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WO2011016529A1 - 組成物およびその製造方法 - Google Patents

組成物およびその製造方法 Download PDF

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Publication number
WO2011016529A1
WO2011016529A1 PCT/JP2010/063316 JP2010063316W WO2011016529A1 WO 2011016529 A1 WO2011016529 A1 WO 2011016529A1 JP 2010063316 W JP2010063316 W JP 2010063316W WO 2011016529 A1 WO2011016529 A1 WO 2011016529A1
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Prior art keywords
water
drug
composition according
composition
particle diameter
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PCT/JP2010/063316
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English (en)
French (fr)
Japanese (ja)
Inventor
秀泰 辻
康広 辻
岡　徹
茂 杉
真澄 鳥居
悠 宮尾
喜光 中山
智之 鳥居
正仁 森
Original Assignee
株式会社協和機設
サンスター技研株式会社
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Application filed by 株式会社協和機設, サンスター技研株式会社 filed Critical 株式会社協和機設
Priority to AU2010279931A priority Critical patent/AU2010279931B2/en
Priority to CA2767993A priority patent/CA2767993C/en
Priority to JP2011525937A priority patent/JPWO2011016529A1/ja
Priority to EP10806528.5A priority patent/EP2463022B1/en
Priority to CN201080035024.0A priority patent/CN102470335B/zh
Priority to SG2012003224A priority patent/SG177681A1/en
Publication of WO2011016529A1 publication Critical patent/WO2011016529A1/ja
Priority to US13/361,150 priority patent/US20120128749A1/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0052—Preparation of gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/54—Mixing with gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Definitions

  • the present invention relates to a composition containing a large amount of ultrafine bubbles and a drug, a dispersion in which a hydrophobic drug is dispersed in water without using a surfactant, a production method thereof, and a cleaning agent having a specific composition
  • the present invention relates to a composition and a cleaning method using the cleaning composition.
  • nanobubbles In recent years, an apparatus for generating ultrafine bubbles called nanobubbles has been developed. However, its use is limited to the use of water containing nanobubbles for cleaning and wastewater treatment, and no research has been conducted on systems containing drugs.
  • JP 2008-238165 is known as a method of using a bubble having a relatively large diameter and a chemical substance instead of nanobubbles.
  • the invention described in this patent application relates to a dispersion method for stably maintaining a dispersion liquid in which a substance is dispersed in a liquid, wherein the dispersion liquid contains bubbles.
  • this method improves the stability of the dispersion obtained by making bubbles present when producing the dispersion, and does not mean that bubbles are present in the obtained dispersion.
  • the preferred diameter of the bubbles used in the invention described in the patent is 30 to 1000 microns, and the bubbles of 1000 microns (1 mm) cannot exist stably in the dispersion for a long time.
  • the particle size of the bubbles is very different from the ultrafine bubbles used in the present invention, and the effect is that 10% or more of the oil dispersed in 48 hours is separated as shown in the examples. And it was never satisfactory.
  • the present inventor has found that a composition containing a novel nano-domain ultrafine bubble and a drug exhibits the effect of the drug better, and when the drug is dispersed, the composition can be stably dispersed without using a surfactant. It was found that the body could be obtained, and the present invention was completed.
  • the present invention relates to a composition comprising a novel nano-domain ultrafine bubble and a drug, and a novel nano-domain ultrafine bubble and a dispersion comprising a hydrophobic drug dispersed as particles. Furthermore, the present invention relates to a cleaning composition having a specific composition and a cleaning method using the cleaning composition. The present invention also provides methods for producing the above compositions and dispersions.
  • the present invention provides a composition comprising ultrafine bubbles having a mode particle diameter of 500 nm or less, a drug, and water.
  • the drug is a water-soluble drug and is dissolved in water.
  • the drug is a hydrophobic drug and is dispersed in water. That is, the hydrophobic drug is dispersed as dispersoid particles in water as a dispersion medium.
  • the mode particle diameter of the dispersed drug particles is preferably in the range of 0.05 ⁇ m to 15 ⁇ m.
  • the average particle size of the drug particles is also preferably in the range of 0.05 ⁇ m to 15 ⁇ m.
  • fine drug particles having a mode particle diameter and / or an average particle diameter of 0.05 ⁇ m to 3 ⁇ m can be formed.
  • the hydrophobic drug refers to a drug that is hardly soluble in water and oil-soluble.
  • the ultrafine bubbles have a mode particle diameter of 500 nm or less, preferably a mode particle diameter of 300 nm or less, most preferably a mode particle diameter of 150 nm or less, and 1 million or more, preferably 3 million or more per ml. More preferably, there are 4 million or more, most preferably 5 million or more.
  • the surface of ultrafine bubbles contained in the composition or dispersion is charged, and the absolute value of the zeta potential is 5 mV or more.
  • the drug is a transpiration substance.
  • the transpirable substance is at least one selected from the group consisting of insecticides, fungicides, repellents, allergen deactivators, deodorants, fungicides, fragrances, essential oils and perfumes. It is a substance.
  • the composition or dispersion of the present invention can be in the form of gel as well as liquid.
  • agar, carrageenan, gelatin, water-absorbing resin, aqueous polymer and the like can be used.
  • carrageenan is added to distilled water, heated to prepare a carrageenan solution, and mixed well with a composition containing fine bubbles, a drug and water. This can be cooled to room temperature to form a gel dispersion.
  • it can also be set as mist using a spraying apparatus.
  • the present invention further uses alkaline electrolyzed water as water, uses one or more compounds selected from terpenes as a drug, and is selected from the group consisting of air, oxygen, hydrogen and nitrogen in ultrafine bubbles.
  • a cleaning composition containing at least one gas, and a cleaning method using the cleaning composition and applying ultrasonic waves are provided.
  • the present invention further includes the generation of ultrafine bubbles having a mode particle diameter of 500 nm or less in an aqueous solution of a water-soluble drug by an ultrafine bubble generator, and the ultrafine bubbles having a mode particle diameter of 500 nm or less. And a water-soluble drug, and water, wherein the water-soluble drug is dissolved in water.
  • the present invention further includes generating ultrafine bubbles having a mode particle diameter of 500 nm or less in a mixture of a dispersoid and a liquid dispersion medium by an ultrafine bubble generator, wherein the mode particle diameter is 500 nm or less.
  • a method for producing a composition comprising ultrafine bubbles, a hydrophobic drug, and water, wherein the hydrophobic drug is dispersed in water.
  • the present invention has a mode particle diameter of 500 nm or less, including adding a hydrophobic agent after generating ultrafine bubbles having a mode particle diameter of 500 nm or less in water by an ultrafine bubble generator.
  • a method for producing a composition comprising ultrafine bubbles, a hydrophobic drug, and water, wherein the hydrophobic drug is dispersed in water.
  • the effect of the drug is better expressed.
  • the drug when the drug is transpirationable, its transpiration performance is improved and the concentration of the drug in the composition can be lowered.
  • the drug is a fungicide or the like, the permeability of the drug is improved and a greater effect can be obtained.
  • a transpiration method a method of evaporating by heating, a method of evaporating chemicals by wind power, a method of evaporating by an ultrasonic oscillator, etc. have been used.
  • the production cost of the transpiration device is increased and the operation cost is also generated.
  • the present invention is advantageous in that it is safe and low in the manufacturing cost of the apparatus, does not require an operating cost, and can be safely applied to a wide variety of substances.
  • the hydrophobic drug when the hydrophobic drug is dispersed in water, an effect of providing a long-term stable dispersion without using a surfactant can be obtained. Since the surfactant is not used, the cost can be reduced and the waste liquid treatment due to the surfactant is not necessary. In particular, when reducing the particle size in order to improve the dispersion stability of the dispersion, it was necessary to use a large amount of surfactant, whereas in the present invention, it is not necessary to use a surfactant. It is possible to solve the problem of further reduction in cost and reduction in the effective amount of the substance that is actually dispersed due to an increase in the amount of surfactant used.
  • production at the time of generating the ultrafine bubble used in this invention and the change of the particle distribution of the bubble until after three months are shown.
  • Measurement device: Multisizer 3 The measurement result of the particle size of the ultrafine bubble used in this invention is shown.
  • Measurement device: Nano particle size analysis system Nanosite series The measurement result of the particle size of the ultrafine bubble used in this invention is shown.
  • Measurement device: Nano particle size analysis system Nanosite series The measurement result of the zeta potential of the ultrafine bubbles used in the present invention is shown.
  • FIG. (Measurement device: ELSZ-1 manufactured by Otsuka Electronics Co., Ltd.) It is a figure which shows the particle size distribution immediately after preparation of the dispersion obtained in Example 2.
  • FIG. (Measuring device: Particle size distribution measuring device LS 13 320) It is a figure which shows the particle size distribution after storing the dispersion obtained in Example 2 at room temperature for 3 months.
  • Measurement device: Particle size distribution measuring device LS 13 320 It is a figure which shows the particle size distribution after preserve
  • FIG. (Measuring device: Particle size distribution measuring device LS 13 320) It is a figure which shows the particle size distribution immediately after preparation of the dispersion obtained in Example 3.
  • FIG. (Measuring device: Particle size distribution measuring device LS 13 320) It is a figure which shows the particle size distribution after preserve
  • (Measuring device: Particle size distribution measuring device LS 13 320) It is a figure which shows the particle size distribution after preserve
  • the present invention provides a composition comprising ultrafine bubbles having a mode particle diameter of 500 nm or less, a drug, and water.
  • the particle size of the ultrafine bubbles used in the present invention is so small that it cannot be accurately measured with a normal particle size distribution analyzer. Therefore, in this specification, numerical values measured by the nanoparticle analysis system Nanosite Series (manufactured by NanoSight) are used. Nanoparticle analysis system Nanosite Series (manufactured by NanoSight) measures the speed of Brownian motion of nanoparticles and calculates the particle diameter from that speed. The mode particle size can be confirmed from the particle size distribution of the existing particles.
  • the inside of the ultrafine bubbles is generally air, but may be other gases such as oxygen, hydrogen, nitrogen, carbon dioxide and ozone.
  • the drug can be any compound that acts effectively for the desired purpose.
  • various water-soluble natural products lower alcohols, glycols, esters, acids, bases, salts, water-soluble polymers, water-soluble proteins such as water-soluble proteins, and plant-derived oils, Hydrophobic substances such as animal-derived oils, fats and oils, hydrocarbons, waxes, esters, fatty acids, higher alcohols, water-insoluble polymers, oil-soluble pigments, and oil-soluble proteins
  • various pharmaceuticals, cosmetics, insecticides, fungicides, agricultural chemicals, fertilizers, vitamins, paints, adhesives, infiltrants, and the like are exemplified, but the invention is not limited thereto.
  • Water can be distilled water, ultra-pure, high-purity, pure water, tap water, ion-exchanged water, filtered water, electrolytic water, natural water, and the like. If there is no problem in performance, a small amount of a water miscible solvent such as alcohol may be included as a cosolvent.
  • a water miscible solvent such as alcohol
  • the drug is dissolved in water.
  • water-soluble drug any water-soluble drug can be used, preferred water-soluble drugs used in this embodiment include, for example, fungicides, fragrances, allergen deactivators, deodorants, bactericides, repellents, etc. Can be given.
  • water-soluble drugs examples include sodium hypochlorite, chlorlime lime mercurochrome, alcohols (ethanol, isopropanol, etc.), hydrogen peroxide, reverse soap (benzalkonium chloride, cetylpyridinium chloride, etc.), surfactants Phenols (such as cresol soap solution), catechol, 4-methylcatechol, 5-methylcatechol, resorcinol, 2-methylresorcinol, 5-methylresorcinol, diphenols such as hydroquinone, 4,4′-biphenyldiol and Polyhydroxyamine compounds such as 3,4'-diphenyldiol, dopa, dopamine, caffeic acid, paracoumarin acid, tyrosine, ethanolamine, triethanolamine, tris (hydroxymethyl) aminomethane, or polyphenol Flavones (apigenin, luteolin, tangerine, diosmine, flavoxate), isoflavones (cumesterol, daidzein, d
  • the drug is dispersed in water.
  • the drug forms a discontinuous phase as a dispersoid and water forms a continuous phase as a dispersion medium.
  • Preferable hydrophobic drugs used in this embodiment include insecticides, bactericides, repellents, allergen deactivators, deodorants, fungicides, fragrances, essential oils, and fragrances.
  • hydrophobic drugs examples include pyrethroid agents (pyretrin, permethrin, etofenprox, etc.), organic phosphorus agents (parathion, dichlorvos, marathon, fenitrothion, etc.), carbamate agents (carbaryl, propoxer, fenocarb, etc.), chloronicotinyl agents (Imidocloprid, acetamiprid, dinotefuran, etc.), iodine agent (iodo tincture, povidone iodine), triclosan, isopropylmethylphenol, acrinol, diethylamide di-N-propylisocincomeronate, 2,3,4,5-bis ( ⁇ 2-butylene) ) Tetrahydrofurfural, dinormalpropyl isocincomeronate, N-octyl-bicycloheptene dicarboximide, ⁇ -naphthol and cycloheximide,
  • the mode particle diameter of the drug particles is in the range of 0.05 ⁇ m to 15 ⁇ m, more preferably in the range of 0.05 ⁇ m to 6 ⁇ m.
  • ultrafine drug particles in the range of 0.05 ⁇ m to 3 ⁇ m can be formed.
  • the average particle diameter of the drug particles can also preferably be in the range of 0.05 ⁇ m to 15 ⁇ m, more preferably in the range of 0.05 ⁇ m to 6 ⁇ m.
  • ultrafine drug particles having an average particle diameter ranging from 0.05 ⁇ m to 3 ⁇ m can be formed.
  • the particle size distribution of the dispersed drug particles referred to in the present invention is measured by a particle size distribution measuring device LS 13-320 (manufactured by Beckman Coulter).
  • the mode diameter is a maximum value of volume% or number% with respect to the particle diameter, and is also called a mode diameter.
  • the average diameter is a number average diameter or a volume average diameter.
  • the particle size distribution shown by the below-mentioned Example is the particle size distribution of the chemical
  • ultrafine bubbles per ml there are 1 million or more ultrafine bubbles per ml, preferably 3 million or more, more preferably 4 million or more, and most preferably 5 million or more per ml.
  • the number of ultrafine bubbles mentioned in the present specification is also measured by a nanoparticle analysis system Nanosite Series (manufactured by NanoSight).
  • alkaline electrolyzed water is used as water, and a terpene compound, preferably at least one compound selected from terpene hydrocarbons and terpene alcohols, is used as a drug.
  • a cleaning composition comprising at least one gas selected from the group consisting of hydrogen, oxygen and nitrogen, and a cleaning method using the cleaning composition and applying ultrasonic waves.
  • alkaline electrolyzed water suitably used in the present invention, those having a pH of 10 or more, preferably 10 to 13, can be used. Examples of such alkaline electrolyzed water include those having a pH of 11.7 sold by Felicity Co., Ltd. under the product name “strong alkaline water”.
  • terpene hydrocarbons preferably used in the present invention include pinene, menten, cymene, ferrandrene, menthane, and limonene.
  • terpene alcohol preferably used in the present invention include citronellol, pinocampheol, geraniol, fentil alcohol, nerol and borneol. The above examples are non-limiting examples and are not limited to these compounds.
  • terpene hydrocarbon is preferably used, and limonene is most preferably used. Within the ultrafine bubbles, air, oxygen, hydrogen and nitrogen gases can be present alone or in a mixed gas.
  • bubbles containing hydrogen and bubbles containing nitrogen may be mixed, or bubbles containing a mixed gas of hydrogen and nitrogen may exist.
  • the most preferable effect is obtained when hydrogen is used as the gas.
  • the mixing ratio of the gas can be appropriately determined experimentally from the viewpoint of safety and cost as well as the cleaning effect.
  • the cleaning composition of the present invention is suitably used for removing metal stains and rust, and stains adhering to various substrates such as plastics and fabrics. Further, cleaning is preferably performed while generating ultrasonic waves in the cleaning agent.
  • a known apparatus can be used for ultrasonic generation, and the frequency and intensity can be easily determined to be appropriate values experimentally. In order to “generate ultrasonic waves in the cleaning agent”, it is generally sufficient to put the cleaning agent in a bath equipped with an ultrasonic generator. However, ultrasonic waves are applied to the cleaning agent and / or the object to be cleaned. Any method can be used as long as it can be irradiated.
  • the excellent effect in the present invention can be obtained by the following mechanism. That is, when the drug is water-soluble, the movement of the drug molecule is activated by the movement of the ultrafine bubbles, and the action effect is increased. It is thought to show an effect.
  • the drug when the drug is hydrophobic and dispersed in water, it is considered that ultrafine bubbles gather on the surface of the drug dispersed particles, and the dispersed particles are stabilized by the surface-active effect caused by the zeta potential of the bubble surface. ing. Therefore, it is important that the number of ultrafine bubbles is kept within a preferable range.
  • the zeta potential on the surface of the ultrafine bubbles contained in the composition or the dispersion is also important for achieving the effects of the present invention.
  • the surface of the ultrafine bubbles used in the present invention is charged, and the absolute value of the zeta potential thereof is 5 mV or more, preferably 7 mV or more. Further, since the absolute value of the zeta potential is proportional to the viscosity of the solution / the dielectric constant of the solution, it is considered that the dispersion stability increases as the ultrafine bubbles, the drug and the water are treated under low temperature conditions.
  • Ultrafine bubbles having a mode particle diameter of 500 nm or less used in the present invention can be obtained by any known means, for example, a static mixer type, a venturi type, a cavitation type, a vapor agglomeration type, an ultrasonic type, a swirling type, It can be generated by a pressure melting method or a fine pore method.
  • a preferred method for generating bubbles is a gas-liquid mixed shearing method.
  • An apparatus useful for generating ultrafine bubbles by the gas-liquid mixed shearing method is, for example, an apparatus disclosed in Japanese Patent No. 4118939.
  • this device most of the gas-liquid mixed fluid introduced into the fluid swirl chamber is temporarily directed in the direction opposite to the direction in which the discharge port is located, unlike the conventional device described above. Proceed as a swirl flow. Then, the swirl flow is reversed by the first end wall member and proceeds from the first end wall member toward the second end wall member. At this time, the swirl rotation radius is changed to the first end wall member. Since the flow velocity is smaller than when traveling, the flow velocity becomes high. Therefore, the shearing force to the gas contained in the liquid is increased, and the miniaturization is promoted.
  • the composition of the present invention in which the drug is dissolved in water is produced by treating the drug aqueous solution with an ultrafine bubble generator and generating ultrafine bubbles in the aqueous solution. can do.
  • compositions of the invention that are dispersed in water can be prepared.
  • the composition of the present invention in which the hydrophobic drug is dispersed in water can be produced by treating the water with an ultrafine bubble generator to generate ultrafine bubbles in water and then adding the hydrophobic drug. it can.
  • a hydrophobic drug that is solid at room temperature by being heated and melted or dissolved in a solvent.
  • Example 1 Ultrafine bubbles were generated using 18.2 M ⁇ / cm of pure water by “BAVITAS” manufactured by Kyowa Kikai Co., Ltd., which is an ultrafine bubble generator using a gas-liquid mixed shear method.
  • the change in particle size distribution at the time of generation and bubble particle distribution up to 3 months later is shown in FIG.
  • the particle size distribution was measured with Multisizer 3 (manufactured by Beckman Coulter). It is shown that no change in the number is observed in the portion having a particle diameter of 1 ⁇ m or less.
  • the particle size of the ultrafine bubbles generated at the same time was measured using a nanoparticle analysis system Nanosite Series (manufactured by NanoSight). The measurement results are shown in FIGS.
  • FIG. 2 shows the measurement results after 24 hours from the generation of ultrafine bubbles
  • FIG. 3 shows the measurement results after 48 hours. It was confirmed that the mode particle diameter of the bubbles was 500 nm or less, about 4 to 8 million bubbles in 1 ml, and the generated ultrafine bubbles were stably present in water for a long time. .
  • the zeta potential of the generated bubbles was measured with a zeta potential measurement system ELSZ-1 manufactured by Otsuka Electronics Co., Ltd. The results are shown in FIG. This measurement indicated that the zeta potential was maintained over a long period of time and that bubbles were present stably.
  • Example 2-5 A mixture having the composition shown in Table 1 below was processed under the same conditions as in Example 1 by “BAVITAS” manufactured by Kyowa Kikai Co., Ltd. However, distilled water was used instead of pure water. The results are shown in Table 1.
  • Example 2-4 it was shown that the hydrophobic drug was stably dispersed. Those stored at room temperature (RT) and those stored at 40 ° C. maintain a good emulsified state.
  • FIG. 5-13 shows the particle size distribution measured immediately after preparation of the dispersion obtained in Example 2-4 and after storage at room temperature and 40 ° C. using a particle size distribution analyzer LS 13 320 (manufactured by Beckman Coulter). The results are shown. Taking the horizontal axis as the particle diameter, volume% (upper figure) and number% (lower figure) with respect to each particle diameter were measured. In addition, the average diameter, median diameter, and mode diameter in FIG. 5-13 are values calculated from volume%.
  • Example 5 70 nm bubbles were formed under the same experimental conditions. From this, it is considered that bubbles of about 70 nm were similarly generated in Example 2-4. Further, as shown in Comparative Example 1, the material dispersed by the homomixer was immediately separated.
  • Example 6-8 As a sample for Examples 6-8, the components in parts by weight shown in Table 2 below were sequentially blended, and the treatment was performed under the same conditions as in Example 1 using “BAVITAS” manufactured by Kyowa Kikai Co., Ltd. . However, distilled water was used instead of pure water. In Comparative Examples 2 and 3, the same transpiration component as in Examples 6 and 7 was emulsified using a surfactant. In Comparative Example 4, the same drug as in Example 8 was dissolved with a homomixer.
  • the odor concentration was obtained by converting the value obtained by the equation 1) by the following equation.
  • Y 10 X ( 2)
  • X threshold value of the entire panel
  • Y odor concentration
  • Table 3 ⁇ indicates that the answer is correct and ⁇ indicates that the answer is incorrect. Since the threshold value is about 10 times higher than that of Comparative Example 2, it can be seen that the transpiration efficiency of the fragrance is improved.
  • Example 7 Antifungal performance evaluation Test method: Performed according to “JIS Z 2911 Mold resistance test method 8. Test of paint”. However, two types of test bacteria were Penicillium funiculosum and Alternaria Alternata. The results are shown in Table 4.
  • Example 8 Deodorant performance evaluation Test method Install a filter paper containing a malodorous component (cigarette odor) in a sealed container and volatilize the malodorous substance sufficiently.
  • the test solution was quantitatively sprayed with a trigger spray into the container, and the strength of the malodorous component one minute later was subjected to sensory evaluation with four panels. The evaluation was performed in order of 1, 2, and 3 in ascending order of malodor intensity.
  • Example 8 the malodor intensity is reduced in Example 8 as compared with Comparative Example 4.
  • Example 9 The mixture having the composition shown in Table 6 below was treated under the same conditions as in Example 1 by “BAVITAS” manufactured by Kyowa Kikai Co., Ltd.
  • Example 10 as ion-exchanged water, ion-exchanged water containing ultrafine bubbles treated by “BAVITAS” was used, and l-menthol was dispersed in the ion-exchanged water containing such ultrafine bubbles with a homomixer. .
  • Comparative Examples 5 and 6 mere ion-exchanged water containing no ultrafine bubbles was used, and l-menthol was dispersed and emulsified with a homomixer. The results are shown in Table 6.
  • Example 9 a better emulsified state is maintained as compared with Comparative Example 5 treated with a homomixer. It was also shown that good dispersibility can be obtained even in Example 10 in which ion-exchanged water was previously treated with “BAVITAS” manufactured by Kyowa Kikai Co., Ltd. and l-menthol was added thereto.
  • Antifungal performance evaluation Test method: A spore suspension was prepared and applied to a plate medium containing potato dextrose agar medium. Further, a filter paper (2.5 cm ⁇ 2.5 cm) impregnated with the sample shown in Table 6 (sample that was uniformly dispersed immediately after preparation) was pasted on the center of the petri dish of the above plate culture medium, and 23 ° C., 100% RH. For 5 days. The test bacterium was Cladosporium cladosporioides, and the spores were adjusted to about 1 ⁇ 10 2 cells / ml. The growth state of the mold after culturing was visually observed and evaluated based on the evaluation criteria for the antifungal performance evaluation of Example 7. The results are shown in Table 8.
  • Example 11 A cleaning test was performed using cleaning water having the composition shown in Table 9.
  • the ultrasonic waves were applied for 3 hours to visually evaluate the contaminated state of the artificially contaminated cloth before and after washing.
  • the ultrasonic waves were generated by an ultrasonic generator of product number USD-4R manufactured by ASONE Co., Ltd., and the frequency was 28 kHz.
  • limonene was used, and as the gas, a mixed gas mixed at a ratio of nitrogen 24 to hydrogen 1 was used. The results are shown in Table 10.

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WO2021085633A1 (ja) * 2019-11-01 2021-05-06 株式会社 資生堂 ウルトラファインバブルの使用方法
JP2022103130A (ja) * 2020-12-25 2022-07-07 三粧化研株式会社 ナノバブル含有化粧料組成物
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JP7227694B2 (ja) * 2017-12-08 2023-02-22 大平 猛 正に帯電したナノバブル分散液
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JP7636774B2 (ja) * 2018-05-30 2025-02-27 株式会社アクアソリューション 果実の防カビ方法
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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013010758A (ja) * 2011-06-02 2013-01-17 Project Japan:Kk 浸透性に優れた殺菌剤、及び殺菌方法
JP2013154342A (ja) * 2012-01-05 2013-08-15 Idec Corp 香り付与液生成装置、香り付与液生成方法、香り付与液、アルコール飲料および物質付与液生成装置
US9220799B2 (en) 2012-02-29 2015-12-29 Sunstar Engineering Inc. Bactericidal agent composition
WO2013129245A1 (ja) * 2012-02-29 2013-09-06 サンスター技研株式会社 殺菌剤組成物
JP2013180956A (ja) * 2012-02-29 2013-09-12 Sunstar Engineering Inc 殺菌剤組成物
CN104135856A (zh) * 2012-02-29 2014-11-05 新时代技研株式会社 杀菌剂组合物
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TWI578909B (zh) * 2012-02-29 2017-04-21 Sunstar Engineering Inc Fungicide composition
JP2013248564A (ja) * 2012-05-31 2013-12-12 Daihatsu Motor Co Ltd 脱脂システム
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JP2016133594A (ja) * 2015-01-19 2016-07-25 株式会社メニコン コンタクトレンズ用保存液、コンタクトレンズの保存方法及びコンタクトレンズの製造方法
JP2018123088A (ja) * 2017-02-01 2018-08-09 有限会社 セイケン九州 消臭方法
JP2019214012A (ja) * 2018-06-12 2019-12-19 株式会社Ｏｋｕｔｅｃ 流体混合装置およびエマルジョンの調製方法
WO2021085633A1 (ja) * 2019-11-01 2021-05-06 株式会社 資生堂 ウルトラファインバブルの使用方法
JP2022103130A (ja) * 2020-12-25 2022-07-07 三粧化研株式会社 ナノバブル含有化粧料組成物
WO2024214823A1 (ja) * 2023-04-13 2024-10-17 株式会社ダイゾー 液状組成物、吐出製品、エアゾール製品

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TWI551343B (zh) 2016-10-01
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US20120128749A1 (en) 2012-05-24
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