[go: up one dir, main page]

ATE346645T1 - Mikrovorrichtung und verfahren zur herstellung - Google Patents

Mikrovorrichtung und verfahren zur herstellung

Info

Publication number
ATE346645T1
ATE346645T1 AT01952607T AT01952607T ATE346645T1 AT E346645 T1 ATE346645 T1 AT E346645T1 AT 01952607 T AT01952607 T AT 01952607T AT 01952607 T AT01952607 T AT 01952607T AT E346645 T1 ATE346645 T1 AT E346645T1
Authority
AT
Austria
Prior art keywords
support
skin
microdevice
penetrating member
skin penetrating
Prior art date
Application number
AT01952607T
Other languages
English (en)
Inventor
Alexander G Lastovich
John D Evans
Ronald J Pettis
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Application granted granted Critical
Publication of ATE346645T1 publication Critical patent/ATE346645T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/150022Source of blood for capillary blood or interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150053Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061Means for enhancing collection
    • A61B5/150099Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150977Arrays of piercing elements for simultaneous piercing
    • A61B5/150984Microneedles or microblades
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142Devices intended for single use, i.e. disposable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Micromachines (AREA)
AT01952607T 2000-07-14 2001-07-11 Mikrovorrichtung und verfahren zur herstellung ATE346645T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/616,771 US6440096B1 (en) 2000-07-14 2000-07-14 Microdevice and method of manufacturing a microdevice

Publications (1)

Publication Number Publication Date
ATE346645T1 true ATE346645T1 (de) 2006-12-15

Family

ID=24470876

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01952607T ATE346645T1 (de) 2000-07-14 2001-07-11 Mikrovorrichtung und verfahren zur herstellung

Country Status (8)

Country Link
US (2) US6440096B1 (de)
EP (1) EP1301237B1 (de)
JP (1) JP4892166B2 (de)
AT (1) ATE346645T1 (de)
AU (1) AU2001273340A1 (de)
DE (1) DE60124917T2 (de)
ES (1) ES2276805T3 (de)
WO (1) WO2002005890A2 (de)

Families Citing this family (281)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
USD526409S1 (en) 1998-07-14 2006-08-08 Unomedical A/S Medical puncturing device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US9717451B2 (en) * 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
WO2002045771A2 (en) * 2000-11-09 2002-06-13 Biovalve Technologies, Inc. Microneedle adapter
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
DK1372708T3 (da) 2001-02-13 2008-10-20 Us Gov Sec Army Vaccine til transkutan immunisering mod rejsediarre
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
CA2444883A1 (en) * 2001-04-20 2002-10-31 Alza Corporation Microprojection array having a beneficial agent containing coating
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
ES2268050T3 (es) * 2001-06-08 2007-03-16 Becton, Dickinson And Company Dispositivo para manipular un conjunto de agujas o abrasion.
JP4383168B2 (ja) * 2001-09-12 2009-12-16 ベクトン・ディキンソン・アンド・カンパニー マイクロ針投与デバイスおよび薬物投与デバイス
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
AU2002360522A1 (en) * 2001-12-06 2003-06-23 University Of Virginia Patent Foundation An apparatus for fluid transport and related method thereof
ITTO20011228A1 (it) 2001-12-28 2003-06-28 Cane Srl Contenitore per ago monouso.
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
DE60304681T2 (de) 2002-02-12 2007-01-25 Unomedical A/S Infusionsvorrichtung mit nadelschutzhülse
AU2003209645A1 (en) * 2002-03-04 2003-09-16 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US7387742B2 (en) * 2002-03-11 2008-06-17 Becton, Dickinson And Company Silicon blades for surgical and non-surgical use
EP1490191B1 (de) 2002-03-11 2012-07-04 Beaver-Visitec International (US), Inc. Verfahren zur herstellung von chirurgischen messern
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
EP1534376B1 (de) * 2002-06-25 2016-08-31 Theraject, Inc. Sich schnell auflösender mikroperforator für die medikamentenabgabe und andere anwendungen
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
CA2497128C (en) * 2002-08-29 2011-10-18 Becton, Dickinson And Company Microprotrusion arrays and methods for using same to deliver substances into tissue
US7594909B2 (en) 2002-09-02 2009-09-29 Unomedical, A/S Apparatus and method for adjustment of the length of an infusion tubing
DK1534378T3 (da) 2002-09-02 2009-05-04 Unomedical As Indretning til subkutan tilförsel af et medikament til en patient, og slange til samme
US20040051019A1 (en) 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
AU2003258487A1 (en) 2002-09-02 2004-03-19 Unomedical A/S A device for subcutaneous administration of a medicament to a patient
AU2003275311A1 (en) * 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
EP1590034B1 (de) * 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Pflaster mit mikronadelanordnung
DK200201823A (da) 2002-11-26 2004-05-27 Maersk Medical As Forbindelsesstykke for en slangeforbindelse
US20040158202A1 (en) 2003-02-12 2004-08-12 Soren Jensen Cover
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20050155955A1 (en) * 2003-03-10 2005-07-21 Daskal Vadim M. Method for reducing glare and creating matte finish of controlled density on a silicon surface
US20090007436A1 (en) * 2003-03-10 2009-01-08 Daskal Vadim M Silicon blades for surgical and non-surgical use
US7070580B2 (en) 2003-04-01 2006-07-04 Unomedical A/S Infusion device and an adhesive sheet material and a release liner
TW566423U (en) * 2003-04-23 2003-12-11 Ind Tech Res Inst Structure for miniature gripping clip
US20050137525A1 (en) * 2003-06-04 2005-06-23 Georgia Tech Research Corporation Drilling microneedle device
IL156374A0 (en) * 2003-06-10 2004-01-04 Danenberg Holdings 2000 Ltd N Method for removing a pigmented section of skin
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
KR20060038407A (ko) * 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
IL157696A0 (en) * 2003-09-01 2004-03-28 Hawk Medical Technologies Ltd Apparatus and method for removing a pigmented section of skin
JP2007514457A (ja) * 2003-09-17 2007-06-07 ベクトン・ディキンソン・アンド・カンパニー シリコンおよびその他の結晶質材料にルータを用いて直線状および非直線状の溝を作成するシステムおよび方法
USD576267S1 (en) 2003-10-15 2008-09-02 Unomedical A/S Medical infusion device
USD554253S1 (en) 2003-10-15 2007-10-30 Unomedical A/S Medical infusion device
USD579541S1 (en) 2003-10-15 2008-10-28 Unomedical A/S Medical insertion device
US7956742B2 (en) 2003-10-30 2011-06-07 Motedata Inc. Method and system for storing, retrieving, and managing data for tags
US7388488B2 (en) * 2003-10-30 2008-06-17 Peter Lupoli Method and system for storing, retrieving, and managing data for tags
CA2546443A1 (en) * 2003-11-18 2005-06-02 Nanopass Technologies Ltd. Enhanced penetration system and method for sliding microneedles
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
WO2005065765A1 (en) * 2003-12-29 2005-07-21 3M Innovative Properties Company Medical devices and kits including same
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US8671544B2 (en) * 2004-03-12 2014-03-18 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
CA2560840C (en) 2004-03-24 2014-05-06 Corium International, Inc. Transdermal delivery device
CA2560784A1 (en) 2004-03-26 2005-10-06 Unomedical A/S Infusion set
JP4971133B2 (ja) * 2004-04-01 2012-07-11 ザ ジェネラル ホスピタル コーポレイション 皮膚科治療のための装置
EP1735044B1 (de) * 2004-04-12 2016-03-23 Allergan, Inc. Multisitus-injektionssystem
US7396484B2 (en) * 2004-04-30 2008-07-08 Becton, Dickinson And Company Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries
CA2566032A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
EP3329960A1 (de) * 2004-06-10 2018-06-06 3M Innovative Properties Company Vorrichtung und kit zur pflasterapplikation
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
EP1786580B1 (de) * 2004-08-16 2010-12-01 Functional Microstructures Limited Verfahren zur herstellung einer mikronadel oder eines mikroimplantats
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
EP1833547A1 (de) 2004-11-18 2007-09-19 3M Innovative Properties Company Niederprofil-mikronadel-applikator
AU2005306429B2 (en) 2004-11-18 2011-04-14 3M Innovative Properties Company Microneedle array applicator and retainer
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
US7846488B2 (en) * 2004-11-18 2010-12-07 3M Innovative Properties Company Masking method for coating a microneedle array
CA2587216C (en) * 2004-11-18 2014-11-18 Nanopass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
AU2005306372B2 (en) 2004-11-18 2011-01-06 Kindeva Drug Delivery L.P. Method of contact coating a microneedle array
AU2005313662B2 (en) 2004-12-10 2011-07-14 Unomedical A/S Cannula inserter
WO2006064270A1 (en) * 2004-12-17 2006-06-22 Functional Microstructures Limited Microneedle device for transdermal transport of fluid
US7985199B2 (en) * 2005-03-17 2011-07-26 Unomedical A/S Gateway system
US10035008B2 (en) 2005-04-07 2018-07-31 3M Innovative Properties Company System and method for tool feedback sensing
US20060253079A1 (en) * 2005-04-25 2006-11-09 Mcdonough Justin Stratum corneum piercing device
US7569050B2 (en) 2005-05-06 2009-08-04 Medtronic Minimed, Inc. Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion
US20080097291A1 (en) * 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US8137314B2 (en) * 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US8512288B2 (en) 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8277415B2 (en) 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8840586B2 (en) * 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
EP1904158B1 (de) 2005-06-24 2013-07-24 3M Innovative Properties Company Faltbares Pflaster mit Mikronadelnanordnung
JP5144510B2 (ja) 2005-06-27 2013-02-13 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイ適用装置
AU2006264122B2 (en) 2005-06-28 2010-12-02 Unomedical A/S Packing for infusion set and method of applying an infusion set
CN101263136A (zh) * 2005-07-13 2008-09-10 弗·哈夫曼-拉罗切有限公司 作为5-ht6、5-ht24的苯并咪唑衍生物
MX2008001803A (es) * 2005-08-01 2008-04-16 Hawk Medical Technologies Ltd Erradicacion de pigmentacion y tejido de cicatriz.
CA2620943A1 (en) * 2005-09-02 2007-03-08 Iomai Corporation Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
AU2006287603B2 (en) * 2005-09-06 2012-05-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
ES2354107T3 (es) 2005-09-12 2011-03-10 Unomedical A/S Dispositivo de inserción para un equipo de infusión con una primera y segunda unidades de resorte.
US8545445B2 (en) 2006-02-09 2013-10-01 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
WO2007047539A2 (en) * 2005-10-14 2007-04-26 Medtronic, Inc. Localized delivery to the lymphatic system
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
DE602006019153D1 (de) 2005-12-23 2011-02-03 Unomedical As Injektionsvorrichtung
KR20080088598A (ko) * 2006-01-12 2008-10-02 나노패스 테크놀러지스 엘티디. 피부의 표면 연마 처리를 위한 장치
US20080306325A1 (en) 2006-10-02 2008-12-11 Emkinetics Method and apparatus for magnetic induction therapy
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
AU2007219546B8 (en) 2006-02-28 2012-07-05 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007140783A2 (en) 2006-06-07 2007-12-13 Unomedical A/S Inserter for transcutaneous sensor
CN101489604B (zh) 2006-06-09 2012-05-23 优诺医疗有限公司 安装垫
EP2029218B1 (de) 2006-06-15 2019-08-14 PolyPharma Pty Ltd Abgabesystem
RU2443436C2 (ru) 2006-08-02 2012-02-27 Уномедикал А/С Канюльное и доставочное устройство
EP1884223A1 (de) 2006-08-04 2008-02-06 IP Randwyck B.V. Wundestimulierende Einheit
US20080051765A1 (en) * 2006-08-23 2008-02-28 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7794434B2 (en) * 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7828764B2 (en) * 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7811262B2 (en) * 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7682338B2 (en) * 2006-08-23 2010-03-23 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
EP1917990A1 (de) 2006-10-31 2008-05-07 Unomedical A/S Infusionsset
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
ES2820335T3 (es) 2007-04-16 2021-04-20 Corium Inc Matrices de microagujas coladas con disolvente que contienen agente activo
DK2146760T3 (en) 2007-04-30 2019-01-28 Medtronic Minimed Inc FILLING OF RESERVOIR, BUBBLE MANAGEMENT AND DELIVERY SYSTEMS FOR INFUSION MEDIA AND PROCEDURES
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
JP2010530266A (ja) 2007-06-20 2010-09-09 ウノメディカル アクティーゼルスカブ カテーテル並びにカテーテルの製造方法及び装置
CN101808685A (zh) 2007-07-03 2010-08-18 优诺医疗有限公司 具有双稳平衡状态的插入器
CN101790394B (zh) 2007-07-10 2012-10-17 优诺医疗有限公司 具有两个弹簧的插入器
WO2009010396A1 (en) 2007-07-18 2009-01-22 Unomedical A/S Insertion device with pivoting action
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
FR2923151B1 (fr) * 2007-11-02 2010-09-03 Commissariat Energie Atomique Dispositif de prelevement sanguin comportant au moins un filtre .
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
GB0802447D0 (en) 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
MX2010008759A (es) 2008-02-13 2010-08-31 Unomedical As Sellado entre una parte de canula y una trayectoria de fluido.
WO2009103759A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
WO2009142741A1 (en) * 2008-05-21 2009-11-26 Theraject, Inc. Method of manufacturing solid solution peforator patches and uses thereof
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
WO2010033878A2 (en) 2008-09-19 2010-03-25 David Brown Solute concentration measurement device and related methods
AU2009331635A1 (en) 2008-12-22 2011-06-23 Unomedical A/S Medical device comprising adhesive pad
CN102405015B (zh) 2009-03-02 2017-01-18 第七感生物系统有限公司 用于分析可提取介质的装置和方法
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9119578B2 (en) 2011-04-29 2015-09-01 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US8926561B2 (en) 2009-07-30 2015-01-06 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
JP2013500099A (ja) 2009-07-30 2013-01-07 ウノメディカル・アー/エス 水平方向の可動部材を備えた挿入デバイス
MX2012000778A (es) 2009-08-07 2012-07-30 Unomedical As Dispositivo de suministro con sensor y una o mas canulas.
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
JP2013508119A (ja) 2009-10-26 2013-03-07 エムキネティクス, インコーポレイテッド 神経、筋肉および身体組織の電磁刺激のための方法および装置
AU2010332400B2 (en) 2009-12-16 2016-08-04 Chrontech Pharma Ab Injection Needle and Device
US8900181B2 (en) 2009-12-18 2014-12-02 Srgi Holdings, Llc Skin treatment and drug delivery device
KR20130018783A (ko) 2010-03-30 2013-02-25 우노메디컬 에이/에스 의료기구
US9522262B2 (en) 2010-04-28 2016-12-20 Kimberly-Clark Worldwide, Inc. Medical devices for delivery of siRNA
CN102958557B (zh) 2010-04-28 2016-08-03 金伯利-克拉克环球有限公司 其上含有纳米结构的复合微针阵列
AU2011311255B2 (en) 2010-04-28 2015-10-08 Sorrento Therapeutics, Inc. Method for increasing permeability of an epithelial barrier
EP2563450B1 (de) 2010-04-28 2017-07-26 Kimberly-Clark Worldwide, Inc. Vorrichtung zur verabreichung eines medikaments gegen rheumatoide arthritis
CA2798145C (en) 2010-05-04 2022-10-18 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
EP2593014B1 (de) 2010-07-16 2015-11-04 Seventh Sense Biosystems, Inc. Niederdruckumgebung für flüssigkeitstransfervorrichtungen
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
EP2433663A1 (de) 2010-09-27 2012-03-28 Unomedical A/S Einführsystem
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
EP2436412A1 (de) 2010-10-04 2012-04-04 Unomedical A/S Sprinklerkanüle
ES2565805T3 (es) 2010-11-09 2016-04-07 Seventh Sense Biosystems, Inc. Sistemas e interfaces para el muestreo de sangre
EP2460553A1 (de) * 2010-12-02 2012-06-06 Debiotech S.A. Vorrichtung für das Einsetzen von Nadeln
US11000310B2 (en) 2010-12-17 2021-05-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10702684B2 (en) 2010-12-17 2020-07-07 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US10856900B2 (en) 2010-12-17 2020-12-08 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10661063B2 (en) 2010-12-17 2020-05-26 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US11103275B2 (en) 2010-12-17 2021-08-31 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10736653B2 (en) 2013-12-06 2020-08-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10342574B2 (en) 2010-12-17 2019-07-09 Srgi Holdings, Llc Pixel array medical devices and methods
US11278309B2 (en) 2010-12-17 2022-03-22 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10368904B2 (en) 2013-12-06 2019-08-06 Srgi Holdings, Llc Pixel array medical systems, devices and methods
CN103635152B (zh) 2011-01-28 2017-02-15 通用医疗公司 用于不连续皮肤磨削的方法和装置
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
EP2701600B1 (de) 2011-04-29 2016-06-08 Seventh Sense Biosystems, Inc. Ausgabe und/oder aufnahme von flüssigkeiten
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP3106092A3 (de) 2011-04-29 2017-03-08 Seventh Sense Biosystems, Inc. Systeme und verfahren zur flüssigkeitsentnahme aus einer person
EP2720740A1 (de) 2011-06-15 2014-04-23 ChronTech Pharma AB Injektionsnadel und vorrichtung
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (de) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
EP2763723B1 (de) 2011-10-05 2016-04-13 Unomedical A/S Inserter zum gleichzeitigen einsetzen mehrerer transkutaner teile
EP2583715A1 (de) 2011-10-19 2013-04-24 Unomedical A/S Infusionsschlauchsystem und Herstellungsverfahren
MX343262B (es) 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
CA2850931A1 (en) 2011-10-27 2013-05-02 Kimberly-Clark Worldwide, Inc. Implantable devices for delivery of bioactive agents
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
JP6145249B2 (ja) * 2012-05-25 2017-06-07 学校法人 関西大学 中空微細針及びその作製方法
KR102140553B1 (ko) * 2012-06-22 2020-08-03 도판 인사츠 가부시키가이샤 바늘 형상체 및 바늘 형상체 제조 방법
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
JP6144355B2 (ja) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドModernaTX,Inc. 化学修飾mRNA
SG11201504495XA (en) 2012-12-06 2015-07-30 Srgi Holdings Llc Pixel array medical devices and methods
MX375307B (es) 2012-12-21 2025-03-06 Corium Inc Microarreglo para la entrega de agente terapeutico y metodos de uso.
EP4039236A1 (de) 2013-02-20 2022-08-10 Cytrellis Biosystems, Inc. System zur hautstraffung
MX383605B (es) 2013-03-12 2025-03-14 Corium Int Inc Aplicadores de microproyeccion.
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
ES2761580T3 (es) 2013-03-15 2020-05-20 Corium Inc Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
ES2908339T3 (es) 2013-03-15 2022-04-28 Corium Inc Micromatriz para el suministro de un agente terapéutico y métodos de uso
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CN104056345B (zh) 2013-03-22 2017-04-19 北京神州汉方医药科技有限公司 一种经皮给药装置
AU2014262382A1 (en) * 2013-05-06 2015-11-19 Mupharma Pty Ltd Non-invasive agent applicator
CA2920662A1 (en) 2013-08-09 2015-02-12 Cytrellis Biosystems, Inc. Methods and apparatuses for skin treatment using non-thermal tissue ablation
SG11201602636PA (en) 2013-10-02 2016-05-30 Srgi Holdings Llc Pixel array medical devices and methods
ES2827049T3 (es) 2013-10-02 2021-05-19 Srgi Holdings Llc Dispositivos médicos de conjunto de píxeles
BR112016007255A2 (pt) 2013-10-03 2017-09-12 Moderna Therapeutics Inc polinucleotídeos que codificam receptor de lipoproteína de baixa densidade
US20170296214A1 (en) 2013-12-06 2017-10-19 Edward KNOWLTON Pixel array medical systems, devices and methods
US11937846B2 (en) 2013-12-06 2024-03-26 Srgi Holdings Llc Pixel array medical systems, devices and methods
US11229452B2 (en) 2013-12-06 2022-01-25 Srgi Holdings, Llc Pixel array medical systems, devices and methods
WO2015095675A1 (en) 2013-12-19 2015-06-25 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
JP2017507732A (ja) * 2014-03-10 2017-03-23 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルデバイス
US20160279401A1 (en) * 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
WO2015159525A1 (ja) * 2014-04-14 2015-10-22 凸版印刷株式会社 注入器具
US20170056637A1 (en) * 2014-05-06 2017-03-02 Mupharma Pty Ltd Non-invasive agent applicator
AU2015308582A1 (en) * 2014-08-29 2017-04-20 Srgi Holdings, Llc Pixel array medical devices and methods
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016074040A2 (en) * 2014-11-12 2016-05-19 Mupharma Pty Ltd Non-invasive agent applicator
KR102670286B1 (ko) 2014-11-14 2024-05-30 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
EP3253308A4 (de) 2015-02-05 2018-10-24 SRGI Holdings LLC Medizinische systeme mit pixelanordnung, vorrichtungen und verfahren
US9730625B2 (en) 2015-03-02 2017-08-15 Verily Life Sciences Llc Automated blood sampling device
US10765361B2 (en) * 2015-03-02 2020-09-08 Verily Life Sciences Llc Automated sequential injection and blood draw
CN107530490B (zh) * 2015-03-10 2021-06-25 爱力根销售有限责任公司 多针注射器
EP3272387A4 (de) * 2015-03-18 2018-12-12 Toppan Printing Co., Ltd. Arzneimittelverabreichungsvorrichtung und verfahren zur herstellung der arzneimittelverabreichungsvorrichtung
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11490952B2 (en) 2015-08-31 2022-11-08 Srgi Holdings, Llc Pixel array medical devices and methods
US11751903B2 (en) 2015-08-31 2023-09-12 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11980389B2 (en) 2015-08-31 2024-05-14 Srgi Holdings Llc Handed spiral slotted scalpet array
CA3007291C (en) * 2015-12-04 2019-10-22 Ascilion Ab A microneedle and a chip
US11564706B2 (en) 2019-10-28 2023-01-31 Srgi Holdings, Llc Pixel array medical systems, devices and methods
JP2019506235A (ja) * 2016-02-11 2019-03-07 エスアールジーアイ ホールディングス エルエルシーSrgi Holdings Llc ピクセルアレイ医療システム、デバイスおよび方法
EP3435890B1 (de) 2016-03-29 2025-01-22 Cytrellis Biosystems, Inc. Vorrichtungen zur kosmetischen hauterneuerung
KR102627434B1 (ko) * 2016-08-08 2024-01-18 주식회사 엘지생활건강 흡착 마이크로니들
CN109922740B (zh) 2016-09-21 2022-08-23 希特利斯生物系统有限公司 用于美容皮肤重建的装置和方法
CN106725894B (zh) * 2017-01-22 2020-06-05 袁晓辉 一种间歇式负压吸引皮肤扩张装置及其使用方法
US10765426B2 (en) * 2017-02-17 2020-09-08 Ethicon Llc Systems for coupling adjuncts to an end effector
EP3582752A1 (de) 2017-02-17 2019-12-25 Allergan, Inc. Mikronadelanordnung mit wirkstoff
WO2018217479A2 (en) 2017-05-11 2018-11-29 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
TWI778065B (zh) 2017-07-25 2022-09-21 瑞典商艾瑟莉恩公司 吸力施加裝置以及用於取樣體液的裝置
US11213667B2 (en) * 2018-07-11 2022-01-04 Santa Clara University 3D printed microneedles for microencapsulated mammalian cell extrusion
JP1632957S (de) 2018-10-30 2019-06-03
WO2020131544A1 (en) 2018-12-19 2020-06-25 ClearIt, LLC Systems and methods for tattoo removal using an applied electric field
CN109938777B (zh) * 2019-04-02 2020-02-07 汕头大学医学院第一附属医院 一种皮肤辅助检查机械
JP7491551B2 (ja) * 2019-04-25 2024-05-28 コスメディ製薬株式会社 水溶性シート状製剤のアプリケータ2
EP4139678A4 (de) * 2020-04-22 2024-05-22 Paul Gilbert Indikator für flüssigkeitseigenschaften
FR3110382B1 (fr) * 2020-05-20 2022-05-13 Pkvitality Capteur pour système de surveillance corporelle monté en surface
FR3113578B1 (fr) * 2020-08-28 2023-02-10 Pkvitality Procede d’alignement de composant(s) d’un systeme de surveillance corporelle
CN116018176A (zh) * 2020-09-30 2023-04-25 株式会社资生堂 带有针状突起的器件
CN115227957A (zh) * 2022-07-26 2022-10-25 空芯微医疗科技(上海)有限责任公司 空心微针的制备方法及其制品

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3167073A (en) * 1962-01-16 1965-01-26 Rosenthal Sol Roy Transcutaneous injection device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5466465A (en) * 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
JP2713255B2 (ja) * 1995-08-11 1998-02-16 日本電気株式会社 浸出液吸引装置
AR008242A1 (es) 1996-06-18 1999-12-29 Alza Corp Dispositivo para atravesar el estrato corneo de una superficie corporal
DK0921840T3 (da) * 1996-07-03 2003-09-22 Altea Therapeutics Corp Multipel mekanisk mikroperforering af hud eller slimhinde
DE69718495T2 (de) * 1996-09-17 2003-11-20 Deka Products Ltd. Partnership, Manchester System zur medikamentenabgabe durch transport
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
AU757230B2 (en) * 1997-12-11 2003-02-06 Alza Corporation Device for enhancing transdermal agent flux
CN1161164C (zh) * 1997-12-11 2004-08-11 阿尔扎有限公司 用于通过体表导入或提取质剂的装置
US6126637A (en) * 1998-04-15 2000-10-03 Science Incorporated Fluid delivery device with collapsible needle cover
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
PT1239917E (pt) * 1999-12-10 2005-08-31 Alza Corp Dispositivo de tratamento cutaneo para administracao transdermica prolongada de um medicamento

Also Published As

Publication number Publication date
DE60124917D1 (de) 2007-01-11
JP4892166B2 (ja) 2012-03-07
ES2276805T3 (es) 2007-07-01
WO2002005890A2 (en) 2002-01-24
EP1301237B1 (de) 2006-11-29
AU2001273340A1 (en) 2002-01-30
EP1301237A2 (de) 2003-04-16
US20020183688A1 (en) 2002-12-05
DE60124917T2 (de) 2007-06-06
WO2002005890A3 (en) 2002-04-25
US6440096B1 (en) 2002-08-27
JP2004503342A (ja) 2004-02-05

Similar Documents

Publication Publication Date Title
ATE346645T1 (de) Mikrovorrichtung und verfahren zur herstellung
ATE389434T1 (de) Verfahren und vorrichtung zum einführen einer perkutanen elektrode
SG130191A1 (en) Method and device for enhancing transdermal agent flux
BRPI0602158A (pt) conjunto de agulhas com batente de profundidade removìvel
EP2556855A3 (de) Verfahren und Vorrichtung für die iontophoretische Verabreichung eines Arzneimittels
DE602005024038D1 (de) Medizinische vorrichtung
ATE516054T1 (de) Mikrodermabrasionssystem und anwendungsverfahren
ATE463202T1 (de) Kapillarrohr-spitzen-design zur unterstützung des blutflusses
EP1611837A3 (de) Vorrichtung zur Handhabung von Fluiden
CO5590879A2 (es) Articulo absorbente y metodo de produccion de un articulo absorbente
AR044963A1 (es) Aparato y metodo para recubrir microproyecciones de perforacion de la piel
WO2005042051A3 (en) Method for transdermal delivery of permeant substances
ATE363310T1 (de) Verfahren und vorrichtung zur epidermischen verabreichung einer substanz
AU2001275388A1 (en) Skin permeability enhancing device to withdraw or administer a substance and method of manufacturing the device
ATE296666T1 (de) Direktionale, reflektierende abschirmung für eine mikrowellenablationsvorrichtung
CY1112846T1 (el) Συγκολλητικη μικροδομη και μεθοδος σχηματισμου αυτης
ATE297325T1 (de) Vorrichtung und mittel zum lösbaren sichern von gegenständen
EP2471571A3 (de) Autonomer, ambulanter Analytenmonitor oder Vorrichtung zur Abgabe von Arzneimitteln
ATE512679T1 (de) Vorrichtung zum absaugen von nasensekreten
EA200970771A1 (ru) Пластырь для применения на коже
ATE394136T1 (de) Inhalationsgerät für pulverförmige substanzen
AU2003269843A8 (en) Needle insertion device
ATE419890T1 (de) Medizinische vorrichtung zur prävention von axialen bewegungen
SE0002287D0 (sv) Biotinderivat
DE60123948D1 (de) Automatisierte vorrichtung zur biologischen analyse

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties