CL2019002304A1 - Compuestos para el tratamiento del cáncer. - Google Patents
Compuestos para el tratamiento del cáncer.Info
- Publication number
- CL2019002304A1 CL2019002304A1 CL2019002304A CL2019002304A CL2019002304A1 CL 2019002304 A1 CL2019002304 A1 CL 2019002304A1 CL 2019002304 A CL2019002304 A CL 2019002304A CL 2019002304 A CL2019002304 A CL 2019002304A CL 2019002304 A1 CL2019002304 A1 CL 2019002304A1
- Authority
- CL
- Chile
- Prior art keywords
- cancer
- treatment
- compounds
- useful compounds
- useful
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6587—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having two phosphorus atoms as ring hetero atoms in the same ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
EN LA PRESENTE SE PROVEEN COMPUESTOS ÚTILES PARA EL TRATAMIENTO DEL CÁNCER.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762460562P | 2017-02-17 | 2017-02-17 | |
| US201762479169P | 2017-03-30 | 2017-03-30 | |
| US201762551645P | 2017-08-29 | 2017-08-29 | |
| US201762551647P | 2017-08-29 | 2017-08-29 | |
| US201762551668P | 2017-08-29 | 2017-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019002304A1 true CL2019002304A1 (es) | 2020-01-10 |
Family
ID=61521844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019002304A CL2019002304A1 (es) | 2017-02-17 | 2019-08-14 | Compuestos para el tratamiento del cáncer. |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US20200055883A1 (es) |
| EP (3) | EP3582854A1 (es) |
| JP (2) | JP6672532B2 (es) |
| KR (1) | KR102645790B1 (es) |
| CN (3) | CN110461416B (es) |
| AU (1) | AU2018221170B2 (es) |
| CA (1) | CA3053932A1 (es) |
| CL (1) | CL2019002304A1 (es) |
| CO (1) | CO2019008783A2 (es) |
| CY (1) | CY1126855T1 (es) |
| DK (1) | DK3582853T3 (es) |
| ES (1) | ES2906299T3 (es) |
| HR (1) | HRP20220110T1 (es) |
| HU (1) | HUE057665T2 (es) |
| IL (1) | IL268721B (es) |
| JO (1) | JOP20190194B1 (es) |
| LT (1) | LT3582853T (es) |
| MA (1) | MA47501A (es) |
| MD (1) | MD3582853T2 (es) |
| MX (1) | MX394380B (es) |
| PE (1) | PE20191686A1 (es) |
| PH (1) | PH12019501914B1 (es) |
| PL (1) | PL3582853T3 (es) |
| PT (1) | PT3582853T (es) |
| RS (1) | RS62842B1 (es) |
| SG (1) | SG11201907496RA (es) |
| SI (1) | SI3582853T1 (es) |
| SM (1) | SMT202200054T1 (es) |
| TW (1) | TWI766948B (es) |
| UA (1) | UA125310C2 (es) |
| WO (2) | WO2018152450A1 (es) |
| ZA (1) | ZA201906111B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| PT3570844T (pt) | 2017-01-20 | 2023-11-15 | Arcus Biosciences Inc | Azolopirimidina para o tratamento de doenças relacionadas com o cancro |
| PL3601233T3 (pl) | 2017-03-27 | 2025-01-07 | HYDRO-QUéBEC | Sole do zastosowania w kompozycjach elektrolitowych lub jako dodatki do elektrod |
| WO2019084060A1 (en) | 2017-10-24 | 2019-05-02 | Silverback Therapeutics, Inc. | CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS |
| SG11202004113VA (en) | 2017-11-10 | 2020-06-29 | Takeda Pharmaceuticals Co | Sting modulator compounds, and methods of making and using |
| US10966999B2 (en) | 2017-12-20 | 2021-04-06 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| AU2019222747B2 (en) | 2018-02-16 | 2024-09-05 | Arcus Biosciences, Inc. | Dosing with an azolopyrimidine compound |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| MX2020012964A (es) | 2018-06-01 | 2021-02-16 | Eisai R&D Man Co Ltd | Metodos para el tratamiento de cancer de vejiga. |
| JP6767589B1 (ja) * | 2018-08-16 | 2020-10-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 化合物の塩及びそれらの結晶 |
| AU2019339344A1 (en) | 2018-09-12 | 2021-03-18 | Silverback Therapeutics, Inc. | Compositions for the treatment of disease with immune stimulatory conjugates |
| WO2020135715A1 (zh) * | 2018-12-29 | 2020-07-02 | 上海济煜医药科技有限公司 | 作为肿瘤免疫类的化合物及其应用 |
| AU2020267486A1 (en) | 2019-05-09 | 2021-11-11 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as STING modulators |
| US11453681B2 (en) * | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| BR112021026876A2 (pt) * | 2019-07-01 | 2022-02-22 | Eisai R&D Man Co Ltd | Métodos para o tratamento do câncer |
| WO2021067644A1 (en) | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| JP2022177332A (ja) * | 2019-10-24 | 2022-12-01 | 日東電工株式会社 | オリゴヌクレオチドを製造する方法 |
| WO2021168274A1 (en) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| US20230210968A1 (en) | 2020-06-11 | 2023-07-06 | Massachusetts Institute Of Technology | Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy |
| CA3183993A1 (en) | 2020-07-01 | 2022-01-06 | Peter R. Baum | Anti-asgr1 antibody conjugates and uses thereof |
| CN111909223A (zh) * | 2020-07-17 | 2020-11-10 | 清华大学 | 环二核苷酸共价修饰物及其制备方法和应用 |
| WO2022079175A1 (en) | 2020-10-14 | 2022-04-21 | Boehringer Ingelheim International Gmbh | Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist |
| JP7397996B2 (ja) | 2020-11-09 | 2023-12-13 | 武田薬品工業株式会社 | 抗体薬物コンジュゲート |
| WO2024182569A2 (en) | 2023-02-28 | 2024-09-06 | Eisai R&D Management Co., Ltd. | Anti-psma antibodies, conjugates, and methods of use |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
| AU2005222626B2 (en) | 2004-03-15 | 2010-05-20 | Karagen Pharmaceuticals, Inc. | A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
| US7592326B2 (en) | 2004-03-15 | 2009-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
| US8076303B2 (en) | 2005-12-13 | 2011-12-13 | Spring Bank Pharmaceuticals, Inc. | Nucleotide and oligonucleotide prodrugs |
| GB0607950D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| WO2009133560A1 (en) | 2008-04-29 | 2009-11-05 | Smart Assays | Non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and uses thereof |
| CN102199183B (zh) | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
| AU2013271375B2 (en) * | 2012-06-08 | 2018-03-22 | Aduro Biotech, Inc. | Compositions and methods for cancer immunotherapy |
| EP2931738B1 (en) * | 2012-12-13 | 2019-02-06 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| CU24376B1 (es) | 2013-04-29 | 2018-12-05 | Memorial Sloan Kettering Cancer Center | ANÁLOGOS DE LA GMP-AMP CÍCLICO (cGAMP) ACTIVOS COMO MODULADORES DE LA GMP-AMP CÍCLICO SINTASA (cGAS) Y COMPOSICIONES FARMACÉUTICAS DEL MISMO |
| ES2822584T3 (es) | 2013-05-03 | 2021-05-04 | Univ California | Inducción de dinucleótidos cíclicos del interferón tipo I |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| SI2996473T1 (sl) | 2013-05-18 | 2019-12-31 | Aduro Biotech, Inc. | Sestavki in postopki za aktiviranje signaliziranja, odvisnega od "stimulator interferonskih genov" |
| JP2016538344A (ja) | 2013-11-19 | 2016-12-08 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 癌処置としてのｓｔｉｎｇアゴニストの使用 |
| US10092644B2 (en) | 2013-11-22 | 2018-10-09 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| EA029856B9 (ru) | 2014-06-04 | 2018-08-31 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические динуклеотиды в качестве модуляторов стимулятора генов интерферона (sting) |
| WO2016079899A1 (ja) * | 2014-11-20 | 2016-05-26 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 異なる核酸アジュバントの組み合わせによる、新規Ｔｈ１誘導性アジュバントおよびその用途 |
| PT3233882T (pt) | 2014-12-16 | 2020-01-21 | Kayla Therapeutics | Dinucleótidos cíclicos fluorados para a indução de citocinas |
| US20170340658A1 (en) | 2014-12-16 | 2017-11-30 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| EP3233089A4 (en) | 2014-12-17 | 2018-11-14 | Lipogen LLC | Method of treating cancer with cgamp or cgasmp |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| BR112017018908A2 (pt) * | 2015-03-10 | 2018-04-17 | Aduro Biotech, Inc. | composições e métodos para ativar a sinalização dependente do "estimulador do gene de interferon |
| TW201717968A (zh) | 2015-07-14 | 2017-06-01 | 春季銀行製藥公司 | 誘導ｒｉｇ－ｉ和其他模式辨識受體之化合物及組成物 |
| WO2017011920A1 (en) | 2015-07-22 | 2017-01-26 | The Royal Institution For The Advancement Of Learning/Mcgill University | Compounds and uses thereof in the treatment of cancers and other medical conditions |
| MA42608A (fr) | 2015-08-13 | 2018-06-20 | Merck Sharp & Dohme | Composés de di-nucléotide cyclique en tant qu'agonistes sting (stimulateur de gène interféron) |
| US9809597B2 (en) | 2015-08-20 | 2017-11-07 | The Board Of Trustees Of The Leland Stanford Junior University | Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy |
| WO2017040670A1 (en) | 2015-09-01 | 2017-03-09 | Ifm Therapeutics, Inc | Immune cells having increased immunity or resistance to an immunosuppressive cytokine and use of the same |
| AU2016343993A1 (en) | 2015-10-28 | 2018-05-10 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
| CN107849084B (zh) | 2015-12-03 | 2021-09-14 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为sting调节剂的环状嘌呤二核苷酸 |
| JP6801956B2 (ja) | 2015-12-04 | 2020-12-16 | 株式会社エクセディ | モータサイクル用クラッチ装置 |
| SG11201805888SA (en) | 2016-01-11 | 2018-08-30 | Innate Tumor Immunity Inc | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| IL280430B2 (en) | 2016-03-18 | 2023-11-01 | Univ Texas | Cyclic dinucleotide compounds and methods of use |
| BR112018070602A2 (pt) | 2016-04-07 | 2019-02-05 | Glaxosmithkline Ip Dev Ltd | composto, composição farmacêutica, uso do composto, e, método para tratar uma doença ou distúrbio |
| US10537590B2 (en) | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
| JOP20170188A1 (ar) | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
| WO2018140831A2 (en) | 2017-01-27 | 2018-08-02 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| WO2018198084A1 (en) | 2017-04-27 | 2018-11-01 | Lupin Limited | Cyclic di-nucleotide compounds with tricyclic nucleobases |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
-
2018
- 2018-02-16 US US16/486,954 patent/US20200055883A1/en not_active Abandoned
- 2018-02-17 ES ES18708032T patent/ES2906299T3/es active Active
- 2018-02-17 EP EP18709835.5A patent/EP3582854A1/en not_active Withdrawn
- 2018-02-17 JP JP2019544817A patent/JP6672532B2/ja active Active
- 2018-02-17 EP EP21208462.8A patent/EP4008403A1/en not_active Withdrawn
- 2018-02-17 DK DK18708032.0T patent/DK3582853T3/da active
- 2018-02-17 LT LTEPPCT/US2018/018556T patent/LT3582853T/lt unknown
- 2018-02-17 AU AU2018221170A patent/AU2018221170B2/en active Active
- 2018-02-17 MD MDE20200009T patent/MD3582853T2/ro unknown
- 2018-02-17 HR HRP20220110TT patent/HRP20220110T1/hr unknown
- 2018-02-17 SG SG11201907496RA patent/SG11201907496RA/en unknown
- 2018-02-17 UA UAA201909860A patent/UA125310C2/uk unknown
- 2018-02-17 PE PE2019001715A patent/PE20191686A1/es unknown
- 2018-02-17 KR KR1020197027073A patent/KR102645790B1/ko active Active
- 2018-02-17 MX MX2019009796A patent/MX394380B/es unknown
- 2018-02-17 JO JOP/2019/0194A patent/JOP20190194B1/ar active
- 2018-02-17 WO PCT/US2018/018556 patent/WO2018152450A1/en active Application Filing
- 2018-02-17 RS RS20220079A patent/RS62842B1/sr unknown
- 2018-02-17 EP EP18708032.0A patent/EP3582853B1/en active Active
- 2018-02-17 CN CN201880021349.XA patent/CN110461416B/zh active Active
- 2018-02-17 MA MA047501A patent/MA47501A/fr unknown
- 2018-02-17 PL PL18708032T patent/PL3582853T3/pl unknown
- 2018-02-17 PH PH1/2019/501914A patent/PH12019501914B1/en unknown
- 2018-02-17 PT PT187080320T patent/PT3582853T/pt unknown
- 2018-02-17 WO PCT/US2018/018561 patent/WO2018152453A1/en unknown
- 2018-02-17 JP JP2019544725A patent/JP2020510638A/ja active Pending
- 2018-02-17 SI SI201830553T patent/SI3582853T1/sl unknown
- 2018-02-17 CA CA3053932A patent/CA3053932A1/en active Pending
- 2018-02-17 CN CN202410024195.7A patent/CN117866030A/zh active Pending
- 2018-02-17 CN CN201880025317.7A patent/CN110536719A/zh active Pending
- 2018-02-17 US US15/898,533 patent/US10246480B2/en active Active
- 2018-02-17 SM SM20220054T patent/SMT202200054T1/it unknown
- 2018-02-17 HU HUE18708032A patent/HUE057665T2/hu unknown
- 2018-02-21 TW TW107105846A patent/TWI766948B/zh active
-
2019
- 2019-02-15 US US16/277,522 patent/US10618930B2/en active Active
- 2019-08-13 CO CONC2019/0008783A patent/CO2019008783A2/es unknown
- 2019-08-14 CL CL2019002304A patent/CL2019002304A1/es unknown
- 2019-08-15 IL IL268721A patent/IL268721B/en unknown
- 2019-09-16 ZA ZA2019/06111A patent/ZA201906111B/en unknown
-
2020
- 2020-02-04 US US16/781,352 patent/US11339188B2/en active Active
-
2022
- 2022-01-26 CY CY20221100065T patent/CY1126855T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2019002304A1 (es) | Compuestos para el tratamiento del cáncer. | |
| CL2018003123A1 (es) | Terapia de combinación para el tratamiento del cáncer | |
| ECSP17073743A (es) | Moduladores de k-ras | |
| CL2019002461A1 (es) | Arn terapéutico. | |
| MX2023007841A (es) | Metodos, composiciones y componentes relacionados con crispr-cpf1 para la inmunoterapia contra el cancer. | |
| MX394062B (es) | Métodos para el tratamiento del cáncer ovárico. | |
| CL2018001230A1 (es) | Tratamiento de osteoartritis | |
| MX2019007030A (es) | Composiciones y metodos para el tratamiento del cancer. | |
| CL2018001358A1 (es) | Composiciones que comprenden cepas bacterianas | |
| CL2018001685A1 (es) | Compuestos heterociclicos como inmuno moduladores. | |
| CL2018001512A1 (es) | Anticuerpos anti-cd73 humanizados. | |
| CO2017004736A2 (es) | Péptidos macrociclicos útiles como inmunomoduladores | |
| HUE050155T2 (hu) | 1-tetrahidropiranilkarbonil-2,3-dihidro-1H-indol vegyületek rák kezelésére | |
| UY34657A (es) | ?derivados macrocíclicos para el tratamiento de enfermedades?. | |
| CR20150316A (es) | Compuestos y sus métodos de empleo | |
| PE20171094A1 (es) | Anticuerpos anti-cd38 para el tratamiento de la leucemia linfoblastica aguda | |
| CL2018003443A1 (es) | Tratamientos para el cancer. | |
| MX2019012734A (es) | Procesos para la preparacion de un compuesto de diariltiohidantoina. | |
| MX382904B (es) | Combinaciones de fármacos para tratar mieloma múltiple. | |
| MX2017001352A (es) | Derivados de pirrolidinona como inhibidores de metionina aminopeptidasa 2 (metap-2). | |
| UY36286A (es) | Tratamientos médicos basados en anamorelina | |
| LT3534885T (lt) | Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui | |
| CL2017001310A1 (es) | Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis | |
| IL281845A (en) | Combination therapy for the treatment of cancer | |
| BR112018012116A2 (pt) | terapia intravesical para câncer de bexiga |