AR057668A1 - Derivados de n-(arilalquil)-1h-pirrolopiridin-2-carboxamidas, su preparacion, composiciones farmaceuticas y su aplicacion en terapeutica - Google Patents
Derivados de n-(arilalquil)-1h-pirrolopiridin-2-carboxamidas, su preparacion, composiciones farmaceuticas y su aplicacion en terapeuticaInfo
- Publication number
- AR057668A1 AR057668A1 ARP060103112A ARP060103112A AR057668A1 AR 057668 A1 AR057668 A1 AR 057668A1 AR P060103112 A ARP060103112 A AR P060103112A AR P060103112 A ARP060103112 A AR P060103112A AR 057668 A1 AR057668 A1 AR 057668A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloalkyl
- aryl
- alkylene
- group
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
Reivindicacion 1: Un compuesto que responde a la formula (1) en la que: n es igual a 0, 1, 2 o 3; el nucleo de pirrolopiridina es un grupo pirrolo[3,2-b]piridina, un grupo pirrolo[3,2-c]piridina, un grupo pirrolo[2,3-3]piridina o un grupo pirrolo[2,3-b]piridina; estando el nucleo de pirrolopiridina opcionalmente sustituido en la posicion del carbono 4, 5, 6 y/o 7 con uno o varios sustituyentes X, idénticos o diferentes uno de otro, seleccionados entre un átomo de halogeno o un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-3, fluoroalquilo C1-6, alcoxilo C1-6, fluoroalcoxilo C1-6, ciano, C(O)NR1R2, nitro, NR1R2, tioalquilo C1-6, -S(O)-alquilo C1-6, -S(O)2-alquilo C1-6, SO2NR1R2, NR3COR4, NR3SO2R5 o arilo, estando el arilo opcionalmente sustituido con uno o varios sustituyentes elegidos entre un halogeno, un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-4, fluoroalquilo C1-6, alcoxilo C1-6, fluoroalcoxilo C1-6, nitro o ciano; Z1, Z2, Z3, Z4 y Z5 representan independientemente uno de otro, un átomo de hidrogeno o de halogeno o un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquilC3-7-alquileno C1-3, fluoroalquilo C1-6, alcoxilo C1-6, fluoroalcoxilo C1-6, ciano, C(O)NR1R2, nitro, NR1R2, tioalquilo C1-6, -S(O)-alquilo C1-6, -S(O)2-alquilo C1-6, SO2NR1R2, NR3COR4, NR3SO2R5, aril-alquileno C1-6 o arilo, estando el arilo y el arilalquileno C1-6 opcionalmente sustituidos con uno o varios sustituyentes seleccionados entre un halogeno, un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-3, fluoroalquilo C1-6, alcoxilo C1-6, fluoroalcoxilo, C1-6, nitro o ciano; R1 y R2, representan, independientemente uno del otro un átomo de hidrogeno o un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-3, aril-alquileno C1-3; o R1 y R2 forman conjuntamente, con el átomo de nitrogeno que les lleva, un grupo azetidino, pirrolidino, piperidino, azepino, morfolino, tiomorfolino, piperazino, homopiperazino, estando este grupo opcionalmente sustituido con un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-3, aril-alquileno C1-6o arilo; R3 y R4 representan, independientemente uno de otro, un átomo de hidrogeno o un grupo alquilo C1-6, aril-alquileno C1-6 o arilo; R5 representa un grupo alquilo C1-6 o arilo; W representa un grupo bicíclico fusionado de la formula (2): unido al átomo de nitrogeno por las posiciones 1, 2, 3 o 4; A representa un heterociclo de 5 a 7 eslabones que comprende de uno a tres heteroátomos elegidos enrte O, S o N; estando él o los átomos de carbono de A opcionalmente sustituidos con uno o varios grupos elegidos entre un átomo de hidrogeno o un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-3, fluoroalquilo C1-6, arilo, aril-alquileno C1-6, oxo o tio; estando el o los átomos de nitrogeno de A opcionalmente sustituidos con R6 cuando el nitrogeno es adyacente a un átomo de carbono sustituido con un grupo oxo, o con R7 en los otros casos; R6 representa un átomo de hidrogeno o un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-3, fluoroalquilo C1-6, aril-alquileno C1-6 o arilo; R7 representa un átomo de hidrogeno o un grupo alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-3, cluoroalquilo C1-6, aril-alquileno C1-6, alquil C1-6-C(O)-, cicloalquil C3-7-alquilen C1-3-(CO)-, fluoroalquil C1-6-C(O)-, cicloalquil C3-7-C(O)-, aril-C(O)-, aril-alquilen C1-6-C(O)-, alquil C1-6-S(O)2-, fluoroalquilo C1-6-S(O)2-, cicloalquilo C3-7-S(O)2-, cicloalquil C3-7-alquilen C1-3-S(O)2-, aril-S(O)2- o aril-alquilen C1-6-S(O)2- o arilo; pudiendo estar el o los átomos de azufre del heterociclo A en forma oxidada; pudiendo estar el o los átomos de nitrogeno del heterociclo A en forma oxidada; el átomo de nitrogeno en la posicion 4, 5, 6 o 7 de la pirrolopiridina puede estar en forma oxidada; en el estado de base o de sal de adicion de ácido, así como en el estado de hidrato o de solvato.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0507804A FR2888848B1 (fr) | 2005-07-22 | 2005-07-22 | Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057668A1 true AR057668A1 (es) | 2007-12-12 |
Family
ID=36039505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103112A AR057668A1 (es) | 2005-07-22 | 2006-07-20 | Derivados de n-(arilalquil)-1h-pirrolopiridin-2-carboxamidas, su preparacion, composiciones farmaceuticas y su aplicacion en terapeutica |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7763636B2 (es) |
| EP (1) | EP1912644B1 (es) |
| JP (1) | JP4938012B2 (es) |
| KR (1) | KR101257969B1 (es) |
| CN (1) | CN101247808B (es) |
| AR (1) | AR057668A1 (es) |
| AT (1) | ATE451923T1 (es) |
| AU (1) | AU2006271518B2 (es) |
| BR (1) | BRPI0614066A2 (es) |
| CA (1) | CA2615676C (es) |
| CR (1) | CR9643A (es) |
| CY (1) | CY1109891T1 (es) |
| DE (1) | DE602006011170D1 (es) |
| DK (1) | DK1912644T3 (es) |
| EA (1) | EA013747B1 (es) |
| EC (1) | ECSP088105A (es) |
| ES (1) | ES2338363T3 (es) |
| FR (1) | FR2888848B1 (es) |
| HR (1) | HRP20100150T1 (es) |
| IL (1) | IL188520A (es) |
| MA (1) | MA29617B1 (es) |
| MX (1) | MX2008001018A (es) |
| MY (1) | MY145062A (es) |
| NI (1) | NI200800021A (es) |
| NO (1) | NO20080394L (es) |
| NZ (1) | NZ564870A (es) |
| PL (1) | PL1912644T3 (es) |
| PT (1) | PT1912644E (es) |
| RS (1) | RS51233B (es) |
| SI (1) | SI1912644T1 (es) |
| TN (1) | TNSN07485A1 (es) |
| TW (1) | TWI386407B (es) |
| UA (1) | UA93881C2 (es) |
| WO (1) | WO2007010138A2 (es) |
| ZA (1) | ZA200800439B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2888847B1 (fr) | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| FR2910473B1 (fr) | 2006-12-26 | 2009-02-13 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique. |
| FR2911605B1 (fr) * | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique |
| US8258152B2 (en) * | 2007-06-12 | 2012-09-04 | Genentech, Inc. | N-substituted azaindoles and methods of use |
| FR2919610B1 (fr) * | 2007-08-02 | 2009-10-16 | Sanofi Aventis Sa | Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique |
| FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| FR2926555B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| GB0915892D0 (en) * | 2009-09-10 | 2009-10-14 | Smithkline Beecham Corp | Compounds |
| GB201913756D0 (en) * | 2019-09-24 | 2019-11-06 | Chromatwist Ltd | Contrast agent |
| WO2021158936A1 (en) * | 2020-02-05 | 2021-08-12 | The Rockefeller University | Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08295667A (ja) * | 1995-04-27 | 1996-11-12 | Takeda Chem Ind Ltd | 複素環化合物、その製造法および剤 |
| JP4241970B2 (ja) * | 1998-10-30 | 2009-03-18 | 中外製薬株式会社 | アミド結合を有するインドール誘導体、及びモノ又はジアザインドール誘導体 |
| US6436965B1 (en) * | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
| AR038420A1 (es) * | 2002-02-15 | 2005-01-12 | Glaxo Group Ltd | Compuesto de amida, procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende |
| JP2004091480A (ja) * | 2002-07-11 | 2004-03-25 | Takeda Chem Ind Ltd | ピロロピリジン誘導体およびその用途 |
| AU2003281044A1 (en) * | 2002-07-11 | 2004-02-02 | Takeda Pharmaceutical Company Limited | Pyrrolopyridine derivative and use thereof |
| JP4909068B2 (ja) * | 2003-02-14 | 2012-04-04 | グラクソ グループ リミテッド | カルボキサミド誘導体 |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| FR2897061B1 (fr) * | 2006-02-03 | 2010-09-03 | Sanofi Aventis | Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique. |
-
2005
- 2005-07-22 FR FR0507804A patent/FR2888848B1/fr not_active Expired - Fee Related
-
2006
- 2006-07-19 UA UAA200802257A patent/UA93881C2/ru unknown
- 2006-07-19 PT PT06778888T patent/PT1912644E/pt unknown
- 2006-07-19 PL PL06778888T patent/PL1912644T3/pl unknown
- 2006-07-19 AT AT06778888T patent/ATE451923T1/de active
- 2006-07-19 ZA ZA200800439A patent/ZA200800439B/xx unknown
- 2006-07-19 WO PCT/FR2006/001767 patent/WO2007010138A2/fr active Application Filing
- 2006-07-19 MX MX2008001018A patent/MX2008001018A/es active IP Right Grant
- 2006-07-19 KR KR1020087001597A patent/KR101257969B1/ko not_active IP Right Cessation
- 2006-07-19 CA CA2615676A patent/CA2615676C/fr not_active Expired - Fee Related
- 2006-07-19 EA EA200800402A patent/EA013747B1/ru not_active IP Right Cessation
- 2006-07-19 SI SI200630591T patent/SI1912644T1/sl unknown
- 2006-07-19 DK DK06778888.5T patent/DK1912644T3/da active
- 2006-07-19 EP EP06778888A patent/EP1912644B1/fr active Active
- 2006-07-19 AU AU2006271518A patent/AU2006271518B2/en not_active Ceased
- 2006-07-19 RS RSP-2010/0116A patent/RS51233B/sr unknown
- 2006-07-19 ES ES06778888T patent/ES2338363T3/es active Active
- 2006-07-19 JP JP2008522019A patent/JP4938012B2/ja not_active Expired - Fee Related
- 2006-07-19 CN CN200680030739.0A patent/CN101247808B/zh not_active Expired - Fee Related
- 2006-07-19 BR BRPI0614066-1A patent/BRPI0614066A2/pt active Search and Examination
- 2006-07-19 DE DE602006011170T patent/DE602006011170D1/de active Active
- 2006-07-19 NZ NZ564870A patent/NZ564870A/en not_active IP Right Cessation
- 2006-07-20 MY MYPI20063489A patent/MY145062A/en unknown
- 2006-07-20 AR ARP060103112A patent/AR057668A1/es unknown
- 2006-07-21 TW TW095126724A patent/TWI386407B/zh not_active IP Right Cessation
-
2007
- 2007-12-26 TN TNP2007000485A patent/TNSN07485A1/fr unknown
- 2007-12-31 IL IL188520A patent/IL188520A/en not_active IP Right Cessation
-
2008
- 2008-01-07 MA MA30554A patent/MA29617B1/fr unknown
- 2008-01-08 US US11/970,886 patent/US7763636B2/en not_active Expired - Fee Related
- 2008-01-08 CR CR9643A patent/CR9643A/es unknown
- 2008-01-14 EC EC2008008105A patent/ECSP088105A/es unknown
- 2008-01-18 NI NI200800021A patent/NI200800021A/es unknown
- 2008-01-21 NO NO20080394A patent/NO20080394L/no not_active Application Discontinuation
-
2010
- 2010-03-12 CY CY20101100239T patent/CY1109891T1/el unknown
- 2010-03-16 HR HR20100150T patent/HRP20100150T1/hr unknown
- 2010-06-15 US US12/815,593 patent/US20100249183A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR057668A1 (es) | Derivados de n-(arilalquil)-1h-pirrolopiridin-2-carboxamidas, su preparacion, composiciones farmaceuticas y su aplicacion en terapeutica | |
| AR064524A1 (es) | Derivados de n-(amino-(hetero)aril)-1h-pirrolopiridin-2-carboxamidas, su preparacion, intermediarios para su sintesis, una composicion farmaceutica que los comprende y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por los receptores de tipo trpv1. | |
| AR064937A1 (es) | Derivados de n-(heteroaril)-1-heteroaril-1h-indol-2-carboxamidas, su preparacion y su aplicacion en terapeutica | |
| AR070207A1 (es) | Derivados biciclicos de carboxamidas aza- biciclicas su preparacion y su aplicacion terapeutica | |
| AR066142A1 (es) | IMIDAZOTRIAZINAS E IMIDAZOPIRIMIDINAS COMO INHIBIDORES DE QUINASA, UNA COMPOSICION QUE LAS INCLUYE Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS A LA DESREGULACIoN DE LA VIA DE SENALIZACIoN HGF/C-MET | |
| AR046711A1 (es) | 5-7-diaminopirazolo[4,3d]pirimidinas como inhibidores de la pde-5,composiciones farmaceuticas que las contienen y usos en el tratamiento de hipertensiones | |
| AR049104A1 (es) | Pirimidinas como inhibidores de plk, composiciones farmaceuticas que las contienen y su uso en la preparacion de medicamentos para el tratamiento de enfermedades proliferativas, inflamatorias y autoinmunes. | |
| AR052903A1 (es) | Compuestos de bis arilo y heteroarilo sustituidos como antagonistas selectivos de 5ht2a, composiciones farmaceuticas que los contienen y su empleo en el tratamiento de trastornos del sueno. | |
| PA8786101A1 (es) | "DERIVADOS DE 6-CICLOAMINO-3-(PIRIDIN-4-IL) IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA" | |
| AR066954A1 (es) | Derivados de 7- alquinil-1,8- naftiridonas , su preparacion y su aplicacion en terapeutica | |
| NI200800015A (es) | Derivados de n-(heteroaril)-1-heteroarilalquil - 1h - indol - 2 - carboxamidas, su preparación y su aplicación en terapéutica. | |
| ES2530884T3 (es) | Derivados de imidazopiridina o imidazopirimidina como inhibidores de fosfodiesterasa 10A | |
| AR049521A1 (es) | Derivados de pirrazol - pirimidina | |
| AR035369A1 (es) | Derivados de tetrahidrobenzazepina composiciones farmaceuticas que los comprenden, el uso de dichos derivados en la fabricacion de medicamentos, e intermediarios utiles en la preparacion de dichos compuestos | |
| AR070206A1 (es) | Derivados de carboxamidas azabiciclicas su preparacion y su aplicacion en terapeutica | |
| AR045010A1 (es) | Pirimidinas utiles como moduladores de canales ionicos cuya activacion es controlada por tension | |
| AR060268A1 (es) | Tiazolil - dihidro - indazoles | |
| AR062499A1 (es) | Derivados de n-fenil pirazol y piridil pirazoles, composiciones farmaceuticas que los contienen y usos como agentes antiagregantes plaquetarios y antitromboticos. | |
| AR064936A1 (es) | Derivados de pirrolopiridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica | |
| AR051334A1 (es) | Derivados de 2- amido-4-feniltiazol | |
| AR067754A1 (es) | Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en la terapeutica | |
| AR054208A1 (es) | Derivados de oxopiperidina, su preparacion, una composicion farmaceutica y compuestos intermediarios | |
| AR004205A1 (es) | Derivados de diarilalquenilaminas, composiciones farmaceuticas que las contienen y el uso de dichos derivados en la preparacion de medicamentos. | |
| AR040140A1 (es) | Derivados de esteres de camptotecina en la posicion 20 | |
| AR056874A1 (es) | Derivados de 6- heteroarilpiridoindolona, su preparacion y su aplicacion en terapeutica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |