EA200800402A1 - Производные n-(арилалкил)-1н-пирролопиридин-2-карбоксамидов, их получение и их применение в терапии - Google Patents
Производные n-(арилалкил)-1н-пирролопиридин-2-карбоксамидов, их получение и их применение в терапииInfo
- Publication number
- EA200800402A1 EA200800402A1 EA200800402A EA200800402A EA200800402A1 EA 200800402 A1 EA200800402 A1 EA 200800402A1 EA 200800402 A EA200800402 A EA 200800402A EA 200800402 A EA200800402 A EA 200800402A EA 200800402 A1 EA200800402 A1 EA 200800402A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrrolo
- aryl
- pyridine group
- alkylene
- alkyl
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 title 1
- XWIYUCRMWCHYJR-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyridine Chemical group C1=CC=C2NC=CC2=N1 XWIYUCRMWCHYJR-UHFFFAOYSA-N 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- -1 (CC) fluoroalkoxyl Chemical group 0.000 abstract 1
- MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical group C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 abstract 1
- XLKDJOPOOHHZAN-UHFFFAOYSA-N 1h-pyrrolo[2,3-c]pyridine Chemical group C1=NC=C2NC=CC2=C1 XLKDJOPOOHHZAN-UHFFFAOYSA-N 0.000 abstract 1
- SRSKXJVMVSSSHB-UHFFFAOYSA-N 1h-pyrrolo[3,2-c]pyridine Chemical group N1=CC=C2NC=CC2=C1 SRSKXJVMVSSSHB-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
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- Obesity (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
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- Ophthalmology & Optometry (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Hematology (AREA)
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Abstract
Изобретение относится к соединениям общей формулы (I)в которой n равно 0, 1, 2 или 3; пирролопиридиновое ядро представляет собой пирроло[3,2-b]пиридиновую группу, пирроло[3,2-с]пиридиновую группу, пирроло[2,3-с]пиридиновую группу или пирроло[2,3-b]пиридиновую группу, причем пирролопиридиновое ядро возможно замещено в положении углерода 4, 5, 6 и/или 7 одним или несколькими заместителями X, одинаковыми или отличающимися друг от друга; Z, Z, Z, Zи Zозначают независимо друг от друга атом водорода или галогена или (C-С)-алкил, (С-С)-циклоалкил, (С-С)-циклоалкил-(C-С)-алкилен, (C-C)-фторалкил, (C-C)-алкоксил, (C-C)-фторалкоксил, цианогруппу, C(O)NRR, нитрогруппу, NRR, (C-С)-тиоалкил, -S(О)-(C-C)-алкил, -S(О)-(C-C)-алкил, SONRR, NRCOR, NRSOR, арил-(C-C)-алкилен или арил, причем арил и арил-(C-C)-алкилен возможно замещены; W означает конденсированную бициклическую группу формулы, связанную с атомом азота в положениях 1, 2, 3 или 4; А означает возможно замещенный 5-7-членный гетероцикл, включающий от одного до трех гетероатомов, выбираемых среди О, S или N; в форме основания или аддитивной соли с кислотой, а также в форме гидрата или сольвата; способу получения и применению в терапии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0507804A FR2888848B1 (fr) | 2005-07-22 | 2005-07-22 | Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| PCT/FR2006/001767 WO2007010138A2 (fr) | 2005-07-22 | 2006-07-19 | Derives de ν-(arylalkyl)-1h-pyrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200800402A1 true EA200800402A1 (ru) | 2008-08-29 |
| EA013747B1 EA013747B1 (ru) | 2010-06-30 |
Family
ID=36039505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200800402A EA013747B1 (ru) | 2005-07-22 | 2006-07-19 | Производные n-(арилалкил)-1н-пирролопиридин-2-карбоксамидов, их получение и их применение в терапии |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7763636B2 (ru) |
| EP (1) | EP1912644B1 (ru) |
| JP (1) | JP4938012B2 (ru) |
| KR (1) | KR101257969B1 (ru) |
| CN (1) | CN101247808B (ru) |
| AR (1) | AR057668A1 (ru) |
| AT (1) | ATE451923T1 (ru) |
| AU (1) | AU2006271518B2 (ru) |
| BR (1) | BRPI0614066A2 (ru) |
| CA (1) | CA2615676C (ru) |
| CR (1) | CR9643A (ru) |
| CY (1) | CY1109891T1 (ru) |
| DE (1) | DE602006011170D1 (ru) |
| DK (1) | DK1912644T3 (ru) |
| EA (1) | EA013747B1 (ru) |
| EC (1) | ECSP088105A (ru) |
| ES (1) | ES2338363T3 (ru) |
| FR (1) | FR2888848B1 (ru) |
| HR (1) | HRP20100150T1 (ru) |
| IL (1) | IL188520A (ru) |
| MA (1) | MA29617B1 (ru) |
| MX (1) | MX2008001018A (ru) |
| MY (1) | MY145062A (ru) |
| NI (1) | NI200800021A (ru) |
| NO (1) | NO20080394L (ru) |
| NZ (1) | NZ564870A (ru) |
| PL (1) | PL1912644T3 (ru) |
| PT (1) | PT1912644E (ru) |
| RS (1) | RS51233B (ru) |
| SI (1) | SI1912644T1 (ru) |
| TN (1) | TNSN07485A1 (ru) |
| TW (1) | TWI386407B (ru) |
| UA (1) | UA93881C2 (ru) |
| WO (1) | WO2007010138A2 (ru) |
| ZA (1) | ZA200800439B (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2888847B1 (fr) | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| FR2910473B1 (fr) | 2006-12-26 | 2009-02-13 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique. |
| FR2911605B1 (fr) * | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique |
| WO2008157179A2 (en) * | 2007-06-12 | 2008-12-24 | Genentech, Inc. | N-substituted azaindoles and methods of use |
| FR2919610B1 (fr) * | 2007-08-02 | 2009-10-16 | Sanofi Aventis Sa | Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique |
| FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| FR2926555B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| GB0915892D0 (en) * | 2009-09-10 | 2009-10-14 | Smithkline Beecham Corp | Compounds |
| GB201913756D0 (en) * | 2019-09-24 | 2019-11-06 | Chromatwist Ltd | Contrast agent |
| JP7678595B2 (ja) * | 2020-02-05 | 2025-05-16 | ザ ロックフェラー ユニバーシティー | ピロロ［２，３‐ｂ］ピリジン‐３‐カルボキサミド組成物及び聴力損失を改善するための方法 |
| WO2025100940A1 (ko) * | 2023-11-07 | 2025-05-15 | 보로노이 주식회사 | 헤테로아릴 유도체 화합물 및 이의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08295667A (ja) * | 1995-04-27 | 1996-11-12 | Takeda Chem Ind Ltd | 複素環化合物、その製造法および剤 |
| JP4241970B2 (ja) * | 1998-10-30 | 2009-03-18 | 中外製薬株式会社 | アミド結合を有するインドール誘導体、及びモノ又はジアザインドール誘導体 |
| US6436965B1 (en) * | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
| EP2033953A1 (en) * | 2002-02-15 | 2009-03-11 | Glaxo Group Limited | Vanilloid receptor modulators |
| JP2004091480A (ja) * | 2002-07-11 | 2004-03-25 | Takeda Chem Ind Ltd | ピロロピリジン誘導体およびその用途 |
| AU2003281044A1 (en) * | 2002-07-11 | 2004-02-02 | Takeda Pharmaceutical Company Limited | Pyrrolopyridine derivative and use thereof |
| EP1606289B1 (en) * | 2003-02-14 | 2009-12-02 | Glaxo Group Limited | Carboxamide derivatives |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| FR2897061B1 (fr) * | 2006-02-03 | 2010-09-03 | Sanofi Aventis | Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique. |
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2005
- 2005-07-22 FR FR0507804A patent/FR2888848B1/fr not_active Expired - Fee Related
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2006
- 2006-07-19 WO PCT/FR2006/001767 patent/WO2007010138A2/fr active Application Filing
- 2006-07-19 NZ NZ564870A patent/NZ564870A/en not_active IP Right Cessation
- 2006-07-19 MX MX2008001018A patent/MX2008001018A/es active IP Right Grant
- 2006-07-19 PL PL06778888T patent/PL1912644T3/pl unknown
- 2006-07-19 EP EP06778888A patent/EP1912644B1/fr active Active
- 2006-07-19 DE DE602006011170T patent/DE602006011170D1/de active Active
- 2006-07-19 ES ES06778888T patent/ES2338363T3/es active Active
- 2006-07-19 BR BRPI0614066-1A patent/BRPI0614066A2/pt active Search and Examination
- 2006-07-19 UA UAA200802257A patent/UA93881C2/ru unknown
- 2006-07-19 CN CN200680030739.0A patent/CN101247808B/zh not_active Expired - Fee Related
- 2006-07-19 AU AU2006271518A patent/AU2006271518B2/en not_active Ceased
- 2006-07-19 AT AT06778888T patent/ATE451923T1/de active
- 2006-07-19 KR KR1020087001597A patent/KR101257969B1/ko active Active
- 2006-07-19 SI SI200630591T patent/SI1912644T1/sl unknown
- 2006-07-19 ZA ZA200800439A patent/ZA200800439B/xx unknown
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2008
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2010
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