DK10191D0 - Hidtil ukendte peptider - Google Patents

Hidtil ukendte peptider

Info

Publication number: DK10191D0
Authority: DK; Denmark
Prior art keywords: molecule; insulin; human insulin; unknown peptides; insulin analogues
Prior art date: 1991-01-22

Application number

DK010191A

Other languages

English (en)

Inventor

Jens Joergen Veilgaard Brange

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-22

Filing date

1991-01-22

Publication date

1991-01-22

1991-01-22 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1991-01-22 Priority to DK010191A priority Critical patent/DK10191D0/da

1991-01-22 Publication of DK10191D0 publication Critical patent/DK10191D0/da

1992-01-22 Priority to AU11902/92A priority patent/AU1190292A/en

1992-01-22 Priority to CA002100565A priority patent/CA2100565A1/en

1992-01-22 Priority to AT92903864T priority patent/ATE136907T1/de

1992-01-22 Priority to PCT/DK1992/000019 priority patent/WO1992012999A1/en

1992-01-22 Priority to DE69210011T priority patent/DE69210011T2/de

1992-01-22 Priority to EP92903864A priority patent/EP0568594B1/en

1992-01-22 Priority to JP4503787A priority patent/JPH06506444A/ja

1994-09-07 Priority to US08/301,838 priority patent/US5597796A/en

Links

102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Emergency Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK010191A 1991-01-22 1991-01-22 Hidtil ukendte peptider DK10191D0 (da)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
DK010191A DK10191D0 (da)	1991-01-22	1991-01-22	Hidtil ukendte peptider
AU11902/92A AU1190292A (en)	1991-01-22	1992-01-22	Novel insulin analogs
CA002100565A CA2100565A1 (en)	1991-01-22	1992-01-22	Insulin analogs
AT92903864T ATE136907T1 (de)	1991-01-22	1992-01-22	Neue insulinanaloge geeignet für die transdermale anwendung
PCT/DK1992/000019 WO1992012999A1 (en)	1991-01-22	1992-01-22	Novel insulin analogs
DE69210011T DE69210011T2 (de)	1991-01-22	1992-01-22	Neue Insulinanaloge geeignet für die transdermale Anwendung
EP92903864A EP0568594B1 (en)	1991-01-22	1992-01-22	NOVEL INSULIN ANALOGS suited for transdermal application
JP4503787A JPH06506444A (ja)	1991-01-22	1992-01-22	新規インスリン類似体
US08/301,838 US5597796A (en)	1991-01-22	1994-09-07	Transdermal insulin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK010191A DK10191D0 (da)	1991-01-22	1991-01-22	Hidtil ukendte peptider

Publications (1)

Publication Number	Publication Date
DK10191D0 true DK10191D0 (da)	1991-01-22

Family

ID=8089747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK010191A DK10191D0 (da)	1991-01-22	1991-01-22	Hidtil ukendte peptider

Country Status (9)

Country	Link
US (1)	US5597796A (da)
EP (1)	EP0568594B1 (da)
JP (1)	JPH06506444A (da)
AT (1)	ATE136907T1 (da)
AU (1)	AU1190292A (da)
CA (1)	CA2100565A1 (da)
DE (1)	DE69210011T2 (da)
DK (1)	DK10191D0 (da)
WO (1)	WO1992012999A1 (da)

Families Citing this family (47)

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CA2087087C (en) *	1992-01-22	2000-07-18	Burton H. Sage, Jr.	Molecules for iontophoretic delivery
US5747453A (en) *	1995-06-06	1998-05-05	Alza Corporation	Method for increasing the electrotransport flux of polypeptides
IT1285405B1 (it)	1995-06-06	1998-06-03	Alza Corp	Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
US5807315A (en) *	1995-11-13	1998-09-15	Minimed, Inc.	Methods and devices for the delivery of monomeric proteins
US6333189B1 (en)	1996-06-06	2001-12-25	Alza Corporation	Method of making an electrotransport device
US5857994A (en) *	1996-10-01	1999-01-12	Becton, Dickinson And Company	Awakenable iontophoretic/delivery device for reducing electrical sensation upon application thereof
DE19726167B4 (de) *	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
EP1028706B1 (en) *	1997-11-12	2003-07-09	Alza Corporation	Buffered drug formulations for transdermal electrotransport delivery
US6562942B1 (en) *	1999-02-23	2003-05-13	Neurocrine Biosciences, Inc.	Methods for treatment of diabetes using peptide analogues of insulin
US6406455B1 (en) *	1998-12-18	2002-06-18	Biovalve Technologies, Inc.	Injection devices
AU767510B2 (en) *	1999-02-18	2003-11-13	Valeritas, Inc.	Electroactive pore
DE10114178A1 (de) *	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
NZ519403A (en) *	2001-06-21	2005-03-24	Pfizer Prod Inc	Use of insulin in a medicament to reduce weight gain in a diabetic patient who is using exogenous insulin to control blood sugar levels
JP4033382B2 (ja) *	2002-04-08	2008-01-16	久光製薬株式会社	インスリン投与装置
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
EP1991575A1 (en) *	2006-02-21	2008-11-19	Novo Nordisk A/S	Single-chain insulin analogues and pharmaceutical formulations thereof
US8796205B2 (en)	2006-05-09	2014-08-05	Novo Nordisk A/S	Insulin derivative
EP2015770B1 (en) *	2006-05-09	2012-09-26	Novo Nordisk A/S	Insulin derivative
ES2542146T3 (es)	2006-07-31	2015-07-31	Novo Nordisk A/S	Insulinas extendidas PEGiladas.
PT2074141T (pt) *	2006-09-22	2016-11-10	Novo Nordisk As	Análogos de insulina resistentes a proteases
ES2563038T3 (es)	2007-04-30	2016-03-10	Novo Nordisk A/S	Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
JP2009067766A (ja) *	2007-09-12	2009-04-02	Kosumedei Seiyaku Kk	経皮吸収促製剤及びそれを用いた経皮吸収システム
KR20100111683A (ko)	2008-01-09	2010-10-15	사노피-아벤티스 도이칠란트 게엠베하	극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체
KR20100111682A (ko)	2008-01-09	2010-10-15	사노피-아벤티스 도이칠란트 게엠베하	극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체
CN101970477B (zh)	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
PL2910570T3 (pl)	2008-03-18	2017-06-30	Novo Nordisk A/S	Stabilizowane względem proteaz, acylowane analogi insuliny
LT3228320T (lt)	2008-10-17	2020-03-10	Sanofi-Aventis Deutschland Gmbh	Insulino ir glp-1 agonisto derinys
JP2012532177A (ja) *	2009-07-06	2012-12-13	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	熱及び振動安定性インスリン製剤
PE20121362A1 (es)	2009-11-13	2012-10-17	Sanofi Aventis Deutschland	Composicion farmaceutica que comprende despro36exendina-4(1-39)-lys6-nh2, insulina gly(a21)-arg(b31)-arg(b32) y metionina
KR101772372B1 (ko)	2009-11-13	2017-08-29	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
WO2011121496A1 (en)	2010-03-31	2011-10-06	Wockhardt Limited	Composition comprising insulin and herbal oil for transdermal or transmucosal administration
EP2611458B1 (en)	2010-08-30	2016-09-21	Sanofi-Aventis Deutschland GmbH	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AU2012300978B2 (en)	2011-08-29	2017-04-27	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CA2898730A1 (en) *	2012-01-20	2013-07-25	Case Western Reserve University	Glutamic acid-stabilized insulin analogues
KR20150002777A (ko)	2012-04-11	2015-01-07	노보 노르디스크 에이/에스	인슐린 제제
JP2016516728A (ja) *	2013-03-15	2016-06-09	ケースウェスタンリザーブユニバーシティＣａｓｅＷｅｓｔｅｒｎＲｅｓｅｒｖｅＵｎｉｖｅｒｓｉｔｙ	第２部位インスリン類似体
AU2014333979B2 (en)	2013-10-07	2018-02-15	Novo Nordisk A/S	Novel derivative of an insulin analogue
GB201321489D0 (en)	2013-12-05	2014-01-22	Chemical & Biopharmaceutical Lab Of Patras S A	Biologically active insulin derivatives
HRP20230470T1 (hr)	2014-12-12	2023-07-21	Sanofi-Aventis Deutschland Gmbh	Formulacija fiksnog omjera inzulin glargin/liksisenatid
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
KR20190043609A (ko)	2016-09-06	2019-04-26	케미컬 앤드 바이오파마슈티컬 라보라토리즈 오브 파트라스 에스.에이.	프로인슐린 유도체
CN115154591B (zh)	2016-12-16	2023-04-14	诺和诺德股份有限公司	含胰岛素的药物组合物
EP3668892A1 (en)	2017-08-17	2020-06-24	Novo Nordisk A/S	Novel acylated insulin analogues and uses thereof
EP3756679A1 (en)	2019-06-28	2020-12-30	Université de Genève	Compositions for use in the treatment of insulin deficiency conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH25772A (en) *	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
DK257988D0 (da) *	1988-05-11	1988-05-11	Novo Industri As	Nye peptider
EP0425482B1 (en) *	1988-07-20	1993-08-18	Novo Nordisk A/S	Human insulin analogs and preparations containing them
JPH04502465A (ja) *	1988-12-23	1992-05-07	ノボ　ノルディスク　アクティーゼルスカブ	ヒトインシュリン類似物質
NZ232375A (en) *	1989-02-09	1992-04-28	Lilly Co Eli	Insulin analogues modified at b29
US5514646A (en) *	1989-02-09	1996-05-07	Chance; Ronald E.	Insulin analogs modified at position 29 of the B chain

1991
- 1991-01-22 DK DK010191A patent/DK10191D0/da not_active Application Discontinuation
1992
- 1992-01-22 CA CA002100565A patent/CA2100565A1/en not_active Abandoned
- 1992-01-22 JP JP4503787A patent/JPH06506444A/ja active Pending
- 1992-01-22 AT AT92903864T patent/ATE136907T1/de not_active IP Right Cessation
- 1992-01-22 WO PCT/DK1992/000019 patent/WO1992012999A1/en not_active Ceased
- 1992-01-22 DE DE69210011T patent/DE69210011T2/de not_active Expired - Fee Related
- 1992-01-22 AU AU11902/92A patent/AU1190292A/en not_active Abandoned
- 1992-01-22 EP EP92903864A patent/EP0568594B1/en not_active Expired - Lifetime
1994
- 1994-09-07 US US08/301,838 patent/US5597796A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69210011T2 (de)	1996-09-05
US5597796A (en)	1997-01-28
EP0568594A1 (en)	1993-11-10
CA2100565A1 (en)	1992-07-23
ATE136907T1 (de)	1996-05-15
DE69210011D1 (de)	1996-05-23
EP0568594B1 (en)	1996-04-17
WO1992012999A1 (en)	1992-08-06
AU1190292A (en)	1992-08-27
JPH06506444A (ja)	1994-07-21

Publication	Publication Date	Title
DK10191D0 (da)	1991-01-22	Hidtil ukendte peptider
DK642587A (da)	1987-12-08	Insulinpraeparat
ATA260690A (de)	1997-04-15	Therapeutische infusionszubereitung auf basis von aminosäurederivaten
ATE73459T1 (de)	1992-03-15	Pharmazeutische zusammensetzungen, welche ein dipeptid enthalten.
DE3676670D1 (de)	1991-02-07	Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung.
IL78103A0 (en)	1986-07-31	Peptides,their preparation and pharmaceutical compositions containing them
DK0439042T3 (da)	1995-10-02	Anvendelse af farmaceutiske og kosmetiske præparater med blandingsmiceller
HUP9904023A2 (hu)	2000-03-28	Leptin antagonisták alkalmazása inzulin rezisztencia kezelésére II. típusú cukorbajban
DK395689D0 (da)	1989-08-11	Pharmaceutisk tilberedning til behandling af diabetes mellitus
MX163955B (es)	1992-07-06	Composicion farmaceutica de dihidrocodeina e ibuprofen
EP0994724A4 (en)	2004-12-08	METHODS AND COMPOSITIONS TO PREVENT THE REPRODUCTION OF HIV-1
DK0725648T3 (da)	2007-08-20	Leverspecifikke farmaceutiske aktivstoffer
DK384089A (da)	1990-05-25	Peptider med bradykinin-antagonistisk virkning og fysiologisk acceptable salte deraf, deres fremstilling og anvendelse
DK414389D0 (da)	1989-08-23	Farmaceutisk praeparat indeholdende et aminosyrederivat med renin-inhibitorisk virkning
ATE125706T1 (de)	1995-08-15	Diphosphonate enthaltende pharmazeutische zusammensetzungen zur behandlung von arthrosis.
FI893681A0 (fi)	1989-08-03	N-2,3-butadienyltri- och tetra-aminoalkanderivat.
PT88539A (pt)	1988-10-01	Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen
DE69004532D1 (de)	1993-12-16	Topisch anzuwendende Defibrotid enthaltende Arzneizubereitungen.
BG97123A (bg)	1993-12-24	Производни на човешка, стимулирана от жлъчните соли, липаза и фармацевтични състави на тяхна основа
DK288789D0 (da)	1989-06-13	Peptider og syreadditionssalte deraf, deres fremstilling og anvendelse
GR3003733T3 (da)	1993-03-16
NO890174L (no)	1989-07-17	Rekombinante interleukin-1alfa-polypeptider.
DK179786D0 (da)	1986-04-18	(-)-1beta-ethyl-1alfa-hydroxylmethyl-1,2,3,4,6,7,12,12balfa-octa-hydroindolo(2,3-a)quinolizin og syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika
AU1318797A (en)	1997-08-20	Peptides and uses thereof for therapy of celiac diseases
YU64192A (sh)	1994-06-10	Analozi insulina

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Date	Code	Title	Description
1991-09-02	AHS	Application shelved for other reasons than non-payment

DK10191D0 - Hidtil ukendte peptider - Google Patents

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