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  1. Data have shown that vitamin B12 has immunomodulatory effects via different pathways, which could influence the pathophysiology of sepsis. The objective of this study was to investigate whether vitamin B12 lev...

    Authors: Andreas Pregernig, Ulrike Held, Martin Schläpfer and Beatrice Beck-Schimmer
    Citation: BMC Medicine 2024 22:330
    Content type: Research article Published on:

  2. Hypersensitivity reactions (HSRs) can occur unexpectedly and be life-threatening when gadolinium-based contrast agents (GBCAs) are used. Gadolinium deposition disease (GDD) and symptoms associated with gadolin...

    Authors: Han Qu, Wenjing Li, Zhenghua Wu, Yuanyuan Wang, Tingting Feng, Nianyun Li, Chendong Qi, Xiang Li, Taishan Wei, Guorong Fan and Yuefen Lou
    Citation: BMC Medicine 2024 22:329
    Content type: Research article Published on:

  3. Mothers play a crucial role in influencing their daughters’ HPV vaccination decisions. Addressing barriers to receiving HPV vaccination among mothers of girls may achieve two goals in one strike: increasing va...

    Authors: Zian Lin, Siyu Chen, Lixian Su, Yuxue Liao, Hongbiao Chen, Zhiqing Hu, Zhuolin Chen, Yuan Fang, Xue Liang, Jianan Chen, Biyun Luo, Chuanan Wu and Zixin Wang
    Citation: BMC Medicine 2024 22:328
    Content type: Research Published on:

  4. Cervical cancer incidence is rising in Puerto Rico (PR). Whether the increase is real or reflective of increased diagnostic scrutiny remains unclear.

    Authors: Ana P. Ortiz, Carlos R. Torres-Cintrón, Eduardo J. Santiago-Rodríguez, Jeslie M. Ramos-Cartagena, Tonatiuh Suárez-Ramos, Haluk Damgacioglu, Vivian Colón-López, Karen J. Ortiz-Ortiz and Ashish A. Deshmukh
    Citation: BMC Medicine 2024 22:327
    Content type: Research Published on:

  5. The causal relationship between daytime napping and the risk of Parkinson’s disease (PD) remains unclear, with prospective studies providing limited evidence. This study investigated the association between da...

    Authors: Fabin Lin, Yisen Shi, Wenjing Song, Yanhong Weng, Xinyang Zou, Xuanjie Chen, Jiayi Zheng, Ke Chen, Qinyong Ye, Xilin Wu and Guoen Cai
    Citation: BMC Medicine 2024 22:326
    Content type: Research article Published on:

  6. Obesity has been linked to arterial stiffness, while no consensus was reached on the association. We aimed to clarify the association of general and central obesity with arterial stiffness by combining observa...

    Authors: Wuqing Huang, Zhaojing Gan, Ziting Gao, Qiaofen Lin, Xiaojiang Li, Wenhui Xie, Zesen Gao, Zhixian Zhou, Ziyi Qiu, Weihong Qiu, Shanshan Du, Liangwan Chen, Huashan Hong and Weimin Ye
    Citation: BMC Medicine 2024 22:325
    Content type: Research Published on:

  7. A stent with characteristics of a hybrid design may have advantages in improving the patency of symptomatic iliofemoral vein obstruction. This study assessed the safety and effectiveness of the V-Mixtent Venou...

    Authors: Chang Sheng, Xin-Wu Lu, Hong-Tao Shi, Lei Zhang, Sheng-Yun Wan, Hong-Pu Li, Ke Li, Sen Shi, Zhen-Jie Liu, Yu-Xian Luo, Guo-Dong Chen, Mao-Rong Liu, You-Gen Kang, Bo Ye, Kai Yao, Pu Yang…
    Citation: BMC Medicine 2024 22:324
    Content type: Research Published on:

  8. Gastroesophageal reflux disease (GERD) is a common condition characterized by the reflux of stomach contents into the esophagus. Despite its widespread prevalence worldwide, the causal link between GERD and va...

    Authors: Gujie Wu, Yaqiong Liu, Dong Ning, Mengnan Zhao, Xiaoqing Li, Lu Chang, Qili Hu, Yao Li, Lin Cheng and Yiwei Huang
    Citation: BMC Medicine 2024 22:323
    Content type: Research Published on:

  9. In recent years, the Middle East has witnessed a significant rise in commercial transplantation activities. This practice is driven by a multitude of factors including economic disparities, inadequate healthca...

    Authors: Reem M. Alameer, Ahmed A. Alhammadi, Yusri Taha, Talal Al Goufi and Reem S. Almaghrabi
    Citation: BMC Medicine 2024 22:322
    Content type: Debate Published on:

  10. Vitamin A is essential for physiological processes like vision and immunity. Vitamin A’s effect on gut microbiome composition, which affects absorption and metabolism of other vitamins, is still unknown. Here ...

    Authors: Ana M. Valdes, Panayiotis Louca, Alessia Visconti, Francesco Asnicar, Kate Bermingham, Ana Nogal, Kari Wong, Gregory A. Michelotti, Jonathan Wolf, Nicola Segata, Tim D. Spector, Sarah E. Berry, Mario Falchi and Cristina Menni
    Citation: BMC Medicine 2024 22:321
    Content type: Research Published on:

  11. Despite surgical and pharmacological interventions, endometriosis can recur. Reliable information regarding risk of recurrence following a first diagnosis is scant. The aim of this study was to examine clinica...

    Authors: Sarah J. Holdsworth-Carson, Jessica Chung, Dorothy A. Machalek, Rebecca Li, Byung Kyu Jun, Meaghan J. Griffiths, Molly Churchill, Tristan McCaughey, Debbie Nisbet, Uri Dior, Jacqueline F. Donoghue, Grant W. Montgomery, Charlotte Reddington, Jane E. Girling, Martin Healey and Peter A. W. Rogers
    Citation: BMC Medicine 2024 22:320
    Content type: Research Published on:

  12. Childhood maltreatment (CM) has been indicated in adverse health outcomes across the lifespan, including severe infection-related outcomes. Yet, data are scarce on the potential role of CM in severe COVID-19-r...

    Authors: Yue Wang, Fenfen Ge, Thor Aspelund, Helga Ask, Arna Hauksdóttir, Kejia Hu, Jóhanna Jakobsdóttir, Helga Zoega, Qing Shen, Heather C. Whalley, Ole Birger Vesterager Pedersen, Kelli Lehto, Ole A. Andreassen, Fang Fang, Huan Song and Unnur A. Valdimarsdóttir
    Citation: BMC Medicine 2024 22:319
    Content type: Research article Published on:

  13. This paper investigates the consequences of the COVID-19 pandemic on mortality and hospitalization among nursing home residents in Norway. While existing evidence shows that nursing home residents were overrep...

    Authors: Henning Øien, Jonas Gjesvik, Katrine Damgaard Skyrud, Torill Alise Rotevatn and Mari Grøsland
    Citation: BMC Medicine 2024 22:318
    Content type: Research article Published on:

  14. The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) serves as a novel composite lipid indicator for atherosclerosis. However, the association between NHHR and mort...

    Authors: Binyang Yu, Min Li, Zongliang Yu, Tao Zheng, Xue Feng, Anran Gao, Haoling Zhang and Rui Gao
    Citation: BMC Medicine 2024 22:317
    Content type: Research Published on:

  16. Oral squamous cell carcinoma (OSCC) causes significant mortality and morbidity worldwide. Surgical resection with adjuvant radiotherapy remains the standard treatment for locally advanced resectable OSCC. Resu...

    Authors: Wen Jiang, Lan Chen, Rongrong Li, Jiang Li, Shengjin Dou, Lulu Ye, Yining He, Zhen Tian, Yanli Yao and Guopei Zhu
    Citation: BMC Medicine 2024 22:314
    Content type: Research article Published on:

  17. Chronic pain was associated with a higher risk of mental disorders (e.g., depression and anxiety). However, the role of 24-h movement behaviors in the association remains unclear.

    Authors: Jiade Chen, Xuanbi Fang, Fan Zhang, Jiaxin Shen, Yuanhang Liu, Peng Xu, Rongrong Ye, Qingguang Zhong, Guanren Chen, Zhehao Wang, Shentong Chen, Lixia Li, Ziqiang Lin and Yanhui Gao
    Citation: BMC Medicine 2024 22:313
    Content type: Research article Published on:

  18. The COVID-19 pandemic disrupted tuberculosis (TB) health services, including treatment support and access to drugs, as patients were not able to access health facilities. While the effect of this disruption on...

    Authors: Vester Gunsaru, Marc Y. R. Henrion and C. Finn McQuaid
    Citation: BMC Medicine 2024 22:312
    Content type: Research Published on:

    The Correction to this article has been published in BMC Medicine 2024 22:316

  19. Clinical practice guidelines are crucial for enhancing healthcare quality and patient outcomes. Yet, their implementation remains inconsistent across various professions and disciplines. Previous findings on t...

    Authors: Theresa Halms, Gabriele Gaigl, Carolin Lorenz, Duygu Güler, Naiiri Khorikian-Ghazari, Astrid Röh, Angelika Burschinski, Wolfgang Gaebel, Marisa Flick, Charline Pielenz, Eva Salveridou-Hof, Thomas Schneider-Axmann, Marco Schneider, Elias Wagner, Peter Falkai, Susanne Lucae…
    Citation: BMC Medicine 2024 22:311
    Content type: Research Published on:

  20. Uterine corpus endometrial carcinoma (UCEC) is a prevalent gynecologic malignancy with a favorable prognosis if detected early. However, there is a lack of accurate and reliable early detection tests for UCEC....

    Authors: Jing Liu, Dan Hu, Yibin Lin, Xiaoxi Chen, Ruowei Yang, Li Li, Yanyan Zhan, Hua Bao, LeLe Zang, Mingxuan Zhu, Fei Zhu, Junrong Yan, Dongqin Zhu, Huiqi Zhang, Benhua Xu and Qin Xu
    Citation: BMC Medicine 2024 22:310
    Content type: Research article Published on:

  21. Exposure to famine in the prenatal period is associated with an increased risk of metabolic disease, including obesity and type 2 diabetes. We employed nuclear magnetic resonance (NMR) metabolomic profiling to...

    Authors: M. Jazmin Taeubert, Thomas B. Kuipers, Jiayi Zhou, Chihua Li, Shuang Wang, Tian Wang, Elmar W. Tobi, Daniel W. Belsky, L. H. Lumey and Bastiaan T. Heijmans
    Citation: BMC Medicine 2024 22:309
    Content type: Research Published on:

  22. A prediction model can be a useful tool to quantify the risk of a patient developing dementia in the next years and take risk-factor-targeted intervention. Numerous dementia prediction models have been develop...

    Authors: Luis H. John, Egill A. Fridgeirsson, Jan A. Kors, Jenna M. Reps, Ross D. Williams, Patrick B. Ryan and Peter R. Rijnbeek
    Citation: BMC Medicine 2024 22:308
    Content type: Research article Published on:

  23. Breast cancer is the second most common cause of cancer mortality worldwide. Biomarker discovery has led to advances in understanding molecular phenotyping and thus has a great potential for precision manageme...

    Authors: K-V. Savva, A. MacKenzie, R. C. Coombes, N. M. Zhifang, B. G. Hanna and C. J. Peters
    Citation: BMC Medicine 2024 22:307
    Content type: Research article Published on:

  24. The net benefit of aspirin cessation in older adults remains uncertain. This study aimed to use observational data to emulate a randomized trial of aspirin cessation versus continuation in older adults without...

    Authors: Zhen Zhou, Katherine L. Webb, Mark R. Nelson, Robyn L. Woods, Michael E. Ernst, Anne M. Murray, Andrew T. Chan, Andrew Tonkin, Christopher M. Reid, Suzanne G. Orchard, Brenda Kirpach, Raj C. Shah, Nigel Stocks, Jonathan C. Broder and Rory Wolfe
    Citation: BMC Medicine 2024 22:306
    Content type: Research article Published on:

  25. Geroscience focuses on interventions to mitigate molecular changes associated with aging. Lifestyle modifications, medications, and social factors influence the aging process, yet the complex molecular mechani...

    Authors: Varun B. Dwaraka, Lucia Aronica, Natalia Carreras-Gallo, Jennifer L. Robinson, Tayler Hennings, Matthew M. Carter, Michael J. Corley, Aaron Lin, Logan Turner, Ryan Smith, Tavis L. Mendez, Hannah Went, Emily R. Ebel, Erica D. Sonnenburg, Justin L. Sonnenburg and Christopher D. Gardner
    Citation: BMC Medicine 2024 22:301
    Content type: Research article Published on:

  27. To systematically analyze differences in atherosclerotic cardiovascular disease (ASCVD) burden between young and older adults.

    Authors: Ziyi Li, Yucheng Yang, Xuechen Wang, Na Yang, Liyun He, Jialu Wang, Fan Ping, Lingling Xu, Huabing Zhang, Wei Li and Yuxiu Li
    Citation: BMC Medicine 2024 22:303
    Content type: Research article Published on:

  28. The prevalence of autism in Denmark has been increasing, reaching 1.65% among 10-year-old children, and similar trends are seen elsewhere. Although there are several factors associated with autism, including g...

    Authors: Filip Ottosson, Francesco Russo, Anna Abrahamsson, Nadia MacSween, Julie Courraud, Kristin Skogstrand, Olle Melander, Ulrika Ericson, Marju Orho-Melander, Arieh S. Cohen, Jakob Grove, Preben Bo Mortensen, David M. Hougaard and Madeleine Ernst
    Citation: BMC Medicine 2024 22:302
    Content type: Research article Published on:

  29. Multiple high doses of 131I therapy in patients with differentiated thyroid cancer (DTC) might disrupt the balance of gut microbiota and metabolites. This study aimed to investigate the alterations of intestinal ...

    Authors: Ganghua Lu, Dingwei Gao, Yixian Liu, Xiaqing Yu, Wen Jiang and Zhongwei Lv
    Citation: BMC Medicine 2024 22:300
    Content type: Research article Published on:

  30. Rett syndrome (RTT) is a rare, life-threatening, genetic neurodevelopmental disorder. Treatment in RTT encounters many challenges. Trofinetide, a modified amino-terminal tripeptide of insulin-like growth facto...

    Authors: Hazem E. Mohammed, Zeyad Bady, Mohamed E. Haseeb, Heba Aboeldahab, Wessam E. Sharaf-Eldin and Maha S. Zaki
    Citation: BMC Medicine 2024 22:299
    Content type: Research article Published on:

  31. Limited evidence demonstrated the potential relationship between dietary sugar intake and dementia. This association demands further clarification in a large-scale population.

    Authors: Sirui Zhang, Yi Xiao, Yangfan Cheng, Yuanzheng Ma, Jiyong Liu, Chunyu Li and Huifang Shang
    Citation: BMC Medicine 2024 22:298
    Content type: Research article Published on:

  32. Many European countries experienced outbreaks of mpox in 2022, and there was an mpox outbreak in 2023 in the Democratic Republic of Congo. There were many apparent differences between these outbreaks and previ...

    Authors: Madhav Chaturvedi, Isti Rodiah, Mirjam Kretzschmar, Stefan Scholz, Berit Lange, André Karch and Veronika K. Jaeger
    Citation: BMC Medicine 2024 22:297
    Content type: Research article Published on:

  33. Sexually transmitted infections (STIs) pose a significant global public health challenge. Early diagnosis and treatment reduce STI transmission, but rely on recognising symptoms and care-seeking behaviour of t...

    Authors: Nyi N. Soe, Zhen Yu, Phyu M. Latt, David Lee, Jason J. Ong, Zongyuan Ge, Christopher K. Fairley and Lei Zhang
    Citation: BMC Medicine 2024 22:296
    Content type: Research article Published on:

  34. The increasing incidence of coeliac disease is leading to a growing interest in active search for associated factors, even the intrauterine and early life. The exposome approach to disease encompasses a life c...

    Authors: María de Lourdes Moreno, María González-Rovira, Cristina Martínez-Pancorbo, María Martín-Cameán, Ana María Nájar-Moyano, Mercedes Romero, Esther de la Hoz, Cristina López-Beltrán, Encarnación Mellado, José Luis Bartha, Petter Brodin, Alfonso Rodríguez-Herrera, José Antonio Sainz-Bueno and Carolina Sousa
    Citation: BMC Medicine 2024 22:295
    Content type: Research Published on:

  35. Endometriosis, defined as the presence of endometrial-like tissue outside of the uterus, is one of the most prevalent gynecological disorders. Although different theories have been proposed, its pathogenesis i...

    Authors: Inmaculada Pérez-Prieto, Eva Vargas, Eduardo Salas-Espejo, Kreete Lüll, Analuce Canha-Gouveia, Laura Antequera Pérez, Juan Fontes, Andres Salumets, Reidar Andreson, Oliver Aasmets, Katrine Whiteson, Elin Org and Signe Altmäe
    Citation: BMC Medicine 2024 22:294
    Content type: Research article Published on:

  36. This study is to propose a clinically applicable 2-echelon (2e) diagnostic criteria for the analysis of thyroid nodules such that low-risk nodules are screened off while only suspicious or indeterminate ones a...

    Authors: Dong Xu, Lin Sui, Chunquan Zhang, Jing Xiong, Vicky Yang Wang, Yahan Zhou, Xinying Zhu, Chen Chen, Yu Zhao, Yiting Xie, Weizhen Kong, Jincao Yao, Lei Xu, Yuxia Zhai and Liping Wang
    Citation: BMC Medicine 2024 22:293
    Content type: Research article Published on:

  38. Authors: Fang-Hua Liu, Jia-Kai Guo, Wei-Yi Xing, Xue-Li Bai, Yu-Jiao Chang, Zhao Lu, Miao Yang, Ying Yang, Wen-Jing Li, Xian-Xian Jia, Tao Zhang, Jing Yang, Jun-Tong Chen, Song Gao, Lang Wu, De-Yu Zhang…
    Citation: BMC Medicine 2024 22:291
    Content type: Correction Published on:

    The original article was published in BMC Medicine 2024 22:206

  40. Epigenetic clocks were known as promising biomarkers of aging, including original clocks trained by individual CpG sites and principal component (PC) clocks trained by PCs of CpG sites. The effects of genetic ...

    Authors: Ke Miao, Shunkai Liu, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao…
    Citation: BMC Medicine 2024 22:289
    Content type: Research Published on:

  41. Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown to be at higher risk of infection and adverse outcomes. The re...

    Authors: Colm D. Andrews, Rohini Mathur, Jon Massey, Robin Park, Helen J. Curtis, Lisa Hopcroft, Amir Mehrkar, Seb Bacon, George Hickman, Rebecca Smith, David Evans, Tom Ward, Simon Davy, Peter Inglesby, Iain Dillingham, Steven Maude…
    Citation: BMC Medicine 2024 22:288
    Content type: Research article Published on:

  42. Despite the many benefits of school meals, not all students participate. One reason students may not participate in school meals is because they instead purchase breakfast or lunch from food outlets located ar...

    Authors: Emily M. Melnick, Francesco Acciai, Michael J. Yedidia and Punam Ohri-Vachaspati
    Citation: BMC Medicine 2024 22:287
    Content type: Research article Published on:

  43. Advanced practice providers (APPs), including physician assistants/associates (PAs), nurse practitioners (NPs) and other non-physician roles, have been developed largely to meet changing healthcare demand and ...

    Authors: Yingxi Zhao, Wesley Quadros, Shobhana Nagraj, Geoff Wong, Mike English and Attakrit Leckcivilize
    Citation: BMC Medicine 2024 22:286
    Content type: Research Published on:

  44. This study employs systematic review and meta-analysis to explore the incidence and characteristics of spinal cord injury (SCI) between 2000 and 2021, aiming to provide the most recent and comprehensive data s...

    Authors: Yubao Lu, Zhizhong Shang, Wei Zhang, Mao Pang, Xuchang Hu, Yu Dai, Ruoqi Shen, Yingjie Wu, Chenrui Liu, Ting Luo, Xin Wang, Bin Liu, Liangming Zhang and Limin Rong
    Citation: BMC Medicine 2024 22:285
    Content type: Research Published on:

  45. Infant neurodevelopment in the first years after birth is determined by multiple factors, including parental care and maternal mental wellbeing. In this study, we aim to assess the impact of persistent materna...

    Authors: Ashish KC, Jaya Chandna, Ankit Acharya, Rejina Gurung, Carin Andrew and Alkistis Skalkidou
    Citation: BMC Medicine 2024 22:284
    Content type: Research article Published on:

  46. Chronic pelvic pain (CPP) is a multifactorial syndrome that can substantially affect a patient’s quality of life. Endometriosis is one cause of CPP, and alterations of the immune and microbiome profiles have b...

    Authors: Nicole Jimenez, Taylor Norton, Gurbeen Diadala, Emerald Bell, Michelle Valenti, Leslie V. Farland, Nichole Mahnert and Melissa M. Herbst-Kralovetz
    Citation: BMC Medicine 2024 22:283
    Content type: Research Published on:

  47. The advances in deep learning-based pathological image analysis have invoked tremendous insights into cancer prognostication. Still, lack of interpretability remains a significant barrier to clinical application.

    Authors: Guang-Yu Ding, Wei-Min Tan, You-Pei Lin, Yu Ling, Wen Huang, Shu Zhang, Jie-Yi Shi, Rong-Kui Luo, Yuan Ji, Xiao-Ying Wang, Jian Zhou, Jia Fan, Mu-Yan Cai, Bo Yan and Qiang Gao
    Citation: BMC Medicine 2024 22:282
    Content type: Research article Published on:

  48. The increase in population aging highlights the growing prevalence of mild cognitive impairment, prompting the adoption of interventions that combine physical exercise and cognitive training to improve health ...

    Authors: Yolanda Castellote-Caballero, María del Carmen Carcelén Fraile, Agustín Aibar-Almazán, Diego Fernando Afanador-Restrepo and Ana María González-Martín
    Citation: BMC Medicine 2024 22:281
    Content type: Research Published on:

  49. Social prescribing is gaining traction internationally. It is an approach which seeks to address non-medical and health-related social needs through taking a holistic person-centred and community-based approac...

    Authors: Amadea Turk, Stephanie Tierney, Bernie Hogan, Kamal R. Mahtani and Catherine Pope
    Citation: BMC Medicine 2024 22:280
    Content type: Research Published on:
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