TW200528437A - Oxazole derivatives of tetracyclines - Google Patents

Oxazole derivatives of tetracyclines Download PDF

Info

Publication number: TW200528437A
Authority: TW; Taiwan
Prior art keywords: carbon atoms; dimethylamino; substituted; trihydroxy; diketo
Prior art date: 2003-12-08

Application number

TW093137032A

Other languages

English (en)

Chinese (zh)

Inventor

Phaik-Eng Sum

David Brian How

Darrin William Hopper

Matthew Douglas Vera

Joshua James Sabatini

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-08

Filing date

2004-12-01

Publication date

2005-09-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34681543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200528437(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-12-01 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-09-01 Publication of TW200528437A publication Critical patent/TW200528437A/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

TW093137032A 2003-12-08 2004-12-01 Oxazole derivatives of tetracyclines TW200528437A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52792803P	2003-12-08	2003-12-08
US58482304P	2004-07-01	2004-07-01

Publications (1)

Publication Number	Publication Date
TW200528437A true TW200528437A (en)	2005-09-01

Family

ID=34681543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW093137032A TW200528437A (en)	2003-12-08	2004-12-01	Oxazole derivatives of tetracyclines

Country Status (25)

Country	Link
US (3)	US7176225B2 (es)
EP (2)	EP2157085B1 (es)
JP (1)	JP4848287B2 (es)
KR (1)	KR101164262B1 (es)
CN (1)	CN100545151C (es)
AR (1)	AR047274A1 (es)
AT (2)	ATE525365T1 (es)
AU (1)	AU2004297243B2 (es)
BR (1)	BRPI0417421A (es)
CA (1)	CA2546895A1 (es)
CO (1)	CO5700818A2 (es)
CR (1)	CR8437A (es)
DE (1)	DE602004023417D1 (es)
EC (1)	ECSP066605A (es)
ES (2)	ES2331574T3 (es)
IL (2)	IL176162A (es)
MY (1)	MY146098A (es)
NO (1)	NO20062629L (es)
PA (1)	PA8619601A1 (es)
PE (1)	PE20050995A1 (es)
RU (1)	RU2415844C2 (es)
SG (1)	SG148216A1 (es)
TW (1)	TW200528437A (es)
UA (2)	UA83266C2 (es)
WO (1)	WO2005056538A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1753713T (pt)	2004-05-21	2016-11-08	Harvard College	Síntese de tetraciclinas e seus análogos
EP2301912A3 (en)	2004-10-25	2012-07-11	Paratek Pharmaceuticals, Inc.	4-aminotetracyclines and methods of use thereof
AR057032A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Tigeciclina y metodos de preparacion
AR057324A1 (es) *	2005-05-27	2007-11-28	Wyeth Corp	Tigeciclina y metodos para preparar 9-aminominociclina
AR057033A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Tigeciclina y metodos para preparar 9-nitrominociclina
WO2007014154A2 (en) *	2005-07-21	2007-02-01	Paratek Pharmaceuticals, Inc.	10-substituted tetracyclines and methods of use thereof
CA2648668C (en)	2006-04-07	2015-06-23	The President And Fellows Of Harvard College	Synthesis of tetracyclines and analogues thereof
EP2479169B1 (en)	2006-10-11	2014-12-03	President and Fellows of Harvard College	Synthesis of Enone Intermediate
US8440646B1 (en)	2006-10-11	2013-05-14	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for treatment of Bacillus anthracis infections
US8121767B2 (en) *	2007-11-02	2012-02-21	GM Global Technology Operations LLC	Predicted and immediate output torque control architecture for a hybrid powertrain system
CN101861300B (zh) *	2007-11-14	2014-07-09	桑多斯股份公司	盐酸替吉环素的晶型
WO2010006292A1 (en) *	2008-07-11	2010-01-14	Neumedics	Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits
SI2376433T1 (sl)	2008-12-18	2015-03-31	Sandoz Ag	Kristalna oblika C tigeciklin dihidroklorida in postopki za njeno pripravo
US9073829B2 (en)	2009-04-30	2015-07-07	President And Fellows Of Harvard College	Synthesis of tetracyclines and intermediates thereto

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US26253A (en) *		1859-11-29		Vegetable-cutter
US2482055A (en)	1948-02-11	1949-09-13	American Cyanamid Co	Aureomycin and preparation of same
US3007965A (en)	1959-02-13	1961-11-07	American Cyanamid Co	New tetracyclines produced by streptomyces aureofaciens
US3043875A (en)	1959-10-22	1962-07-10	Pfizer & Co C	Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (es)	1960-05-23	1966-05-25
US3338963A (en)	1960-10-28	1967-08-29	American Cyanamid Co	Tetracycline compounds
US3148212A (en)	1961-12-22	1964-09-08	American Cyanamid Co	Reductive alkylation process
US3360557A (en)	1963-05-10	1967-12-26	American Cyanamid Co	9-hydroxytetracyclines and a process of preparing same
USRE26253E (en)	1963-05-17	1967-08-15		And z-alkylamino-g-deoxytetracycline
US3341585A (en)	1966-05-06	1967-09-12	American Cyanamid Co	Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3360561A (en)	1967-06-19	1967-12-26	American Cyanamid Co	Nitration of tetracyclines
US3518306A (en)	1968-02-19	1970-06-30	American Cyanamid Co	7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US4806529A (en)	1982-11-18	1989-02-21	Trustees Of Tufts College, Tufts University	Tetracycline activity enhancement
US5494903A (en)	1991-10-04	1996-02-27	American Cyanamid Company	7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DK0536515T3 (da) *	1991-10-04	2002-04-08	American Cyanamid Co	Nye 7-substitueret-9-substitueret amino-6-demethyl-6-deoxytetracycliner
US5328902A (en) *	1992-08-13	1994-07-12	American Cyanamid Co.	7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
CZ2002460A3 (cs) *	1999-08-10	2002-06-12	Smithkline Beecham Corporation	1,4-Substituované 4,4-diarylcyklohexany
EP2332550A1 (en) *	2001-07-13	2011-06-15	Paratek Pharmaceuticals, Inc.	Tetracyclines for the treatment of neurodegenerative diseases

2004
- 2004-07-12 UA UAA200606344A patent/UA83266C2/ru unknown
- 2004-10-30 UA UAA200606646A patent/UA83268C2/ru unknown
- 2004-12-01 TW TW093137032A patent/TW200528437A/zh unknown
- 2004-12-07 CN CNB2004800364939A patent/CN100545151C/zh not_active Expired - Fee Related
- 2004-12-07 MY MYPI20045049A patent/MY146098A/en unknown
- 2004-12-07 ES ES04813199T patent/ES2331574T3/es not_active Expired - Lifetime
- 2004-12-07 WO PCT/US2004/040850 patent/WO2005056538A1/en active Application Filing
- 2004-12-07 AU AU2004297243A patent/AU2004297243B2/en not_active Ceased
- 2004-12-07 AT AT09010915T patent/ATE525365T1/de not_active IP Right Cessation
- 2004-12-07 BR BRPI0417421-6A patent/BRPI0417421A/pt not_active IP Right Cessation
- 2004-12-07 PE PE2004001203A patent/PE20050995A1/es not_active Application Discontinuation
- 2004-12-07 EP EP09010915A patent/EP2157085B1/en not_active Expired - Lifetime
- 2004-12-07 SG SG200809014-4A patent/SG148216A1/en unknown
- 2004-12-07 PA PA20048619601A patent/PA8619601A1/es unknown
- 2004-12-07 ES ES09010915T patent/ES2372635T3/es not_active Expired - Lifetime
- 2004-12-07 DE DE602004023417T patent/DE602004023417D1/de not_active Expired - Lifetime
- 2004-12-07 JP JP2006542866A patent/JP4848287B2/ja not_active Expired - Fee Related
- 2004-12-07 CA CA002546895A patent/CA2546895A1/en not_active Abandoned
- 2004-12-07 EP EP04813199A patent/EP1692117B1/en not_active Expired - Lifetime
- 2004-12-07 AT AT04813199T patent/ATE444290T1/de not_active IP Right Cessation
- 2004-12-07 KR KR1020067013606A patent/KR101164262B1/ko not_active Expired - Fee Related
- 2004-12-07 AR ARP040104570A patent/AR047274A1/es unknown
- 2004-12-07 RU RU2006118367/04A patent/RU2415844C2/ru not_active IP Right Cessation
- 2004-12-08 US US11/007,621 patent/US7176225B2/en not_active Expired - Fee Related
2006
- 2006-06-05 EC EC2006006605A patent/ECSP066605A/es unknown
- 2006-06-06 IL IL176162A patent/IL176162A/en not_active IP Right Cessation
- 2006-06-06 CR CR8437A patent/CR8437A/es not_active Application Discontinuation
- 2006-06-08 NO NO20062629A patent/NO20062629L/no not_active Application Discontinuation
- 2006-06-08 CO CO06055450A patent/CO5700818A2/es unknown
- 2006-12-13 US US11/638,138 patent/US7365087B2/en not_active Expired - Fee Related
2008
- 2008-03-24 US US12/053,856 patent/US20080177080A1/en not_active Abandoned
2010
- 2010-05-27 IL IL206050A patent/IL206050A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1890226A (zh)	2007-01-03
ES2331574T3 (es)	2010-01-08
PE20050995A1 (es)	2006-01-11
US20080177080A1 (en)	2008-07-24
RU2415844C2 (ru)	2011-04-10
AU2004297243B2 (en)	2011-02-17
RU2006118367A (ru)	2008-01-20
ATE525365T1 (de)	2011-10-15
ATE444290T1 (de)	2009-10-15
US7176225B2 (en)	2007-02-13
US20080064667A1 (en)	2008-03-13
SG148216A1 (en)	2008-12-31
IL206050A0 (en)	2010-11-30
KR101164262B1 (ko)	2012-07-09
WO2005056538A1 (en)	2005-06-23
AU2004297243A1 (en)	2005-06-23
CR8437A (es)	2006-10-06
IL176162A (en)	2011-09-27
BRPI0417421A (pt)	2007-03-13
EP2157085A1 (en)	2010-02-24
DE602004023417D1 (de)	2009-11-12
JP4848287B2 (ja)	2011-12-28
KR20060105047A (ko)	2006-10-09
IL206050A (en)	2013-01-31
PA8619601A1 (es)	2006-03-24
CO5700818A2 (es)	2006-11-30
JP2007515411A (ja)	2007-06-14
EP2157085B1 (en)	2011-09-21
CA2546895A1 (en)	2005-06-23
AR047274A1 (es)	2006-01-11
UA83268C2 (en)	2008-06-25
ECSP066605A (es)	2006-10-25
NO20062629L (no)	2006-09-06
MY146098A (en)	2012-06-29
CN100545151C (zh)	2009-09-30
IL176162A0 (en)	2006-10-05
US20050153944A1 (en)	2005-07-14
UA83266C2 (en)	2008-06-25
EP1692117B1 (en)	2009-09-30
US7365087B2 (en)	2008-04-29
ES2372635T3 (es)	2012-01-25
EP1692117A1 (en)	2006-08-23

Publication	Publication Date	Title
US7365087B2 (en)	2008-04-29	Oxazole derivatives of tetracyclines
KR100261528B1 (ko)	2000-07-15	신규한9-아미노-7-(치환아미노)-6-데메틸-6-데옥시테트라사이클린 및 그의 생성 방법
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