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ATE489365T1 - Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon - Google Patents

Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon

Info

Publication number
ATE489365T1
ATE489365T1 AT04776626T AT04776626T ATE489365T1 AT E489365 T1 ATE489365 T1 AT E489365T1 AT 04776626 T AT04776626 T AT 04776626T AT 04776626 T AT04776626 T AT 04776626T AT E489365 T1 ATE489365 T1 AT E489365T1
Authority
AT
Austria
Prior art keywords
ühexane
carboxylates
dimethyl
salts
producing
Prior art date
Application number
AT04776626T
Other languages
English (en)
Inventor
Jeonghan Park
Anantha Sudhakar
George Wong
Minzhang Chen
Juergen Weber
Xiaojing Yang
Daw-Iong Kwok
Ingyu Jeon
Ramani Raghavan
Maria Tamarez
Weidong Tong
Eugene Vater
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE489365T1 publication Critical patent/ATE489365T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT04776626T 2003-06-17 2004-06-15 Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon ATE489365T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47951603P 2003-06-17 2003-06-17
PCT/US2004/019135 WO2004113295A1 (en) 2003-06-17 2004-06-15 Process and intermediates for the preparation of (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof

Publications (1)

Publication Number Publication Date
ATE489365T1 true ATE489365T1 (de) 2010-12-15

Family

ID=33539184

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04776626T ATE489365T1 (de) 2003-06-17 2004-06-15 Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon

Country Status (13)

Country Link
US (3) US7309717B2 (de)
EP (1) EP1633711B1 (de)
JP (1) JP4825129B2 (de)
CN (2) CN1805931B (de)
AT (1) ATE489365T1 (de)
CA (1) CA2526635C (de)
DE (1) DE602004030239D1 (de)
ES (1) ES2354817T3 (de)
HK (1) HK1081199A1 (de)
MX (1) MXPA05013752A (de)
SG (1) SG180022A1 (de)
WO (1) WO2004113295A1 (de)
ZA (1) ZA201006378B (de)

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CN101415676A (zh) 2006-04-17 2009-04-22 住友化学株式会社 N-叔丁氧基羰基-2-吡咯烷酮类及其制造方法
JP5272325B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 多環式プロリン誘導体またはその酸付加塩の製造方法
WO2007122744A1 (ja) 2006-04-17 2007-11-01 Sumitomo Chemical Company, Limited 多環式プロリン誘導体又はその酸付加塩の製造方法
CA2672570A1 (en) * 2006-12-19 2008-07-10 Schering Corporation Preparation of 3-amino-3-(cyclobutylmethyl)-2-(hydroxy)-propionamide hydrochloride
EP2205584A1 (de) * 2007-10-10 2010-07-14 Novartis Ag Spiropyrrolidine und ihre verwendung gegen hcv- und hiv-infektionen
WO2009073380A1 (en) * 2007-11-28 2009-06-11 Schering Corporation Dehydrohalogenation process for the preparation of intermediates useful in providing 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds
CN102282135A (zh) * 2008-06-05 2011-12-14 帝斯曼知识产权资产管理有限公司 一种(4s，5r)-半酯的制备方法
EP2481737A1 (de) 2008-06-24 2012-08-01 Merck Sharp & Dohme Corp. Biokatalytische Verfahren zur Herstellung substantiell stereomer reinkondensierter, bicyclischer Prolinverbindungen
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
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CN101863866B (zh) * 2009-04-16 2012-07-04 上海联友制药技术有限公司 3,3-二甲基环丙烷-1,2-二甲酸酐的合成方法
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CN102070575B (zh) * 2010-12-28 2012-10-17 上海北卡医药技术有限公司 卡隆酸酐的合成方法
CN102127040B (zh) * 2010-12-30 2013-05-01 西安彩晶光电科技股份有限公司 6,6-二甲基-3-氧杂双环[3.1.0]己烷-2,4-二酮的制备方法
FR2972453B1 (fr) * 2011-03-09 2013-11-29 Minakem Nouveau procede de synthese du (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate de methyle ou de l'un de ses sels
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CN103435532B (zh) * 2013-09-02 2015-07-08 苏州永健生物医药有限公司 波普瑞韦中间体的合成方法
CN104151279A (zh) * 2014-08-26 2014-11-19 广西梧松林化集团有限公司 卡龙酸酐的合成方法
CN114539125B (zh) * 2022-03-07 2024-02-09 杭州国瑞生物科技有限公司 一种帕西洛韦中间体的合成方法
CN114478690B (zh) * 2022-03-08 2024-01-02 新发药业有限公司 一种6,6-二甲基-3-氮杂双环[3.1.0]己烷衍生物的制备方法
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CN114605309B (zh) * 2022-03-23 2023-07-21 浙江新和成股份有限公司 一种氮杂双环衍生物的合成方法
CN114989067B (zh) * 2022-07-18 2022-10-28 苏州奥普拓新材料有限公司 一种帕罗韦德中间体的合成方法
CN115947679B (zh) * 2022-12-16 2024-06-07 杭州澳赛诺生物科技有限公司 一种6,6-二甲基-3-杂氮-双环[3.1.0]己烷-2-羧酸甲酯的合成方法

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Also Published As

Publication number Publication date
CA2526635A1 (en) 2004-12-29
MXPA05013752A (es) 2006-03-08
US7309717B2 (en) 2007-12-18
JP2007520434A (ja) 2007-07-26
US7569705B2 (en) 2009-08-04
CN1805931B (zh) 2010-06-23
JP4825129B2 (ja) 2011-11-30
DE602004030239D1 (de) 2011-01-05
US20090247784A1 (en) 2009-10-01
CN101823965A (zh) 2010-09-08
ZA201006378B (en) 2011-05-25
US20080114179A1 (en) 2008-05-15
US7728165B2 (en) 2010-06-01
US20050059648A1 (en) 2005-03-17
ES2354817T3 (es) 2011-03-18
EP1633711B1 (de) 2010-11-24
CA2526635C (en) 2012-06-05
CN101823965B (zh) 2012-12-19
CN1805931A (zh) 2006-07-19
HK1081199A1 (en) 2006-05-12
SG180022A1 (en) 2012-05-30
WO2004113295A1 (en) 2004-12-29
EP1633711A1 (de) 2006-03-15

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