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MX2023007841A - Metodos, composiciones y componentes relacionados con crispr-cpf1 para la inmunoterapia contra el cancer. - Google Patents

Metodos, composiciones y componentes relacionados con crispr-cpf1 para la inmunoterapia contra el cancer.

Info

Publication number
MX2023007841A
MX2023007841A MX2023007841A MX2023007841A MX2023007841A MX 2023007841 A MX2023007841 A MX 2023007841A MX 2023007841 A MX2023007841 A MX 2023007841A MX 2023007841 A MX2023007841 A MX 2023007841A MX 2023007841 A MX2023007841 A MX 2023007841A
Authority
MX
Mexico
Prior art keywords
cpf1
crispr
compositions
components
related methods
Prior art date
Application number
MX2023007841A
Other languages
English (en)
Inventor
Christopher Borges
Gordon Grant Welstead
Hariharan Jayaram
John Anthony Zuris
Tongyao Wang
Original Assignee
Editas Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Editas Medicine Inc filed Critical Editas Medicine Inc
Publication of MX2023007841A publication Critical patent/MX2023007841A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2320/00—Applications; Uses
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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Abstract

Composiciones y métodos relacionados con CRISPR/Cpf1 para el tratamiento del cáncer.
MX2023007841A 2016-03-04 2018-08-30 Metodos, composiciones y componentes relacionados con crispr-cpf1 para la inmunoterapia contra el cancer. MX2023007841A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662304057P 2016-03-04 2016-03-04

Publications (1)

Publication Number Publication Date
MX2023007841A true MX2023007841A (es) 2023-07-07

Family

ID=58358928

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018010484A MX2018010484A (es) 2016-03-04 2017-03-03 Métodos, composiciones y componentes relacionados con crispr-cpf1 para la inmunoterapia contra el cáncer.
MX2023007841A MX2023007841A (es) 2016-03-04 2018-08-30 Metodos, composiciones y componentes relacionados con crispr-cpf1 para la inmunoterapia contra el cancer.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018010484A MX2018010484A (es) 2016-03-04 2017-03-03 Métodos, composiciones y componentes relacionados con crispr-cpf1 para la inmunoterapia contra el cáncer.

Country Status (11)

Country Link
US (1) US12325854B2 (es)
EP (1) EP3423580A1 (es)
JP (2) JP7251980B2 (es)
KR (4) KR102438360B1 (es)
CN (1) CN109312340A (es)
AU (2) AU2017226172B9 (es)
CA (1) CA3016331A1 (es)
IL (2) IL291971B2 (es)
MX (2) MX2018010484A (es)
SG (1) SG11201807538PA (es)
WO (1) WO2017152015A1 (es)

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