CN108496978A - A kind of miticide composition containing loop coil ether derivative - Google Patents

Abstract

The invention provides an acaricidal composition, containing two active ingredients, the first active ingredient includes at least one selected from the compounds shown in A-7, A-8 and A-10, the second active ingredient Including at least one selected from abamectin, emamectin, spinosyn, spinosad, ivermectin, milbemycin, avermectin and mibaymectin. The acaricidal composition provided by the invention can improve the control effect, reduce the agricultural cost, and delay the generation of insecticide resistance.

Description

Acaricidal composition containing spirocyclic ether derivatives

technical field

The present invention relates to an insecticidal composition, in particular to an acaricidal composition.

Background technique

Agricultural pest mites are one of the most difficult pests to control due to their small size, rapid reproduction, strong adaptability, and easy resistance. Pest mites are important organisms of fruit trees, vegetables, and agricultural and forestry crops. They mainly harm leaves, but also young shoots, flower buds and fruits. After a sharp increase in the number of insect populations, it often causes plant defoliation, growth inhibition or even death. The crops in the affected area are often slightly shorter, and the quality and yield are obviously reduced.

Spirocyclic ether derivatives, as shown in the following structural formulas A-7, A-8 and A-10, have the same mechanism of action as spirodiclofen, which mainly inhibits the fat synthesis in harmful mites, and is comparable to existing acaricides. No cross-resistance, suitable for use against harmful mites that have developed resistance to existing acaricides. Moreover, it has a wide spectrum of acaricide and strong adaptability, and has good control effects on red spider mites, yellow spiders, rust ticks, tea yellow mites, cinnabar spider mites, and two-spotted spider mites. It can be used for citrus, grapes and other fruit trees. It can control the mite infestation of solanaceous crops such as eggplant, pepper, tomato; the ovum killing effect is particularly excellent, and it also has a good contact killing effect on young nymphs, and the long-lasting effect can control the damage of citrus panonychia for 40-50 days .

In actual use, the long-term use of a single acaricide species is likely to cause the problem of resistance of harmful mites to a single acaricide. The development of a new acaricide composition is one of the methods to solve the problem of delaying the service life of acaricides and slowing down the development of resistance of harmful mites to a single acaricide.

Contents of the invention

The purpose of the present invention is to provide an acaricidal composition, which can improve the control effect, reduce the agricultural cost and delay the generation of insecticide resistance.

The present invention provides following technical scheme:

A composition, the composition contains two active ingredients, the first active ingredient includes at least one of the compounds shown in the following A-7, A-8 and A-10, the second active ingredient includes At least one selected from abamectin, emamectin, spinosad, ethyl spinosyn, ivermectin, milbemycin, avermectin and mibaymectin,

The composition provided by the present invention contains two active ingredients, wherein: the first active ingredient may comprise at least one selected from the compound shown in A-7, the compound shown in A-8 and the compound shown in A-10 The second active ingredient may be selected from the group consisting of abamectin, emamectin, spinosyn, ethyl spinosyn, ivermectin, milbemycin, severamectin and Mibai bacteria at least one of the elements.

The composition provided by the invention has no special requirement on the ratio of the two active ingredients. Theoretically, the two active ingredients can be mixed in any proportion.

Preferably, the mass ratio of the first active ingredient to the second active ingredient is 50:1˜1:50.

Further preferably, the mass ratio of the first active ingredient to the second active ingredient is 20:1˜1:20.

Even more preferably, the mass ratio of the first active ingredient to the second active ingredient is 20:1˜1:6.

When the first active ingredient includes more than one compound selected from the compounds shown in A-7, the compound shown in A-8 and the compound shown in A-10, the compounds included in the first active ingredient can be in any ratio exist.

When the second active ingredient is selected from the group consisting of abamectin, emamectin, spinosyn, ethyl spinosyn, ivermectin, milbemycin, asvermectin and mibaycin When more than one is selected from abamectin, emamectin, spinosyn, ethyl spineramectin, ivermectin, milbemycin, tenvermectin and mibaycin Two or three of them can exist in any ratio.

The present invention also provides an acaricide, which contains more than 0.1% by weight of the above-mentioned composition containing two active ingredients.

Preferably, the acaricide contains 1% to 80% by weight of the above-mentioned composition containing two active ingredients as claimed in claim 1 .

The acaricide provided by the present invention, in addition to the above-mentioned composition, may further include pesticide-acceptable carriers and adjuvants usually used for preparing acaricides. The carrier can be solid or liquid.

Suitable solid carriers include: minerals, plants, synthetic fillers and inorganic salts. Minerals include silicates, carbonates, sulfates and oxides. Silicates such as kaolin, sepiolite, nacrite, montmorillonite, mica, vermiculite, pyrophyllite, talc. Carbonates such as: calcium carbonate, dolomite. Sulfates such as ammonium sulfate, sodium sulfate, calcium sulfate. Oxides such as quicklime, magnesium lime, diatomaceous earth. Vegetables such as: citrus pomace, corn cob, chaff powder, rice husk, soybean straw powder, tobacco powder, walnut shell, sawdust. Synthetic fillers such as precipitated calcium carbonate hydrate, precipitated calcium carbonate, white carbon black. Inorganic salts such as potassium chloride, sodium chloride.

Liquid carriers include water and organic solvents. When the active ingredient is water emulsion or suspoemulsion, the organic solvent plays the role of solubilization and antifreeze. Suitable organic solvents include: aromatics such as benzene, xylene, toluene, alkylbenzenes, alkylnaphthalenes and chlorinated aromatics; chlorinated aliphatics such as vinyl chloride, chloroform, methylene chloride, chloroform, tetrachloride carbon and polychloroethanes; aliphatic hydrocarbons such as petroleum distillates, cyclohexane, light mineral oil and paraffins; alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, Glycerol, fatty alcohol, etc.; ethers, such as methyl glycol ether, ethyl glycol ether, petroleum ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, isoflurane ketone, N-methyl-pyrrolidone; specialty solvents such as dimethylformamide, dimethylsulfoxide, polyethylene glycol, hexanonitrile; vegetable oils and methylated vegetable oils. The above-mentioned organic solvents may be used alone, or in combination, or in combination with water.

The auxiliary agent in the present invention may include at least one selected from surfactants, defoamers, thickeners, suspending agents and antifreeze agents as required, and may also include other auxiliary agents commonly used in this industry as required.

Surfactants can be emulsifiers, dispersants, stabilizers or wetting agents, and can be ionic or nonionic. Suitable surfactants include: sodium and calcium salts of polyacrylic acid and lignosulfonic acid; polycondensation products of fatty acids or fatty amines having at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide; glycerol, Fatty acid esters of 1-lauryl alcohol, 1-myristyl alcohol, sorbitol, sucrose or pentaerythritol; and their polycondensation products with ethylene oxide and/or propylene oxide; sulfate salts or Sulfonates; alkali or alkaline earth metal salts, preferably sodium, of sulfuric or sulfonic acids containing at least 10 carbon atoms in the molecule, such as sodium lauryl sulfate, sodium secondary alkyl sulfate, ricinium sulfonate Sodium salt of sesame oil, sodium alkylarylsulfonate and sodium dodecylbenzenesulfonate; polymer of ethylene oxide, copolymer of ethylene oxide and propylene oxide.

Emulsifiers include nonionic emulsifiers and commercially available emulsifiers. Nonionic emulsifiers are preferably polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers and polyoxyethylene fatty ammonia, such as ethoxylated castor oil, polyoxyethylene (n ₂₀ ) phenethylphenol ether oleate, Alkylaryl polyoxyethylene polyoxypropylene ether, alkylaryl formaldehyde resin polyoxyethylene ether, tristyrylphenol polyoxyethylene (n ₂₀ ), ether phosphorylated triethanolamine salt, diphenylethylphenol polyoxyethylene Oxyethylene ether (n ₁₈ ) formaldehyde condensate, diphenylphenol polyoxyethylene (n ₁₈ ) polyoxypropylene ether (n ₂₀ ), etc. Commercially available emulsifiers include: Agricultural Milk 0201B, Agricultural Milk 0203B, Agricultural Milk 100 ^# , Agricultural Milk 500 ^# , Agricultural Milk 600 ^# , Agricultural Milk 600-2 ^# , Agricultural Milk 1601, Agricultural Milk 2201, Agricultural Milk NP-10 , Nongru NP-15, Nongru 507 ^# , Nongru OX-635, Nongru OX-622, Nongru OX-653, Nongru OX-667, Nongru CS-7, Ningru 36 ^# .

The dispersant of the present invention includes: sodium lignosulfonate, pull-open powder, calcium lignosulfonate, methylnaphthalenesulfonic acid formaldehyde condensate, naphthalenesulfonic acid formaldehyde condensate, sodium methylenenaphthalenesulfonate, oil Sodium acid methyl amino ethyl sulfonate, epoxy polyether, p-tert-butyl ether, dibutyl naphthalene sulfonic acid formaldehyde condensate, phosphates such as sodium hexametaphosphate, alkylphenol polyoxyethylene phosphate, alkanes Alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, N-methyl-fatty acyl-taurine sodium alkylphenol polyoxyethylene ether formaldehyde condensate, aralkylphenol polyoxyethylene ether phosphate ester alkylphenol poly Oxyethylene ether, castor oil ethylene oxide adduct, ethylene oxide-propylene oxide block copolymer alkylphenol polyoxyethylene ether formaldehyde condensate, alkylphenol polyoxyethylene polyoxypropylene ether and methyl cellulose.

The wetting agent of the present invention includes: sodium lauryl sulfate, sodium alkyl alcohol polyoxyethylene ether sulfate, octylphenol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, Sodium Alkyl Sulfonate, Sodium Dodecyl Benzene Sulfonate, Sodium Alkyl Naphthalene Sulfonate, Alkyl Succinate Sulfonate, Sodium Lauryl Polyoxyethylene Ether Sulfonate, Sodium Alkylamide Taurate, Fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene block polymer, sorbitan fatty acid ester polyoxyethylene ether, etc.

The thickener of the present invention can be artificially synthesized, such as carboxymethyl alcohol, polyvinyl alcohol or polyvinyl acetate; it can also be a natural water-soluble polymer, such as xanthan gum, gelatin, gum arabic , polyvinylpyrrolidone, aluminum magnesium silicate, polyvinyl alcohol, polyethylene glycol, phenolic resin, shellac, carboxymethyl cellulose and sodium alginate, etc.

The defoaming agent described in the present invention is preferably: foam enemy, silicones, C _{8 ~ 10} fatty alcohols, C _{10 ~ 20} saturated fatty acids and amides, etc.

The acaricide of the present invention can be formulated into emulsifiable concentrate, suspension, suspoemulsion, microemulsion, water emulsion, wettable powder, soluble powder, granule or capsule. When formulated into a preparation, the emulsifiable concentrate, suspension, suspoemulsion, microemulsion, aqueous emulsion, wettable powder, soluble powder, granule or capsule contains more than 0.1% of the above-mentioned composition containing two active ingredients .

When the acaricide is a wettable powder, it contains by weight percentage: 0.1% to 80% of a composition containing two active ingredients, 2% to 10% of a wetting agent, 5% to 10% of a dispersant, and 8% of a filler ~90%.

When the acaricide is a suspending agent, it contains by weight percentage: 0.1% to 60% of a composition containing two active ingredients, 1% to 5% of a wetting agent, 1% to 8% of a dispersing agent, and a thickener 0.1% to 1%, antifreeze 2% to 5%, and water to 100%.

When the acaricide is a microemulsion, it contains by weight percentage: 0.1% to 40% of a composition containing two active ingredients, 1% to 12% of an emulsifier, 0% to 10% of a cosolvent, and 0% of a stabilizer. %~5%, solvent 0%~40%, water to make up to 100%.

When the acaricide is an emulsion in water, it contains by weight percentage: 0.1%-80% of a composition containing two active ingredients, 1%-20% of an emulsifier, 0%-15% of a cosolvent, and 0% of a stabilizer. % ~ 5%, solvent 10% ~ 40%, water to make up to 100%.

When the acaricide is a suspoemulsion, it contains by weight percentage: 0.1% to 50% of a composition containing two active ingredients, 1% to 5% of a solvent, 1% to 5% of a dispersant, and 1% of an emulsifier ～10%, wetting agent 1%～5%, stabilizer 1%～5%, antifreeze 0%～5%, thickener 0%～5%, defoamer 0%～5%, water to 100%.

When the acaricide is a water-dispersible granule, it contains by weight percentage: 0.1% to 80% of a composition containing two active ingredients, 0% to 2% of a surfactant, 1% to 15% of a wetting agent, Dispersant 1% to 15%, disintegrant 1% to 10%, stabilizer 0% to 5%, and filler to 100%.

When the acaricide is a microcapsule suspension, it contains by weight percentage: 0.1% to 40% of a composition containing two active ingredients, 1% to 20% of an emulsifier, 1% to 20% of a solvent, and a thickener 0% to 10% antifreeze, 0% to 10% antifreeze, 0% to 5% stabilizer, 0% to 5% defoamer, 1% to 10% microcapsule carrier, and 100% water.

The composition containing two active components of the present invention can be directly made into a finished preparation form, that is, each material in the composition has been mixed and directly used for insecticide; the composition of the composition can also be provided by a separate preparation, before use Mix directly in barrel (tank). The concentrates of the present invention are generally mixed with water to obtain the desired concentration of active substance.

The present invention also includes the use of the composition containing the two active ingredients in controlling agricultural and forestry pests. The composition containing two active components provided by the invention is suitable for controlling agricultural pest mites. Specifically, it is suitable for controlling a variety of important agricultural pests such as cotton spider mite, vegetable spider mite, hawthorn spider mite, citrus panonychia, citrus rust mite, apple spider mite, two-spotted spider mite, gall mite, and acaroid mite. It is also suitable for controlling harmful mites in the following crops, for example: fruit trees such as apples, pears, citrus litchi, etc.; cereals such as wheat, rice, etc.; beans such as soybeans, beans, etc.; vegetables such as cabbage, cauliflower, cabbage, rapeseed , tomato, pepper, etc.; flowers such as rose, etc.; cotton, tea tree.

The place where the acaricide is applied in the present invention is farmland, orchard, warehouse or the like.

The composition or acaricide containing two active ingredients of the present invention can be applied by common methods, such as pouring, spraying and spraying. The amount of application varies with climatic conditions or crop status, and the application time can be before or after pest damage. The duration of the protective effect is usually related to the content of the individual compounds in the composition, but also to external factors, such as climate, which can be mitigated by using appropriate formulations.

The composition containing two active ingredients described in the present invention can also be used in combination with other compounds with insecticidal, herbicidal and bactericidal properties, and can also be used with nematicides, protective agents, growth regulators, plant nutrients or soil conditioners Mixed use.

Compared with the prior art, the composition containing two active components provided by the invention has the following advantages:

(1) The two active ingredients show a strong synergistic effect, and the acaricidal effect of the mixed composition is significantly improved compared with its single agent, and can kill eggs, larvae, nymphs and adults, and has a persistent effect long-term characteristics;

(2) Reduced dosage and reduced farmers' medication costs;

(3) The two active ingredients are used to rationally mix different modes of action and different mechanisms of action of harmful mites, which not only prolongs the service life of pesticides, but also delays the generation of resistance of harmful mites.

Detailed ways

The present invention will be further described below in conjunction with specific examples, but the present invention is not limited to these specific implementations. Those skilled in the art will realize that the present invention covers all alternatives, modifications and equivalents as may be included within the scope of the claims.

In the following examples, the proportions of solid preparations are all weight percentages, the proportions of liquid preparations are all volume percentages, and the treatment doses of biologically active parts are all effective content, that is, "active ingredient ratio".

1. Preparation of preparations

1. Preparation of EC

According to the formula requirements, add the solvent, the original drug and the emulsifier respectively, mix evenly, and if necessary, heat and dissolve in a water bath to obtain a transparent emulsifiable oil.

Embodiment 1, 20% emulsifiable concentrate, active ingredient ratio 9:1

A-8 18%, Abamectin 2%, Nongru 0203B 6%, Nongru 0201B 9%, cyclohexanone 8%, mineral spirits 150 to make up to 100%.

Embodiment 2, 30% emulsifiable concentrate, active ingredient ratio 5:1

A-8 25%, Abamectin 5%, Nongru 2201# 6%, Nongru 0201B 8%, cyclohexanone 8%, mineral spirits 150 to make up to 100%.

It is also possible to replace A-8 with one of the spirocyclic ether compounds described in the cost specification, and abamectin can be replaced by emamectin, spinosad, spinosad, ivermectin A new emulsifiable cream product is formed from one of milbemycin, milbemycin, and mibaycin.

2. Preparation of wettable powder

According to the requirements of the formula, the original drug, various additives and fillers are fully mixed, and the processed product is obtained after being pulverized by an ultra-fine pulverizer.

Embodiment 3,50% wettable powder

A-8 45%, Abamectin 5%, Sodium Dodecyl Benzene Sulfonate 1.8%, 4-tert-Butyl Ether 2%, White Carbon Black 10%, Sodium Lignosulfonate 10%, Light Calcium Carbonate Top up to 100%.

Embodiment 4, 40% wettable powder

A-8 38%, Abamectin 2%, Sodium Dodecylbenzene Sulfonate 2%, 4-tert-Butyl Ether 2%, White Carbon Black 5%, Sodium Lignosulfonate 10%, Light Calcium Carbonate Top up to 100%.

It is also possible to replace A-8 with one of the spirocyclic ether compounds described in the cost specification, and abamectin can be replaced by emamectin, spinosad, spinosad, ivermectin A new wettable powder product is formed from one of milbemycin, milbemycin, and mibaycin.

3. Preparation of water dispersible granules

Mix and pulverize the original drug, powdery carrier, wetting and spreading agent, binder, etc., add water and knead, then add to a granulator equipped with a certain size screen for granulation. Then dry and sieve (according to the range of the sieve) to obtain granular products.

Embodiment 5, 40% water dispersible granule

A-8 38%, Abamectin 2%, N-Methyl-Oleoyl-Taurine Sodium 8%, Naphtholsulfonic Acid Formaldehyde Condensate 10%, Soluble Starch 8%, Sodium Sulfate 10%, Kaolin Supplement to 100%.

Embodiment 6, 32% water dispersible granule

A-8 30%, abamectin 2%, sodium lignin sulfonate 15%, sodium methylnaphthalene sulfonate formaldehyde condensate 5%, epoxy polyether 5%, bentonite 10%, kaolin supplemented to 100%.

It is also possible to replace A-8 with one of the spirocyclic ether compounds described in the cost specification, and abamectin can be replaced by emamectin, spinosad, spinosad, ivermectin A new water-dispersible granule product is formed from one of milbemycin, milbemycin, and mibaymectin.

4. Preparation of suspending agent

According to the requirements of the formula, use water as the medium, mix the original drug, dispersant, wetting agent, suspending agent and antifreeze evenly, then add it to the sand mill, perform sand grinding to a certain particle size and filter, then add the thickener Shear and mix well.

Embodiment 7, 20% suspending agent

A-8 18%, abamectin 2%, sodium lignosulfonate 5%, white carbon black 0.3%, mixture of alkylnaphthalene sulfonate and anionic wetting agent (EFW) 2.0%, potassium dihydrogen phosphate 0.2%, ethylene glycol 4%, tributyl phosphate 0.2%, water to make up to 100%.

Embodiment 8, 20% suspending agent

A-8 19%, abamectin 1%, sodium methylnaphthalene sulfonate formaldehyde condensate 2.5%, mixture of alkylnaphthalene sulfonate and anionic wetting agent (EFW) 2.0%, Nongru OX-656 3.0 %, glycerol 4%, tributyl phosphate 0.2%, and water to make up to 100%.

It is also possible to replace A-8 with one of the spirocyclic ether compounds described in the cost specification, and abamectin can be replaced by emamectin, spinosad, spinosad, ivermectin A new suspension concentrate product is formed from one of milbemycin, milbemycin, and mibaycin.

5. Preparation of water emulsion

Mix and stir the original drug, solvent and emulsifier evenly to form a uniform oil phase, mix and stir water and ethylene glycol to form a water phase, and slowly add the oil phase to the water phase under high shear conditions, that is Emulsions in water are available.

Embodiment 9, 14% water emulsion

A-8 12%, Abamectin 2%, solvent naphtha S-150 30%, tristyrylphenol polyoxyethylene ether phosphate 3%, styrylphenol formaldehyde resin polyoxyethylene polyoxypropylene ether 5% , propylene glycol 3%, water to make up to 100%.

Embodiment 10, 16% water emulsion

A-8 15%, Abamectin 1%, solvent naphtha S-150 30%, tristyrylphenol polyoxyethylene ether phosphate 4%, hydroxyl-terminated polyoxyethylene polyoxypropylene ether block copolymer 5% , Ethylene glycol 3%, water make up to 100%.

It is also possible to replace A-8 with one of the spirocyclic ether compounds described in the cost specification, and abamectin can be replaced by emamectin, spinosad, spinosad, ivermectin A new water-emulsion product formed from one of milbemycin, milbemycin, and mibaycin.

6. Preparation of microemulsion

Mix and stir the original drug, solvent, and emulsifier evenly to form a uniform oil phase, gradually add water to the oil phase, and stir until uniform and transparent.

Embodiment 11, 10% microemulsion

ZJ-1 9%, Abamectin 1%, Isopropyl Alcohol 10%, Solvent Oil S-150 15%, Calcium Dodecylbenzene Sulfonate 2%, Styrylphenyl Polyoxyethylene Ether 19%, Water up to 100%.

Embodiment 12,6% microemulsion

A-8 5%, Abamectin 1%, N-octylpyrrolidone 6%, solvent naphtha S-150 15%, calcium dodecylbenzenesulfonate 2%, alkylphenol formaldehyde resin polyoxyethylene ether 16 %, water up to 100%.

It is also possible to replace A-8 with one of the spirocyclic ether compounds described in the cost specification, and abamectin can be replaced by emamectin, spinosad, spinosad, ivermectin A new microemulsion product formed from one of milbemycin, milbemycin, and mibaycin.

2. Indoor bioactivity assay

In order to further understand the relationship between spirocyclic ether compounds and abamectin, emamectin, spinosad, ethyl spinosad, ivermectin, milbemycin, tenvermectin, and Mibai A large number of formula screening tests have been carried out to determine the toxicity of the composition of the element to pests. The test refers to the Indoor Bioassay Test Guidelines for Pesticides and Pesticides (Agricultural Industry Standard NY/T1154.7-2006) and the SOP for Bioactivity Evaluation of Pesticides (Insecticide Volume), using the spray method. The mixing test with abamectin is to cut off the broad bean leaves with stalks and insert them into a glass bottle with water. Pick up a certain number of adult mites. After 24 hours of adult mites laying eggs, remove the adult mites, spray the leaves with enough eggs, put the leaves back in the ampoule, and let them dry naturally. Place them in an observation room (25±2°C, humidity 70%-80%, 16h light/d) for cultivation. The experiment was repeated 3 times, and a blank control was set up, and the investigation was carried out after all the controls were hatched. When surveying, they were regarded as dead insects that could not hatch. The test of mixing with spinosad was to cut off broad bean leaves with stalks and insert them into glass bottles with water. Pick up a certain number of adult mites. After 24 hours of adult mites laying eggs, remove the adult mites, spray them after 48 hours after all eggs hatch, and let them dry naturally. Place them in an observation room (25±2°C, humidity 70%-80%, 16h light/d) for cultivation. The experiment was repeated 3 times, and a blank control was set up, and the investigation was carried out after 48 hours. During the investigation, the insects that could not crawl normally were regarded as dead insects.

Theoretical mixed toxicity index (TTI) = Toxicity index of A × A content in mixed use (%)

Toxicity index of +B × B content in the mixture (%)

If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if it is less than 80, it indicates an antagonistic effect; if it is greater than 80 but less than 120, it indicates an additive effect.

The results showed that: Spirocyclic ether compounds and abamectin, emamectin, spinosad, ethyl spinosad, ivermectin, milbemycin, avermectin, mibai The mixtures of all the primes have very high activity on the tested targets, and show a significant synergistic effect after mixing.

Embodiment 13, A-8 and Abamectin joint synergistic effect

(Tetranychus cinnabarinus)

Embodiment 14, A-9 and Abamectin joint synergistic effect

(Tetranychus cinnabarinus)

deal with Proportion LC50(mg/L) measured toxicity index theoretical virulence index co-toxicity coefficient Avermectin - 0.0366 872.40 A-9 - 0.3193 100.00 Abamectin: A-9 50:1 0.0306 1042.48 857.26 121.61 Abamectin: A-9 20:1 0.0311 1025.72 835.62 122.75 Abamectin: A-9 12:1 0.0299 1066.89 812.99 131.23 Abamectin: A-9 9:1 0.0292 1092.47 795.16 137.39 Abamectin: A-9 6:1 0.0297 1074.07 762.06 140.94 Abamectin: A-9 3:1 0.0328 972.56 679.30 143.17 Abamectin: A-9 1:1 0.0466 684.55 486.20 140.80 Abamectin: A-9 1:3 0.0764 417.54 293.10 142.46 Abamectin: A-9 1:6 0.1051 303.52 210.34 144.30 Abamectin: A-9 1:9 0.1234 258.51 177.24 145.85 Abamectin: A-9 1:12 0.1362 234.21 159.42 146.92 Abamectin: A-9 1:20 0.1601 199.25 136.78 145.67 Abamectin: A-9 1:50 0.2072 153.96 115.15 133.71

Embodiment 15, A-10 and Abamectin joint synergistic effect

(Tetranychus cinnabarinus)

deal with Proportion _LC50 (mg/L) measured toxicity index theoretical virulence index co-toxicity coefficient Avermectin - 0.0397 1066.75 A-10 - 0.4235 100.00 Abamectin: A-10 50:1 0.0335 1262.69 1047.79 120.51 Abamectin: A-10 20:1 0.0339 1247.79 1020.71 122.25 Abamectin: A-10 12:1 0.0324 1305.56 992.39 131.56 Abamectin: A-10 9:1 0.0321 1317.76 970.08 135.84 Abamectin: A-10 6:1 0.0325 1301.54 928.64 140.15 Abamectin: A-10 3:1 0.0371 1140.16 825.06 138.19 Abamectin: A-10 1:1 0.0523 808.80 583.38 138.64 Abamectin: A-10 1:3 0.0864 489.58 341.69 143.28 Abamectin: A-10 1:6 0.1234 342.79 238.11 143.96 Abamectin: A-10 1:9 0.1507 280.69 196.68 142.72 Abamectin: A-10 1:12 0.1681 251.64 174.37 144.32 Abamectin: A-10 1:20 0.1974 214.29 146.04 146.74 Abamectin: A-10 1:50 0.2741 154.32 118.96 129.73

Embodiment 16, A-8 and spinosad combined synergistic effect

(Tetranychus cinnabarinus)

Embodiment 17, A-9 and spinosad combined synergistic effect

(Tetranychus cinnabarinus)

Embodiment 18, A-10 and spinosad combined synergistic effect

(Tetranychus cinnabarinus)

deal with Proportion _LC50 (mg/L) measured toxicity index theoretical virulence index co-toxicity coefficient spinosad - 1.664 19.65 A-10 - 0.327 100.00 Spinosad: A-10 50:1 1.261 25.93 21.23 122.16 Spinosad: A-10 20:1 1.159 28.21 23.48 120.17 Spinosad: A-10 12:1 0.961 34.03 25.83 131.72 Spinosad: A-10 9:1 0.851 38.43 27.69 138.79 Spinosad: A-10 6:1 0.748 43.72 31.13 140.43 Spinosad: A-10 3:1 0.587 55.71 39.74 140.18 Spinosad: A-10 1:1 0.389 84.06 59.83 140.51 Spinosad: A-10 1:3 0.288 113.54 79.91 142.08 Spinosad: A-10 1:6 1.964 166.70 113.82 146.46 Spinosad: A-10 1:9 2.057 159.16 109.68 145.12 Spinosad: A-10 1:12 2.104 155.61 107.44 144.83 Spinosad: A-10 1:20 2.141 152.92 104.61 146.18 Spinosad: A-10 1:50 2.434 134.51 101.90 132.01

3. The effect of field plot control

Embodiment 19, field efficacy test to citrus spider mite

The control effect against citrus spider mite was determined under field conditions. The test was carried out in accordance with the provisions of "Pesticide Field Efficacy Test Guidelines (1) - Insecticides Control Citrus Red Spiders". The citrus leaves of each test plot were marked with 5 fixed points according to the east, south, west, and north orientations. Investigate 2 strains and investigate the number of live insects on each strain.

Test results: 7 days, 14 days, and 21 days after application, the control effects of each mixed preparation on citrus spider mite were 95.6%-97.8%, 96.9%-98.4%, and 96.8%-97.9%, respectively, and the control effects on citrus spider mite were uniform. Better than 1.8% Abamectin EC, 20% A-8 Suspension, 20% A-9 Suspension and 20% A-10 Suspension.

The results of the field efficacy test on citrus spider mite

Embodiment 20, field efficacy test to apple spider mite

The control effect on apple spider mite was determined under field conditions. The test site is located in Anzhuang Town, Feicheng City, Shandong Province. The variety is Xinhongxing, and the row spacing between plants is 3m*4m. The application rate is 1150kg/hm ² . 7 days, 14 days, 21 days survey results after taking medicine. The apple leaves of each test plot were marked with 5 fixed points according to the five orientations of east, south, west and north, and 2 plants were investigated in each plot, and the number of live insects on each plant was investigated.

Test results: 7 days, 14 days, and 21 days after application, the control effects on apple spider mites were 97.6%-99.4%, 95.1%-99.5%, and 94.2%-97.7%, respectively, and the control effects were better than 1.8% % Abamectin EC, 20% A-8 suspension, 20% A-9 suspension and 20% A-10 suspension.

Results of field efficacy test on apple spider mite

From the above data, it can be seen that the composition provided by the present invention not only has obvious synergistic effect on preventing and treating citrus spider mite and apple spider mite, and the effect is better than that of a single agent, but also can reduce the dosage and delay the drug resistance problem caused by a single agent.

Claims (8)

1. A composition, characterized in that said composition contains two active components, the first active component comprising at least one selected from the following compounds shown in A-7, A-8 and A-10, the first The two active ingredients comprise at least A sort of, 2. The composition according to claim 1, characterized in that the mass ratio of the first active ingredient to the second active ingredient is 50:1˜1:50. 3. The composition according to claim 2, characterized in that the mass ratio of the first active ingredient to the second active ingredient is 20:1˜1:12. 4. The composition according to claim 3, characterized in that the mass ratio of the first active ingredient to the second active ingredient is 20:1˜1:6. 5. An acaricide, characterized in that the acaricide contains more than 0.1% of the composition according to claim 1 by weight. 6. The acaricide according to claim 5, characterized in that the acaricide contains 1% to 80% by weight of the composition according to claim 1. 7. The acaricide according to claim 5, characterized in that the acaricide is formulated as emulsifiable concentrate, suspension concentrate, suspoemulsion, water emulsion, wettable powder, soluble powder, granule or capsule. 8. The composition according to claim 1, characterized in that the composition is used for controlling agricultural pest mites.