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BRPI0208210B8 - preparação de insulina pobre em zinco e isenta de zinco com estabilidade aperfeiçoada - Google Patents

preparação de insulina pobre em zinco e isenta de zinco com estabilidade aperfeiçoada

Info

Publication number
BRPI0208210B8
BRPI0208210B8 BRPI0208210A BRPI0208210B8 BR PI0208210 B8 BRPI0208210 B8 BR PI0208210B8 BR PI0208210 A BRPI0208210 A BR PI0208210A BR PI0208210 B8 BRPI0208210 B8 BR PI0208210B8
Authority
BR
Brazil
Prior art keywords
zinc
insulin
combinations
poor
preparation
Prior art date
Application number
Other languages
English (en)
Inventor
Boderke Peter
Original Assignee
Aventis Pharma Deutschland Gmbh
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh, Sanofi Aventis Deutschland filed Critical Aventis Pharma Deutschland Gmbh
Publication of BR0208210A publication Critical patent/BR0208210A/pt
Publication of BRPI0208210B1 publication Critical patent/BRPI0208210B1/pt
Publication of BRPI0208210B8 publication Critical patent/BRPI0208210B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"preparação de insulina pobre em zinco e isenta de zinco com estabilidade aperfeiçoada". a invenção refere-se a uma formulação farmacêutica contendo um polipeptídeo escolhido de um grupo contendo insulina, um metabólito de insulina, um análogo de insulina, um derivado de insulina ou combinações destes; um tensoativo ou combinações de vários tensoativos; opcionalmente um conservante ou combinações de vários conservantes; e opcionalmente um agente isotonizante, tampões ou outras substâncias auxiliares ou combinações dos mesmos, sendo que a formulação farmacêutica é pobre em ou isenta de zinco; e à produção de tais preparados de insulina.
BR0208210-1 2001-03-23 2002-03-09 preparação de insulina pobre em zinco e isenta de zinco com estabilidade aperfeiçoada BRPI0208210B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10114178A DE10114178A1 (de) 2001-03-23 2001-03-23 Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10114178.5 2001-03-23
PCT/EP2002/002625 WO2002076495A1 (de) 2001-03-23 2002-03-09 Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität

Publications (3)

Publication Number Publication Date
BR0208210A BR0208210A (pt) 2004-03-09
BRPI0208210B1 BRPI0208210B1 (pt) 2018-05-02
BRPI0208210B8 true BRPI0208210B8 (pt) 2021-05-25

Family

ID=7678654

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208210-1 BRPI0208210B8 (pt) 2001-03-23 2002-03-09 preparação de insulina pobre em zinco e isenta de zinco com estabilidade aperfeiçoada

Country Status (31)

Country Link
US (5) US6960561B2 (pt)
EP (2) EP2289539B1 (pt)
JP (1) JP4231292B2 (pt)
KR (2) KR20100061868A (pt)
CN (1) CN1273187C (pt)
AR (2) AR033059A1 (pt)
AT (1) ATE497777T1 (pt)
AU (1) AU2002302409B2 (pt)
BR (1) BRPI0208210B8 (pt)
CA (1) CA2441260C (pt)
CY (2) CY1111413T1 (pt)
DE (2) DE10114178A1 (pt)
DK (2) DK2289539T3 (pt)
ES (2) ES2360505T3 (pt)
HR (1) HRP20030765B1 (pt)
HU (1) HU228847B1 (pt)
IL (2) IL158057A0 (pt)
ME (1) ME00408B (pt)
MX (1) MXPA03007942A (pt)
MY (1) MY129417A (pt)
NO (1) NO326780B1 (pt)
NZ (1) NZ528335A (pt)
PE (1) PE20020968A1 (pt)
PL (1) PL205465B1 (pt)
PT (2) PT2289539E (pt)
RS (1) RS51579B (pt)
RU (1) RU2311922C2 (pt)
SI (1) SI1381385T1 (pt)
TW (1) TWI301761B (pt)
WO (1) WO2002076495A1 (pt)
ZA (1) ZA200306637B (pt)

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