AT392470B - Verfahren zur herstellung von hochreinem kristallinem cefuroxim-acetoxyethylester - Google Patents

Verfahren zur herstellung von hochreinem kristallinem cefuroxim-acetoxyethylester Download PDF

Info

Publication number: AT392470B
Authority: AT; Austria
Prior art keywords: minutes; stirred; cefuroxime; solvent; hplc
Prior art date: 1983-07-29

Application number

AT2444/84A

Other languages

German (de)

English (en)

Other versions

ATA244484A (de

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-29

Filing date

1984-07-27

Publication date

1991-04-10

1984-07-27 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1990-09-15 Publication of ATA244484A publication Critical patent/ATA244484A/de

1991-04-10 Application granted granted Critical

1991-04-10 Publication of AT392470B publication Critical patent/AT392470B/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT2444/84A 1983-07-29 1984-07-27 Verfahren zur herstellung von hochreinem kristallinem cefuroxim-acetoxyethylester AT392470B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB838320521A GB8320521D0 (en)	1983-07-29	1983-07-29	Chemical process

Publications (2)

Publication Number	Publication Date
ATA244484A ATA244484A (de)	1990-09-15
AT392470B true AT392470B (de)	1991-04-10

Family

ID=10546505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT2444/84A AT392470B (de)	1983-07-29	1984-07-27	Verfahren zur herstellung von hochreinem kristallinem cefuroxim-acetoxyethylester

Country Status (21)

Country	Link
JP (1)	JPH0613526B2 (pt)
KR (1)	KR910008377B1 (pt)
AT (1)	AT392470B (pt)
AU (2)	AU582121B2 (pt)
BE (1)	BE900241A (pt)
CA (1)	CA1265511A (pt)
CH (1)	CH662121A5 (pt)
DE (1)	DE3427828A1 (pt)
DK (1)	DK165505C (pt)
ES (1)	ES534695A0 (pt)
FI (1)	FI76808C (pt)
FR (1)	FR2549837B1 (pt)
GB (2)	GB8320521D0 (pt)
IE (1)	IE57726B1 (pt)
IL (1)	IL72536A (pt)
NL (1)	NL8402372A (pt)
NO (1)	NO167292C (pt)
NZ (1)	NZ209046A (pt)
PT (1)	PT78985B (pt)
SE (1)	SE463263B (pt)
ZA (1)	ZA845830B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8400024D0 (en) *	1984-01-03	1984-02-08	Glaxo Group Ltd	Cephalosporin antibiotics
GB8524001D0 (en) *	1985-09-30	1985-11-06	Glaxo Group Ltd	Pharmaceutical composition
US5063224A (en) *	1990-07-09	1991-11-05	Eli Lilly And Company	R-cefuroxime axetil
IT1277426B1 (it) *	1995-08-03	1997-11-10	Acs Dobfar Spa	Forma cristallina biodisponibile del cefuroxima axetil
CN1111537C (zh) *	1997-05-15	2003-06-18	第一制糖株式会社	高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
KR100228264B1 (ko) *	1997-08-02	1999-11-01	김선진	결정형 세푸록심 악세틸의 제조방법
CA2209868C (en) *	1997-08-15	2001-08-14	Bernard Charles Sherman	Pharmaceutical compositions comprising cefuroxime axetil
IN186539B (pt) *	1997-09-29	2001-09-29	Ranbaxy Lab Ltd
PT937727E (pt) *	1998-02-20	2002-07-31	Fako Ilaclari A S	Processo para a producao de cefuroxima azetil cristalina soluvel
IN190849B (pt)	2000-07-17	2003-08-23	Ranbaxy Lab Ltd
AT411996B (de)	2000-09-11	2004-08-26	Sandoz Ag	Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
ITMI20011763A1 (it) *	2001-08-10	2003-02-10	Antibioticos Spa	Processo di preparazione di cefuroxime axelite ad elevata purezza
ITMI20011925A1 (it) *	2001-09-14	2003-03-14	Antibioticos Spa	Metodo applicabile su scala industriale per la preparazione di cefuroxime axetile cristallino
TWI328006B (en) *	2003-12-26	2010-08-01	Nissan Chemical Ind Ltd	Crystal form of quinoline compound and process for its production
CN100448879C (zh) *	2004-07-22	2009-01-07	北京化工大学	一种无定型头孢呋辛酯的制备方法
DE102005019458A1 (de)	2005-04-25	2006-10-26	Grünenthal GmbH	Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
CN118561870A (zh) *	2024-05-15	2024-08-30	广东立国制药有限公司	一种制备头孢呋辛酸的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT363183B (de) *	1977-04-19	1981-07-10	Glaxo Lab Ltd	Verfahren zur herstellung von neuen cephalosporinderivaten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1571683A (en) *	1976-02-16	1980-07-16	Glaxo Operations Ltd	Ester derivatives of cefuroxime
CA1094545A (en) *	1976-02-16	1981-01-27	Michael Gregson	Cephalosporin antibiotics
JPS577485A (en) *	1980-06-13	1982-01-14	Takeda Chem Ind Ltd	Cephalosporin
YU44680B (en) *	1982-07-30	1990-12-31	Glaxo Lab Ltd	Process for obtaining very pure amorphous form of cephuroxim axetile
GB8400024D0 (en) *	1984-01-03	1984-02-08	Glaxo Group Ltd	Cephalosporin antibiotics

1983
- 1983-07-29 GB GB838320521A patent/GB8320521D0/en active Pending
1984
- 1984-07-27 NO NO843055A patent/NO167292C/no not_active IP Right Cessation
- 1984-07-27 FI FI843011A patent/FI76808C/fi not_active IP Right Cessation
- 1984-07-27 DE DE19843427828 patent/DE3427828A1/de not_active Ceased
- 1984-07-27 AU AU31256/84A patent/AU582121B2/en not_active Ceased
- 1984-07-27 SE SE8403897A patent/SE463263B/sv not_active IP Right Cessation
- 1984-07-27 DK DK366684A patent/DK165505C/da not_active IP Right Cessation
- 1984-07-27 JP JP59155694A patent/JPH0613526B2/ja not_active Expired - Lifetime
- 1984-07-27 AT AT2444/84A patent/AT392470B/de not_active IP Right Cessation
- 1984-07-27 ZA ZA845830A patent/ZA845830B/xx unknown
- 1984-07-27 ES ES534695A patent/ES534695A0/es active Granted
- 1984-07-27 IE IE1938/84A patent/IE57726B1/en not_active IP Right Cessation
- 1984-07-27 FR FR8412011A patent/FR2549837B1/fr not_active Expired
- 1984-07-27 BE BE0/213398A patent/BE900241A/fr not_active IP Right Cessation
- 1984-07-27 KR KR1019840004465A patent/KR910008377B1/ko not_active IP Right Cessation
- 1984-07-27 NL NL8402372A patent/NL8402372A/nl not_active Application Discontinuation
- 1984-07-27 PT PT78985A patent/PT78985B/pt unknown
- 1984-07-27 CH CH3672/84A patent/CH662121A5/de not_active IP Right Cessation
- 1984-07-27 GB GB08419202A patent/GB2145409B/en not_active Expired
- 1984-07-27 CA CA000459929A patent/CA1265511A/en not_active Expired - Fee Related
- 1984-07-29 IL IL72536A patent/IL72536A/xx not_active IP Right Cessation
- 1984-07-30 NZ NZ209046A patent/NZ209046A/en unknown
1989
- 1989-06-16 AU AU36601/89A patent/AU634965B2/en not_active Ceased

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT363183B (de) *	1977-04-19	1981-07-10	Glaxo Lab Ltd	Verfahren zur herstellung von neuen cephalosporinderivaten

Also Published As

Publication number	Publication date
ZA845830B (en)	1986-03-26
CH662121A5 (de)	1987-09-15
AU3125684A (en)	1985-01-31
GB2145409B (en)	1987-02-18
FI76808C (fi)	1988-12-12
DK366684A (da)	1985-01-30
IL72536A (en)	1988-01-31
AU3660189A (en)	1989-10-05
NO167292C (no)	1991-10-23
FI76808B (fi)	1988-08-31
PT78985A (en)	1984-08-01
AU634965B2 (en)	1993-03-11
IL72536A0 (en)	1984-11-30
GB2145409A (en)	1985-03-27
DE3427828A1 (de)	1985-02-14
BE900241A (fr)	1985-01-28
AU582121B2 (en)	1989-03-16
IE841938L (en)	1985-01-29
GB8320521D0 (en)	1983-09-01
KR910008377B1 (ko)	1991-10-12
DK366684D0 (da)	1984-07-27
GB8419202D0 (en)	1984-08-30
CA1265511A (en)	1990-02-06
SE8403897L (sv)	1985-01-30
FI843011A0 (fi)	1984-07-27
SE463263B (sv)	1990-10-29
NO843055L (no)	1985-01-30
DK165505B (da)	1992-12-07
JPH0613526B2 (ja)	1994-02-23
FI843011A (fi)	1985-01-30
DK165505C (da)	1993-04-19
PT78985B (en)	1986-10-23
ES8601869A1 (es)	1985-11-01
FR2549837A1 (fr)	1985-02-01
NO167292B (no)	1991-07-15
JPS6075484A (ja)	1985-04-27
ATA244484A (de)	1990-09-15
IE57726B1 (en)	1993-03-24
NZ209046A (en)	1988-02-29
SE8403897D0 (sv)	1984-07-27
ES534695A0 (es)	1985-11-01
NL8402372A (nl)	1985-02-18
FR2549837B1 (fr)	1986-12-26
KR850001221A (ko)	1985-03-16

Publication	Publication Date	Title
AT392470B (de)	1991-04-10	Verfahren zur herstellung von hochreinem kristallinem cefuroxim-acetoxyethylester
DE2713272C2 (de)	1983-01-20	Derivate der 7-Aminothiazolyl-acetamido-cephalosporansäure, ihre Herstellung und pharmazeutische Zusammensetzungen
DE3427859C2 (de)	1995-10-12	Verfahren zur Herstellung von Natrium-Cefuroxim
DD150898A5 (de)	1981-09-23	Verfahren zur herstellung von bisestern von methandiol mit penicillinen
DE2228012B2 (de)	1979-05-23	-Aminophenylacetamido] -penicülansäure und Verfahren zu seiner Herstellung
AT399155B (de)	1995-03-27	Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
DE2700552C2 (de)	1985-02-28	Derivate der 7-Aminocephalosporansäure, ihre Herstellung und pharmazeutische Mittel
AT402928B (de)	1997-09-25	Neues verfahren zur herstellung von cefotaxim
DE2900118C2 (pt)	1987-09-17
DE1670324B2 (de)	1977-03-10	7-cyanacetylamino-cephalosporansaeurederivate
CH627475A5 (en)	1982-01-15	Process for preparing cephem compounds as intermediates for the synthesis of cephalosporins
DD202032A5 (de)	1983-08-24	Verfahren zur herstellung von makroliden
DE2360620C2 (de)	1983-11-17	Verfahren zur Herstellung von lactolartigen Cephalosporinen
CH646706A5 (de)	1984-12-14	Verfahren zur herstellung von natrium-cefuroxim und das tetrahydrofuran-solvat davon.
DE1445633A1 (de)	1968-12-05	Verfahren zur Herstellung neuer Amide
DE2549608A1 (de)	1976-05-13	Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2128605A1 (de)	1971-12-23	Neue Cephalosporansäurederivaten und Verfahren zu ihrer Herstellung
DE2559913C2 (de)	1984-02-09	Verfahren zur Herstellung von Cephalosporinderivaten
CH644865A5 (de)	1984-08-31	Cephalosporinderivate, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte.
DE2302745C2 (de)	1982-05-06	Penicillin G-1(5)-oxid-acetonsolvat und Verfahren zu seiner Herstellung
DE953974C (de)	1956-12-13	Verfahren zur Herstellung saurer Dicarbonsaeureester des Erythromycins
DE2311117A1 (de)	1973-09-20	Cephalosporinderivate
DE2142424A1 (de)	1972-03-02	Cephalosporin C und seine Derivate
DE2331243C2 (de)	1982-03-04	Dimethylformamid-1:1-Addukt des Natriumsalzes des D-2-(1,4-Cyclohexadien-1-yl)glycin-enamins von Acetessigsäuremethylester und Verfahren zu seiner Herstellung
DE2841706C2 (de)	1982-11-04	N,N-Dimethylacetamid-Addukt der 7-[D(-)-&alpha;-(4-Äthyl-2,3-dioxo-1-piperazincarboxamido)-&alpha;-(4-hydroxyphenyl)-acetamido]-3-[5-(1-methyl-1,2,3,4-tetrazolyl)-thiomethyl]-&Delta;&uarr;3&uarr;-cephem--4-carbonsäure, Verfahren zu seiner Herstellung und seine Verwendung

Legal Events

Date	Code	Title	Description
2003-05-15	ELJ	Ceased due to non-payment of the annual fee