TW202421217A - Microneedles molding set and method for manufacturing microneedle patches using the same - Google Patents

Abstract

A microneedle mold set at least includes: a pressure-holding upper cover with an inner space and an outer surface, and the inner space has a top surface, a side surface and a downward opening; a two-way connector is arranged on the outer surface of the pressure-holding upper cover; a channel, which penetrates through the pressure-holding upper cover from the top surface of the inner space, so that the inner space communicates with the two-way connector of the outer surface; a microneedle template has an upper surface, a lower surface and a side surface; wherein, the upper surface has a plurality of microneedle molding holes, each opening of the microneedle molding holes is provided with a gate, and each gate is connected by a flow runner, and the flow runner and the gate are used to guide a solution into the microneedle molding holes; a rubber gasket, sleeved on the side surface of the microneedle template; a pressure-holding lower cover; and a locking device, used to tightly lock the pressure-holding upper cover with the pressure-holding lower cover after assembling the microneedle molding set.

Description

Microneedle mold set and method for manufacturing microneedle patch using the same

The present disclosure relates to a microneedle mold set, in particular to a microneedle mold set that can be used to make a microneedle patch using a microinjection molding technology. The present disclosure also relates to a method for making a microneedle patch using the microneedle mold set.

Microneedle patches have become a new generation of effective way to deliver drugs or active substances through the skin. Microneedles can stably deliver drugs or active substances to subcutaneous tissue or blood in an effective and almost painless way. The current mass production methods of microneedle patches include centrifugal method or air-blast stretch air-drying method. When making microneedle patches by centrifugal method, the microneedle formula solution needs to be introduced into the tiny microneedle mold holes by centrifugation, and the centrifugation time needs to be at least 30 minutes, which is not suitable for mass production process; and the air-blast stretching air-drying method is limited by the manufacturing characteristics of this method. Not only can the microneedles not be produced according to the designed length, but also because of the cutting and stretching fracture process after the microneedles are dried and solidified, the needle body shape will be uncontrollably produced. Products with irregular shapes and different lengths of microneedles will be produced, resulting in the inability of the microneedle patch to stably deliver drugs.

Further considering the length, size, distribution and other characteristics of traditional microneedles during use, it is not possible to perform specific designs for the skin surface characteristics or subcutaneous blood vessel distribution of different users. Therefore, the inventor of the present disclosure has disclosed a method for manufacturing a microneedle element and a method for manufacturing a microneedle mold in a previous patent application (TWI698263), which utilizes interference scanning technology to obtain longitudinal and transverse cross-sectional data of the user's skin tissue, and obtains a skin model based on the obtained data, thereby establishing a microneedle template, so that the microneedles can be designed and produced more accurately.

Generally, a microneedle template can be made by selecting a suitable master mold material and processing method. For example, the previous technology (TWI725900) used a laser method to process a plurality of micrometer or nanometer holes on a substrate to obtain a master mold; the master mold was used as a template, and then a silicone material was used for mold casting to obtain a template with a microneedle structure. Another example: the prior art (CN103568160A) uses micro-electromechanical technology or manufactures a master mold structure of a microneedle array on a substrate, and pours a first type of polymer material on the master mold, and demolds it after solidification to obtain a microneedle array mold with a structure opposite to the master mold structure of the microneedle array, and then adds a second type of polymer material to the upper surface of the microneedle array mold, softens the second type of polymer material by heating, and then cuts off the heat source, and mechanically presses the softened second type of polymer material into the micropores on the microneedle array mold by mechanical pressure, and after cooling and demolding, a polymer material microneedle array patch is obtained.

Previous technologies for making microneedle patches mostly involve re-molding the master mold, which not only requires more steps, but the resulting microneedle patches are also easily distorted due to re-molding. Furthermore, as mentioned earlier, when pouring the microneedle formula solution, most of them use a centrifugal method, or use the above-mentioned mechanical pressure method to press the softened microneedle formula into the micropores on the microneedle array mold. The centrifugal method is time-consuming and less suitable for mass production processes, and the microneedle patches obtained by the mechanical pressure method are prone to microneedles of different lengths and poor yields due to residual gas in the micropores of the mold during the pouring process.

In view of the various deficiencies in the above-mentioned microneedle patch manufacturing process, the inventors of the present disclosure use interference scanning technology to obtain the longitudinal and transverse cross-sectional data of the user's skin tissue, and obtain a skin model based on the obtained data to establish a three-dimensional microneedle template data, and then use 3D printing technology to produce a three-dimensional microneedle template that more accurately conforms to the skin model. Furthermore, the inventors of the present disclosure further apply micro-injection technology to the microneedle formula solution perfusion, and then match the design of the microneedle mold set to produce microneedle patches in a faster, more convenient and better yielding manner, and can be applied to mass production processes.

The present disclosure provides a microneedle mold set, which at least includes a pressure-maintaining upper cover, a two-way connector, a channel, a microneedle template, a rubber gasket, a pressure-maintaining lower cover, and a locking device. The pressure-maintaining upper cover has an internal space and an external surface, and the internal space has a top surface, a side surface, and a downward opening. The two-way connector is arranged on the external surface of the pressure-maintaining upper cover. The channel passes through the pressure-maintaining upper cover from the top surface to connect the internal space with the two-way connector on the external surface. The microneedle template has an upper surface, a lower surface, and a side surface. The upper surface has a plurality of microneedle mold holes, each of which is provided with a spout at the opening of the microneedle mold hole, and each spout is connected by a flow channel, and the flow channel and the spout are used to guide the solution into the microneedle mold hole. The rubber gasket is set on the side surface of the microneedle template. The locking device is used to tightly lock the pressure-retaining upper cover and the pressure-retaining lower cover of the assembled microneedle mold set. When assembling the microneedle mold, the rubber gasket is set on the microneedle template, and then the inner space of the pressure-retaining upper cover is used to cover and accommodate it, so that the upper surface of the microneedle template is tightly fitted with the top surface of the inner space, and the rubber gasket is tightly fitted with the side surface of the inner space, and the lower surface of the microneedle template does not protrude from the downward opening of the inner space. Then, the downward opening of the inner space is covered with the pressure-retaining lower cover, and the pressure-retaining upper cover and the pressure-retaining lower cover are locked to each other by the locking device so that the two are tightly fitted.

In one embodiment of the present disclosure, the shape of each microneedle mold hole can be any one of an inverted cone, an inverted triangular pyramid, and an inverted quadrangular pyramid, or a combination thereof.

In one embodiment of the present disclosure, the shape of each microneedle mold hole can be any one of an inverted cone, an inverted triangular pyramid, an inverted quadrangular pyramid, or a combination thereof, and the opening diameter or side length of the microneedle mold hole is not greater than 1 mm.

In one embodiment of the present disclosure, the depths of the microneedle mold holes can be the same depth or different depths.

In one embodiment of the present disclosure, the depth of each microneedle mold hole is no greater than 2 mm.

In one embodiment of the present disclosure, the spacing between each microneedle mold hole can be the same spacing or different spacing.

In one embodiment of the present disclosure, the flow channel can be any one of an H-type flow channel and an S-type flow channel or a combination thereof.

In one embodiment of the present disclosure, the cross section of the flow channel can be rectangular, arc-shaped, circular or trapezoidal.

The present disclosure further proposes a method for manufacturing a microneedle patch, which includes at least the following steps: providing a microneedle mold set as in any of the above-mentioned embodiments; connecting an injection device to one opening of a two-way connector of the microneedle mold set with an injection pipeline; and then connecting an exhaust device to the other opening of the two-way connector of the microneedle mold set with an exhaust pipeline; starting the injection device to inject a volume of microneedle patch formula solution into the microneedle mold set at an injection flow rate, and then closing the injection device after the injection is completed; starting the exhaust device to exhaust the microneedle mold set to discharge the residual gas in the microneedle mold holes in the internal space of the microneedle mold set; and demolding after the microneedle patch formula solution is solidified, and a microneedle patch can be obtained after completion.

The following will refer to the relevant drawings to illustrate the embodiments of the disclosed microneedle mold set and the method of manufacturing a microneedle patch using the microneedle mold set. For the sake of clarity and convenience of the diagram, the components in the diagram may be exaggerated or reduced in size and proportion. In the following description and/or patent application, when it is mentioned that an element is "connected" or "coupled" to another element, it may be directly connected or coupled to the other element or there may be an intervening element; and when it is mentioned that an element is "directly connected" or "directly coupled" to another element, there is no intervening element, and other words used to describe the relationship between elements or layers should be interpreted in the same way. For ease of understanding, the same elements in the following embodiments are illustrated with the same symbols.

Please refer to FIG. 1, which is a schematic diagram of a microneedle mold assembly structure diagram of an embodiment of the present disclosure. As shown in the figure, in this embodiment, the microneedle mold assembly 10 at least includes a pressure-maintaining upper cover 100, a microneedle template 200, a rubber gasket 300, a pressure-maintaining lower cover 400, and a locking device 500. The pressure-maintaining upper cover 100 has a two-way connector 103, which is disposed on the outer surface 102 of the pressure-maintaining upper cover 100.

Please refer to FIG. 2A and FIG. 2B, which are the structural diagram and cross-sectional diagram of the pressure-maintaining cover 100 of the microneedle mold set 10 in one embodiment of the present disclosure. In this embodiment, the pressure-maintaining cover 100 has an inner space 101 and an outer surface 102, and the inner space 101 has a top surface 1011, a side surface 1014, and a downward opening 1013. A two-way connector 103 is disposed on the outer surface 102 of the pressure-maintaining cover 100. A channel 1012 passes through the pressure-maintaining cover 100 from the top surface 1011, so that the inner space 101 is connected to the two-way connector 103 on the outer surface 102.

Please refer to Figures 3A to 3C, which are schematic diagrams of the structure of a microneedle template 200 of an embodiment of the present disclosure. As shown in Figure 3A, the microneedle template 200 shown in this embodiment has an upper surface 201, a lower surface 203 and a side surface 202. In one embodiment, as shown in Figure 3B, the upper surface 201 has a plurality of microneedle mold holes 2011, each microneedle mold hole 2011 is provided with a spout 2013, and each spout is connected by an S-shaped flow channel 2012, and the S-shaped flow channel 2012 and the spout 2013 are used to guide the solution into the microneedle mold hole 2011. In another embodiment, as shown in FIG. 3C , each of the gates 2013 is connected by an H-shaped channel 2014 , and the H-shaped channel 2014 and the gate 2013 are used to guide the solution into the microneedle mold hole 2011 .

To further illustrate, a microneedle mold assembly 10 of an embodiment of the present disclosure at least includes a pressure-maintaining upper cover 100, a two-way connector 103, a channel 1012, a microneedle template 200, a rubber gasket 300, a pressure-maintaining lower cover 400, and a locking device 500. The pressure-maintaining upper cover 100 has an inner space 101 and an outer surface 102. The inner space has a top surface 1011, a side surface 1014, and a downward opening 1013. The two-way connector 103 is disposed on the outer surface 102 of the pressure-maintaining upper cover 100. The channel 1012 passes through the pressure-maintaining upper cover 100 from the top surface 1011, so that the inner space 1013 is connected to the two-way connector 103 on the outer surface 102. The microneedle template 200 has an upper surface 201, a lower surface 203 and a side surface 202. The upper surface 201 has a plurality of microneedle mold holes 2011, each microneedle mold hole 2011 is provided with a pouring port 2013, and each pouring port is connected by an S-shaped flow channel 2012 (as shown in FIG. 3B) or an H-shaped flow channel 2014 (as shown in FIG. 3C), and the S-shaped flow channel or the H-shaped flow channel and the pouring port are used to guide the solution into the microneedle mold hole. The rubber gasket 300 is sleeved on the side surface 202 of the microneedle template 200. The locking device 500 is used to tightly lock the pressure-retaining upper cover 100 and the pressure-retaining lower cover 400 of the assembled microneedle mold set 10. When the microneedle mold set 10 is assembled, the microneedle template 200 is covered with the rubber gasket 300, and then covered and accommodated by the inner space 101 of the pressure-retaining cover 100, so that the upper surface 201 of the microneedle template 200 is closely fitted with the top surface 1011 of the inner space 101, and the rubber gasket 300 is closely fitted with the side surface 1014 of the inner space 101. The lower surface 203 of the microneedle template 200 does not protrude from the downward opening 1013 of the inner space 101. Then, the downward opening 1013 of the inner space 101 is covered with the pressure-maintaining lower cover 400, and the pressure-maintaining upper cover 100 and the pressure-maintaining lower cover 400 are locked to each other by the locking device 500 so that the two are tightly fitted.

In one embodiment of the present disclosure, the inventor uses the previously disclosed method for manufacturing a microneedle template, first using interference scanning technology to obtain the longitudinal section data and transverse section data of the user's skin tissue, and then obtains a skin model based on the obtained data to establish a three-dimensional microneedle template data, and then uses 3D printing technology to produce a three-dimensional microneedle template that more accurately conforms to the skin model. Therefore, in one embodiment, the arrangement position, shape, size, and microneedle depth of the microneedle mold hole 2011 on the upper surface 201 of the microneedle template 200 can all be designed based on the above model.

Please refer to Figures 4A to 4C, which are the first schematic diagram, the second schematic diagram, and the third schematic diagram of the shape of the microneedle mold hole of one embodiment of the present disclosure. As shown in Figure 4A, the shape of each microneedle mold hole 2011 can be an inverted cone as shown in Figure 4A. As shown in Figure 4B, the shape of each microneedle mold hole 2011 can be an inverted triangular pyramid as shown in Figure 4B. As shown in Figure 4B, the shape of each microneedle mold hole 2011 can be an inverted tetrahedron as shown in Figure 4C. In another embodiment, the shape of each microneedle mold hole 2011 can be any one of an inverted cone, an inverted triangular pyramid, and an inverted tetrahedron, or a combination thereof, and the opening diameter or side length of the microneedle mold hole 2011 is not greater than 1 mm.

In another embodiment, the depth of each microneedle mold hole can be the same depth or different depths; in one embodiment, the depth of each microneedle mold hole is not more than 2 mm. For example: in one embodiment, the depth of each microneedle mold hole is designed based on the data of the skin model, and the depth of the microneedle mold hole is between 250 um ~ 1.8 mm, between 300 um ~ 1.6 mm, between 310 um ~ 1.4 mm, between 320 um ~ 1.2 mm, between 330 um ~ 1.0 mm, between 335 um ~ 800 um.

In one embodiment, the spacing between each microneedle mold hole 2011 on the upper surface 201 of the microneedle template 200 can be the same spacing or different spacing. For example, the arrangement of each microneedle mold hole can be a matrix or non-matrix arrangement, or the arrangement of the microneedle mold holes can be performed according to the skin model to avoid subcutaneous blood vessels.

A microneedle mold set 10 disclosed in the present invention utilizes microinjection molding technology to design the microneedle mold set 10, so that the microinjection molding technology can be applied to quickly mass-produce microneedle patches with high yields, and the microneedle patch products can also be customized by obtaining a skin model and combining 3D printing technology. Therefore, in the design of the microneedle template 200 disclosed in the present invention, a spout 2013 is provided at the opening of each microneedle mold hole 2011, and each spout 2013 is connected through a flow channel. The design of the flow channel can be designed according to the position of each microneedle mold hole. For example, in one embodiment, the flow channel is an S-shaped flow channel 2012 as shown in FIG. 3B; and in another embodiment, the flow channel is an H-shaped flow channel 2014 as shown in FIG. 3C. In addition, to match the position of the microneedle mold hole 2011 arranged in the skin model, the flow channel can also be an S-shaped flow channel 2012 and an H-shaped flow channel 2014, or a flow channel of a non-specific shape. A person skilled in the art should be able to make equal modifications without departing from the design concept of this disclosure.

In addition, considering that the microneedle formula solution may have different viscosities due to different formulas, the microneedle formula solution may encounter resistance when flowing in the flow channel when using microinjection molding technology. Therefore, in one embodiment of the present disclosure, the cross-sectional shape of the flow channel on the microneedle template 200 can be designed to be rectangular, arc-shaped, circular or trapezoidal to reduce the resistance of the microneedle formula solution when flowing in the flow channel.

Please refer to Figure 5, which is a flow chart of a method for manufacturing a microneedle patch according to an embodiment of the present disclosure. As shown in the figure, the method for manufacturing a microneedle patch according to the present embodiment at least includes the following steps:

Step S5a: Provide a microneedle mold set of any of the above embodiments. A method for manufacturing a microneedle patch disclosed herein utilizes microinjection molding technology to manufacture the microneedle patch, so the microneedle mold set used is any of the microneedle mold sets of any of the above embodiments, which integrates microneedle template model design and 3D printing casting technology to manufacture the microneedle template, and then the microneedle template is matched with components such as a pressure-retaining upper cover and a pressure-retaining lower cover to form a microneedle mold set suitable for manufacturing microneedle patches using microinjection molding technology.

Step S5b: Connect the injection device to the opening of the two-way connector of the microneedle mold set with an injection line. In one embodiment, the injection device is a microinjection pump, which can set the flow rate of the perfusion solution and the volume of the perfusion solution per unit time.

Step S5c: Connect the vacuum device to the other opening of the two-way connector of the microneedle mold assembly via a vacuum pipeline.

Step S5d: Start the injection device, and inject a volume of microneedle patch formula solution into the microneedle mold set at a perfusion flow rate, and then close the injection device after the perfusion is completed. People with ordinary knowledge in the field should understand that since the microneedle patch formula solution has different formula solution viscosities due to different components, the perfusion flow rate used is mainly adjusted through the injection pump, and the perfusion flow rate range is adjusted according to the formula solution viscosity and the design of the microneedle template. For example: in one embodiment, the perfusion flow rate range used is 0.5 ml/min ~ 2.0 ml/min. It should be understood that when the injection pump is started and a volume of microneedle patch formula solution is injected into the microneedle mold set, pressure is applied to the internal space of the microneedle mold set, that is, like microinjection molding technology, the formula solution is injected into the mold with the above pressure, which helps to accelerate the injection molding speed.

Step S5e: Start the vacuum device to vacuum the microneedle mold set to remove the residual gas in the microneedle mold holes in the internal space of the microneedle mold set. Generally speaking, when the viscosity of the microneedle formula solution is high, the fluidity of the solution is poor, and it is difficult to completely fill the microneedle mold holes, and gas often remains in the microneedle mold holes. Therefore, the manufacturing method disclosed herein uses a vacuum device to vacuum the microneedle mold set that has been filled, so that the gas remaining in the microneedle mold holes can be removed.

Step S5f: After the microneedle patch formula solution is solidified, demolding is performed, and the microneedle patch is obtained after completion.

The above-mentioned vacuuming and injection steps can also be performed by vacuuming first, and then starting the injection step after the residual gas in the internal space of the microneedle mold assembly is exhausted. This can also avoid the generation of residual gas in the microneedle mold hole during infusion. It should be noted that the above-mentioned vacuuming or injection steps are performed separately, and the vacuum pipeline and the injection pipeline each have an airtight valve. When the vacuuming step is performed, the vacuum pipeline valve is opened first and the injection pipeline valve is closed before vacuuming. After the vacuuming is completed, the vacuum pipeline valve is closed and the injection pipeline valve is opened to start the injection step; vice versa. Furthermore, those skilled in the art should understand that the valve may also be disposed in a two-way connector. As long as the exhaust line and the injection line are kept in an airtight state and do not interfere with each other, the same effect can be achieved. This does not limit the scope of the invention.

Of course, this embodiment is only used for illustration and is not intended to limit the scope of the present disclosure. Equivalent modifications or changes made to the method for manufacturing the microneedle patch of this embodiment should still be included in the patent scope of the present disclosure.

It is worth mentioning that most of the existing methods for manufacturing microneedle patches use a centrifugal method for molding. In addition to the relatively time-consuming centrifugal process involved in the process, its operation requires more experienced personnel to perform. Therefore, the microneedle patch manufacturing method according to the embodiment of the present disclosure has obvious advantages in terms of production efficiency, process simplification, and production cost.

Furthermore, the present disclosure can be combined with the inventor's previous modeling technology and 3D printing casting technology. The microneedle patch produced in one embodiment can be customized in a variety of ways to produce microneedle patches that respond to various skin surface structural characteristics according to the customer's skin model or usage requirements, making it more flexible for mass production.

Although the steps of the methods described in the present disclosure are shown and described in a specific order, the order of operation of each method can be changed, and some steps can be performed in the opposite order, or some steps can be performed simultaneously with other steps. In another embodiment, different steps can be implemented in an intermittent and/or alternating manner.

In summary, the present disclosure combines skin modeling technology and 3D printing casting technology to produce a microneedle mold set that can be used in a microinjection molding manufacturing method, and further utilizes microinjection molding technology to produce a microneedle patch. Compared with the existing method for manufacturing a microneedle patch, the present disclosure can significantly and effectively shorten the time for producing a microneedle patch. Furthermore, when microinjection molding is performed by applying pressure using an injection device, the design of the gutter and flow channel on the microneedle template allows the microneedle formula solution to flow more effectively into the microneedle mold hole, and then combined with the exhaust step after the injection is completed, the residual gas in the microneedle mold hole can be discharged, thereby improving the integrity and yield of the microneedle. The microneedle mold set according to the embodiment of the present disclosure and the method for manufacturing a microneedle patch using the same have obvious advantages in terms of production efficiency and process simplification.

It can be seen that the present disclosure has indeed achieved the desired improved effect by breaking through the previous technology, and it is not easy for people familiar with the technology to think of. Its progress and practicality obviously meet the patent application requirements. Therefore, a patent application is filed in accordance with the law. I sincerely request that your office approve this invention patent application to encourage creativity. I am truly grateful for your kindness.

The above description is for illustrative purposes only and is not intended to be limiting. Any other equivalent modifications or changes that do not depart from the spirit and scope of this disclosure should be included in the scope of the attached patent application.

10: Microneedle mold set 100: Pressure-maintaining cover 101: Inner space of pressure-maintaining cover 1011: Top surface 1012: Channel 1013: Downward opening 1014: Side surface of inner space 102: External surface of pressure-maintaining cover 103: Two-way connector 200: Microneedle template 201: Upper surface of microneedle template 2011: Microneedle mold hole 2012: S-type flow channel 2013: Gutter 2014: H-type flow channel 202: Side surface of microneedle template 203: Lower surface of microneedle template 300: Rubber gasket 400: Pressure-maintaining cover 500: Locking device S5a~S5f: Step flow

Figure 1 is a structural diagram of a microneedle mold set according to an embodiment of the present disclosure. Figure 2A is a structural diagram of a pressure-retaining cover of a microneedle mold set according to an embodiment of the present disclosure. Figure 2B is a structural diagram of the internal space of the pressure-retaining cover of a microneedle mold set according to an embodiment of the present disclosure. Figures 3A to 3C are schematic diagrams of a microneedle template structure according to an embodiment of the present disclosure. Figure 4A is a first schematic diagram of the shape of a microneedle mold hole according to an embodiment of the present disclosure. Figure 4B is a second schematic diagram of the shape of a microneedle mold hole according to an embodiment of the present disclosure. Figure 4C is a third schematic diagram of the shape of a microneedle mold hole according to an embodiment of the present disclosure. Figure 5 is a flow chart of a method for manufacturing a microneedle patch according to an embodiment of the present disclosure.

10: Microneedle mold set

100: Pressure-maintaining cover

101: Inner space of the pressure-retaining cover

102: External surface of the pressure-retaining cover

103: Two-way connector

200: Microneedle template

300: Rubber gasket

400: Pressure-maintaining lower cover

500: Locking device

Claims (9)

A microneedle mold assembly comprises at least: A pressure-maintaining cover having an inner space and an outer surface, wherein the inner space has a top surface, a side surface and a downward opening; a two-way connector disposed on the outer surface of the pressure-maintaining cover; a channel penetrating the pressure-maintaining cover from the top surface to connect the inner space with the two-way connector on the outer surface; A microneedle template having an upper surface, a lower surface and a side surface; wherein the upper surface has a plurality of microneedle mold holes, each of which has a spout, and each of the spouts is connected by a flow channel, and the flow channel and the spout are used to guide a solution into the microneedle mold hole; A rubber gasket sleeved on the side surface of the microneedle template; A pressure-maintaining lower cover; and A locking device for tightly locking the pressure-maintaining upper cover and the pressure-maintaining lower cover of the assembled microneedle mold set; When assembling the microneedle mold assembly, the microneedle template is sleeved with the rubber gasket, and then the inner space of the pressure-retaining upper cover is covered and accommodated, so that the upper surface of the microneedle template is closely fitted with the top surface of the inner space, and the rubber gasket is closely fitted with the side surface of the inner space, wherein the lower surface of the microneedle template does not protrude from the downward opening of the inner space; then the downward opening of the inner space is covered with the pressure-retaining lower cover, and the pressure-retaining upper cover and the pressure-retaining lower cover are locked to each other by a locking device, so that the two are closely fitted. As in the microneedle mold set of claim 1, the shape of each microneedle mold hole is any one of an inverted cone, an inverted triangular pyramid, and an inverted quadrangular pyramid, or a combination thereof. A microneedle mold set as claimed in claim 2, wherein the diameter or side length of each microneedle mold hole opening is no greater than 1 mm. A microneedle mold set as claimed in claim 1, wherein the depth of each microneedle mold hole is the same depth or different depths. As in the microneedle mold set of claim 4, wherein the depth of each microneedle mold hole is no more than 2 mm. A microneedle mold set as claimed in claim 1, wherein the spacing between each microneedle mold hole is the same spacing or different spacing. A microneedle mold set as claimed in claim 1, wherein the flow channel is any one of an H-type flow channel and an S-type flow channel or a combination thereof. A microneedle mold set as claimed in claim 1, wherein the flow channel cross-section is rectangular, arc-shaped, circular or trapezoidal. A method for manufacturing a microneedle patch comprises at least the following steps: Providing a microneedle mold set as described in any one of claims 1-8; Connecting an injection device to one opening of the two-way connector of the microneedle mold set with an injection pipeline; Connecting an exhaust device to the other opening of the two-way connector of the microneedle mold set with an exhaust pipeline; Starting the injection device to inject a volume of microneedle patch formula solution into the microneedle mold set at an injection flow rate, and then closing the injection device after the injection is completed; Starting the exhaust device to exhaust the microneedle mold set to discharge the residual gas in the microneedle mold hole in the internal space of the microneedle mold set; and Demolding after the microneedle patch formula solution is solidified, and a microneedle patch is obtained after completion.

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