[go: up one dir, main page]

ATE395413T1 - Antikörperkategorisierung auf der grundlage von bindungseigenschaften - Google Patents

Antikörperkategorisierung auf der grundlage von bindungseigenschaften

Info

Publication number
ATE395413T1
ATE395413T1 AT02804495T AT02804495T ATE395413T1 AT E395413 T1 ATE395413 T1 AT E395413T1 AT 02804495 T AT02804495 T AT 02804495T AT 02804495 T AT02804495 T AT 02804495T AT E395413 T1 ATE395413 T1 AT E395413T1
Authority
AT
Austria
Prior art keywords
antibodies
binding properties
categorization based
epitope
methods
Prior art date
Application number
AT02804495T
Other languages
English (en)
Inventor
Xiao-Chi Jia
Michael Gallo
Jaspal Kang
Wynn Walker
Keith Joho
Original Assignee
Amgen Fremont Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Fremont Inc filed Critical Amgen Fremont Inc
Application granted granted Critical
Publication of ATE395413T1 publication Critical patent/ATE395413T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/16—Matrix or vector computation, e.g. matrix-matrix or matrix-vector multiplication, matrix factorization
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Data Mining & Analysis (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • Evolutionary Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Artificial Intelligence (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioethics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Mathematical Physics (AREA)
  • Computational Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
AT02804495T 2001-12-03 2002-12-02 Antikörperkategorisierung auf der grundlage von bindungseigenschaften ATE395413T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33724501P 2001-12-03 2001-12-03
US41938702P 2002-10-16 2002-10-16

Publications (1)

Publication Number Publication Date
ATE395413T1 true ATE395413T1 (de) 2008-05-15

Family

ID=26990607

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02804495T ATE395413T1 (de) 2001-12-03 2002-12-02 Antikörperkategorisierung auf der grundlage von bindungseigenschaften

Country Status (9)

Country Link
US (4) US7771951B2 (de)
EP (1) EP1461423B1 (de)
JP (1) JP2005512044A (de)
AT (1) ATE395413T1 (de)
AU (1) AU2002357060A1 (de)
CA (1) CA2467633C (de)
DE (1) DE60226641D1 (de)
ES (1) ES2307832T3 (de)
WO (1) WO2003048731A2 (de)

Families Citing this family (278)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US20040018485A1 (en) * 1999-04-15 2004-01-29 Ilya Ravkin Multiplexed analysis of cells
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
JP2004537712A (ja) * 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
ES2307832T3 (es) 2001-12-03 2008-12-01 Amgen Fremont Inc. Clasificacion de anticuerpos basada en las caracteristicas de union.
AU2003224864A1 (en) * 2002-04-04 2003-10-27 Vitra Bioscience, Inc. Connection of cells to substrates using association pairs
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
JP2007525434A (ja) 2003-03-19 2007-09-06 アブジェニックス インコーポレイテッド Ｔ細胞、免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体およびその使用。
KR101435167B1 (ko) 2003-06-27 2014-11-04 암젠 프레몬트 인코포레이티드 상피 성장 인자 수용체의 결실 돌연변이체 지향 항체 및 그용도
HN2004000285A (es) 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
US20050208468A1 (en) * 2003-09-15 2005-09-22 Beske Oren E Assays with primary cells
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US20050136055A1 (en) 2003-12-22 2005-06-23 Pfizer Inc CD40 antibody formulation and methods
AU2005227313A1 (en) 2004-03-19 2005-10-06 Amgen Inc. Reducing the risk of human and anti-human antibodies through V gene manipulation
AU2005322410B2 (en) 2004-11-30 2011-11-10 Amgen Fremont Inc. Antibodies directed to GPNMB and uses thereof
CN101272802A (zh) 2005-04-25 2008-09-24 辉瑞大药厂 肌肉生长抑制素的抗体
BRPI0608096A2 (pt) 2005-04-26 2009-11-10 Pfizer anticorpos p-caderina
EP1933871B1 (de) 2005-09-07 2013-04-24 Amgen Fremont Inc. Humane monoklonale antikörper gegen activin-rezeptor-artige kinase-1
JP2009515897A (ja) 2005-11-10 2009-04-16 キュラジェン コーポレイション Ｔ細胞の免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体を用いて卵巣癌および腎臓癌を処置する方法
US8014590B2 (en) * 2005-12-07 2011-09-06 Drvision Technologies Llc Method of directed pattern enhancement for flexible recognition
DK3056568T3 (da) 2006-03-31 2021-11-01 Chugai Pharmaceutical Co Ltd Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik
CN101522717A (zh) 2006-08-04 2009-09-02 阿斯利康(瑞典)有限公司 针对ErbB2的人抗体
TW200904470A (en) 2007-04-02 2009-02-01 Pfizer Anti-IgE antibodies
EP3689912A1 (de) 2007-09-26 2020-08-05 Chugai Seiyaku Kabushiki Kaisha Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstitution in cdr
DK2242771T3 (da) 2007-12-14 2013-08-26 Pfizer Bindingsmolekyler til den humane ox40-receptor
KR102057826B1 (ko) 2008-04-11 2019-12-20 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복 결합하는 항원 결합 분자
CN102341411A (zh) * 2008-12-31 2012-02-01 比奥根艾迪克Ma公司 抗-淋巴细胞毒素抗体
CN110016081A (zh) 2009-05-13 2019-07-16 基酶有限公司 抗人cd52免疫球蛋白
NZ707327A (en) 2010-08-02 2017-01-27 Regeneron Pharma Mice that make binding proteins comprising vl domains
WO2012019061A2 (en) 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
MY162825A (en) 2010-08-20 2017-07-31 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
US20130224191A1 (en) 2010-08-27 2013-08-29 Robert A. Stull Notum protein modulators and methods of use
WO2013119964A2 (en) 2012-02-08 2013-08-15 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
WO2012031280A2 (en) 2010-09-03 2012-03-08 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
CN106620693A (zh) 2010-09-03 2017-05-10 艾伯维施特姆森特克斯有限责任公司 新型调节剂及使用方法
SI2614082T1 (sl) 2010-09-09 2018-12-31 Pfizer Inc. Molekule, ki vežejo 4-1BB
BR112013012396A2 (pt) 2010-11-19 2020-11-10 Toshio Imai anticorpos anti-ccl20 de neutralização
TWI761912B (zh) 2010-11-30 2022-04-21 日商中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
AU2011338425A1 (en) 2010-12-08 2013-05-02 Stemcentrx, Inc. Novel modulators and methods of use
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
US20120240072A1 (en) * 2011-03-18 2012-09-20 Serious Materials, Inc. Intensity transform systems and methods
US9238689B2 (en) 2011-07-15 2016-01-19 Morpho Sys AG Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT)
KR20200058583A (ko) 2011-08-16 2020-05-27 모르포시스 아게 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법
HUE058855T2 (hu) 2011-08-16 2022-09-28 Morphosys Ag Kombinációs terápia, CD19 elleni ellenanyag és purinanalóg alkalmazásával
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
EP3360897A1 (de) 2011-10-19 2018-08-15 MorphoSys AG Il17c-antagonisten zur behandlung von entzündungskrankheiten
CN104271599A (zh) 2011-11-08 2015-01-07 辉瑞公司 使用抗m-csf抗体治疗炎性疾病的方法
US20140314667A1 (en) 2011-11-16 2014-10-23 Amgen Inc. Methods of treating epidermal growth factor deletion mutant viii related disorders
TW201328706A (zh) 2011-12-05 2013-07-16 Novartis Ag 表皮生長因子受體３（ｈｅｒ３）之抗體
IN2014CN04373A (de) 2011-12-05 2015-09-04 Novartis Ag
EP3093294A1 (de) 2012-02-24 2016-11-16 Stemcentrx, Inc. Dll3-antikörper und verfahren zur verwendung
CN103483421B (zh) 2012-06-11 2019-10-22 厦门大学 用于治疗hbv感染及相关疾病的多肽及抗体
WO2014004549A2 (en) 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
EP3540438A1 (de) 2012-08-17 2019-09-18 MorphoSys AG Komplex-spezifische antikörper und antikörperfragmente und deren verwendung
JP6774164B2 (ja) 2012-08-24 2020-10-21 中外製薬株式会社 マウスＦｃγＲＩＩ特異的Ｆｃ抗体
BR112015001955A2 (pt) 2012-08-24 2017-11-07 Chugai Pharmaceutical Co Ltd variante de região fc específica de fcgamariib
EP2900232B1 (de) 2012-09-25 2017-11-15 MorphoSys AG Kombinationen und verwendungen davon
WO2014096333A1 (en) 2012-12-20 2014-06-26 Morphosys Ag Anti-staphylococcal antibodies
US10160813B2 (en) * 2013-01-22 2018-12-25 University Of Tennessee Research Foundation Tissue plasminogen activator antibodies and methods of use
SMT201900339T1 (it) 2013-02-22 2019-07-11 Medimmune Ltd Coniugati anticorpo anti-dll3/pbd e loro usi
JP6462599B2 (ja) 2013-03-15 2019-01-30 シャアメン ユニバーシティ Ｒｓｖ融合タンパク質のエピトープ及びそのエピトープを認識する抗体
AR095199A1 (es) 2013-03-15 2015-09-30 Genzyme Corp Anticuerpos anti-cd52
WO2014161483A1 (zh) 2013-04-02 2014-10-09 厦门大学 识别流感病毒血凝素蛋白ha1结构域的广谱单克隆抗体
JP6598680B2 (ja) 2013-04-02 2019-10-30 中外製薬株式会社 Ｆｃ領域改変体
WO2014167088A1 (en) 2013-04-12 2014-10-16 Morphosys Ag Antibodies targeting m-csf
US20160060347A1 (en) 2013-04-17 2016-03-03 Morphosys Ag Antibodies targeting specifically human cxcr2
TWI671317B (zh) 2013-08-02 2019-09-11 輝瑞大藥廠 抗ｃｘｃｒ４抗體及抗體-藥物結合物
CA2922529A1 (en) 2013-08-28 2015-03-05 Stemcentrx, Inc. Novel sez6 modulators and methods of use
WO2015031698A1 (en) 2013-08-28 2015-03-05 Stem Centrx, Inc. Site-specific antibody conjugation methods and compositions
US10825548B2 (en) * 2013-12-02 2020-11-03 Carterra, Inc. Systems and methods of sensing and analyzing antibody blocking interactions
MX2016009047A (es) 2014-01-10 2017-04-13 Anaptysbio Inc Anticuerpos dirigidos contra interleucina-33 (il-33).
KR20170008202A (ko) 2014-02-21 2017-01-23 애브비 스템센트알엑스 엘엘씨 흑색종에 사용하기 위한 항-ｄｌｌ3 항체 및 약물 접합체
US9817855B2 (en) * 2014-03-17 2017-11-14 SynerScope B.V. Method and system for determining a measure of overlap between data entries
EP3895528A1 (de) 2014-03-21 2021-10-20 Regeneron Pharmaceuticals, Inc. Einzeldomänenbindende proteine produzierende nichtmenschliche tiere
KR20160131118A (ko) 2014-03-21 2016-11-15 리제너론 파마슈티칼스 인코포레이티드 상이한 결합 특징을 전시하는 vl 항원 결합 단백질
KR20160143808A (ko) 2014-04-11 2016-12-14 메디뮨 엘엘씨 이중특이적 her2 항체
EP3711780A3 (de) 2014-04-30 2020-12-09 Pfizer Inc Anti-ptk7-antikörper-arzneimittel-konjugate
CN107257691B (zh) 2014-07-16 2021-09-21 达娜-法勃肿瘤研究所公司 低级别浆液性卵巢癌中的her3抑制
EP4600372A3 (de) 2014-12-19 2025-11-19 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin-antikörper, polypeptide mit abweichenden fc-regionen und verfahren zur verwendung
UY36449A (es) 2014-12-19 2016-07-29 Novartis Ag Composiciones y métodos para anticuerpos dirigidos a bmp6
MA41463A (fr) 2015-02-03 2017-12-12 Anaptysbio Inc Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3)
CN114773469B (zh) 2015-02-05 2025-12-19 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
EP3271403A1 (de) 2015-03-19 2018-01-24 Regeneron Pharmaceuticals, Inc. Nichtmenschliche tiere zur selektion von leichtkettigen variablen regionen zur antigenbindung
SG10201909173PA (en) 2015-04-01 2019-11-28 Anaptysbio Inc Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
CA2979732A1 (en) 2015-04-03 2016-10-06 Eureka Therapeutics, Inc. Constructs targeting afp peptide/mhc complexes and uses thereof
US10526410B2 (en) 2015-04-15 2020-01-07 Anaptysbio, Inc. Antibodies directed against interleukin 36 receptor (IL-36R)
PL3302550T3 (pl) 2015-05-26 2020-02-28 Morphosys Ag Kombinacja przeciwciała anty-cd19 i inhibitora kinazy tyrozynowej brutona i jej zastosowania
JP2018522540A (ja) 2015-06-05 2018-08-16 ノバルティス アーゲー 骨形成タンパク質９（ｂｍｐ９）を標的とする抗体およびそれらのための方法
KR20230074843A (ko) 2015-08-19 2023-05-31 화이자 인코포레이티드 조직 인자 경로 억제제 항체 및 그의 용도
EP3337506B1 (de) 2015-08-21 2021-07-21 MorphoSys AG Kombinationen und verwendungen davon
AU2016320748B2 (en) 2015-09-09 2019-05-02 Novartis Ag Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies
EP3347377B1 (de) 2015-09-09 2021-02-17 Novartis AG Thymus-stroma-lymphopoietin(tslp)-bindende antikörper und verfahren zur verwendung der antikörper
CA2993423C (en) * 2015-09-18 2024-03-12 Chugai Seiyaku Kabushiki Kaisha Il-8-binding antibodies and uses thereof
CN108135913A (zh) 2015-10-05 2018-06-08 莫佛塞斯公司 治疗和/或预防特应性皮炎的il-17c拮抗剂
EP3365364B1 (de) 2015-10-23 2024-04-10 Eureka Therapeutics, Inc. Chimäre antikörper/t-zell-rezeptor-konstrukte und verwendungen davon
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
CA3008102A1 (en) 2015-12-18 2017-06-22 Novartis Ag Antibodies targeting cd32b and methods of use thereof
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
TW201734041A (zh) 2016-02-19 2017-10-01 莫菲西斯公司 抗ｉｌ-１７ｃ抗體
CN109415436A (zh) 2016-04-27 2019-03-01 辉瑞公司 抗il-33抗体及其组合物、方法及用途
MX394513B (es) 2016-04-29 2025-03-24 Pfizer Anticuerpos de interferon beta y usos de los mismos
US11434269B2 (en) 2016-06-15 2022-09-06 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6)
EP3909985A1 (de) 2016-06-27 2021-11-17 MorphoSys AG Anti-cd19-antikörperformulierungen
KR102102734B1 (ko) 2016-08-05 2020-04-22 추가이 세이야쿠 가부시키가이샤 Il-8 관련 질환의 치료용 또는 예방용 조성물
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
KR20190084264A (ko) 2016-10-25 2019-07-16 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) Cd160 막 횡단 동형체에 결합하는 단클론 항체
RS62036B1 (sr) 2016-10-28 2021-07-30 Morphosys Ag Kombinacija anti cd19 antitela sa bcl-2 inhibitorom i njihova upotreba
MA50677A (fr) 2016-11-01 2021-07-14 Anaptysbio Inc Anticorps dirigés contre la protéine d'immunoglobuline de lymphocytes t et mucine 3 (tim-3)
JOP20190155A1 (ar) 2016-12-21 2019-06-23 Novartis Ag مترافقات عقار جسم مضاد لإزالة خلايا جذعية مكونة للدم
TWI793094B (zh) 2017-01-09 2023-02-21 美商提薩羅有限公司 用抗tim-3抗體治療癌症之方法
US11274157B2 (en) 2017-01-12 2022-03-15 Eureka Therapeutics, Inc. Constructs targeting histone H3 peptide/MHC complexes and uses thereof
CA3059820A1 (en) 2017-04-26 2018-11-01 Eureka Therapeutics, Inc. Constructs specifically recognizing glypican 3 and uses thereof
JP2020517287A (ja) 2017-04-26 2020-06-18 ユーリカ セラピューティックス， インコーポレイテッド キメラ抗体／ｔ細胞受容体構築物及びその使用
AR111651A1 (es) 2017-04-28 2019-08-07 Novartis Ag Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
WO2018217630A1 (en) * 2017-05-21 2018-11-29 University Of Tennessee Research Foundation Methods and compositions for targeting tissue lesions
WO2018227063A1 (en) 2017-06-09 2018-12-13 Pfizer Inc. Anti-robo2 antibodies, compositions, methods and uses thereof
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
WO2019018647A1 (en) 2017-07-20 2019-01-24 Pfizer Inc. ANTI-GD3 ANTIBODIES AND CONJUGATES ANTIBODY-MEDICATION
US11541103B2 (en) 2017-08-03 2023-01-03 Amgen Inc. Interleukin-21 mutein/ anti-PD-1 antibody conjugates
CN111511762B (zh) 2017-08-21 2025-05-06 天演药业公司 抗cd137分子及其用途
US20210332141A1 (en) 2017-08-30 2021-10-28 Amgen Inc. Insulin-like growth factor-1 receptor (igf-1r) binding proteins and methods of use
UY37870A (es) 2017-09-08 2019-03-29 Amgen Inc Inhibidores de kras g12c y métodos para utilizarlos campo de la invención
HUE067603T2 (hu) 2017-09-18 2024-10-28 Univ California Klaudin-6 antitestek és rákkezelési eljárások
EP3470426A1 (de) 2017-10-10 2019-04-17 Numab Therapeutics AG Multispezifischer antikörper
EP3470429A1 (de) 2017-10-10 2019-04-17 Numab Innovation AG Auf pdl1 gerichtete antikörper und verfahren zur verwendung davon
US12202911B2 (en) 2017-10-10 2025-01-21 Numab Therapeutics AG Multispecific antibody comprising CD137 binding domain and PDL1 binding domain
EP3470428A1 (de) 2017-10-10 2019-04-17 Numab Innovation AG Anti cd137 antikörper und deren verwendung
EP3700933A1 (de) 2017-10-25 2020-09-02 Novartis AG Gegen cd32b gerichtete antikörper und verfahren zur verwendung davon
BR112020010753A2 (pt) 2017-12-01 2020-11-24 The Regents Of The University Of California anticorpos anti-cxcr5 e composições e usos dos mesmos
MX2020007291A (es) 2018-01-12 2020-09-10 Amgen Inc Anticuerpos anti-pd-1 y metodos de tratamiento.
WO2019148445A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Precision/context-dependent activatable antibodies, and methods of making and using the same
WO2019148444A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Anti-ctla4 antibodies and methods of making and using the same
US11891432B2 (en) 2018-03-15 2024-02-06 Chugai Seiyaku Kabushiki Kaisha Anti-dengue virus antibodies having cross-reactivity to Zika virus and methods of use
EP3767629A4 (de) * 2018-03-16 2022-01-19 KOTAI Biotechnologies, Inc. Effektive gruppierung von immunologischen einheiten
JP6500144B1 (ja) * 2018-03-28 2019-04-10 Ｋｏｔａｉバイオテクノロジーズ株式会社 免疫実体の効率的クラスタリング
WO2019217913A1 (en) 2018-05-10 2019-11-14 Sensei Biotherapeutics, Inc. Aspartate beta-hydroxylase chimeric antigen receptors and uses thereof
AU2019264712A1 (en) 2018-05-11 2021-01-07 Wuxi Biologics (Shanghai) Co., Ltd. Fully human antibodies against OX40, method for preparing same, and use thereof
AU2019270342A1 (en) 2018-05-16 2020-10-29 Morphosys Ag Antibodies targeting glycoprotein VI
WO2019227490A1 (en) 2018-06-01 2019-12-05 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and methods for imaging
US11987629B2 (en) 2018-06-01 2024-05-21 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and uses thereof for treating disease or condition
CA3103936A1 (en) 2018-06-18 2019-12-26 Eureka Therapeutics, Inc. Constructs targeting prostate-specific membrane antigen (psma) and uses thereof
JP2021527706A (ja) 2018-06-18 2021-10-14 アンウィタ バイオサイエンシス， インク． 抗メソテリンコンストラクト及びその使用
UY38265A (es) 2018-06-20 2020-01-31 Novartis Ag Conjugados anticuerpo droga para ablación de células madre hematopoyéticas
EP3816186A4 (de) 2018-06-29 2022-04-06 Suzhou Smartnuclide Biopharmaceutical Co., Ltd. Pd-l1-bindende polypeptide und verwendung davon
PE20211091A1 (es) 2018-07-02 2021-06-14 Amgen Inc Proteina de union al antigeno anti-steap1
MA53381A (fr) 2018-07-24 2021-06-02 Amgen Inc Association d'inhibiteurs de la voie lilrb1/2 et d'inhibiteurs de la voie pd-1
JP7155403B2 (ja) 2018-08-20 2022-10-18 ファイザー・インク 抗ｇｄｆ１５抗体、組成物および使用の方法
PE20211605A1 (es) 2018-09-07 2021-08-23 Pfizer ANTICUERPOS ANTI-avß8 Y COMPOSICIONES Y USOS DE LOS MISMOS
EP3850008A1 (de) 2018-09-10 2021-07-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung eines inhibitors der ntsr1-aktivierung oder expression zur verhinderung von gewichtsverlust, muskelschwund und verringertem proteinblutspiegel bei probanden, die diese benötigen
JP7592585B2 (ja) 2018-10-04 2024-12-02 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 粘膜炎症性疾患の処置のための方法及び医薬組成物
KR20240135884A (ko) 2018-10-11 2024-09-12 화이자 인코포레이티드 Tfpi 길항제의 투여량 섭생법
BR112021006783A2 (pt) 2018-10-12 2021-07-13 Xencor, Inc. proteína de fusão fc heterodimérica de il-15/r¿ direcionada, composição de ácido nucleico, composição de vetor de expressão, célula hospedeira, e, métodos de produção da proteína de fusão fc heterodimérica de il-15/r¿ direcionada e de tratamento de um câncer.
UY38407A (es) 2018-10-15 2020-05-29 Novartis Ag Anticuerpos estabilizadores de trem2
EP3873532A1 (de) 2018-10-31 2021-09-08 Novartis AG Dc-sign-antikörper-arzneimittelkonjugate
CA3120729A1 (en) 2018-11-27 2020-06-04 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Antibodies specifically recognizing granulocyte-macrophage colony stimulating factor receptor alpha and uses thereof
JP2022513708A (ja) 2018-12-05 2022-02-09 モルフォシス・アーゲー 多重特異性抗原結合分子
SG11202107257UA (en) 2019-01-03 2021-07-29 Inst Nat Sante Rech Med Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer
US12263234B2 (en) 2019-01-23 2025-04-01 Tayu Huaxia Biotech Medical Group Co., Ltd. Anti-PD-L1 diabodies and the use thereof
KR20210121102A (ko) 2019-01-28 2021-10-07 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 항-cd79b 항체, 이의 항원-결합 단편, 및 이의 약학적 용도
US11541086B2 (en) 2019-03-14 2023-01-03 Northwestern Univeristy Compositions and methods for treating Alzheimer's disease
CA3134055A1 (en) 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 antibodies and drug conjugates
CA3134056A1 (en) 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 bispecific antibodies
KR20220002316A (ko) 2019-04-30 2022-01-06 인스티튜토 데 메디시나 몰레큘라 조앙 로보 안투네스 Cdk 억제제와 조합된 rank 경로 억제제
JP7600218B2 (ja) 2019-05-24 2024-12-16 サンヨウ バイオファーマシューティカルズ カンパニー リミテッド 新規なｃｌｄｎ１８．２結合分子
US20220259295A1 (en) 2019-06-20 2022-08-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Method useful in tolerance induction therapy and kits therefore
WO2020263793A1 (en) 2019-06-24 2020-12-30 Amgen Inc. Inhibition of sirp-gamma for cancer treatment
JP7315259B2 (ja) 2019-07-01 2023-07-26 スジョウ・アルファマブ・カンパニー・リミテッド 百日咳毒素結合タンパク質
CA3145139A1 (en) 2019-07-09 2021-01-14 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Antibodies specifically recognizing pseudomonas pcrv and uses thereof
EP4025604A1 (de) 2019-09-04 2022-07-13 Institut National de la Santé et de la Recherche Médicale (INSERM) Für il20-rb spezifische antikörper und verwendungen davon zur behandlung akuter exazerbation von chronisch obstruktiver lungenerkrankung
EP4028053A1 (de) 2019-09-11 2022-07-20 Bausch Health Ireland Limited Verfahren zur behandlung von nicht-alkoholischer fettleberkrankheit (nafld) mit il-17ra-antikörper
TW202124446A (zh) 2019-09-18 2021-07-01 瑞士商諾華公司 與ｅｎｔｐｄ２抗體之組合療法
CN114502590A (zh) 2019-09-18 2022-05-13 诺华股份有限公司 Entpd2抗体、组合疗法、以及使用这些抗体和组合疗法的方法
WO2021058729A1 (en) 2019-09-27 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance type i receptor antibodies and uses thereof
EP3800201A1 (de) 2019-10-01 2021-04-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd28h-stimulierung verbessert nk-zellen-abtötungsaktivitäten
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
CN113045655A (zh) 2019-12-27 2021-06-29 高诚生物医药(香港)有限公司 抗ox40抗体及其用途
WO2021148983A1 (en) 2020-01-24 2021-07-29 Pfizer Inc. Anti-e-selectin antibodies, compositions and methods of use
JP2023515480A (ja) 2020-02-21 2023-04-13 江蘇恒瑞医薬股▲ふん▼有限公司 抗ｉｌ－２抗体、その抗原結合断片及びその医薬用途
BR112022016491A2 (pt) 2020-02-28 2022-10-11 Shanghai Henlius Biotech Inc Construto anti-cd137 e usos do mesmo
WO2021170071A1 (en) 2020-02-28 2021-09-02 Shanghai Henlius Biotech, Inc. Anti-cd137 constructs, multispecific antibody and uses thereof
JP7705873B2 (ja) 2020-03-13 2025-07-10 江蘇恒瑞医薬股▲ふん▼有限公司 Ｐｖｒｉｇ結合タンパク質及びその医薬用途
JP2023525085A (ja) 2020-05-13 2023-06-14 アダジーン アーゲー がんを治療するための組成物および方法
US20230174670A1 (en) 2020-05-14 2023-06-08 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Anti-cd25 antibodies, antigen-binding fragments thereof, and medical uses thereof
US20230220057A1 (en) 2020-05-27 2023-07-13 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Antibodies specifically recognizing nerve growth factor and uses thereof
US20230235075A1 (en) 2020-06-02 2023-07-27 Dynamicure Biotechnology Llc Anti-cd93 constructs and uses thereof
CN116529260A (zh) 2020-06-02 2023-08-01 当康生物技术有限责任公司 抗cd93构建体及其用途
US20230265211A1 (en) 2020-06-29 2023-08-24 Inserm (Institut National De La Santé Et De Ls Recherche Médicale) Anti-protein s single-domain antibodies and polypeptides comprising thereof
JP7807081B2 (ja) 2020-07-02 2026-01-27 北京拓界生物医薬科技有限公司 抗ＦＸＩ／ＦＸＩａ抗体、その抗原結合断片と医薬用途
WO2022002233A1 (zh) 2020-07-03 2022-01-06 苏州康宁杰瑞生物科技有限公司 凝血因子xi(fxi)结合蛋白
TW202216778A (zh) 2020-07-15 2022-05-01 美商安進公司 Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷
US20240209089A1 (en) 2020-07-21 2024-06-27 Suzhou Smartnuclide Biopharmaceutical Co., Ltd. Cd8 binding polypeptide and use thereof
EP4188550A1 (de) 2020-07-29 2023-06-07 Dynamicure Biotechnology LLC Anti-cd93 konstrukte und deren verwendungen
WO2022026829A1 (en) 2020-07-30 2022-02-03 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for skin toxicity
EP4188441A1 (de) 2020-07-30 2023-06-07 AnaptysBio, Inc. Anti-interleukin-36-rezeptor (il-36r)-therapie für ichthyose
EP4193151A1 (de) 2020-08-04 2023-06-14 Abbott Rapid Diagnostics International Unlimited Company Assays zum nachweis von sars-cov-2
CN116348593A (zh) 2020-08-21 2023-06-27 上海吉倍生物技术有限公司 特异性结合糖基化ceacam5的抗体
EP4217389A4 (de) 2020-09-28 2025-03-19 Angitia Incorporated Limited Anti-sclerostin-konstrukte und verwendungen davon
WO2022077021A1 (en) 2020-10-09 2022-04-14 Pfizer Inc. CD1a ANTIBODIES AND USES THEREOF
KR20230096024A (ko) 2020-10-23 2023-06-29 아납티스바이오, 아이엔씨. B 및 t 림프구 약화인자 (btla) 조절제 및 이의 사용 방법
AU2021371709A1 (en) 2020-10-30 2023-06-22 Biotroy Therapeutics Use of regulator of itpripl1 in preparation of drug that regulates immune responses or fights tumors
EP4251648A2 (de) 2020-11-24 2023-10-04 Novartis AG Anti-cd48-antikörper, antikörper-wirkstoff-konjugate und verwendungen davon
CN112480248B (zh) 2020-11-24 2023-05-05 三优生物医药(上海)有限公司 与cld18a2特异性结合的分子
WO2022150644A1 (en) 2021-01-08 2022-07-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for acne
US20240084021A1 (en) 2021-01-08 2024-03-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for hidradenitis suppurativa
WO2022162569A1 (en) 2021-01-29 2022-08-04 Novartis Ag Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof
KR20230142768A (ko) 2021-02-08 2023-10-11 바이오트로이 테라퓨틱스 Ccdc112를 기반으로 하는 종양세포 성장을 억제하는 방법 및 적용
WO2022187863A1 (en) 2021-03-05 2022-09-09 Dynamicure Biotechnology Llc Anti-vista constructs and uses thereof
US20250136711A1 (en) 2021-03-16 2025-05-01 Shanghai Biotroy Biotechnique Co., Ltd Semenogelin neutralizing antibody and epitope and application thereof
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
CN117616041A (zh) 2021-03-25 2024-02-27 当康生物技术有限责任公司 抗-igfbp7构建体及其用途
CA3216079A1 (en) 2021-04-05 2022-10-13 Bionoxx Inc. Chimeric antigen receptor targeting oncolytic virus-derived protein, immunocyte expressing same, and uses of both
US20240156865A1 (en) 2021-04-05 2024-05-16 Bionoxx Inc. Viral vector-derived target protein for anticancer therapy and binding molecule or fragment thereof specifically binding thereto
TW202305010A (zh) 2021-04-25 2023-02-01 大陸商江蘇恆瑞醫藥股份有限公司 抗ｍａｓｐ２抗體、其抗原結合片段及醫藥用途
CN117615788A (zh) 2021-05-12 2024-02-27 安奈普泰斯生物有限公司 抗体组合物
US20230115257A1 (en) 2021-05-17 2023-04-13 Curia Ip Holdings, Llc Sars-cov-2 spike protein antibodies
US20240239875A1 (en) 2021-05-17 2024-07-18 Curia Ip Holdings, Llc Sars-cov-2 spike protein antibodies
MX2023013714A (es) 2021-05-21 2024-01-16 Leo Pharma As Anticuerpos anti-proteina accesoria del receptor de interleucina 1 (il-1).
EP4347647A1 (de) 2021-06-01 2024-04-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Verwendung von b-zell-depletionsmitteln zur behandlung von rheumatischen herzerkrankungen
WO2022256740A1 (en) 2021-06-04 2022-12-08 Curia Ip Holdings, Llc Polymeric fusion proteins and compositions for inducing an immune response against infection
WO2022266660A1 (en) 2021-06-17 2022-12-22 Amberstone Biosciences, Inc. Anti-cd3 constructs and uses thereof
MX2023015070A (es) 2021-06-28 2024-01-17 Jiangsu Hengrui Pharmaceuticals Co Ltd Anticuerpo anti-cd40, fragmento de union a antigeno y uso medico del mismo.
US20250011448A1 (en) 2021-07-08 2025-01-09 Staidson Biopharma Inc. Antibodies specifically recognizing tnfr2 and uses thereof
KR20240058075A (ko) 2021-07-14 2024-05-03 스테이드슨 (베이징) 바이오팔마슈티칼스 캄퍼니 리미티드 Cd40을 특이적으로 식별하는 항체 및 이의 응용
MX2024002261A (es) 2021-08-24 2024-03-06 Jiangsu Hengrui Pharmaceuticals Co Ltd Molecula de union de fap/cd40 y uso medicinal de la misma.
WO2023040935A1 (zh) 2021-09-15 2023-03-23 江苏恒瑞医药股份有限公司 一种含抗pvrig/tigit双特异性抗体的药物组合物
JP2024541933A (ja) 2021-11-02 2024-11-13 ファイザー・インク 抗ｇｄｆ１５抗体を使用してミトコンドリア筋症を処置する方法
WO2023098637A1 (zh) 2021-11-30 2023-06-08 苏州康宁杰瑞生物科技有限公司 预防和/或治疗血栓栓塞性疾病的方法
EP4445911A4 (de) 2021-12-06 2025-10-22 Beijing Solobio Genetechnology Co Ltd Bispezifischer antikörper mit spezifischer bindung an klebsiella pneumoniae-o2- und o1-antigene sowie zusammensetzung
WO2023137161A1 (en) 2022-01-14 2023-07-20 Amgen Inc. Triple blockade of tigit, cd112r, and pd-l1
JP2025508472A (ja) 2022-02-25 2025-03-26 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） メタロプロテアーゼによるｃｄ９５ｌの切断を阻止するための抗体
WO2023193239A1 (en) 2022-04-08 2023-10-12 Peter Peizhi Luo Anti-cd28 antibodies and methods of use thereof
EP4508077A1 (de) 2022-04-14 2025-02-19 Invisishield Technologies Ltd. Zusammensetzungen zur prävention oder behandlung von influenza-infektionen
EP4514850A1 (de) 2022-04-27 2025-03-05 AnaptysBio, Inc. B- und t-lymphozyten-dämpfungsmodulatoren und verfahren zur verwendung davon
WO2023212294A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Angiopoietin-related protein 7-specific antibodies and uses thereof
IL316610A (en) 2022-04-29 2024-12-01 Broadwing Bio Llc 4-specific antibodies related to complement factor H and uses thereof
EP4514845A1 (de) 2022-04-29 2025-03-05 Broadwing Bio LLC Bispezifische antikörper und verfahren zur behandlung von augenerkrankungen
KR20250009454A (ko) 2022-05-07 2025-01-17 베이징 투오 지에 바이오파마수티컬 컴퍼니 리미티드 릴랙신 또는 유사체의 융합 단백질 및 이의 의약적 용도
EP4524158A4 (de) 2022-05-09 2025-12-17 Staidson Beijing Biopharmaceuticals Co Ltd Antikörper mit spezifischer gdf15-erkennung und verwendung davon
JP2025524727A (ja) 2022-07-15 2025-07-30 フィアン セラピューティクス エルティーディー Ｃｄｃｐ１と結合する抗体薬物複合体及びその使用
AU2023326586A1 (en) 2022-08-17 2025-02-13 Institut National de la Santé et de la Recherche Médicale Improved anti-albumin nanobodies and their uses
CN119790065A (zh) 2022-08-24 2025-04-08 美国安进公司 抗药物抗体测定
EP4581051A1 (de) 2022-08-31 2025-07-09 Boost Biopharma, Inc. Sars-cov-2-bindende wirkstoffe und verwendungen davon
CN120077071A (zh) 2022-09-07 2025-05-30 当康生物技术有限责任公司 抗vista构建体及其用途
WO2024067344A1 (zh) 2022-09-27 2024-04-04 舒泰神（北京）生物制药股份有限公司 特异性识别light的抗体及其应用
EP4606886A1 (de) 2022-10-20 2025-08-27 Beijing SoloBio Genetechnology Company Ltd. Antikörperkombination mit spezifischer bindung an trail oder fasl und bispezifischer antikörper
KR20250106304A (ko) 2022-11-17 2025-07-09 사노피 Ceacam5 항체-약물 접합체 및 이의 사용 방법
CN120282801A (zh) 2022-12-28 2025-07-08 苏州盛迪亚生物医药有限公司 一种cd40结合分子的组合物及医药用途
WO2024149237A1 (zh) 2023-01-09 2024-07-18 北京拓界生物医药科技有限公司 TGFβ1结合分子、GARP-TGFβ1结合分子及其医药用途
CN120603852A (zh) 2023-02-24 2025-09-05 上海迈晋生物医药科技有限公司 一种fap/cd40结合分子的药物组合物及其医药用途
WO2024227154A1 (en) 2023-04-28 2024-10-31 Broadwing Bio Llc Complement component 3 (c3)-specific antibodies and uses thereof
WO2024243561A1 (en) 2023-05-25 2024-11-28 The Regents Of The University Of California Methods of treating cancer
WO2024243594A1 (en) 2023-05-25 2024-11-28 Anaptysbio, Inc. Btla agonist for mudulation of dendritic cells
WO2024251199A1 (zh) 2023-06-09 2024-12-12 舒泰神（北京）生物制药股份有限公司 特异性结合masp3的抗体以及特异性结合masp3和masp2的多特异性抗体
WO2024256527A1 (en) 2023-06-13 2024-12-19 Institut National de la Santé et de la Recherche Médicale Use of a cxcl 10 inhibitor for the treatment of transplant vasculopathy
WO2024255794A1 (zh) 2023-06-16 2024-12-19 舒泰神（北京）生物制药股份有限公司 特异性识别因子XIIa的抗体及其应用
WO2025036848A1 (en) 2023-08-11 2025-02-20 Wuxi Biologics (Shanghai) Co., Ltd. Anti-muc16 antibodies and uses thereof
WO2025049858A1 (en) 2023-09-01 2025-03-06 Amgen Inc. Molecules for treatment of cancer
WO2025045250A1 (en) 2023-09-03 2025-03-06 Kira Pharmaceuticals (Us) Llc Anti-human factor d antibody constructs and uses thereof
US12122842B1 (en) 2023-09-27 2024-10-22 R&D Systems, Inc. Human CD30-specific binding proteins and uses thereof
WO2025096842A2 (en) 2023-11-03 2025-05-08 Amgen Inc. Fibroblast targeting molecules
WO2025104253A1 (en) 2023-11-17 2025-05-22 Wuxi Biologics (Shanghai) Co., Ltd. Anti-muc16 antibodies and uses thereof
US20250163168A1 (en) 2023-11-17 2025-05-22 Pfizer Inc. Novel antibodies and antibody conjugates for the treatment of metabolic disorders
WO2025120015A1 (en) 2023-12-06 2025-06-12 Institut National de la Santé et de la Recherche Médicale Cd5 targeting antibodies with depleting and t or b-cell activation effects
WO2025132833A1 (en) 2023-12-20 2025-06-26 Institut National de la Santé et de la Recherche Médicale Anti trypsin-3 single domain antibody
US20250295801A1 (en) 2024-03-21 2025-09-25 Seagen Inc. Cd25 antibodies, antibody drug conjugates, and uses thereof
WO2025238052A1 (en) 2024-05-15 2025-11-20 Institut National de la Santé et de la Recherche Médicale Depletion of plasmacytoid dendritic cells for the treatment of respiratory viral infections
WO2025247913A1 (en) 2024-05-28 2025-12-04 Institut National de la Santé et de la Recherche Médicale Anti-ifn-omega1 monoclonal antibodies
WO2025247917A1 (en) 2024-05-28 2025-12-04 Institut National de la Santé et de la Recherche Médicale ANTI-IFN-α2 AND ANTI-IFN-ω1 MONOCLONAL ANTIBODIES
WO2025247918A1 (en) 2024-05-28 2025-12-04 Institut National de la Santé et de la Recherche Médicale ANTI-IFN-α2 MONOCLONAL ANTIBODIES
WO2025247924A1 (en) 2024-05-28 2025-12-04 Institut National de la Santé et de la Recherche Médicale ANTI-IFN-α2 MONOCLONAL ANTIBODIES
WO2025248500A1 (en) 2024-05-31 2025-12-04 Janssen Biotech, Inc. Antibody drug conjugates that target enpp3
WO2025257715A1 (en) 2024-06-12 2025-12-18 Seagen Inc. Anti-ceacam5 antibodies, antibody-drug conjugates and methods of uses thereof
WO2025262564A1 (en) 2024-06-17 2025-12-26 Pfizer Inc. Use of anti-cxcr5 antibodies

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800815A (en) 1903-05-05 1998-09-01 Cytel Corporation Antibodies to P-selectin and their uses
US5426029A (en) 1986-03-31 1995-06-20 T Cell Diagnostics, Inc. Therapeutic and diagnostic methods using leukocyte surface antigens
US5300425A (en) * 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US6165469A (en) * 1988-01-13 2000-12-26 University Of Virginia Recombinant Entamoeba histolytica lectin subunit peptides and reagents specific for members of the 170 kD subunit multigene family
NO164622C (no) 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US5434076A (en) * 1989-12-18 1995-07-18 Board Of Regents, The University Of Texas System Tumor-specific, cell surface-binding monoclonal antibodies
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
EP0656367A1 (de) 1991-08-22 1995-06-07 Becton, Dickinson and Company Methoden und Zusammensetzungen zur Krebstherapie und zur Vorhersagbarkeit der Reaktionen auf diese Behandlung
AU2499892A (en) 1991-08-23 1993-03-16 Board Of Regents Of The University Of Nebraska, The Method and compositions for cellular reprogramming
US5402285A (en) 1991-09-30 1995-03-28 Conner Peripherals, Inc. Five and one-quarter inch form factor combination DAT tape drive and cassette magazine loader
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5958708A (en) 1992-09-25 1999-09-28 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US5501917A (en) * 1994-01-28 1996-03-26 Hong; Kuochih Hydrogen storage material and nickel hydride batteries using same
FR2717081B1 (fr) 1994-03-14 1996-06-21 Centre Nat Rech Scient Rétropeptides, anticorps dirigés contre ces derniers, et leurs utilisations pour la vaccination et le diagnostic in vitro.
US5656499A (en) * 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
US5874409A (en) 1995-06-07 1999-02-23 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
US5834597A (en) * 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US6449562B1 (en) * 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US20030118985A1 (en) * 1997-05-14 2003-06-26 Hunt Jeffrey C. Mouse monoclonal antibody (5-21-3) to human immunodeficiency virus gp41 protein
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
EP1328808A2 (de) * 2000-10-20 2003-07-23 Children's Medical Center Corporation Verfahren zur analyse von dynamischen veränderungen in zelleinformatika
US7135296B2 (en) * 2000-12-28 2006-11-14 Mds Inc. Elemental analysis of tagged biologically active materials
JP4864240B2 (ja) * 2001-07-12 2012-02-01 富士フイルム株式会社 レトロフォーカス型撮影レンズ
AU2002353017A1 (en) 2001-12-03 2003-06-17 Abgenix, Inc. Discovery of therapeutic products
ES2307832T3 (es) * 2001-12-03 2008-12-01 Amgen Fremont Inc. Clasificacion de anticuerpos basada en las caracteristicas de union.

Also Published As

Publication number Publication date
US20030157730A1 (en) 2003-08-21
EP1461423A2 (de) 2004-09-29
EP1461423B1 (de) 2008-05-14
US20140178905A1 (en) 2014-06-26
US7771951B2 (en) 2010-08-10
ES2307832T3 (es) 2008-12-01
US8206936B2 (en) 2012-06-26
JP2005512044A (ja) 2005-04-28
WO2003048731A3 (en) 2004-01-15
AU2002357060A1 (en) 2003-06-17
US20130085074A1 (en) 2013-04-04
DE60226641D1 (de) 2008-06-26
US8568992B2 (en) 2013-10-29
WO2003048731A2 (en) 2003-06-12
EP1461423A4 (de) 2006-03-22
CA2467633C (en) 2012-03-27
US20110021373A1 (en) 2011-01-27
CA2467633A1 (en) 2003-06-12

Similar Documents

Publication Publication Date Title
ATE395413T1 (de) Antikörperkategorisierung auf der grundlage von bindungseigenschaften
DE69839492D1 (de) Monoklonale antikörper zur apoptosis-induzierung
DE69735445D1 (de) Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
DE69942314D1 (de) Versuchsanordnung zum nachweis von bindungspartnern
ATE500523T1 (de) Signalsuchverfahren für ein positionierungssystem
DE69813158D1 (de) Assays zur Bestimmung von Proteinfragmenten in biologischen Medien
DE60215495D1 (de) Verfahren und system zur automatischen erkennung ähnlicher oder identischer segmente in audioaufzeichnungen
EP1168199A3 (de) Verfahren und Gerät zum Indizieren
TR200001765T2 (tr) Duyguları ayırt etmek için aletler ve yöntemler.
TR200001313T2 (tr) Protein etkileşimlerini ve fonksiyonel ilişkileri kaydeden tarama sistemleri
PT1307833E (pt) Metodo para pesquisar numa base de dados audio
WO2005102012A3 (en) System and method for mapping relationship management intelligence
EP1387593A3 (de) Informationsverarbeitungsterminal und Methode zur Informationsverarbeitung
WO2006078265A3 (en) Efficient classification of three dimensional face models for human identification and other applications
WO2007001896A3 (en) Identification and risk evaluation
DK0741870T3 (da) Fremgangsmåde til kvantificering af LBP i kropsvæsker
WO2002037102A3 (en) Methods for analyzing dynamic changes in cellular informatics
TW200606816A (en) Method of and system for classification of an audio signal
ATE523773T1 (de) Verfahren und installation zur bestimmung der rheologischen eigenschaften eines fluids sowie entsprechendes identifizierungsverfahren
GB2447574A (en) Systems and methods of conducting clinical research
FR2843212B1 (fr) Detection d'une image de reference robuste a de grandes transformations photometriques
ATE529961T1 (de) Verfahren und system fur die übertragung von identifikationssignalen
BR0209929A (pt) Biomarcador, métodos para identificar microorganismos, e toxinas maromoleculares, e, aparelho para a realização automática do método
ATE305825T1 (de) Verfahren und vorrichtung zur bearbeitung von postsendungen
WO2002034876A3 (en) Protein data analysis

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties