the agricultural insecticide composition described in one of claims 1 to 3, it is characterized in that the insecticide composition is formulated as a suspension, suspoemulsion, microemulsion, water emulsion, powder, granule or Capsules, said suspensions, suspoemulsions, microemulsions, water emulsions, powders, granules or capsules contain 0.5-95% by weight of the insecticide composition. 5. The agricultural insecticide composition according to claim 4, characterized in that said powder is a wettable powder, and said granule is a water-dispersible granule. 6. The agricultural insecticide composition according to claim 4, characterized in that the suspension contains 20% to 40% by weight of the insecticide composition. 7. The agricultural insecticide composition according to claim 5, characterized in that the wettable powder contains 30% to 40% by weight of the insecticide composition, and the water-dispersible granules The insecticide composition contains 20%-40% by weight. 8. According to the application of the agricultural insecticide composition described in claim 1, it is characterized in that it is used for controlling Lepidoptera and Homoptera pests. 9. The application of the agricultural pesticide composition according to claim 8, characterized in that the dosage of the pesticide composition in the field is 40g ai/hm ² -60ga.i./hm ² .