TWI817854B - Microneedles molding set and method for manufacturing microneedle patches using the same - Google Patents

Abstract

A microneedle mold set at least includes: a pressure-holding upper cover with an inner space and an outer surface, and the inner space has a top surface, a side surface and a downward opening; a two-way connector is arranged on the outer surface of the pressure-holding upper cover; a channel, which penetrates through the pressure-holding upper cover from the top surface of the inner space, so that the inner space communicates with the two-way connector of the outer surface; a microneedle template has an upper surface, a lower surface and a side surface; wherein, the upper surface has a plurality of microneedle molding holes, each opening of the microneedle molding holes is provided with a gate, and each gate is connected by a flow runner, and the flow runner and the gate are used to guide a solution into the microneedle molding holes; a rubber gasket, sleeved on the side surface of the microneedle template; a pressure-holding lower cover; and a locking device, used to tightly lock the pressure-holding upper cover with the pressure-holding lower cover after assembling the microneedle molding set.

Description

Microneedle mold set and method of manufacturing microneedle patch using same

The present disclosure relates to a microneedle mold set, particularly a microneedle mold set that can be used to produce microneedle patches using microinjection molding technology. The present disclosure also relates to a method of manufacturing a microneedle patch using the microneedle mold set.

Microneedle patches have become a new generation of effective means of transdermal delivery of drugs or active substances. Microneedles can stably transport drugs or active substances into subcutaneous tissue or blood in an effective and almost painless manner. The current mass production methods for manufacturing microneedle patches include centrifugal method or air-blast stretching and air-drying method. When using the centrifugal method to make microneedle patches, the microneedle formula solution needs to be introduced into the tiny microneedle mold holes in a centrifugal method, and the centrifugation time needs to be at least 30 minutes, which is not suitable for mass production processes; while air blast pulling The air-expanded drying method is limited by the manufacturing characteristics of this method. Not only can microneedles not be produced according to the designed length, but also due to the cutting and tensile breaking process after drying and solidification of microneedles, the shape of the needle body will be uncontrollably produced and the shape will be different. Products with regular shapes and different microneedle lengths make the microneedle patch unable to deliver drugs stably.

Further consideration is given to the characteristics of the length, size, distribution and other characteristics of the microneedles when using traditional microneedles, which cannot be specifically designed according to the skin surface characteristics or subcutaneous blood vessel distribution of different users. Therefore, the inventor of the present disclosure has proposed in a previous patent application The case (TWI698263) has disclosed a method for manufacturing microneedle components and a method for manufacturing microneedle molds, which uses interference scanning technology to obtain user information. The vertical section data and transverse section data of the skin tissue are obtained, and the skin model is obtained based on the obtained data to establish a microneedle template so that the microneedle can be designed and produced more accurately.

Generally, microneedle templates can be made by selecting suitable master mold materials and processing methods. For example, the previous technology (TWI725900) used laser processing to process a plurality of micron or nano holes on a substrate to obtain a master mold; The master mold is used as a template, and a silicone material is used to flip the mold over to obtain a template with a microneedle structure. Another example: the previous technology (CN103568160A) uses micro-electromechanical technology or makes a master mold structure of a microneedle array on a substrate, and pours the first type of polymer material on the master mold. After solidification and molding, it is demoulded to obtain a microneedle array. Create a microneedle array mold with the opposite structure of the master mold, and then add the second type of polymer material to the upper surface of the microneedle array mold, soften the second type of polymer material through heating, then cut off the heat source, and use mechanical pressure to soften the The second type of polymer material is pressed into the micropores on the microneedle array mold, and after cooling and demoulding, the polymer material microneedle array is patched.

The production of microneedle patches using the previous technology mostly involves re-molding the master mold, which not only requires more processes, but also results in microneedle patches that are easily distorted due to the re-molding. Furthermore, as mentioned previously, when infusing the microneedle formula solution, most methods are centrifuged, or the softened microneedle formula is pressed into the micropores on the microneedle array mold using the above-mentioned mechanical pressure method. The centrifugal method takes a long time and is less suitable for mass production processes. Microneedle patches obtained by filling molds with mechanical pressure are prone to residual gas in the micropores of the mold during molding, resulting in uneven microneedle lengths. , poor yield.

In view of the various shortcomings in the above-mentioned microneedle patch production process, the inventor of the present disclosure uses interference scanning technology to obtain vertical and horizontal cross-sectional data of the user's skin tissue, and obtains a skin model based on the obtained data. To create three-dimensional microneedle template data, and then use 3D printing technology to produce a more accurate three-dimensional microneedle template that fits the skin model. Furthermore, the inventor of the present disclosure further Micro-injection technology is applied to the infusion of microneedle formula solutions, and coupled with the design of microneedle mold sets, microneedle patches can be produced in a faster, more convenient and yield-producing manner, and can be applied to mass production processes.

The present disclosure provides a microneedle mold set, which at least includes a pressure-maintaining upper cover, a two-way connector, a channel, a microneedle template, a rubber gasket, a pressure-maintaining lower cover, and a locking device. The pressure-maintaining upper cover has an internal space and an external surface, and the internal space has a top surface, a side surface and a downward opening. The two-way connector is arranged on the outer surface of the pressure-maintaining upper cover. The channel runs through the pressure-maintaining upper cover from the top surface to connect the two-way connector between the internal space and the external surface. The microneedle template has an upper surface, a lower surface and a side surface. The upper surface has a plurality of microneedle mold holes. Each microneedle mold hole opening is provided with a gate. The gates are connected by flow channels. The flow channels and gates are used to guide the solution into the microneedle mold holes. The rubber gasket is set on the side surface of the microneedle template. The locking device is used to tightly lock the pressure-maintaining upper cover and pressure-maintaining lower cover of the assembled microneedle mold set. Among them, when assembling the microneedle mold, the microneedle template is covered with a rubber gasket, and then the internal space of the pressure-maintaining upper cover is used to cover and accommodate it, so that the upper surface of the microneedle template closely fits the top surface of the internal space, and The rubber gasket is in close contact with the side surface of the internal space, and the lower surface of the microneedle template does not protrude from the downward opening of the internal space. Then, the pressure-maintaining lower cover is used to cover the downward opening of the internal space, and a locking device is used to lock the pressure-maintaining upper cover and the pressure-maintaining lower cover to each other so that the two are tightly sealed.

In one embodiment of the present disclosure, the shape of each microneedle mold hole may be any one of an inverted cone, an inverted triangular pyramid, an inverted quadrangular pyramid, or a combination thereof.

In one embodiment of the present disclosure, the shape of each microneedle mold hole can be any one of an inverted cone, an inverted triangular pyramid, an inverted quadrangular pyramid, or a combination thereof, and the opening aperture or side length of the microneedle mold hole Not larger than 1mm.

In an embodiment of the present disclosure, the depths of the microneedle mold holes may be the same depth or different depths.

In one embodiment of the present disclosure, the depth of each microneedle mold hole is no greater than 2 mm.

In an embodiment of the present disclosure, the spacing between microneedle mold holes may be the same spacing or different spacings.

In an embodiment of the present disclosure, the flow channel may be any one of an H-shaped flow channel or an S-shaped flow channel or a combination thereof.

In an embodiment of the present disclosure, the cross section of the flow channel may be rectangular, arc-shaped, circular or trapezoidal.

The present disclosure further proposes a method for manufacturing a microneedle patch, which at least includes the following steps: providing a microneedle mold set as in any of the above embodiments; connecting an injection device with an injection pipeline to the two-way connection of the microneedle mold set One opening of the head; then connect an air extraction device with an air extraction pipeline to the other opening of the two-way connector of the microneedle mold set; start the injection device and inject a volume of microneedle patch formula solution at a perfusion flow rate Enter the microneedle mold set and close the injection device after the perfusion is completed; start the air extraction device to evacuate the microneedle mold set so that the residual gas in the microneedle mold holes in the internal space of the microneedle mold set is eliminated; wait until the microneedle After the patch formula solution is solidified, it is demoulded. After completion, a microneedle patch can be obtained.

10: Microneedle mold set

100: Pressure-maintaining upper cover

101:Internal space

1011: Top surface

1012:Channel

1013:Open downward

1014: Internal space side surface

102:External surface

103: Two-way connector

200: Microneedle template

201: Upper surface of microneedle template

2011: Microneedle mold hole

2012:S-type flow channel

2013: Gate

2014:H-type flow channel

202: Side surface of microneedle template

203: Lower surface of microneedle template

300:Rubber gasket

400: pressure maintaining lower cover

500: Locking device

S5a~S5f: step process

Figure 1 is a structural diagram of a microneedle mold set according to an embodiment of the present disclosure.

Figure 2A is a structural diagram of the pressure-maintaining upper cover of the microneedle mold set according to an embodiment of the present disclosure.

Figure 2B is a cross-sectional view of the pressure-maintaining upper cover of the microneedle mold set according to one embodiment of the present disclosure.

Figures 3A to 3C are schematic structural diagrams of a microneedle template according to an embodiment of the present disclosure.

Figure 4A is a first schematic diagram of the shape of the microneedle mold hole according to an embodiment of the present disclosure.

Figure 4B is a second schematic diagram of the shape of the microneedle mold hole according to an embodiment of the present disclosure.

Figure 4C is a third schematic diagram of the shape of the microneedle mold hole according to an embodiment of the present disclosure.

Figure 5 is a flow chart of a manufacturing method of a microneedle patch according to an embodiment of the present disclosure.

The following will describe embodiments of the microneedle mold set of the present disclosure and the method of manufacturing microneedle patches using the microneedle mold set with reference to the relevant drawings. For the sake of clarity and convenience in the illustration of the drawings, each component in the drawings is Size and proportions may be exaggerated or reduced. In the following description and/or patent claims, when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may be present; and when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may be present; When a component is "directly connected" or "directly coupled" to another component, there are no intervening components present, and other words used to describe the relationship between components or layers should be interpreted in a like manner. To facilitate understanding, the same components in the following embodiments are labeled with the same symbols for description.

Please refer to Figure 1, which is a schematic structural diagram of a microneedle mold set according to an embodiment of the present disclosure. As shown in the figure, in this embodiment, the microneedle mold set 10 at least includes a pressure-maintaining upper cover 100, a microneedle template 200, a rubber gasket 300, a pressure-maintaining lower cover 400, and a locking device 500. The pressure-maintaining upper cover 100 has a two-way connector 103 disposed on the outer surface 102 of the pressure-maintaining upper cover 100 .

Please refer to Figures 2A and 2B, which are structural views and cross-sectional views of the pressure-maintaining upper cover 100 of the microneedle mold set 10 in one embodiment of the present disclosure. In this embodiment, the pressure-maintaining upper cover 100 has an inner space 101 and an outer surface 102. The inner space 101 has a top surface 1011, a side surface 1014 and a downward opening 1013. The two-way connector 103 is provided on the outer surface 102 of the pressure-maintaining upper cover 100 . Pass The channel 1012 passes through the pressure-maintaining upper cover 100 from the top surface 1011, so that the inner space 101 is connected to the two-way connector 103 of the outer surface 102.

Please refer to Figures 3A to 3C, which are schematic structural diagrams of the microneedle template 200 according to one embodiment of the present disclosure. As shown in Figure 3A, the microneedle template 200 shown in this embodiment has an upper surface 201, a lower surface 203 and a side surface 202. Among them, in one embodiment, as shown in Figure 3B, the upper surface 201 has a plurality of microneedle mold holes 2011. Each microneedle mold hole 2011 is provided with a gate 2013 at the opening, and an S-shaped flow channel is used between the gates. 2012 connection, S-shaped flow channel 2012 and gate 2013 are used to guide the solution into the microneedle mold hole 2011. In another embodiment, as shown in Figure 3C, each gate 2013 is connected by an H-shaped flow channel 2014. The H-shaped flow channel 2014 and the gate 2013 are used to guide the solution into the microneedle mold hole 2011.

To further explain, a microneedle mold set 10 according to an embodiment of the present disclosure at least includes a pressure-maintaining upper cover 100, a two-way connector 103, a channel 1012, a microneedle template 200, a rubber gasket 300, a pressure-maintaining lower cover 400 and a locking device. 500. The pressure-maintaining upper cover 100 has an inner space 101 and an outer surface 102. The interior space has a top surface 1011, side surfaces 1014 and a downward opening 1013. The two-way connector 103 is provided on the outer surface 102 of the pressure-maintaining upper cover 100 . The channel 1012 passes through the pressure-maintaining upper cover 100 from the top surface 1011, so that the inner space 101 is connected to the two-way connector 103 of the outer surface 102. The microneedle template 200 has an upper surface 201, a lower surface 203 and a side surface 202. Among them, the upper surface 201 has a plurality of microneedle mold holes 2011, and each microneedle mold hole 2011 is provided with a gate 2013. An S-shaped flow channel 2012 (as shown in Figure 3B) or an H-type flow channel is used between the gates. Channel 2014 (as shown in Figure 3C) is connected, and the S-shaped runner or H-shaped runner and gate are used to guide the solution into the microneedle mold hole. The rubber gasket 300 is set on the side surface 202 of the microneedle template 200. The locking device 500 is used to tightly lock the pressure-maintaining upper cover 100 and the pressure-maintaining lower cover 400 of the assembled microneedle mold set 10 . When the microneedle mold set 10 is assembled, the microneedle template 200 is set with a rubber gasket 300, and then the internal space 101 of the pressure-maintaining upper cover 100 is used to cover and accommodate it, so that the upper surface 201 of the microneedle template 200 is in contact with the interior. The top surface 1011 of the space 101 is in close fit, and the rubber gasket 300 is in close fit with the side surface 1014 of the inner space 101 . The lower surface 203 of the microneedle template 200 does not protrude from the downward opening 1013 of the internal space 101 . Then, the pressure-maintaining lower cover 400 is used to cover the downward opening 1013 of the internal space 101, and the pressure-maintaining upper cover 100 and the pressure-maintaining lower cover 400 are locked to each other with the locking device 500, so that the two are tightly connected.

In one embodiment of the present disclosure, the inventor uses the previously disclosed manufacturing method of microneedle templates, first uses interference scanning technology to obtain vertical and horizontal cross-sectional data of the user's skin tissue, and based on the obtained data, Obtain the skin model to create three-dimensional microneedle template data, and then use 3D printing technology to produce a three-dimensional microneedle template that more accurately matches the skin model. Therefore, in one embodiment, the arrangement position, shape, size, and microneedle depth of the microneedle mold holes 2011 on the upper surface 201 of the microneedle template 200 can all be designed based on the above model.

Please refer to Figures 4A to 4C, which are the first schematic diagram, the second schematic diagram and the third schematic diagram of the shape of the microneedle mold hole according to an embodiment of the present disclosure. As shown in Figure 4A, the shape of each microneedle mold hole 2011 may be an inverted cone as shown in Figure 4A. As shown in Figure 4B, the shape of each microneedle mold hole 2011 may be an inverted triangular pyramid as shown in Figure 4B. As shown in Figure 4B, the shape of each microneedle mold hole 2011 may be an inverted quadrangular pyramid as shown in Figure 4C. In another embodiment, the shape of each microneedle mold hole 2011 can be any one of an inverted cone, an inverted triangular pyramid, an inverted quadrangular pyramid, or a combination thereof, and the opening aperture or side length of the microneedle mold hole 2011 does not vary. Greater than 1mm.

In another embodiment, the depths of each of the microneedle mold holes may be the same depth or different depths; in one embodiment, the depth of each of the microneedle mold holes is not greater than 2 mm. For example: in one embodiment, the depth of each microneedle mold hole is designed based on the data of the skin model, and the depth of the microneedle mold hole is between 250um~1.8mm, between 300um~1.6mm, Between 310um~1.4 mm, between 320um~1.2mm, between 330um~1.0mm, between 335um~800um.

In one embodiment, the spacing between the microneedle mold holes 2011 on the upper surface 201 of the microneedle template 200 may be the same spacing or different spacings. For example, the microneedle mold holes can be arranged in a matrix or non-matrix arrangement, or the microneedle mold holes can be arranged according to the skin model to avoid subcutaneous blood vessels.

The microneedle mold set 10 disclosed in this disclosure uses microinjection molding technology to design the microneedle mold set 10 so that it can use microinjection molding technology to quickly mass-produce microneedle patches with high yield, and at the same time, it can also obtain skin models. And incorporate 3D printing technology to customize microneedle patch products. Therefore, in the design of the microneedle template 200 of the present disclosure, a gate 2013 is provided at the opening of each microneedle mold hole 2011, and each gate 2013 is connected through a flow channel. The design of the flow channel can be based on each microneedle mold hole. For example, in one embodiment, the above-mentioned flow channel is an S-shaped flow channel 2012 as shown in Figure 3B; and in another embodiment, the above-mentioned flow channel is an H-shaped flow channel as shown in Figure 3C. Type runner 2014. In addition, in order to match the position of the microneedle mold holes 2011 arranged in the skin model, the above-mentioned flow channels may also be S-shaped flow channels 2012 and H-shaped flow channels 2014 used in conjunction with each other, or they may be flow channels of non-specific shapes. Those of ordinary skill in the art should be able to make equivalent modifications without departing from the design concept of the present disclosure.

In addition, considering that the microneedle formula solution may have different viscosities due to different formulas, when infused using micro-injection molding technology, the microneedle formula solution may encounter resistance in the flow channel. Therefore, in one embodiment of the present disclosure, where The cross-sectional shape of the flow channel on the microneedle template 200 can be designed as a rectangle, an arc, a circle or a trapezoid to reduce the resistance of the microneedle formula solution when flowing in the flow channel.

Please refer to Figure 5, which is a flow chart of a manufacturing method of a microneedle patch according to one embodiment of the present disclosure. As shown in the figure, the manufacturing method of the microneedle patch of this embodiment includes at least the following steps:

Step S5a: Provide the microneedle mold set of any of the above embodiments. The manufacturing method of the microneedle patch disclosed in the present disclosure uses micro-injection molding technology to manufacture the microneedle patch. Therefore, the microneedle mold set used is any of the microneedle mold sets of any of the above embodiments, and its integration Microneedle template model design and 3D printing molding technology are used to produce the microneedle template, and then the microneedle template is combined with components such as a pressure-maintaining upper cover and a pressure-maintaining lower cover to form a microneedle suitable for making microneedle patches using micro-injection molding technology. Mold set.

Step S5b: Connect the injection device to the opening of the two-way connector of the microneedle mold set using the injection pipeline. In one embodiment, the injection device is a microinjection pump, which can set the flow rate of the perfusion solution and the volume of the perfusion solution per unit time.

Step S5c: Connect the air extraction device with the air extraction pipeline to the other opening of the two-way connector of the microneedle mold set.

Step S5d: Start the injection device, pour a volume of the microneedle patch formula solution into the microneedle mold set at a perfusion flow rate, and close the injection device after the perfusion is completed. Those with ordinary knowledge in the field should be able to understand that since the microneedle patch formula solution will have different viscosity of the formula solution due to different components, the perfusion flow rate used is mainly adjusted through the injection pump, depending on the formula. The solution viscosity and the design of the microneedle template are used to adjust the perfusion flow rate range. For example: in one embodiment, the perfusion flow rate range used is 0.5ml/min~2.0ml/min. It should be understood that when the injection pump is started and a volume of microneedle patch formula solution is poured into the microneedle mold set, pressure will be exerted on the internal space of the microneedle mold set. That is, like micro-injection molding technology, the formula will be The solution is poured into the mold at the above pressure, which helps to speed up the injection molding speed.

Step S5e: Start the air extraction device to evacuate the microneedle mold set so that the residual gas in the microneedle mold holes in the internal space of the microneedle mold set is eliminated. Generally speaking, when the viscosity of the microneedle formula solution is high, the fluidity of the solution is poor, and it is difficult to completely fill the microneedle mold holes. Gas will often remain in the microneedle mold holes. Therefore, the manufacturing method of the present disclosure uses pumping. The air device evacuates the filled microneedle mold set so that the gas remaining in the microneedle mold holes can be eliminated.

Step S5f: After the microneedle patch formula solution is solidified, demoulding is performed. After completion, the microneedle patch can be obtained.

The above air extraction and injection steps can also be performed by air extraction first, and then the injection step can be started after the residual gas in the internal space of the microneedle mold set is eliminated. This can also avoid the occurrence of residual gas in the microneedle mold hole during filling. It should be noted that the above-mentioned pumping or injection steps are performed separately, and the pumping pipeline and the injection pipeline each have air-tight valves. When the pumping step is carried out, first open the pumping pipeline valve and close the injection pipeline valve before pumping. After the exhaustion is completed, close the exhaust line valve and then open the injection line valve to start the injection step; vice versa. Furthermore, those of ordinary skill in the art should understand that the above-mentioned valve can also be provided in the two-way connector, as long as the air-tight state between the exhaust pipeline and the injection pipeline can be maintained to avoid mutual influence. The same effect can be achieved, and this is not intended to limit the scope of the present invention.

Of course, this embodiment is only for illustration and does not limit the scope of the present disclosure. Equivalent modifications or changes based on the manufacturing method of the microneedle patch of this embodiment should still be included in the patent scope of the present disclosure.

It is worth mentioning that the existing manufacturing methods of microneedle patches mostly use centrifugal methods for mold filling. In addition to the time-consuming centrifugal process involved in the manufacturing process, the operation also requires more skill. Therefore, the microneedle patch manufacturing method according to the embodiment of the present disclosure has obvious advantages in terms of production efficiency, process simplification, and production cost.

Furthermore, this disclosure can be combined with the inventor's previous modeling technology and 3D printing molding technology. In one embodiment, the microneedle patch produced can be diversified and customized according to the customer's skin model or usage needs. Chemically produce microneedle patches that respond to a variety of skin surface structural characteristics, making mass production more flexible.

Although the steps of the methods described in this disclosure are shown and described in a specific order, the order of operations of each method may be changed, some steps may be performed in reverse order, or some steps may be performed concurrently with other steps. In another embodiment, the different steps may be performed in an intermittent and/or alternating manner.

To sum up, this disclosure uses skin modeling technology and 3D printing casting technology to produce a microneedle mold set that can be used in micro-injection molding manufacturing methods, and further uses micro-injection molding technology to produce microneedle patches. Compared with the existing manufacturing methods of microneedle patches, the present disclosure can significantly effectively shorten the time for producing microneedle patches. Furthermore, when using the injection device to apply pressure for micro-injection molding, the design of the gate and flow channel on the microneedle template can allow the microneedle formula solution to flow into the microneedle mold hole more effectively. The air extraction step allows the remaining gas in the microneedle mold holes to be eliminated, improving the integrity and yield of the microneedle. The microneedle mold set and the manufacturing method using the same to manufacture microneedle patches according to the embodiments of the present disclosure have obvious advantages in terms of production efficiency and process simplification.

It can be seen that this disclosure has indeed achieved the desired improvement effect by breaking through the previous technology, and it is not easily imagined by those familiar with the technology. Its progress and practicality clearly meet the requirements for patent application. I have filed a patent application in accordance with the law, and I sincerely request your office to approve this application for an invention patent to encourage creation and I feel it is very convenient.

The above is only illustrative and not restrictive. Any other equivalent modifications or changes that do not depart from the spirit and scope of this disclosure should be included in the appended patent application scope.

10: Microneedle mold set

100: Pressure-maintaining upper cover

101:Internal space

102:External surface

103: Two-way connector

200: Microneedle template

300:Rubber gasket

400: pressure maintaining lower cover

500: Locking device

Claims (9)

A microneedle mold set, at least including: A pressure-maintaining upper cover has an inner space and an outer surface. The inner space has a top surface, a side surface and a downward opening; a two-way connector provided on the outer surface of the pressure-maintaining upper cover; a channel, The top surface penetrates the pressure-maintaining upper cover, so that the two-way connector of the internal space and the external surface is connected; A microneedle template has an upper surface, a lower surface and a side surface; wherein, the upper surface has a plurality of microneedle mold holes, and each microneedle mold hole opening is provided with a gate, and there is a gate between each gate. A channel is connected, and the channel and the gate are used to guide a solution into the microneedle mold hole; A rubber gasket is placed on the side surface of the microneedle template; a pressure-maintaining lower cover; and A locking device for tightly locking the pressure-maintaining upper cover and the pressure-maintaining lower cover of the assembled microneedle mold set; Wherein, when assembling the microneedle mold set, the rubber gasket is placed on the microneedle template, and then the internal space of the pressure-maintaining upper cover is used to cover and house it, so that the upper surface of the microneedle template is in contact with the rubber gasket. The top surface of the internal space is in close contact, and the rubber gasket is in close contact with the side surface of the internal space, wherein the lower surface of the microneedle template does not protrude from the downward opening of the internal space; then The pressure-maintaining lower cover is then used to cover the downward opening of the internal space, and a locking device is used to lock the pressure-maintaining upper cover and the pressure-maintaining lower cover to each other so that the two are tightly sealed. The microneedle mold set of claim 1, wherein the shape of each microneedle mold hole is any one of an inverted cone, an inverted triangular pyramid, an inverted quadrangular pyramid, or a combination thereof. Such as the microneedle mold set of claim 2, wherein the opening diameter or side length of each microneedle mold hole is not greater than 1 mm. The microneedle mold set of claim 1, wherein the depths of the microneedle mold holes are the same depth or different depths. For example, the microneedle mold set of claim 4, wherein the depth of each microneedle mold hole is not greater than 2 mm. Such as the microneedle mold set of claim 1, wherein the distance between the microneedle mold holes is the same distance or different distances. The microneedle mold set of claim 1, wherein the flow channel is either an H-shaped flow channel or an S-type flow channel or a combination thereof. The microneedle mold set of claim 1, wherein the cross-section of the flow channel is rectangular, arc-shaped, circular or trapezoidal. A method for manufacturing a microneedle patch includes at least the following steps: Provide a microneedle mold set as in any one of requests 1-8; Connect an injection device with an injection pipeline to an opening of the two-way connector of the microneedle mold set; Connect an air extraction device with an air extraction pipeline to the other opening of the two-way connector of the microneedle mold set; Start the injection device, inject a volume of microneedle patch formula solution into the microneedle mold set at a perfusion flow rate, and close the injection device after the infusion is completed; Activate the air extraction device to evacuate the microneedle mold set so that the residual gas in the microneedle mold holes in the internal space of the microneedle mold set is eliminated; and After the microneedle patch formula solution is solidified, demoulding is performed, and a microneedle patch is obtained upon completion.

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