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CL2009001779A1 - Anticuerpos humanos y porciones de enlace antigeno de estos, agonistas de cd40; composicion farmaceutica que los contiene; linea celular que los produce; molecula de adn que los codifica; vector; celula huesped; metodo de preparacion; usos en el tratamiento de cancer. (divisional sol. n°2577-02). - Google Patents

Anticuerpos humanos y porciones de enlace antigeno de estos, agonistas de cd40; composicion farmaceutica que los contiene; linea celular que los produce; molecula de adn que los codifica; vector; celula huesped; metodo de preparacion; usos en el tratamiento de cancer. (divisional sol. n°2577-02).

Info

Publication number
CL2009001779A1
CL2009001779A1 CL2009001779A CL2009001779A CL2009001779A1 CL 2009001779 A1 CL2009001779 A1 CL 2009001779A1 CL 2009001779 A CL2009001779 A CL 2009001779A CL 2009001779 A CL2009001779 A CL 2009001779A CL 2009001779 A1 CL2009001779 A1 CL 2009001779A1
Authority
CL
Chile
Prior art keywords
antigen
light chain
agonists
cancer
produces
Prior art date
Application number
CL2009001779A
Other languages
English (en)
Inventor
Bedian Vahe
Corvalan Jose
Jia Xiao-Chi
Feng Xiao
P Gladue Ronald
Original Assignee
Pfizer Prod Inc
Amgen Fremont Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23370387&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2009001779(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc, Amgen Fremont Inc filed Critical Pfizer Prod Inc
Publication of CL2009001779A1 publication Critical patent/CL2009001779A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ANTICUERPOS HUMANOS Y PORCIONES DE ENLACE DE ANTIGENO DE ESTOS, AGONISTAS ED CD40, Y COMPRENDIENDO UNA CADENA PESADA Y UNA CADENA LIVIANA, DONDE DICHA CADENA PESADA COMPRENDE LAS SECUENCIAS DE AMINO ACIDOS CDR1, CDR2  Y CDR3 DE LA SEQ ID NO:42 Y DICHA CADENA LIVIANA COMPRENDE LAS SECUENCIAS DE AMINO ACIDO DE CDR1, CDR3 Y CDR3 DE CADENA LIVIANA DE LA SEQ ID NO; 44 ANTICUERPO MONOCLONAL HUMANO O UNA PORCION QUE ENLAZA ANTIGENO DEL MISMO QUE ESPECIFICAMENTE SE UNE CD40, AGONISTA CD40, COMPRENDIENDOUNA CADENA PESADA Y UNA CADENA LIVIANA, DONDE DIHA CADENA PESADA COMPRENDE LAS SECUENCIAS DE AMINO ACIDOS CDR1, CDR2 Y CDR3 DE CADENA PESADA, Y DICHA CADENA LIVIANA COMPRENDE LAS SECUENCIAS DE AMINO ACIDOS CDR1, CDR2 Y CDR3 DE CADENA LIVIANA, EN EL ANTICUERPO MONOCLONAL 21.4.1 (ATCC NUMERO DE ACCESO PTA-3605); COMPOSICION FARMACEUTICA QUE LOS CONTIENE; LINEA CELULAR QUE LOS PRODUCE; MOLECULA DE ADN QUE LOS CODIFICA; CELULA HUESPED; METODO DE PREPARACION; Y USOS EN EL TRATAMIENTO DEL CANCER Y PARA MEJORAR LA RESPUESTA INMUNE.
CL2009001779A 2001-11-09 2009-08-27 Anticuerpos humanos y porciones de enlace antigeno de estos, agonistas de cd40; composicion farmaceutica que los contiene; linea celular que los produce; molecula de adn que los codifica; vector; celula huesped; metodo de preparacion; usos en el tratamiento de cancer. (divisional sol. n°2577-02). CL2009001779A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34898001P 2001-11-09 2001-11-09

Publications (1)

Publication Number Publication Date
CL2009001779A1 true CL2009001779A1 (es) 2010-02-05

Family

ID=23370387

Family Applications (1)

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CL2009001779A CL2009001779A1 (es) 2001-11-09 2009-08-27 Anticuerpos humanos y porciones de enlace antigeno de estos, agonistas de cd40; composicion farmaceutica que los contiene; linea celular que los produce; molecula de adn que los codifica; vector; celula huesped; metodo de preparacion; usos en el tratamiento de cancer. (divisional sol. n°2577-02).

Country Status (46)

Country Link
US (9) US7288251B2 (es)
EP (2) EP2343086A3 (es)
JP (3) JP4616555B2 (es)
KR (1) KR100830086B1 (es)
CN (2) CN1582165B (es)
AP (1) AP1918A (es)
AR (1) AR039067A1 (es)
AU (1) AU2002356926B2 (es)
BR (1) BRPI0214137B8 (es)
CA (1) CA2466128C (es)
CL (1) CL2009001779A1 (es)
CR (2) CR7343A (es)
CU (1) CU23745A3 (es)
CY (1) CY1115675T1 (es)
DK (1) DK1476185T3 (es)
DO (1) DOP2002000507A (es)
EA (1) EA011449B1 (es)
EC (1) ECSP045093A (es)
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IS (1) IS2940B (es)
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ME (1) ME00503B (es)
MX (1) MXPA04004467A (es)
MY (1) MY137641A (es)
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US11136406B2 (en) 2011-04-21 2021-10-05 Bristol-Myers Squibb Company Methods of treating immune diseases by administering antibody polypeptides that antagonize CD40

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