DK414389D0 - Farmaceutisk praeparat indeholdende et aminosyrederivat med renin-inhibitorisk virkning - Google Patents

Farmaceutisk praeparat indeholdende et aminosyrederivat med renin-inhibitorisk virkning

Info

Publication number: DK414389D0
Authority: DK; Denmark
Prior art keywords: inhibitorial; purine; amino acid; effect; acid derivative
Prior art date: 1988-08-24

Application number

DK414389A

Other languages

English (en)

Other versions

DK414389A (da

Inventor

Irving S Sigal

Paul L Darke

Joel R Huff

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-24

Filing date

1989-08-23

Publication date

1989-08-23

1989-08-23 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1989-08-23 Publication of DK414389D0 publication Critical patent/DK414389D0/da

1990-02-26 Publication of DK414389A publication Critical patent/DK414389A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/553—Renin inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK414389A 1988-08-24 1989-08-23 Farmaceutisk praeparat indeholdende et aminosyrederivat med renin-inhibitorisk virkning DK414389A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23584188A	1988-08-24	1988-08-24
US32864489A	1989-03-28	1989-03-28

Publications (2)

Publication Number	Publication Date
DK414389D0 true DK414389D0 (da)	1989-08-23
DK414389A DK414389A (da)	1990-02-26

Family

ID=26929267

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK414389A DK414389A (da)	1988-08-24	1989-08-23	Farmaceutisk praeparat indeholdende et aminosyrederivat med renin-inhibitorisk virkning

Country Status (3)

Country	Link
EP (1)	EP0357332A3 (da)
JP (1)	JPH02117615A (da)
DK (1)	DK414389A (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
DE3912829A1 (de) *	1989-04-19	1990-10-25	Bayer Ag	Verwendung von renininhibitorischen peptiden als mittel gegen retroviren
US5539122A (en) *	1989-05-23	1996-07-23	Abbott Laboratories	Retroviral protease inhibiting compounds
CA1340682C (en) *	1989-07-07	1999-07-27	Pierre Lavallee	Antiviral peptides having a 2-oxoalkyl amino acid side chain
DE3941235A1 (de) *	1989-12-14	1991-06-20	Bayer Ag	Neue peptide, ihre herstellung und ihre verwendung in arzneimitteln
DE4001236A1 (de) *	1990-01-18	1991-07-25	Bayer Ag	Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren
CA2036398C (en) *	1990-02-23	2000-06-13	Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee	Hiv protease inhibiting agents
CA2036413C (en) *	1990-02-23	2000-12-12	Paul Cates Anderson	Hiv protease inhibitors
CA2036397C (en) *	1990-02-23	2000-12-12	Paul Cates Anderson	Hiv protease inhibitors containing derived amino acid units
AU8233491A (en) *	1990-07-06	1992-02-04	Smithkline Beecham Corporation	Retroviral protease inhibitors
DE4026614A1 (de) *	1990-08-23	1992-02-27	Bayer Ag	Phosphonopyrrolidin- und piperidin-haltige pseudopeptide vom statintyp, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel gegen retroviren
US6313094B1 (en)	1990-12-11	2001-11-06	Japan Energy Corporation	β-amino-α-hydroxycarboxylic acid derivatives and HIV protease inhibitors
WO1992015319A1 (en) *	1991-03-08	1992-09-17	Smithkline Beecham Corporation	Hiv protease inhibitors
US5554728A (en) *	1991-07-23	1996-09-10	Nexstar Pharmaceuticals, Inc.	Lipid conjugates of therapeutic peptides and protease inhibitors
DE4126485A1 (de) *	1991-08-10	1993-02-11	Bayer Ag	Trifluormethyl-haltige pseudopeptide
US5413999A (en) *	1991-11-08	1995-05-09	Merck & Co., Inc.	HIV protease inhibitors useful for the treatment of AIDS
US6071895A (en)	1992-03-11	2000-06-06	Narhex Limited	Polar-substituted hydrocarbons
US5888992A (en)	1992-03-11	1999-03-30	Narhex Limited	Polar substituted hydrocarbons
JPH07504654A (ja)	1992-03-11	1995-05-25	ナルヘックス　リミテッド	オキソ及びヒドロキシ置換炭化水素のアミン誘導体
DE4215874A1 (de) *	1992-05-14	1993-11-18	Bayer Ag	Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp
US5559256A (en) *	1992-07-20	1996-09-24	E. R. Squibb & Sons, Inc.	Aminediol protease inhibitors
FR2694196B1 (fr) *	1992-07-30	1994-10-21	Rochade	Composition médicinale utilisable comme agent antiviral.
GB2270914A (en) *	1992-09-14	1994-03-30	Merck & Co Inc	HIV protease inhibitor compounds
RU2132334C1 (ru) *	1992-12-16	1999-06-27	Басф Акциенгезельшафт	Аналог долостатина
ES2100109B1 (es) *	1993-07-14	1998-02-16	Squibb & Sons Inc	Inhibidores de proteasas de aminodiol.
KR0125117B1 (ko)	1994-06-15	1997-12-05	성재갑	항 에이즈(aids)효과를 갖는 신규한 인간 면역 결핍 바이러스(hiv)프로테아제 억제 화합물 및 그의 제조방법
US5733882A (en) *	1994-01-17	1998-03-31	Smithkline Beecham Corporation	Retroviral protease inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4661473A (en) *	1984-03-27	1987-04-28	Merck & Co., Inc.	Renin inhibitors containing peptide isosteres
BE1002213A5 (fr) *	1987-04-23	1990-10-16	Sandoz Sa	Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments.

1989
- 1989-08-23 EP EP19890308551 patent/EP0357332A3/en not_active Withdrawn
- 1989-08-23 DK DK414389A patent/DK414389A/da not_active Application Discontinuation
- 1989-08-24 JP JP1216193A patent/JPH02117615A/ja active Pending

Also Published As

Publication number	Publication date
EP0357332A2 (en)	1990-03-07
EP0357332A3 (en)	1991-07-31
DK414389A (da)	1990-02-26
JPH02117615A (ja)	1990-05-02

Publication	Publication Date	Title
DK414389A (da)	1990-02-26	Farmaceutisk praeparat indeholdende et aminosyrederivat med renin-inhibitorisk virkning
DK286389D0 (da)	1989-06-12	Aminosyrederivater
DK96889D0 (da)	1989-02-28	Aminosyrederivater
DK340088A (da)	1988-12-23	Aminosyrederivater
DK89090A (da)	1990-04-09	Farmaceutisk praeparat
DK481989D0 (da)	1989-09-29	Farmaceutiske formuleringer
DK708088A (da)	1989-06-29	Farmaceutisk praeparat med forlaenget frigivelsestid
DK361786D0 (da)	1986-07-30	Granulaere farmaceutiske praeparater med forskudt afgivelse
SE8801813D0 (sv)	1988-05-13	Pharmaceutical composition
KR890701101A (ko)	1989-12-19	제약학적 조성물
DK489189A (da)	1989-10-04	Farmaceutisk praeparat
DK705488D0 (da)	1988-12-19	Farmaceutisk praeparat
DK523288A (da)	1989-04-07	Aminosyrederivater
KR870700618A (ko)	1987-12-30	크로모글릭산유도체와 그 제조방법 및 약학적 조성물
IT8922216A0 (it)	1989-10-31	Soluzione farmaceutica
DK603988D0 (da)	1988-10-28	Farmaceutisk praeparat
DK336489A (da)	1990-01-08	Farmaceutisk praeparat
DK139388D0 (da)	1988-03-15	Farmaceutisk praeparat
DK298389D0 (da)	1989-06-16	Farmaceutisk praeparat til topisk anvendelse omfattende et amin-funktionelt medikament
DK99085D0 (da)	1985-03-04	Farmaceutiske praeparater indeholdende a-vitaminsyrederivater
DK276288A (da)	1988-11-24	Farmaceutisk praeparat
DK624587A (da)	1988-05-29	Farmaceutisk praeparat indeholdende imidazolderivater
DK37589A (da)	1989-07-30	Farmaceutisk praeparat for 4-aroylimidazol-2-oner
DK138888A (da)	1988-09-19	Farmaceutisk praeparat
IT1224244B (it)	1990-09-26	Composizione farmaceutica anoressizzante comprendente 5-idrossitrpofano

Legal Events

Date	Code	Title	Description
1994-04-25	AHB	Application shelved due to non-payment