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IT1285405B1 - Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. - Google Patents

Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.

Info

Publication number
IT1285405B1
IT1285405B1 IT96TO000496A ITTO960496A IT1285405B1 IT 1285405 B1 IT1285405 B1 IT 1285405B1 IT 96TO000496 A IT96TO000496 A IT 96TO000496A IT TO960496 A ITTO960496 A IT TO960496A IT 1285405 B1 IT1285405 B1 IT 1285405B1
Authority
IT
Italy
Prior art keywords
electrotransport
modification
increase flow
polypeptide drugs
polypeptide
Prior art date
Application number
IT96TO000496A
Other languages
English (en)
Inventor
Leslie A Holladay
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of ITTO960496A0 publication Critical patent/ITTO960496A0/it
Publication of ITTO960496A1 publication Critical patent/ITTO960496A1/it
Application granted granted Critical
Publication of IT1285405B1 publication Critical patent/IT1285405B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Electrotherapy Devices (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IT96TO000496A 1995-06-06 1996-06-05 Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. IT1285405B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46661095A 1995-06-06 1995-06-06

Publications (3)

Publication Number Publication Date
ITTO960496A0 ITTO960496A0 (it) 1996-06-05
ITTO960496A1 ITTO960496A1 (it) 1997-12-05
IT1285405B1 true IT1285405B1 (it) 1998-06-03

Family

ID=23852435

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96TO000496A IT1285405B1 (it) 1995-06-06 1996-06-05 Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.

Country Status (12)

Country Link
US (2) US7324846B2 (it)
JP (2) JP4354529B2 (it)
AU (1) AU6590396A (it)
BE (1) BE1009704A3 (it)
BR (1) BR9609149A (it)
CA (1) CA2220146A1 (it)
DE (1) DE19681439T1 (it)
FR (1) FR2735132B1 (it)
GB (1) GB2317179B (it)
IT (1) IT1285405B1 (it)
NL (1) NL1003283C2 (it)
WO (1) WO1996039422A2 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
US7197359B1 (en) 1999-10-14 2007-03-27 Pola Chemical Industries Inc. Compositions for electroporation
JP2004524005A (ja) * 2000-09-08 2004-08-12 マサチューセッツ　インスティテュート　オブ　テクノロジー Ｇ−ｃｓｆアナログ組成物および方法
WO2004022033A1 (en) * 2002-09-04 2004-03-18 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
RU2005111253A (ru) * 2002-09-18 2005-11-20 Сантр Оспиталье Де Л` Юниверсите Де Монреаль (Схюм) (Ca) Аналоги ghrh
CA2595457A1 (en) 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
PE20130557A1 (es) 2010-03-04 2013-05-19 Pfenex Inc Metodo para producir proteinas de interferon recombinantes solubles sin desnaturalizacion
AU2011235210B2 (en) 2010-04-01 2015-07-16 Pfenex Inc. Methods for G-CSF production in a Pseudomonas host cell
CN104080441B (zh) 2011-11-30 2020-02-28 3M创新有限公司 包括肽治疗剂和氨基酸的微针装置、制备和使用其的方法
CN108135177B (zh) 2015-04-29 2021-06-01 雷迪厄斯制药公司 用于治疗癌症的方法
CN110191707A (zh) 2017-01-05 2019-08-30 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250878A (en) 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4431739A (en) 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4628043A (en) * 1983-04-26 1986-12-09 The Salk Institute For Biological Studies Hypothalamic GRF agonists
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4722726A (en) 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US5250022A (en) 1990-09-25 1993-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
AU609769B2 (en) 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
GB9107846D0 (en) * 1990-04-30 1991-05-29 Ici Plc Polypeptides
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
CA2087087C (en) 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
WO1993025197A1 (en) * 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
CA2145642C (en) * 1992-12-31 2004-05-04 Gary A. Lattin Electrotransport system having flexible means
ATE217204T1 (de) * 1993-06-08 2002-05-15 Hisamitsu Pharmaceutical Co Iontophoretisches system
EP0643981B1 (en) * 1993-09-22 2002-01-09 Hisamitsu Pharmaceutical Co., Inc. A matrix for iontophoreses
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.

Also Published As

Publication number Publication date
NL1003283C2 (nl) 1997-05-02
US20090275877A1 (en) 2009-11-05
JP2009149639A (ja) 2009-07-09
JPH11507341A (ja) 1999-06-29
GB9725981D0 (en) 1998-02-04
BE1009704A3 (fr) 1997-07-01
GB2317179A (en) 1998-03-18
US20020107505A1 (en) 2002-08-08
ITTO960496A1 (it) 1997-12-05
DE19681439T1 (de) 1998-07-23
GB2317179B (en) 1999-07-28
FR2735132B1 (fr) 1998-04-24
FR2735132A1 (fr) 1996-12-13
WO1996039422A3 (en) 1997-03-06
IE960413A1 (en) 1996-12-11
US7324846B2 (en) 2008-01-29
NL1003283A1 (nl) 1996-12-09
ITTO960496A0 (it) 1996-06-05
AU6590396A (en) 1996-12-24
CA2220146A1 (en) 1996-12-12
WO1996039422A2 (en) 1996-12-12
BR9609149A (pt) 1999-02-23
JP4354529B2 (ja) 2009-10-28

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Legal Events

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